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| 1 | 土家族药物扣子七中三萜皂苷成分及抗肿瘤活性研究显示文摘目的研究土家族药物扣子七Panax japonicus var. major中三萜皂苷类成分,对其抑制肿瘤细胞增殖活性进行筛选,并初步探讨化合物结构与活性的关系。方法应用多种色谱方法对土家族药物扣子七正丁醇部位进行分离,所分离化合物运用核磁共振方法进行结构鉴定,应用MTT法测定分离化合物对体外培养人肿瘤细胞增殖的影响。结果从扣子七根茎正丁醇部位分离得到14个三萜皂苷,分别鉴定为竹节参皂苷IVa甲酯(1)、竹节参皂苷Ⅳa丁酯(2)、竹节参皂苷Ⅳ(3)、竹节参皂苷Ⅳa(4)、28-去糖竹节参皂苷Ⅳa(5)、齐墩果酸-3-O-β-D-(6′-甲酯)-吡喃葡萄糖醛酸苷(6)、(24R)-珠子参苷R1(7)、(24R)-拟人参皂苷F11(8)、(20S)-三七皂苷R2(9)、(20S)-人参皂苷Rg2(10)、人参皂苷Rg1(11)、人参皂苷Re(12)、人参皂苷Rd(13)、竹节参皂苷V甲酯(14)。活性研究结果显示,化合物5和6对胃癌BGC-823细胞、结肠癌HCT-116细胞、宫颈癌HeLa细胞及肝癌Hep G2细胞均显示了较强的活性,呈良好的剂量依赖关系,其中化合物5对BGC-823、HCT-116细胞的IC50分别为9.94、14.17μmol/L,化合物6对肝癌HepG2细胞的抑制作用最强(IC50=12.70μmol/L)。结论首次从扣子七中分离得到化合物6并报道了其光谱数据;其部分化学成分显示出抗肿瘤活性,其抗肿瘤活性与齐墩果烷型皂苷密切相关,且活性强弱可能与C-28取代基有关联,相关抗肿瘤机制值得进一步研究。 | 王晓娟 谢谦 刘杨 陆世银 Muhammad Daniyal 李斌 段淑莉 龚力民 梁娜 毛羽 于勇 王炜 | 2020 | 中草药2020，51，7： | 9 |
| 2 | PEGylated mBPEI-rGO nanocomposites facilitate hepotocarcinoma treatment combining photothermal therapy and chemotherapy显示文摘Despite chemotherapy has been widely used for tumor therapy, the serious side effect is still a major challenge. Recently, two dimensional nanomaterial-based drug delivery systems have attracted wide concern due to their high drug loading and low side effect. In addition, some kinds of nanomaterials can directly act as a photosensitizer to induce cancer destruction. In this study, we developed a drug delivery system of mixture of high/low molecular weight branched polyethylenimine-polyethylene glycol-reduced graphene oxide(mBPEI-PEG-rGO) using reduced graphene oxide as matrix. A model drug of doxorubicin(DOX) was loaded on the nanocomposites with the efficiency of 81% and the release rate of more than 50% at acidic environment. In vitro experiments indicated that mBPEI-PEG-rGO-DOX with enhanced stability and biocompatibility efficiently delivered and released DOX into cells mainly through micropinocytosis and killed SMMC-7721 cells by inducing reactive oxygen species(ROS) and cell apoptosis. Furthermore, in vivo experiments indicated that the combination of intratumoral injection of mBPEI-PEG-rGO-DOX and local laser irradiation nearly ablated hepatocarcinoma. In conclusion, this new drug delivery system provided an alternative for combinational photothermal and chemotherapy against hepatocarcinoma. | Chunyi Tong Xizhi Zhang Jialong Fan Bin Li Bin Liu Muhammad Daniyal Wei Wang | 2018 | Science Bulletin2018，63，14： | 6 |
| 3 | 土家药白三七三萜皂甙及其对Hep G2和BGC-823细胞系的细胞毒性(英文)显示文摘目的生活在中国中南部的土家族人民传承并应用的土家医药是一种独特的医疗体系。在土家药中,白三七(Panax japonicus C. A. Mey.)被认为是一种用于治疗虚劳和风湿病的有效且珍贵的药材。本文期望为土家药的应用提供更多的物质证据。方法柱色谱和制备型高效液相用于分离和纯化;1H-NMR,13C-NMR,1H-1H COSY,HSQC 和HMBC 核磁共振谱用于结构鉴定;MTT 法用于细胞毒性评价。结果 12 个已知化合物从白三七中分离得到,这些化合物的结构是根据它们的核磁共振谱鉴定的,所有12 种化合物均为三萜皂苷,其中5 个化合物是齐墩果酸型,其余7 个是达玛烷型;本研究对11 个化合物进行了Hep G2 和BGC-823 细胞系的细胞毒性测试,其中3 个化合物显示了相对显著的细胞毒性。结论 12 个已知化合物从白三七中分离得到;具有相似骨架的化合物的核磁共振谱显示了特定的规律;其中3 个化合物显示了对于Hep G2 和BGC-823 细胞系相对显著的细胞毒性,当与阳性对照紫杉醇对比时,该结果可评价为毒性较低。 | 李伟 Muhammad Daniyal 谢青玲 刘杨 谢谦 李斌 彭彩云 王炜 | 2019 | Digital Chinese Medicine2019，2，2： | 1 |
| 4 | Lanostane Tetracyclic Triterpenoids as Important Sources for Anti-Inflammatory Drug Discovery显示文摘Inflammation is a defensive reaction of the human body to numerous detrimental stimuli,including physical trauma,noxious chemicals,as well as microbial agents.Uncontrolled inflammation is the pathological basis of multiple diseases,such as rheumatoid arthritis(RA),neurodegenerative diseases,liver disease,and lung inflammation.Lanostane triterpenoids are natural tetracyclic triterpenoids with significant anti-inflammatory activity.An extensive review of the published literature regarding the phytochemistry and anti-inflammatory pharmacology of lanostane triterpenoids has been performed and analyzed using several search engines,such as SciFinder,Web of Science,Scopus,PubMed,Google Scholar,and ScienceDirect.This review is devoted to naturally occurring lanostane-type triterpenes with anti-inflammatory activity,including their sources,biosynthesis,and mechanism of action.This review also discusses the inflammation-related diseases and the clinical significance of traditional Chinese medicine as multi-target therapeutic agents for the prevention and treatment of inflammatory diseases.In the past 30 years,more than 100 new lanostane-type triterpenes have been reported from the families Schisandraceae,Ganodermataceae,and Polyporaceae.Six compounds,fomitopinic acid A,fomitosides E and F,obtusifoliol,4α,l4α-dimethyl-5α-ergosta-7,9(11),24(28)-trien-3β-ol,and gramisterol exhibited the most potent anti-inflammatory activity against cyclooxygenase-1(COX-1)and COX-2,with IC50 values ranging from 0.087 to 1.15μM.Some of these compounds exhibited significant activity by mediating the inhibition of the pro-inflammatory cytokines,inducible nitric oxide synthase,and COX-2 expression.This review provides a basis for identifying anti-inflammatory drugs with high selectivity,high potency,and few adverse effects from lanostane-type triterpenes. | Yu-Pei Yang Shumaila Tasneem Muhammad Daniyal Liu Zhang Yan-Zhe Jia Yu-Qing Jian Bin Li Wei Wang | 2020 | World Journal of Traditional Chinese Medicine2020，6，3： | 1 |
