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| 1 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 2 | The Tribological Properties of the Hot-extrusion Nylon Coating in the Oil Well Environment显示文摘 | Mo Yimin Pan Yunping Wang Xiumei | 2003 | Journal of Wuhan University of Technology:Materials Science Edition2003，18，4： | 1 |
| 3 | On Nonnegative Solution of Multi-Linear System with Strong M_(z)-Tensors显示文摘A class of structured multi-linear system defined by strong M_(z)-tensors is considered.We prove that the multi-linear system with strong M_(z)-tensors always has a nonnegative solution under certain condition by the fixed point theory.We also prove that the zero solution is the only solution of the homogeneous multi-linear system for some structured tensors,such as strong M-tensors,H^(+)-tensors,strictly diagonally dominant tensors with positive diagonal elements.Numerical examples are presented to illustrate our theoretical results. | Changxin Mo Yimin Wei | 2021 | Numerical Mathematics(Theory,Methods and Applications)2021，14，1： | 0 |
| 4 | Using Autocorrelation Analysis to Build the Evaluating Model of Train Impulse Grade显示文摘To the shortage of the traditional analysis methods about train impact,this paper put forward a new method us- ing autocorrelation theory and virtual instrument technology to analyze train impulse Using a double-MCU system,the accelera- tion signals were acquired at different speed by train,and were transmitted into PC through USB interface.Besides the impulse signals,the acquisition data included other useless signals.The autocorrelation function was small when trains run steadily,but was greater during train impact happened.So the autocorrelation function was adopted to distill the valid impulse data.After frequency domain analyzed and autocorrelation analyzed on the Virtual Instrument flat,a new train impulse grade assessment cri- terion was built,based on the correlation peak and the width of the peak.In experiment,the impulse signal was separated from noise signal well and truly,and the quantitative model of evaluating train impulse was believable.This system possessed a certain extent theory value and application value. | LIU Chuanbo MO Yimin (School of Mechanical and Electronic Engineering,Wuhan University of Technology,Wnhan 430070 ,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 5 | The Development of Intelligent Detector for Train Longitudinal Impact显示文摘This paper introduces a new kind of train impact detecting system that detect the train impact through detecting the train running acceleration,proposes that uniting the train running acceleration and the change rate of acceleration to token the train impact. The detector takes the portable computer as platform of data processing,utilizes the database technology to process data,making instrument Pc true,and improving the data processing ability of the instrument. The detector can show the train running acceleration on-line and real-timely,indicating the train impact situation directly,and uses the method that the software and hardware unifies to strengthen the system anti-jamming ability. At present,this detector has been tryout in some locomotive depots,each design function and the performance index conforms to request of the scene; the anti-jamming ability is strong,the monitor precision is reasonable,the detector can carry out the on-line examination to the train impact and monitoring the train running condition. | TIAN E,MO Yimin,NIU Wei (Department of Mechanical and Electrical Engineering,Wuhan University of Technology, Wuhan 430070,China) | 2006 | 武汉理工大学学报2006，28，S1： | 0 |
| 6 | Design and Realization of Numerical Control Ladder Diagram Edition Software显示文摘The thesis is directed by the idea of oriented-object. Considering the basic functions that NC system Ladder Diagram editor should provide,and through theoretical research and practice,the thesis developed a set of NC system Ladder Diagram editor which can form a Ladder Diagram editor based on vector plotting,intelligently compiling,simulation. This system uses the ladder diagram symbol to express operational order and use the chart symbol series-parallel connection and the position order to express the logical relations between the operational orders,divide the ladder diagram into four parts: the stave,the line,the row and the part,uses the standard order vessel list vessel of the standard template stack (STL) to save the data which involved in the design process. This system can write PLC program by ladder diagram language and is easy to use. The compilation and simulation for PLC diagram have been achieved. It greatly improves the work-efficiency. | ZHAO Haixin,MO Yimin,PAN Yunping (School of Mechanical and Electronical Engineering,Wuhan University of Technology, Wuhan 430070,China) | 2006 | 武汉理工大学学报2006，28，S1： | 0 |
| 7 | COVID-19 mortality in ICUs associated with critical care staffing显示文摘To the Editor Coronavirus disease 2019(COVID-19)has been around for over a year since December 2019,and the global outlook is not optimistic.Because of its high transmissibility and high mortality,management of the COVID-19 pandemic has become a major challenge for health systems globally,especially for critical care. | Jingjing Xi Lin Zeng Shusheng Li Yuhang Ai Xiandi He Yan Kang Yimin Li Yanping Mo Yue Peng Kejian Qian Bingyu Qin Chunting Wang Jing Yan Fachun Zhou Hua Zhang Penglin Ma | 2021 | Burns & Trauma2021，9，1： | 0 |
| 8 | Intense Photoluminescence and Movement of Optical Absorption Edge in Alumina Aerogels显示文摘Alumina aerogels with high porosity of nanometer size were prepared from Al, n-butanol and ethyl acetoacetate by the sol-gel route and the N2 supercritical extraction drying technique. Optical experiment results showed that for alumina aerogels after annealing at 500℃ for 4 h one intense blue emission band appeared in the wavelength range of 400 to 800 nm, and the optical absorption edge moved from 8.0 eV of coarse grain Al2O3 to 3-5 eV and with increasing the annealing temperature, this luminescence band presented blue shifts. The reasons of these new optical properties are discussed in detail. | Xianting SUN, Lianzeng YAO, Chimei MO, Gang SHI, Weili CAI and Yimin ZHANG (Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, China) Lide ZHANG (Institute of Solid State Physics, Chinese Academy | 2000 | Journal of Materials Science & Technology2000，16，3： | 0 |
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