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| 1 | Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures显示文摘AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple failures.METHODS:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were included.Study subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 mo.Complete virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during treatment.Safety assessment was based on serum creatinine and phosphorus level.Eleven patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ETV.Twenty-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/mL.The median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to it.Resistance to ADV was present in 7 patients and 10 subjects had a resistance to ETV.One patient had a resistance to both ADV and ETV.The cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,respectively.Although one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near CVR.No patients in this study showed viral breakthrough or primary non-response during the follow-up period.The cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,respectively.Treatment efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutations.History of prior exposure to specific antiviral agents did not make a difference to treatment outcome.Treatment efficacy of TDF was not affected by combination therapy with LAM or ETV.No patient developed renal toxicity and no cases of hypophosphatemia associated with TDF therapy were observed.There were no other adverse events related to TDF therapy observed in the study subjects.CONCLUSION:TDF can be an effective and safe rescue therapy in CHB patients after multiple NA therapy failures. | Yu Jin Kim Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Joon Hyeok Lee | 2012 | World Journal of Gastroenterology2012，18，47： | 16 |
| 2 | 1997-2007年上呼吸道感染患儿鼻咽部6群肺炎链球菌分离株的耐药性变化显示文摘目的明确1997—2007年分离自北京儿童医院门诊上呼吸道感染患儿鼻咽部的6群肺炎链球菌的型别构成和对抗菌药物敏感性状况,及其年代变化特点。方法采用荚膜肿胀试验鉴定6群、6A和6B型;采用multi-bead assay分型方法从6A型中鉴定6C型;用E试验法检测青霉素等8种抗菌药物对细菌的MIC。结果 1997—2007年分离到肺炎链球菌893株,从中鉴定出6群119株(13.3%),包括6A型71株(59.7%)、6B型39株(32.7%)和6C型9株(7.6%)。6群菌株对青霉素、头孢呋辛和红霉素的不敏感率分别从1997—2000年的3.4%、1.7%和86.2%上升到2005—2007年的29.4%、23.5%和100%,MIC90和最大MIC值也升高。6A、6B和6C型菌对青霉素的不敏感率分别为7.2%、24.3%和0。结论北京儿童医院呼吸道感染患儿分离的病原菌6群肺炎链球菌以6A型(59.7%)为主,存在新发现的6C型;6群肺炎链球菌对β内酰胺类抗生素和红霉素的耐药性在增加,6B型菌株抗生素耐药性较6A型、6C型强。 | 刘尊杰 姚开虎 袁林 Yu Jigui 高薇 俞桑洁 Moon H.Nahm 杨永弘 | 2010 | 中国感染与化疗杂志2010，10，3： | 9 |
| 3 | Timing of upper gastrointestinal endoscopy does not influence short-term outcomes in patients with acute variceal bleeding显示文摘AIM To examine the association between the timing of endoscopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients.METHODS This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting(IPW) method. The primary outcome was the mortality of patients within 6 wk.RESULTS A total of 173 patients received urgent endoscopy(i.e., ≤ 12 h after admission), and 101 patients received nonurgent endoscopy(> 12 h after admission). The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before(P = 0.266) and after IPW(P = 0.639). The length of hospital stay was statistically different between the urgent group and non-urgent group(P = 0.033); however, there was no significant difference in the inhospital mortality rate between the two groups(8.1% vs 7.9%, P = 0.960). In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality(hazard ratio, 1.297; 95% confidence interval, 0.806-2.089; P = 0.284).CONCLUSION In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality. | Jeong-Ju Yoo Young Chang Eun Ju Cho Ji Eun Moon Sang Gyune Kim Young Seok Kim Yun Bin Lee Jeong-Hoon Lee Su Jong Yu Yoon Jun Kim Jung-Hwan Yoon | 2018 | World Journal of Gastroenterology2018，24，44： | 8 |
| 4 | 3-Dimensional liver volume assessment in patients with hepatitis B virus-related liver cirrhosis during long-term oral nucleos(t)ide analogues therapy显示文摘AIM To assess the effect of long-term oral nucleos(t)ide analogues(NUCs) therapy on liver volume change in patients with suppress hepatitis B virus(HBV)-related liver cirrhosis.METHODS We reviewed the data of na?ve patients with HBVrelated liver cirrhosis, who had taken oral NUCs therapy, between 2003 and 2007 at Chonbuk University Hospital. We analyzed two consecutive sets of abdominal computerized tomography scans-one at the time oftreatment initiation and another at the second-year follow-up. Liver volume was calculated by 3-dimensional liver extraction volumetry program.RESULTS A total of 55 patients(34 males) were included. There was 