|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical application of a new device for minimally invasive circumcision显示文摘瞄准:与 phimosis 或过量包皮在不同年龄的男病人的治疗学习一台可处理的割礼设备的临床的效果。方法:在 5 和 95 年的年龄之间的 1200 个病人在在 2005 年 10 月和 2007 年 9 月之间的 2 年的时期用这个过程经历了割礼。这些盒子, 904 有过量包皮, 296 是 phimosis 的盒子。结果:在 96.33% 盒子中,切口愈合了,离开没有使好化妆结果留下疤痕并且生产的内部包皮的最小的数量。没有到系带的设备脱臼或损坏的事件。平均起作用的时间为 phimosis 是为过量包皮,和 3.5 min 的 2.5 min。在穿设备的 7 天期间,对中等浮肿温和与 phimosis 与过量包皮并且在那些的 2.58 % 发生在盒子的 10.08 % 。在系带的浮肿在 1.67% 病人被看见,并且仅仅, 0.67% 有切口的感染。86.25% 病人的一个总数由于阴茎勃起报导了疼痛。在设备的移动以后, 0.58% 案例有在切口附近的最小的流血,并且 2.42% 弯屈裂开。结论:新设备能与 phimosis 和过量包皮被用于病人的一个压到优势的多数。这种技术相对简单表现,并且经历了这个手术的病人有很少的复杂并发症。抗菌素没比用常规方法被割除的那些被要求,病人们报导了更少的疼痛。有这台设备的割礼要求最小的组织操作,并且比用常规技术的割礼更快、安全。 | Yi-Feng Peng Yue Cheng Guo-Yao Wang Suo-Qun Wang Chao Jia Ben-Hai Yang Ru Zhu Shu-Chuan Jian Qing-Wen Li Da-Wei Geng | 2008 | Asian Journal of Andrology2008，10，3： | 105 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Improving Yield and Nitrogen Use Efficiency Simultaneously for Maize and Wheat in China: A Review显示文摘同时完成两高收益和高氮使用效率(NUE ) 与对食物,自然资源的弄空,和环境的恶化的增加的全球需求成为了主要挑战。作为在世界上的 N 化肥的最伟大的消费者,中国农民滥用了 N,并且因为 N 举起收益关系的有限理解,在庄稼 N 需求和 N 供应之间有差的 synchrony。处理这个问题,这研究为二个学生的不同收益范围评估了全部、动态的 N 要求庄稼(玉米和小麦) ,和到 N 管理策略的建议改进。整个植物的 N 未葬举起要求每谷物产量(N req ) 开始与谷物收益改进死亡了然后停滞,并且然而,大多数农民仍然相信更多的化肥和更高的谷物产量是同义的。当玉米产量增加了从时 < 7.5 到 > 12.0 Mg 哈 −1, N req 从 19.8 ~ 17.0 kg Mg −1 谷物减少了。为小麦,它为谷物产量从 27.1 kg Mg −1 谷物减少了 < 4.5 Mg 哈 −1 到为产量的 22.7 kg Mg −1 谷物 > 9.0 Mg 哈 −1 。同时,干燥物质的百分比和在中间迟了的成长季节的 N 累积与谷物产量显著地增加了,它显示 N 授精应该在中间迟了的阶段被集中当农民们经常在播种前或在早生长阶段期间使用了 N 化肥的多数时,匹配庄稼需求。我们因此开发了同时增加谷物产量和 NUE 的综合土壤庄稼系统管理策略。 | MENG Qingfeng YUE Shanchao HOU Peng CUI Zhenling CHEN Xinping | 2016 | Pedosphere2016，26，2： | 51 |
| 4 | Research progress on the etiology and pathogenesis of adolescent idiopathic scoliosis显示文摘Etiology of adolescent idiopathic scoliosis(AIS),a complicated three-dimensional spinal deformity with early-onset,receives continuous attention but remains unclear.To gain an insight into AIS pathogenesis,this review searched PubMed database up to June 2019,using key words or medical subject headings terms including'adolescent idiopathic scoliosis,''scoliosis,''pathogenesis,''etiology,''genetics,''mesenchymal stem cells,'and their combinations,summarized existing literatures and categorized the theories or hypothesis into nine aspects.These aspects include bone marrow mesenchymal stem cell studies,genetic studies,tissue analysis,spine biomechanics measurements,neurologic analysis,hormone studies,biochemical analysis,environmental factor analysis,and lifestyle explorations.These categories could be a guidance for further etiology or treatment researches to gain inspiration. | Yue Peng Sheng-Ru Wang Gui-Xing Qiu Jian-Guo Zhang Qian-Yu Zhuang | 2020 | Chinese Medical Journal2020，，4： | 45 |
| 5 | Kaili Biota: A Taphonomic Window on Diversification of Metazoans from the Basal Middle Cambrian: Guizhou, China显示文摘A Burgess Shale-type biota is, in part, characterized by a wide diversity of taxa and soft-part preservation. Each provides unique historical insights into early metazoan evolution. Among the more than 40 globally distributed biotas, the early Cambrian Chengjiang and Middle Cambrian Burgess-type biotas are the largest. The Kaili Biota, from the earliest Middle Cambrian of Guizhou, China, contains representatives of 110 metazoan genera belonging to 10 phyla. It contains many well-persevered soft-bodied specimens. This Chinese biota has become the third most taxonomically diverse Burgess Shale-type fauna. Because the Kaili Biota formed in an outer-shelf environment, its main faunal character is large numbers of eocrinoids and planktoic trilobites. The Kaili is younger than the Chengjiang Biota but older than the Canadian Burgess Shale Biota; it shares 30 genera with the Chengjiang and 38 genera with the Burgess Biota. The Kaili Biota displays a taphonomic window to the diversification and evolution of marine offshore organisms covering 5.13 million years between the Early and Middle Cambrian. | ZHAO Yuanlong ZHU Maoyan Loren E. BABCOCK YUAN Jinliang Ronald L. PARSLEY PENG Jin YANG Xinglian WANG Yue | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 32 |
