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| 1 | Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma显示文摘AIM To clarify the role of neoadjuvant concurrent chemoradiotherapy(NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma(CCA).METHODS We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows:(1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or(2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging. RESULTS The median disease-free survival(DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were26.0 and 15.1 mo, respectively(P = 0.91). The median overall survival(OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively(P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis(P = 0.01). CONCLUSION NACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability. | Jang Han Jung Hyun Jik Lee Hee Seung Lee Jung Hyun Jo In Rae Cho Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Seungmin Bang | 2017 | World Journal of Gastroenterology2017，23，18： | 21 |
| 2 | Colonoscopy evaluation after short-term anti-tuberculosis treatment in nonspecific ulcers on the ileocecal area显示文摘AIM: To evaluate the eff icacy of colonoscopy follow-up after short-term anti-tuberculosis treatment in patients with nonspecific ulcers on ileocecal areas being suspicious of tuberculous colitis. METHODS: We prospectively analyzed the colonoscopic fi ndings before and after short term anti- tuberculosis treatment in 18 patients with nonspecifi c ulcers on the ileocecal area and compared them with 7 patients of confi rmed tuberculous colitis by acid-fast bacilli or caseating granuloma on colonic biopsy. RESULTS: Mean duration for short-term follow- up was 107.3 d with combined chemotherapy containing isoniazid, rifampicin, ethambutol and pyrazinamide. Seven patients with tuberculous colitis showed complete healing of active ulcers after short- term medication. After short-term anti-tuberculosis treatment, follow-up colonoscopy findings devided 18 patients with nonspecific ulcers into two groups by ulcer state. One is the 'suspicious tuberculous colitis group' showing healing of ulcers and erosions and another is the 'suspicious inflammatory bowel disease group' showing active ulcers with or without aggravation of the lesion. Finally, all 9 of the 'suspicious tuberculous colitis group' were diagnosed as tuberculous colitis showing no recurrence of ulcers after termination of 9 mo of anti-tuberculosis medication. Patients of the 'suspicious inflammatorybowel disease group' were f inally diagnosed as Crohn's disease or nonspecifi c colonic ulcers during long-term follow up. CONCLUSION: Follow-up colonoscopy shows a healing stage ulcer or scarring change without an active ulcer with just 2 mo to 3 mo of medication in patients with tuberculous colitis. Colonoscopy follow-up after short term anti-tuberculosis trial in patients with nonspecif ic ulcers on the ileocecal area is valuable in making early differential diagnosis of tuberculous colitis. | Young Sook Park Dae Won Jun Seong Hwan Kim Han Hyo Lee Yun Ju Jo Moon Hee Song Nam In Kim Jun Seok Lee | 2008 | World Journal of Gastroenterology2008，14，32： | 14 |
| 3 | Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer显示文摘AIM To directly compare the efficacy and toxicity of standarddose FOLFIRINOX(sFOLFIRINOX) and modified-dose FOLFIRINOX(mFOLFIRINOX, 75% of standard-dose) for pancreatic cancer.METHODS One hundred and thirty pancreatic cancer patients who received sFOLFIRINOX(n = 88) or mFOLFIRINOX(n = 42) as their first-line chemotherapy from January 2013 to July 2017 were retrospectively reviewed. For efficacy analysis, the objective response rate(ORR),disease control rate(DCR), progression-free survival(PFS), and overall survival(OS) were evaluated and compared using Pearson's chi-square test, Kaplan-Meier plot and log-rank test. The adverse events(AEs) were evaluated, and severe(≥ grade 3) AEs rates of the two groups were compared for toxicity analysis.RESULTS The mFOLFIRINOX group included more female patients(30.7% vs 57.1%; P = 0.004) and older patients [age(median), 57 vs 63.5; P = 0.018] than the sFOLFIRINOX group. In