114.3 m L ± 167.8 m L(12.9% ± 17.9%) of increase in liver volume during the two years of NUCs therapy(993.8 m L ± 242.8 m L at baseline vs 1108.1 m L ± 263.3 m L at two-year follow-up, P < 0.001). The ratio of the measured baseline liver volume to the estimated standard liver volume was improved from 70.8% to 78.0%. An increase in liver volume was shown not only in patients with compensated cirrhosis(P = 0.046) but also in those with decompensated cirrhosis(P < 0.001). Significant factors for volume increases were Child-Turcotte-Pugh grade and model for end-stage liver disease score improvement without virological breakthrough. In multiple linear regression analysis, delta albumin and delta alanine aminotransferase levels showed a significant association with the increase in liver volume(P = 0.002 and 0.005, respectively).CONCLUSION Long-term oral NUCs therapy in patients with HBVrelated liver cirrhosis lead to significant increase in liver volume assessed with 3-dimensional liver extraction volumetry program. | Chang Hun Lee In Hee Kim Jin Chang Moon Seung Young Seo Seong Hun Kim Sang Wook Kim Seung Ok Lee Soo Teik Lee Dae Ghon Kim Jae Do Yang Hee Chul Yu | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 5 | Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis显示文摘AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic diverticulitis.METHODS:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ACD.RESULTS:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan. | Jeong Ah Hwang Sun Moon Kim Hyun Jung Song Yu Mi Lee Kyung Min Moon Chang Gi Moon Hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung | 2013 | World Journal of Gastroenterology2013，19，40： | 6 |
| 6 | Prevalence of upper gastrointestinal bleeding risk factors among the general population and osteoarthritis patients显示文摘AIM To assess the prevalence of possible risk factors of upper gastrointestinal bleeding(UGIB) and their agegroup specific trend among the general population and osteoarthritis patients.METHODS We utilized data from the National Health InsuranceService that included claims data and results of the national health check-up program. Comorbid conditions(peptic ulcer, diabetes, liver disease, chronic renal failure, and gastroesophageal reflux disease), concomitant drugs(aspirin, clopidogrel, cilostazol, non-steroidal anti-inflammatory drugs, steroid, anticoagulants, and SSRI), personal habits(smoking, and alcohol consumption) were considered as possible UGIB risk factors. We randomly imputed the prevalence of infection in the data considering the age-specific prevalence of Helicobacter pylori(H. pylori) infection in Korea. The prevalence of various UGIB risk factors and the age-group specific trend of the prevalence were identified. Prevalence was compared between osteoarthritis patients and others.RESULTS A total of 801926 subjects(93855 osteoarthritis patients) aged 20 and above were included. The prevalence of individual and concurrent multiple risk factors became higher as the age increased. The prevalence of each comorbid condition and concomitant drug were higher in osteoarthritis patients. Thirty-five point zero two percent of the overall population and 68.50% of osteoarthritis patients had at least one or more risk factors of UGIB. The prevalence of individual and concurrent multiple risk factors in younger age groups were also substantial. Furthermore, when personal habits(smoking, and alcohol consumption) and H. pylori infection were included, the prevalence of concurrent multiple risk factors increased greatly even in younger age groups.CONCLUSION Prevalence of UGIB risk factors was high in elderly population, but was also considerable in younger population. Patient with osteoarthritis was at higher UGIB risk than those without osteoarthritis. Physicians s h o u ld c o n s id e r in d i v i d u a li z e d r i s k a s s e s s m e n t regardless of age when prescribing drugs or performing procedures that may increase the risk of UGIB, and take necessary measures to reduce modifiable risk factors such as H. pylori eradication or lifestyle counseling. | Sang Hyuck Kim Jae Moon Yun Chong Bum Chang Heng Piao Su Jong Yu Dong Wook Shin | 2016 | World Journal of Gastroenterology2016，22，48： | 6 |
| 7 | The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Hee Chul Park Jeong Il Yu Won Sohn Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Liver Int2014，，5： | 5 |