| 6 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 7 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China显示文摘Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March 2008.The EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral therapeutics.Here we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Åresolution.The structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus RdRp.And the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue binding.The model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the polymerase.These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. | Yang Wu Zhiyong Lou Yi Miao Yue Yu Hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe Rao | 2010 | Protein & Cell2010，1，5： | 30 |
| 8 | Principles and construction of MSD adder in ternary optical computer显示文摘The two remarkable features of ternary values and a massive unit with thousands bits of parallel computation will make the ternary optical computer (TOC) with modified signed-digit (MSD) adder more powerful and e?cient than ever before for numerical calculations. Based on the decrease-radix design presented previously, a TOC can satisfy either a user requiring huge capacity for data calculations or one with a moderate amount of data, if it is equipped with a prepared adder. Furthermore, with the application of pipelined operations and the proposed data editing technique, the e?ciency of the prepared adder can be greatly improved, so that each calculated result can be obtained almost within one clock cycle. It is hopeful that by employing a MSD adder, users will be able to enter a new dimension with the creation of a new multiplier, new divider, as well as new matrix operator in a TOC in the near future. | JIN Yi SHEN YunFu PENG JunJie XU ShiYi DING GuangTai YUE DongJian YOU HaiHang | 2010 | Science China(Information Sciences)2010，53，11： | 26 |
| 9 | Networked Control Systems:A Survey of Trends and Techniques显示文摘Networked control systems are spatially distributed systems in which the communication between sensors, actuators,and controllers occurs through a shared band-limited digital communication network. Several advantages of the network architectures include reduced system wiring, plug and play devices,increased system agility, and ease of system diagnosis and maintenance. Consequently, networked control is the current trend for industrial automation and has ever-increasing applications in a wide range of areas, such as smart grids, manufacturing systems,process control, automobiles, automated highway systems, and unmanned aerial vehicles. The modelling, analysis, and control of networked control systems have received considerable attention in the last two decades. The ‘control over networks’ is one of the key research directions for networked control systems. This paper aims at presenting a survey of trends and techniques in networked control systems from the perspective of ‘control over networks’, providing a snapshot of five control issues: sampled-data control, quantization control, networked control, event-triggered control, and security control. Some challenging issues are suggested to direct the future research. | Xian-Ming Zhang Qing-Long Han Xiaohua Ge Derui Ding Lei Ding Dong Yue Chen Peng | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 25 |