the efficacy analysis, the ORR and DCR were not significantly different between the two groups(ORR: 39.8% vs 35.7%; P = 0.656; DCR: 80.7% vs 83.3%; P = 0.716). The median PFS and OS were also not different between the groups(PFS: 8.7 mo vs 8.1 mo, P = 0.272; OS: 13.9 mo vs 13.7 mo, P = 0.476). In the safety analysis with severe AEs, the rates of neutropenia(83.0% vs 66.7%; P = 0.044), anorexia(48.9% vs 28.6%; P = 0.029) and diarrhea(13.6% vs 0.0%; P = 0.009) were markedly lower in the mFOLFIRINOX group.CONCLUSION m FOLFIRINOX showed comparable efficacy but better safety compared to sFOLFIRINOX. If clinically necessary, initiating FOLFIRINOX with 75% of the standard-dose can alleviate toxicity concerns without compromising efficacy. | Huapyong Kang Jung Hyun Jo Hee Seung Lee Moon Jae Chung Seungmin Bang Seung Woo Park Si Young Song Jeong Youp Park | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 6 |
| 4 | High-risk esophageal varices in patients treated with locoregional therapy for hepatocellular carcinoma:Assessment with liver computed tomography显示文摘AIM:To assess the diagnostic performance of followup liver computed tomography(CT) for the detection of high-risk esophageal varices in patients treated with locoregional therapy for hepatocellular carcinoma(HCC).METHODS:We prospectively enrolled 100 patients with cirrhosis who underwent transcatheter arterial chemoembolization,radiofrequency ablation or both procedures for HCCs.All patients underwent upper endoscopy and subsequently liver CT.Three radiologists independently evaluated the presence of high-risk esophageal varices with transverse images alone and with three orthogonal multiplanar reformation(MPR) images,respectively.With endoscopic grading as the reference standard,diagnostic performance was assessed by using receiver operating characteristic(ROC) curve analysis.RESULTS:The diagnostic performances(areas under the ROC curve) of three observers with transverse images alone were 0.947 ± 0.031,0.969 ± 0.024,and 0.916 ± 0.038,respectively.The mean sensitivity,specificity,positive predicative value(PPV),and negative predicative value(NPV) with transverse images alone were 90.1%,86.39%,70.9%,and 95.9%,respectively.The diagnostic performances,mean sensitivity,specificity,PPV,and NPV with three orthogonal MPR images(0.965 ± 0.025,0.959 ± 0.027,0.938 ± 0.033,91.4%,89.5%,76.3%,and 96.6%,respectively) were not superior to corresponding values with transverse images alone(P > 0.05),except for the mean specificity(P = 0.039).CONCLUSION:Our results showed excellent diagnostic performance,sensitivity and NPV to detect high-risk esophageal varices on follow-up liver CT after locoregional therapy for HCC. | Hyojin Kim Dongil Choi Joon Hyeok Lee Soon Jin Lee Hangi Jo Geum-Youn Gwak Kwang Cheol Koh Moon Seok Choi Seonwoo Kim | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 5 | Distant skeletal muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome显示文摘Intrahepatic cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium, which frequently invades adjacent organs or metastasizes to other visceral organs such as the lungs, bones, adrenals, and brain. However, distant skeletal muscle metastasis of cholangiocarcinoma has never been described before to the best of our knowledge and, furthermore, Budd-Chiari syndrome secondary to intrahepatic cholangiocarcinoma is also extremely rare. Here we present the first case overall of distant muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome. A 44-year-old man admitted to the hospital with complaints of abdominal distension, edema of both legs, back pain and anorexia of 30 d' duration. Computed tomography and ultrasonography-guided percutaneous muscle biopsy established intrahepatic cholangiocarcinoma with disseminated thrombosis from inferior vena cava to bilateral iliac and femoral veins, and multiple skeletal muscle metastases in bilateral buttock and erector spinal muscle. | Oh Sung Kwon Dae Won Jun Sang Heum Kim Mee Yeon Chung Nam In Kim Moon Hee Song Han Hyo Lee Seung Hwan Kim Yoon Ju Jo Young Sook Park Jong Eun Joo | 2007 | World Journal of Gastroenterology2007，13，22： | 2 |