| 8 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 9 | Development of seeder for mixed planting of corn and soybeans显示文摘Corn and soybeans should be sown between 5 cm and 10 cm apart in mixed cultivation to increase protein content and improve productivity of the forage.However,existing sowers cannot plant at intervals of less than 20 cm.Consequently,mixed cultivation of corn and soybeans is currently performed by first sowing corn seeds with a tractor and then manually planting soybean seeds.This method results in irregular intervals between the seeds,it is laborious and time consuming.This study aimed at developing a seeder that can simultaneously,precisely and efficiently plant corn and soybean.The geometrical and rheological properties of corn and soybeans were initially measured.The seed conveying equipment were designed using the EDEM software.The sowing interval between seeds,depth of soil over planted seed,and sowing performance were analyzed.The EDEM simulation results indicated that a 6-mm-wide and 3-mm-deep grooved seed-delivering roller had the highest particle mobility of the designs considered,with a 2.5%misplanting rate.A performance test showed that no misplanting occurred in the sections sowed with soybean seeds at a seeding interval that averaged 32 mm(321 seeds sown in 10 m)and that misplanting occurred in one section sowed with corn at a seeding interval that averaged 247 mm(40 seeds sown over 10 m).The sowing efficiency for both corn and soybeans was found to be 0.42 h/hm2.The average depth of soil over seed was 32.7 mm for soybean and 39.7 mm for corn.These average depths are within the stipulated range for the depth of soil over seed,which is 5 to 10 times the seed size.This study developed an efficient seeding machine that can simultaneously plant soybean and corn precisely,consequently improving forage yield and saving man-hours. | Seung Min Woo Daniel Dooyum Uyeh Moon Sang Sagong Yu Shin Ha | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 3 |
| 10 | Frequency and risk factors of renal impairment during long‐term adefovir dipivoxil treatment in chronic hepatitis B patients显示文摘 | Yu JinKim Hyun ChinCho Dong HyunSinn Geum‐YounGwak Moon SeokChoi Kwang CheolKoh Seung WoonPaik Byung ChulYoo Joon HyeokLee | 2012 | Journal of Gastroenterology and Hepatology2012，，2： | 2 |
| 11 | Comparison of Endoscopic Papillary Balloon Dilation and Sphincterotomy in Young Patients with CBD Stones and Gallstones显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Ji Su Ha Tae Hoon Lee Sang-Woo Cha Young Deok Cho Sang-Heum Park Sun-Joo Kim | 2014 | Digestive Diseases and Sciences2014，，5： | 2 |
| 12 | Papillary balloon dilation is not itself a cause of post‐endoscopic retrograde cholangiopancreatography pancreatitis; results of anterograde and retrograde papillary balloon dilation显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park Sun‐Joo Kim | 2013 | J Gastroenterol Hepatol2013，，8： | 2 |
| 13 | Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein显示文摘 | Dae-Yeul Yu Hyung-Bae Moon Jin-Kyong Son Sangkyun Jeong Seong-Lan Yu Heesik Yoon Yong-Mahn Han Chul-Sang Lee Jung-Sun Park Chul-Ho Lee Byung-Hwa Hyun Seishi Murakami Kyung-Kwang Lee | 1999 | Journal of Hepatology1999，，1： | 2 |
| 14 | Mediastinal tuberculous lymphadeni- tis : MR imaging appearance With clinicopathologic correlation 显示文摘 | Moon WK Im JG Yu IK | 1996 | A JR1996，166，： | 1 |
| 15 | Mechanism of 3,4-methylenedioxymethamphetamine(MDMA,ecstasy)-mediated mitochondrial dysfunction in rat liver显示文摘 | Moon K H Upreti V V Yu L R | 2008 | Proteomics2008，8，18： | 1 |
| 16 | Mediastinal tuberculous lymphadenitis:MR imaging appearance with clinicopathologic correlation显示文摘 | Moon W K Im J G Yu I K | 1996 | AJR1996，166，5： | 1 |
| 17 | Multilevel LDPC Codes Design for Multimedia Communication CDMA System显示文摘 | Jia Hou Yu Yi Moon Ho Lee | 2004 | EURASIP Journal on wireless Communication and Networking2004，1，： | 1 |
| 18 | Mediastinal tuberculous lymphadenitis:MR imaging appearance with clinicopathologic correlation显示文摘 | Moon W K In J G Yu I K | 1996 | AJR1996，166，1： | 1 |
| 19 | Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma显示文摘 | Jin C. Kim Kum H. Koo Seon A. Roh Yong K. Cho Hee C. Kim Chang S. Yu Ho J. Kim Jung S. Kim Moon K. Cho | 2003 | International Journal of Colorectal Disease2003，，3： | 1 |
| 20 | A Newly Formed and Ruptured Atheromatous Plaque within Neointima after Drug-Eluting Stent Implantation: 2-Year Follow-Up Intravascular Ultrasound and Optical Coherence Tomography Studies 显示文摘 | Chang-Myung Oh Jeonggeun Moon Hee Tae Yu | 2011 | Yonsei Med J2011，52，6： | 1 |
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