| 10 | The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer显示文摘Background:N6-methyladenosine(m6A)RNA modification has been demonstrated to be a significant regulatory process in the progression of various tumors,including breast cancer.Fat mass and obesity-associated(FTO)enzyme,initially known as the obesity-related protein,is the first identified m6A demethylase.However,the relationship between FTO and breast cancer remains controversial.In this study,we aimed to elucidate the role and clinical significance of FTO in breast cancer and to explore the underlying mechanism.Methods:We first investigated the expression of FTO in breast cancer cell lines and tissues by quantitative reverse transcription-PCR(qRT-PCR),Western blotting,and immunohistochemistry.Wound healing assay and Transwell assay were performed to determine the migration and invasion abilities of SKBR3 and MDAMB453 cells with either knockdown or overexpression of FTO.RNA sequencing(RNA-seq)was conducted to decipher the downstream targets of FTO.qRT-PCR,luciferase reporter assay,and Western blotting were employed to confirm the existence of the FTO/miR-181b-3p/ARL5B axis.The biological function of ADP ribosylation factor like GTPase 5B(ARL5B)in breast cancer cells was evaluated by wound healing assay and Transwell invasion assay.Results:High FTO expression was observed in human epidermal growth factor receptor 2(HER2)-positive breast cancer,predicting advanced progression(tumor size[P<0.001],nuclear grade[P=0.001],peritumoral lymphovascular invasion[P<0.001),lymph node metastasis[P=0.002],and TNM stage[P=0.001])and poor prognosis.Moreover,FTO promoted cell invasion and migration in vitro.Mechanistically,RNA-seq and further confirmation studies suggested that FTO up-regulated ARL5B by inhibiting miR-181b-3p.We further verified that ARL5B also displayed carcinogenic activity in breast cancer cells.Conclusion:Our work demonstrated the carcinogenic activity of FTO in promoting the invasion and migration of breast cancer cells via the FTO/miR-181b-3p/ARL5B signaling pathway. | Yuanyuan Xu Shuang Ye Nan Zhang Shuhui Zheng Huatao Liu Kewen Zhou Ling Wang Yue Cao Peng Sun Tinghuai Wang | 2020 | Cancer Communications2020，40，10： | 24 |
| 11 | Ti-based composite coatings with gradient TiC_x reinforcements on TC4 titanium alloy prepared by laser cladding显示文摘TiCx-NiTi2/Ti cermet composite coatings C1 and C2 with gradient TiCx reinforcements were prepared on TC4 titanium alloy by laser cladding method.The microstructure and phase compositions were analyzed by means of scanning electron microscopy(SEM),energy-dispersive spectroscopy(EDS)and X-ray diffraction(XRD)meter.The TiCx exhibited a dendritic microstructure,and homogeneously dispersed in the Ti-based matrix where NiTi2 was embedded.With increasing ingredient supercooling,temperature gradient and cooling temperature,the dendrites displayed a finer morphology with longer primary trunks and intensified side branches in the dilution zone.But the smoothed,coarse columnar ones became dominant in the upper clad layer due to the repeated energy input during multi-track cladding.The Vickers microhardness presented a linear change trend through the cross-sections,which well confirmed the gradient distribution of TiCx.With more TiCx,C1 presented higher hardness than C2. | LIU ShuNv LIU ZongDe WANG Yang YUE Peng | 2014 | Science China(Technological Sciences)2014，57，7： | 20 |
| 12 | Introgression of qPE9-1 allele,conferring the panicle erectness,leads to the decrease of grain yield per plant in japonica rice(Oryza sativa L.)显示文摘圆锥花序建筑学是仔细与产量有关形成。qPE9-1 基因被证明了广泛地在产量很高的米饭栽培变种开发被过去常,授与在装饰用的梨树米饭的直立的圆锥花序特性。最近, qPE9-1 成功地被克隆;然而,谷物产量上的基因效果还每直立的圆锥花序等位基因 qPE9-1 的植物是争论的。在现在的学习,低垂的圆锥花序父母 Nongken 57,带 qpe9-1 等位基因,被用作周期性父母到连续地回交到从双 haploid (DH ) 的一根典型直立的圆锥花序线人口(Wuyunjing 8/Nongken 57 ) ,它以前被显示带 qPE9-1 等位基因。因此,一双 near-isogenic 线(无) 被开发。在无之间的农学的特点的比较证明当 qpe9-1 被 qPE9-1 代替时,圆锥花序建筑学从低垂树立被改变;而且,圆锥花序长度,植物高度, 1000 谷物重量和 tillers 显著地被减少,因而在 30% 每植物导致谷物产量的戏剧的减少。因此,我们断定 qPE9-1 是控制圆锥花序建筑学的一个主要因素,并且 qPE9-1 有多种的自然,与每植物的谷物产量上的否定效果。这结果强烈建议直立的圆锥花序等位基因 qPE9-1 应该在产量很高的繁殖实践和另外的有利基因被使用。另外,吃并且煮质量上的 qPE9-1 的效果也在现在的学习被讨论。 | Xiuhua Yi Zujian Zhang Shengyuan Zeng Chunyan Tian Juncheng Peng Min Li Yue Lu Qingcai Meng Minghong Gu Changjie Yan | 2011 | Journal of Genetics and Genomics2011，38，5： | 20 |
