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| 1 | 颅内出血患者抗栓药逆转指南美国神经重症监护学会和美国重症医学会对医疗卫生专业人员的声明显示文摘背景抗栓药的使用,包括抗凝药、抗血小板药和溶栓药,在过去10年中日益增多并且预计将继续上升。虽然抗栓药相关性颅内出血可能是灾难性的,但快速逆转凝血功能障碍可能有助于限制血肿增大和改善转归。方法美国神经重症监护学会联合美国重症医学会组建了一个国际性多机构委员会,涉及的专业领域包括神经重症监护、神经内科、神经外科、卒中、血液学、血液病理学、急诊医学、药学、护理和指南制定,目的是进行文献评价并制定一份循证实践指南。该委员会进行了正式的文献检索,并对符合标准的研究进行了评价。结果利用GRADE方法学,委员会提出了在颅内出血情况下逆转维生素K拮抗药、直接Xa因子拮抗药、直接凝血酶抑制药、普通肝素、低分子肝素、类肝素、戊多糖、溶栓药和抗血小板药的推荐意见。结论该指南提供了及时和循证的抗栓药逆转策略以协助临床医生治疗抗栓药相关性颅内出血。 | Jennifer A. Frontera John J. Lewin Ⅲ Alejandro A. Rabinstein Imo P. Aisiku Anne W. Alexandrov Aaron M. Cook Gregory J. del Zoppo Monisha A. Kumar Ellinor I. B. Peerschke Michael F. Stiefel Jeanne S Teitelbaum Katja E. Wartenberg Cindy L. Zerfoss 杨一萍 谢丽丽 宁小金 季宇腾 柯开富 | 2016 | 国际脑血管病杂志2016，24，11： | 24 |
| 2 | Pharmacogenetic studies update in type 2 diabetes mellitus显示文摘Type 2 diabetes mellitus(T2DM) is a silent progressive polygenic metabolic disorder resulting from ineffective insulin cascading in the body. World-wide, about 415 million people are suffering from T2DM with a projected rise to 642 million in 2040. T2DM is treated with several classes of oral antidiabetic drugs(OADs) viz. biguanides, sulfonylureas, thiazolidinediones, meglitinides, etc. Treatment strategies for T2DM are to minimize long-term micro and macro vascular complications by achieving an optimized glycemic control. Genetic variations in the human genome not only disclose the risk of T2DM development but also predict the personalized response to drug therapy. Inter-individual variability in response to OADs is due to polymorphisms in genes encoding drug receptors, transporters, and metabolizing enzymes for example, genetic variants in solute carrier transporters(SLC22A1, SLC22A2, SLC22A3, SLC47A1 and SLC47A2) are actively involved in glycemic/HbA1c management of metformin. In addition, CYP gene encoding Cytochrome P450 enzymes also play a crucial role with respect to metabolism of drugs. Pharmacogenetic studies provide insights on the relationship between individual genetic variants and variable therapeutic outcomes of various OADs. Clinical utility of pharmacogenetic study is to predict the therapeutic dose of various OADs on individual basis. Pharmacogenetics therefore, is a step towards personalized medicine which will greatly improve the efficacy of diabetes treatment. | Shalini Singh Kauser Usman Monisha Banerjee | 2016 | World Journal of Diabetes2016，7，15： | 5 |
| 3 | WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus显示文摘Diabetes mellitus is a combined metabolic disorder which includes hyperglycemia,dyslipidemia,stroke and several other complications.Various groups all over the world are relentlessly working out the possible role of a vast number of genes associated with type 2 diabetes(T2DM).Inflammation is an important outcome of any kind of imbalance in the body and is therefore an indicator of several diseases,including T2DM.Various ethnic populations around the world show different levels of variations in single nucleotide polymorphisms(SNPs).The present review was undertaken to explore the association of cytokine gene polymorphisms with T2DM in populations of different ethnicities.This will lead to the understanding of the role of cytokine genes in T2DM risk and development.Association studies of genotypes of SNPs present in cytokine genes will help to identify risk haplotype(s)for disease susceptibility by developing prognostic markers and alter treatment strategies for T2DM and related complications.This will enable individuals at risk to take prior precautionary measures and avoid or delay the onset of the disease.Future challenges will be to understand the genotypic interactions between SNPs in one cytokine gene or several genes at different loci and study their association with T2DM. | Monisha Banerjee Madhukar Saxena | 2014 | World Journal of Diabetes2014，5，4： | 5 |