| 5 | Bit Rate Reduction in Cloud Gaming Using Object Detection Technique显示文摘The past two decades witnessed a broad-increase in web technology and on-line gaming.Enhancing the broadband confinements is viewed as one of the most significant variables that prompted new gaming technology.The immense utilization of web applications and games additionally prompted growth in the handled devices and moving the limited gaming experience from user devices to online cloud servers.As internet capabilities are enhanced new ways of gaming are being used to improve the gaming experience.In cloud-based video gaming,game engines are hosted in cloud gaming data centers,and compressed gaming scenes are rendered to the players over the internet with updated controls.In such systems,the task of transferring games and video compression imposes huge computational complexity is required on cloud servers.The basic problems in cloud gaming in particular are high encoding time,latency,and low frame rates which require a new methodology for a better solution.To improve the bandwidth issue in cloud games,the compression of video sequences requires an alternative mechanism to improve gaming adaption without input delay.In this paper,the proposed improved methodology is used for automatic unnecessary scene detection,scene removing and bit rate reduction using an adaptive algorithm for object detection in a game scene.As a result,simulations showed without much impact on the players’quality experience,the selective object encoding method and object adaption technique decrease the network latency issue,reduce the game streaming bitrate at a remarkable scale on different games.The proposed algorithm was evaluated for three video game scenes.In this paper,achieved 14.6%decrease in encoding and 45.6%decrease in bit rate for the first video game scene. | Daniyal Baig Tahir Alyas Muhammad Hamid Muhammad Saleem Saadia Malik Nadia Tabassum Natash Ali Mian | 2021 | Computers, Materials & Continua2021，，9： | 0 |
| 6 | Gain-Enhanced Metamaterial Based Antenna for 5G Communication Standards显示文摘Metamaterial surfaces play a vital role to achieve the surface waves suppression and in-phase reflection,in order to improve the antenna performance.In this paper,the performance comparison of a fifth generation(5G)antenna design is analyzed and compared with a metamaterial-based antenna for 5G communication system applications.Metamaterial surface is utilized as a reflector due to its in-phase reflection characteristic and high-impedance nature to improve the gain of an antenna.As conventional conducting ground plane does not give enough surface waves suppression which affects the antenna performance in terms of efficiency and gain etc.These factors are well considered in this work and improved by using the metamaterial surface.The radiating element of the proposed metamaterial based antenna is made up of copper material which is backed by the substrate,i.e.,Rogers-4003 with a standard thickness,loss tangent and a relative permittivity of 1.524 mm,0.0027 and 3.55,correspondingly.The proposed antenna with and without metamaterial surface operates at the central frequency of 3.32 GHz and 3.60 GHz,correspondingly.The traditional antenna yields a boresight gain of 2.76 dB which is further improved to 6.26 dB,using the metamaterial surface.The radiation efficiency of the proposed metamaterial-based 5G antenna is above 85%at the desired central frequency. | Daniyal Ali Sehrai Fazal Muhammad Saad Hassan Kiani Ziaul Haq Abbas Muhammad Tufail Sunghwan Kim | 2020 | Computers, Materials & Continua2020，，9： | 0 |
