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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Interesting physical properties of the new spinel phase of Si《,3》N《,4》 and C《,3》N《,4》显示文摘 | Ouyang L Z and Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 3 | Noniso- thermal crystallization and melting behavior of poly(β- hydroxybutyrate)-poly(vinyl-acetate) blends显示文摘 | An Y X Li L X Dong L S Mo Z S Feng Z L | 1999 | J Polym Sci Part B: Polym Phys1999，37，5： | 1 |
| 4 | Nitrogen availability in disturbed,rehabilitated and mature forests of tropical China显示文摘 | MO J M BROWN S PENG S L | 2003 | Forest Ecology and Management2003，175，3： | 1 |
| 5 | Evaluation of gamma interferon release assays using Mycobacterium tuberculosis antigens for diagnosis of latent and active tuberculosis in Mycobacterium bovis BCG-vaccinated populations显示文摘 | Zhang S Shao L Mo L | 2010 | Clin Vaccine Immunol2010，17，12： | 1 |
| 6 | Theoretical prediction of the structure and properties of cubic spinel nitrides显示文摘 | Mo S D Ouyang L Z | 2002 | Journal of the American Ceramic Society2002，85，： | 1 |
| 7 | Investigation of the conductivity of asphalt concrete containing conductive fillers 显示文摘 | WU S P MO L T SHUI Z H | 2005 | Carbon2005，43，： | 1 |
| 8 | Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo显示文摘 | He L Mo I-I Hadisusilo S | 1997 | J Nutr1997，127，5： | 1 |
| 9 | Undetstanding PRRSV Infection in Porcine Lung Based on Genome-Wide Transcriptome Response Identified by Deep Sequencing显示文摘 | Xiao S Q Jia J Y Mo D L | 2010 | PLoS ONE2010，5，6： | 1 |
| 10 | Interesting physical properties of the new spinel phase of Si3 N4 and C3N4显示文摘 | MO S D OUYANG L CHING W Y | 1999 | Phys Rev Lett1999，83，24： | 1 |
| 11 | Evaluation of gamma interferon release assays using Mycobacterium tuberculosis antigens for diagnosis of latent and active tuberculosis in Mycobacterium bovis BCG-vaccinated populations 显示文摘 | Zhang S Shao L Mo L | 2010 | Clin Vaccine Immunol2010，17，12： | 1 |
| 12 | 2D and 3D meso-scale finite element models for ravelling analysis of porous asphalt concrete显示文摘 | MO L T HUURMAN M WU S P | 2008 | Finite Elements in Analysis and Design2008，，44： | 1 |
| 13 | Torsional behavior of prestressed concrete box-girder bridges with corrugated steel webs 显示文摘 | Jeng Chyuan-Hwan Mo Y L Chang Y S | 2000 | ACI Structural Journal2000，97，6： | 1 |
| 14 | Geochemical investigation of Early Cretaceous igneous rocks along an east-west traverse throughout the central Lhasa Terrane, Tibet显示文摘 | Zhu D C Mo X X Niu Y L Zhao Z D Wang L Q Liu Y S Wu F Y | 2009 | Chem Geol2009，268，34： | 1 |
| 15 | A nonstationary signal simulation model for continuous wave and pulsed doppler ultrasound显示文摘 | MO L Y L (30BBOLD R S C | 1989 | IEEE Trans Ultrason Ferroelec Freq Contr1989，36，： | 1 |
| 16 | The crosstalk between Nrf2and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice显示文摘 | Mo C Wang L Zhang J Numazawa S | 2014 | Antioxid Redox Signal2014，20，4： | 1 |
| 17 | Investigation of the conductivity of asphalt concrete containing conductive fillers显示文摘 | Wu S P Mo L T Shui Z H | 2005 | Carbon2005，43，7： | 1 |
| 18 | Effects of calcination condition on expansion property of MgO-type expansive agent used in cement-based materials 显示文摘 | Mo L W Deng M Tang M S | 2010 | Cement and Concrete Research2010，40，： | 1 |
| 19 | Seismic behavior of RC columns with various tie configurations显示文摘 | Mo Y L Wang S J | | 0，，10： | 1 |
| 20 | Antiviralgene expression in rheumatoid arthritis : role ofIKKepsilon and interferon regulatory factor 3 显示文摘 | SWEENEY S E MO L FIRESTEIN G S | 2007 | Arthritis Rheum2007，56，3： | 1 |
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