| 4 | Angle closure glaucoma: a mechanistic review显示文摘 | Monisha E Nongpiur Judy YF Ku Tin Aung | 2011 | Current Opinion in Ophthalmology2011，，2： | 2 |
| 5 | Bioactive compounds from marine actinomycetes显示文摘 | Renu Solanki Monisha Khanna Rup Lal | 2008 | Indian Journal of Microbiology2008，，4： | 2 |
| 6 | The macrophage Ox-LDL receptor, CD36 and its association with type II diabetes mellitus显示文摘 | Sunaina Gautam Monisha Banerjee | 2010 | Molecular Genetics and Metabolism2010，，4： | 1 |
| 7 | The role of antimicrobial peptides in animal defenses显示文摘 | Robert E Monisha G | 2000 | Proc Natl Acad Sci USA2000，97，16： | 1 |
| 8 | The human antimicrobial peptide LL-37 is a muhifunctional modulator of innate immune responses显示文摘 | Monisha GS Davidson DJ Gold MR | 2002 | Immunol2002，169，： | 1 |
| 9 | Effect of frozen storage and freeze-thaw cycles on the rheological and baking properties of frozen doughs显示文摘 | Monisha Bhattacharya | 2003 | Food Research International2003，36，： | 1 |
| 10 | Effect of frozen storage and freeze-thaw cycles on the rheological and baking properties of frozen doughs显示文摘 | MONISHA BHATTACHARYA TAMI M LANGSTAFF WILLIAM A BERZONSKY | 2003 | Food Research International2003，36，4： | 1 |
| 11 | The role of antimicrobial peptides in animal defenses显示文摘 | ROBERT E MONISHA G | 2000 | Proc Natl Acad Sci USA2000，97，16： | 1 |
| 12 | Effect of frozen storage and freeze-thaw cycles显示文摘 | Monisha Bhattacharyaa Tami M Langstaffa William A Berzonskyb | 1991 | Cereal Chemistry1991，68，： | 1 |
| 13 | Staling of bread as affected by waxy wheat flour blends显示文摘 | Monisha B Sofia V E -C Douglas C D | 2002 | Cereal Chemistry2002，79，2： | 1 |
| 14 | Numerical studies of a tube-in-tube helically coiled heat exchanger显示文摘 | VIMAL K BURHANUDDIN F MONISHA M | 2008 | Chem Eng and Processing2008，，： | 1 |
| 15 | Chronic treatment with trans resveratrol prevents intracerebroven -tricular streptozotoein indueed cognitive impairment and oxidative stress in rats显示文摘 | Monisha Sharma and YK Gupta | 2002 | Life Science2002，71，21： | 1 |
| 16 | Developing Moral Agency through Narrative显示文摘 | Pasupathi Monisha Wainryb Cecilia | 2010 | Human Development2010，，2： | 1 |
| 17 | The role of estrogen receptor and 13 in regulating vascular smooth muscle cell prolif eration is based on sex 显示文摘 | Melissa E Hogg M D Ashley K Vavra M D Monisha N Banerjee 13 S | 2011 | Journal of Surgical Re- search2011，9，21： | 1 |
| 18 | Effect of frozen storage and freeze-thaw cycles on the rheological and baking properties of frozen doughs 显示文摘 | Monisha B Tami M L William A B | 2003 | Food Research International2003，36，4： | 1 |
| 19 | Determinants of Lens Vault and Association With Narrow Angles in Patients From Singapore显示文摘 | Gavin S. Tan Mingguang He Wanting Zhao Lisandro M. Sakata Jialiang Li Monisha E. Nongpiur Raghavan Lavanya David S. Friedman Tin Aung | 2012 | American Journal of Ophthalmology2012，，1： | 1 |
| 20 | Determinants of Anterior Chamber Depth: The Singapore Chinese Eye Study显示文摘 | Chelvin C. Sng Li-Lian Foo Ching-Yu Cheng John C. Allen Mingguang He Gita Krishnaswamy Monisha E. Nongpiur David S. Friedman Tien Y. Wong Tin Aung | 2012 | Ophthalmology2012，，6： | 1 |
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