| 6 | Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma显示文摘 | Ho Lee Kyung Ryoul Kim Sang Jae Noh Ho Sung Park Keun Sang Kwon Byung-Hyun Park Sung Hoo Jung Hyun Jo Youn Byoung Kil Lee Myoung Ja Chung Dai Ha Koh Woo Sung Moon Kyu Yun Jang | 2011 | Human Pathology2011，，2： | 2 |
| 7 | Self-optimized coverage coordi- nation in femtocell networks 显示文摘 | JO H S MUN C MOON J | 2010 | IEEE Transactions on Wireless Communications2010，9，10： | 1 |
| 8 | Bladder reconstruction using bovine pericardium in a case of enterovesical fistula显示文摘 | Moon S J Kim DH Jo JK Chung JH Lee JY Park SY | | 0，，02： | 1 |
| 9 | Recurrent cervical esophageal stenosis after colon conduit failure:Use of myocutaneous flap显示文摘A 53-year-old male developed cervical esophageal stenosis after esophageal bypass surgery using a right colon conduit.The esophageal bypass surgery was performed to treat multiple esophageal strictures resulting from corrosive ingestion three years prior to presentation.Although the patient underwent several endoscopic stricture dilatations after surgery,he continued to suffer from recurrent esophageal stenosis.We planned cervical patch esophagoplasty with a pedicled skin flap of sternocleidomastoid(SCM) muscle.Postoperative recovery was successful,and the patient could eat a solid meal without difficulty and has been well for 18 mo.SCM flap esophagoplasty is an easier and safer method of managing complicated and recurrent cervical esophageal strictures than other operations. | Young Jo Sa Young Du Kim Chi Kyung Kim Jong Kyung Park Seok Whan Moon | 2013 | World Journal of Gastroenterology2013，19，2： | 1 |
| 10 | Electrochemical characteristics of TMPTA-and TMPETA-based gel polymer electrolyte显示文摘 | Kim S I Kim H S Na S H Moon S I Kim Y J Jo N J | 2004 | Electrochim Acta2004，50，： | 1 |
| 11 | Reduced liver fibrosis in hypoxia-inducible factor-lalpha-deficient mice显示文摘 | Moon JO Welch TP Gonzalez F J | 2009 | Am J Physiol Gastrointest Liver Physiol2009，296，3： | 1 |
| 12 | Laparoscopyassisted distal gastrectomy with intra corporeal Billroth I stapled anastomosis using a hand access device for patients with gastric cancer显示文摘 | Jo YT Moon HG Lee SH | 2007 | Surg Endosc2007，21，1： | 1 |
| 13 | A Co-Operative Study: Clinical Characteristics of 334 Korean Patients with Moyamoya Disease Treated at Neurosurgical Institutes (1976–1994)显示文摘 | Dae Hee Han O-Ki Kwon Bark Jang Byun Byung Yeon Choi Chang Wha Choi Joong Uhn Choi Seon Gil Choi Jong Oung Doh Jong Woo Han Shin Jung Sung Don Kang Dae Jo Kim Hyoung-Ihl Kim Hyung Dong Kim Moon Chul Kim Sang Chul Kim Soo Chun Kim Youn Kim Byung Duk Kwun B | 2000 | Acta Neurochirurgica2000，，11： | 1 |
| 14 | CO 2 capture characteristics of dry sorbents in a fast fluidized reactor显示文摘 | Chang-Keun Yi S.H. Jo Y. Seo S.D. Park K.H. Moon J.S. Yoo J.B. Lee C.K. Ryu | 2006 | Studies in Surface Science and Catalysis2006，，： | 1 |
| 15 | Interference mitigation using uplinkpower control for two-tier femtocell network显示文摘 | JO H S MUN C MOON J | 2009 | IEEE Trans on tire-less Commun2009，8，10： | 1 |
| 16 | Performance of Mo-Bi-Co-Fe-K-O catalysts prepared from a sol-gel solution containing a drying control chemical additive in the partial oxidation of propylene 显示文摘 | Jo Bu Young Kim Eun Ju Moon Sang Heup | 2007 | Applied Catalysis: A2007，，332： | 1 |
| 17 | The incidence of new vertebral compression fractures in women after kyphoplasty and factors involved显示文摘 | Moon ES Kim HS Park JO | 2007 | Yonsei Medical Journal2007，48，4： | 1 |
| 18 | On the formation of MoSi2 by self-propagating high-temperature synthesis显示文摘 | JO SUNG Won LEE Gi Wook JONG Tae MOON | 1996 | Acta Mater1996，44，： | 1 |
| 19 | Bladder reconstruction using bo- vine pericardium in a case of enterovesical fistula显示文摘 | Moon ST Kim DH Jo JK | 2011 | Voream J Urol2011，52，2： | 1 |
| 20 | Soft Tissue Balancing of Varus Arthritic Knee in Minimally Invasive Surgery Total Knee Arthroplasty:Comparison between Posterior Oblique Ligament Release and Superficial MCLRelease显示文摘 | Seo J G Moon Y W Jo B C | 2013 | Knee Surg Relat Res2013，25，2： | 1 |
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