| 7 | Design of a Compact Monopole Antenna for UWB Applications显示文摘In this paper,a low cost,highly efficient and low profile monopole antenna for ultra-wideband(UWB)applications is presented.A new inverted triangular-shape structure possessing meander lines is designed to achieve a wideband response and high efficiency.To design the proposed structure,three steps are utilized to achieve an UWB response.The bandwidth of the proposed antenna is improved with changing meander lines parameters,miniaturization of the ground width and optimization of the feeding line.The measured and simulated frequency band ranges from 3.2 to 12 GHz,while the radiation patterns are measured at 4,5.3,6 and 8 GHz frequency bands.The overall volume of the proposed antenna is 26×25×1.6 mm^(3);whereas the FR4 material is used as a substrate with a relative permittivity and loss tangent of 4.3 and 0.025,correspondingly.The peak gain of 4 dB is achieved with a radiation efficiency of 80 to 98%for the entire wideband.Design modelling of proposed antenna is performed in ANSYS HFSS 13 software.A decent consistency between the simulated and measured results is accomplished which shows that the proposed antenna is a potential candidate for the UWB applications. | Naeem Ahmad Jan Saad Hassan Kiani Daniyal Ali Sehrai Muhammad Rizwan Anjum Amjad Iqbal Mujeeb Abdullah Sunghwan Kim | 2021 | Computers, Materials & Continua2021，，1： | 0 |
| 8 | On the construction of balanced repeated measurements designs with good circular properties显示文摘Several fields,such as biological,medical,public health,agricultural sciences,etc.,require circular balanced repeated measurement designs with fewer unequal number of repeated measure-ments than the number of treatments.Also,the availability and high cost of experimental subjects in these fields prefer the design in fewer experimental units.However,balancing the carryover effects of the treatments in minimal experimental subjects is one of the problems in this case.In this paper,several new series of minimal circular nearly strongly balanced RMDs in periods of two and three different sizes are constructed.The proposed construction of designs has high efficiency and,therefore,can save the cost of experimentations due to a fewer exper-imental subjects.Most of the designs are very useful because of the unavailability of strongly balanced RMDs for these combinations of parameters.A list of sets of shifts for the construction of minimal circular nearly SBRMDs has also been mentioned in the Appendix. | Muhammad Daniyal Jigneshkumar Gondaliya Rashid Ahmed | 2023 | Statistical Theory and Related Fields2023，7，2： | 0 |
| 9 | Engineered Nano−Bio Interfaces for Stem Cell Therapy显示文摘Engineered nanomaterials(ENMs)with different topographies provide effective nano−bio interfaces for controlling the differentiation of stem cells.The interaction of stem cells with nanoscale topographies and chemical cues in their microenvironment at the nano−bio interface can guide their fate.The use of nanotopographical cues,in particular nanorods,nanopillars,nanogrooves,nanofibers,and nanopits,as well as biochemical forces mediated factors,including growth factors,cytokines,and extracellular matrix proteins,can significantly impact stem cell differentiation.These factors were seen as very effective in determining the proliferation and spreading of stem cells.The specific outgrowth of stem cells can be decided with size variation of topographic nanomaterial along with variation in matrix stiffness and surface structure like a special arrangement.The precision chemistry enabled controlled design,synthesis,and chemical composition of ENMs can regulate stem cell behaviors.The parameters of size such as aspect ratio,diameter,and pore size of nanotopographic structures are the main factors for specific termination of stem cells.Protein corona nanoparticles(NPs)have shown a powerful facet in stem cell therapy,where combining specific proteins could facilitate a certain stem cell differentiation and cellular proliferation.Nano−bio reactions implicate the interaction between biological entities and nanoparticles,which can be used to tailor the stem cells’culmination.The ion release can also be a parameter to enhance cellular proliferation and to commit the early differentiation of stem cells.Further research is needed to fully understand the mechanisms underlying the interactions between engineered nano−bio interfaces and stem cells and to develop optimized regenerative medicine and tissue engineering designs. | Arsalan Umer Muhammad Daniyal Ghouri Theoneste Muyizere Raja Muhammad Aqib Abdul Muhaymin Rong Cai Chunying Chen | 2023 | Precision Chemistry2023，1，6： | 0 |