| 13 | Higher CO_2-insufflation pressure inhibits the expression of adhesion molecules and the invasion potential of colon cancer cells显示文摘AIM:To investigate the influence of CO2-insufflation pressure on adhesion,invasion and metastatic potential of colon cancer cells based on adhesion molecules expression.METHODS:With an in vitro artificial pneumoperitoneum model,SW1116 human colon carcinoma cells were exposed to CO2-insufflation in 5 different pressure groups:6 mmHg,9 mmHg,12 mmHg,15 mmHg and control group,respectively for 1 h.Expression of E-cadherin,ICAM-1,CD44 and E-selectin was measured at 0,12,24,48 and 72 h after CO2-insufflation using flow cytometry.The adhesion and invasion capacity of SW1116 cells before and after exposure to CO2-insufflation was detected by cell adhesion/invasion assay in vitro.Each group of cells was injected intraperitoneally into 16 BALB/C mice.The number of visible abdominal cavity tumor nodules,visceral metastases and survival of the mice were recorded in each group.RESULTS:The expression of E-cadherin,ICAM-1,CD44 and E-selectin in SW1116 cells were changed significantly following exposure to CO2 insufflation at different pressures(P<0.05).The expression of E-cadherin,CD44 and ICAM-1 decreased with increasing CO2-insufflation pressure.The adhesive/invasive cells also decreased gradually with increasing pressure as determined by the adhesion/invasion assay.In animal experiments,the number of abdominal cavity tumor nodules in the 15 mmHg group was also signif icantly lower than that in the 6 mmHg group(29.7±9.91 vs 41.7±14.90,P=0.046).However,the survival in each group was not statistically different.CONCLUSION:CO2-insufflation induced a temporary change in the adhesion and invasion capacity of cancer cells in vitro.Higher CO2-insufflation pressure inhibited adhesion,invasion and metastatic potential in vitro and in vivo,which was associated with reduced expression of adhesion molecules. | Jun-Jun Ma Bo Feng Yi Zhang Jian-Wen Li Ai-Guo Lu Ming-Liang Wang Yuan-Fei Peng Wei-Guo Hu Fei Yue Min-Hua Zheng | 2009 | World Journal of Gastroenterology2009，15，22： | 16 |
| 14 | Direct evidence of transformation from smectite to palygorskite:TEM investigation显示文摘Palygorskite clays sampled from palygorskite clay deposits in Jiangsu and Anhui provinces were investigated by transmission electron microscopy (TEM). Many intergrowth phenomena of special ultra-microstructure between smectite and palygorskite were found. The ultra-microstructure indicates that palygorsite fiberrous crystals grow along (001) of primary smectite through structural transformation and decomposition of the primary smectite. According to field investigation and X-ray diffraction (XRD) analyses, the transformation mechanism and process can be described as: formation of smectite from basalt weathering deposited in localiza- tion basin; evaporation of lake water in aridity environment causing pH increase and concentra- tion of magnesium ion in interstice water of sediment smectite in the lake basin. Under alkaline conditions, magnesium ion occupied interlayer positions of the smectite. Because of the misfit between magnesium octahedral sheet and smectite layer, magnesium ion interaction with smec- tite layers caused the smectite to transform into palygorskite, and resulted in the formation of smectite and palygorskite complex particulates, and even smaller secondary smectite crystal plates. The transformation of smectite structure resulted in the formation of nanometer minerals with large specific surface area and excellent property of physics and chemistry in smec- tite-palygorskite mixing clay. The results from TEM investigation are important for understanding properties of palygorskite clay and application. | CHEN Tianhu1,,XU Huifang2,LU Anhuai3,XU Xiaochun1,PENG Shuchuan1 2 &YUE Shucang1 1.College of Resources and Environmental Engineering,Hefei University of Technology,Hefei 230009,China 2.Department of Geology and Geophysics,University of Wisconsin,Madison,WI53706,USA 3.Department of Geology,Peking University,Beijing 100871,China Correspondence should be addressed to Chen Tianhu(email: tianhu@mail.hf.ah.cn or cth168@hotmail.com) | 2004 | Science China Earth Sciences2004，47，11： | 16 |
| 15 | Cold-Induced CBF–PIF3 Interaction Enhances Freezing Tolerance by Stabilizing the phyB Thermosensor in Arabidopsis显示文摘Growth inhibition and cold-acclimation strategies help plants withstand cold stress,which adversely affects growth and survival.PHYTOCHROME B(phyB)regulates plant growth through perceiving both light and ambient temperature signals.However,the mechanism by which phyB mediates the plant response to cold stress remains elusive.Here,we show that the key transcription factors mediating cold acclimation,C-REPEAT BINDING FACTORs(CBFs),interact with PHYTOCHROME-INTERACTING FACTOR 3(PIF3)under cold stress,thus attenuating the mutually assured destruction of PIF3–phyB.Cold-stabilized phyB acts downstream of CBFs to positively regulate freezing tolerance by modulating the expression of stress-responsive and growth-related genes.Consistent with this,phyB mutants exhibited a freezing-sensitive phenotype,whereas phyB-overexpression transgenic plants displayed enhanced freezing tolerance.Further analysis showed that the PIF1,PIF4,and PIF5 proteins,all of which negatively regulate plant freezing tolerance,were destabilized by cold stress in a phytochrome-dependent manner.Collectively,our study reveals that CBFs–PIF3–phyB serves as an important regulatory module for modulating plant response to cold stress. | Bochen Jiang Yiting Shi Yue Peng Yuxin Jia Yan Yan Xiaojing Dong Hui Li Jie Dong Jigang Li Zhizhong Gong Michael F.Thomashow Shuhua Yang | 2020 | Molecular Plant2020，13，6： | 13 |
| 16 | Chemical poison and regeneration of SCR catalysts for NOx removal from stationary sources显示文摘有 NH 3 的没有 x 的选择催化减小(SCR ) 是一种有效技术不把 x 从静止来源移开,例如开火煤的发电厂和工业锅炉。一些在苍蝇灰的元素撤销催化剂由于活跃地点上的强壮的化学吸着。毒物可以由简单地堵住活跃地点行动或由一个电子相互作用改变反应物和产品的吸附行为。这评论主要集中于在 V 2 O 5-based 催化剂,环境良性的催化剂和低温度催化剂。几普通毒物包括 alkali/alkaline 地球金属, 2 和重金属等等因此被提交,他们催化剂上的毒害的机制被讨论。毒害的催化剂的新生方法和毒物抵抗催化剂的发展也被比较并且分析。最后,在发展毒害抵抗催化剂的未来研究方向和为 SCR 催化剂的灵巧的有效新生方法被建议。 | Junhua LI Yue PENG Huazhen CHANG Xiang LI John C. CRITTENDEN Jiming HAO | 2016 | Frontiers of Environmental Science & Engineering2016，10，3： | 12 |
| 17 | Effect of Hot Extrusion on Interfacial Microstructure and Tensile Properties of SiC_p/2009Al Composites Fabricated at Different Hot Pressing Temperatures显示文摘The effects of hot extrusion on the interfacial microstructures and tensile properties of 15 vol.SiCp/2009Al composites fabricated at different hot pressing temperatures were investigated.After hot extrusion,the relative density of the composites increased,the SiC particle distribution became more uniform,and the SiC particles tended to align along the extrusion direction.Furthermore,the interface bonding was improved after hot extrusion;however,the extrusion exerted no obvious effect on the interfacial reaction products formed during sintering process.Tensile tests indicated that the mechanical properties of the composites were improved significantly after extrusion.Fractography revealed that the fracture mechanism of the extruded composites fabricated at the hot pressing temperatures below 540℃ was mainly the interfacial debonding.For the extruded composites fabricated at 560-600℃,the fracture was the matrix ductile fracture and the SiC particle fracture.When the composites were hot pressed at or above 620℃,after extrusion,the fracture mechanism of the composites was the matrix ductile fracture,the interface cracking and the SiC particle fracture. | Peng Jin Bolu Xiao Quanzhao Wang Zongyi Ma Yue Liu Shu Li | 2011 | Journal of Materials Science & Technology2011，27，6： | 11 |