| 10 | Predictive modeling of COVID-19 death cases in Pakistan显示文摘Background:The world is presently facing the challenges posed by COVID-19(2019-nCoV),especially in the public health sector,and these challenges are dangerous to both health and life.The disease results in an acute respiratory infection that may result in pain and death.In Pakistan,the disease curve shows a vertical trend by almost 256K established cases of the diseases and 6035 documented death cases till August 5,2020.Objective:The primary purpose of this study is to provide the statistical model to predict the trend of COVID-19 death cases in Pakistan.The age and gender of COVID-19 victims were represented using a descriptive study.Method:ology:Three regression models,which include Linear,logarithmic,and quadratic,were employed in this study for the modelling of COVID-19 death cases in Pakistan.These three models were compared based on R2,Adjusted R2,AIC,and BIC criterions.The data utilized for the modelling was obtained from the National Institute of Health of Pakistan from February 26,2020 to August 5,2020.Conclusion:The finding deduced after the prediction modelling is that the rate of mortality would decrease by the end of October.The total number of deaths will reach its maximum point;then,it will gradually decrease.This indicates that the curve of total deaths will continue to be flat,i.e.,it will shift to be constant,which is also the upper bound of the underlying function of absolute death. | Muhammad Daniyal Roseline Oluwaseun Ogundokun Khadijah Abid Muhammad Danyal Khan Opeyemi Eyitayo Ogundokun | 2020 | Infectious Disease Modelling2020，5，1： | 0 |
| 11 | V-Shaped Monopole Antenna with Chichena Itzia Inspired Defected Ground Structure for UWB Applications显示文摘Due to rapid growth in wireless communication technology,higher bandwidth requirement for advance telecommunication systems,capable of operating on two or higher bands with higher channel capacities and minimum distortion losses is desired.In this paper,a compact Ultra-Wideband(UWB)V-shaped monopole antenna is presented.UWB response is achieved by modifying the ground plane with Chichen Itzia inspired rectangular staircase shape.The proposed V-shaped is designed by incorporating a rectangle,and an inverted isosceles triangle using FR4 substrate.The size of the antenna is 25 mm×26 mm×1.6 mm.The proposed V-shaped monopole antenna produces bandwidth response of 3 GHz Industrial,Scientific,and Medical(ISM),Worldwide Interoperability for Microwave Access(WiMAX),(IEEE 802.11/HIPERLAN band,5G sub 6 GHz)which with an additional square cut amplified the bandwidth response up to 8 GHz ranging from 3.1 GHz to 10.6 GHz attaining UWB defined by Federal Communications Commission(FCC)with a maximum gain of 3.83 dB.The antenna is designed in Ansys HFSS.Results for key performance parameters of the antenna are presented.The measured results are in good agreement with the simulated results.Due to flat gain,uniform group delay,omni directional radiation pattern characteristics and well-matched impedance,the proposed antenna is suitable for WiMAX,ISM and heterogeneous wireless systems. | Naeem Ahmad Jan Saad Hassan Kiani Fazal Muhammad Daniyal Ali Sehrai Amjad Iqbal Muhammad Tufail Sunghwan Kim | 2020 | Computers, Materials & Continua2020，，10： | 0 |
| 12 | Nanotechnological strategies for prostate cancer imaging and diagnosis显示文摘The high incidence rates and complicated subtypes of prostate cancer(PCa)call for the demand of the precise diagnostic and therapeutic strategies.Current clinical imaging techniques,such as MRI,CT,and ultrasonography are difficult to accurately detect the early-stage tumor lesions,and biochemical assays or biopsies are invasive and cannot provide sufficient information for the PCa staging and classification.Nanotechnology has the potential to improve the accuracy of current diagnosis strategies by targeting specific PCa biomarkers and/or integrating multiple imaging modes.In this review,we briefly introduce current clinical PCa imaging strategies and their major limitations,and highlight representative works on nanoparticle-mediated multimode imaging strategies.We also discuss the challenges of nanotechnology-based PCa diagnosis,and come up with suggestions and perspectives. | Thecla Trinity Wheeler Pei Cao Muhammad Daniyal Ghouri Tianjiao Ji Guangjun Nie Yuliang Zhao | 2022 | Science China Chemistry2022，65，8： | 0 |
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