| 18 | Optimal proportion of wind and PV capacity in provincial power systems based on bilevel optimization algorithm under low-carbon economy显示文摘In order to boost contributions of power systems to a low-carbon economy,the installed capacity of renewable power generation,such as wind and photovoltaic(PV)power generation should be well planned.A bilevel formulation is presented to optimize the proportion of wind and PV capacity in provincial power systems,in which,carbon emissions of generator units and features of renewable resources are taken into account.In the lowerlevel formulation,a time-sequence production simulation(TSPS)model that is suitable for actual power system has been adopted.In order to maximize benefits of energy conservation and emissions reduction resulting from renewable power generation,the commercial software called General Algebraic Modeling System(GAMS)is employed to optimize the annual operation of the power system.In the upper-level formulation,the optimal pattern search(OPS)algorithm is utilized to optimize the proportion of wind and PV capacity.The objective of the upper-level formulation is to maximize benefits of energy conservation and carbon emissions reductions optimized in the lowerlevel problem.Simulation results in practical provincial power systems validate the proposed model and corresponding solving algorithms.The optimization results can provide support to policy makers to make the polices related to renewable energy. | Yue YUAN Yang CAO Xinsong ZHANG Chun LIU Yuehui HUANG Peng LI Kejun QIAN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 11 |
| 19 | Commissioning progress of the FAST显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) was completed with its main structure installed on September 25, 2016, after which it entered the commissioning phase. This paper aims to introduce the commissioning progress of the FAST over the past two years. To improve its operational reliability and ensure effective observation time, FAST has been equipped with a real-time information system for the active reflector system and hierarchical commissioning scheme for the feed support system, which ultimately achieves safe operation of the two systems. For meeting the high-performance indices, a highprecision measurement system was set up based on the effective control methods that were implemented for the active reflector system and feed support system. Since the commissioning of the FAST, a low-frequency ultra-wideband receiver and 19-beam1.05-1.45 GHz receiver have been mainly used. Telescope efficiency, pointing accuracy, and system noise temperature were completely tested and ultimately achieved the acceptance indices of the telescope. The FAST has been in the process of national acceptance preparations and has begun to search for pulsars. In the future, it will still strive to improve its capabilities and expand its application prospects. | Peng Jiang YouLing Yue HengQian Gan Rui Yao Hui Li GaoFeng Pan JingHai Sun DongJun Yu HongFei Liu NingYu Tang Lei Qian JiGuang Lu Jun Yan Bo Peng ShuXin Zhang QiMing Wang Qi Li Di Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 11 |
| 20 | Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer显示文摘Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking angiogenesis.This study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast cancer.Methods:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were enrolled.Anlotinib was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity occurred.Simultaneously,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment cycles.The primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and biomarkers.Results:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)years.The median follow-up time was 10.5 months.The ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 months.The changes in the detectable ct DNA variant allele frequency were consistent with the tumor response.The most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast cancer.The dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response. | Nanlin Hu Yiran Si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan | 2021 | Cancer Biology & Medicine2021，18，3： | 11 |
您所在的机构暂未开通此部分的功能，请联系管理员