|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preparation of folate-conjugated starch nanoparticles and its application to tumor-targeted drug delivery vector显示文摘Anion starch nanoparticles (StNP) were prepared in water-in-oil microemulsion. Folate modi-fied with PEG was conjugated to the surface of StNP to obtain the folate-conjugated starch nanoparticles (FA-PEG/StNP). The average diameter of FA-PEG/ StNP determined by AFM and Zeta-Sizer apparatus was about 130 nm. Doxorubicin (DOX)-loaded FA- PEG/StNP was obtained via infiltrating combination. The result of UV spectrophotometer showed that the saturation concentration of DOX-loaded FA-PEG/ StNP was 28 μg/mg, which was effective for the con-trolled release of anticancer drug DOX. The cell ex-periments showed that the Lc50 of DOX-loaded FA-PEG/StNP and DOX-loaded StNP was higher than that of DOX, which indicates that FA-PEG/StNP and StNP can decrease the toxicity of DOX; while the lethal rate of DOX-loaded FA-PEG/StNP was 3 times that of DOX-loaded StNP with the same quantity of DOX, which indicates that FA in FA-PEG/StNP is ef-fective for improving the targeting function of nanoparticles, thus enhancing the inhibition effect of anticancer drug to cancer cell. This work demon-strates that the FA-PEG/StNP system is a potentially useful system for the targeted delivery of anticancer drug DOX. | XlAO Suyao TONG Chunyi LIU Xuanming YU Danmi LIU Qiaoling XUE Changgang TANG Dongyin ZHAO Lijian | 2006 | Chinese Science Bulletin2006，51，14： | 12 |
| 2 | Studies of poly-L-lysine-starch nanoparticle preparation and its application as gene carrier显示文摘Anion starch nanoparticle (StNP) with a diameter of 50 nm was prepared in wa- ter-in-oil microemulsion, with soluble starch as raw materials and POCl3 as crosslinking agent. PLL-StNP was prepared by linking poly-L-lysine (PLL) on the surface of StNP. At the same time, the size of PLL-StNP and its stability in aqueous solution were checked by AFM. The analysis of plasmid DNA binding, DNase I enzymatic degradation, toxicity and transfection were done. We discovered that PLL-StNP may be used as non-virus nanoparticle gene carrier. And we devel- oped the method of preparing PLL-StNP gene carrier and used it in cell transfection. As non-virus gene carrier, PLL-StNP has some advantages, such as large load of DNA, high transfection effi- ciency, low cell toxicity and biodegradability. | XIAO Suyao LIU Xuanming TONG Chunyi LIU Jun TANG Dongying ZHAO Lijian | 2005 | Science China Chemistry2005，48，2： | 7 |
| 3 | PEGylated mBPEI-rGO nanocomposites facilitate hepotocarcinoma treatment combining photothermal therapy and chemotherapy显示文摘Despite chemotherapy has been widely used for tumor therapy, the serious side effect is still a major challenge. Recently, two dimensional nanomaterial-based drug delivery systems have attracted wide concern due to their high drug loading and low side effect. In addition, some kinds of nanomaterials can directly act as a photosensitizer to induce cancer destruction. In this study, we developed a drug delivery system of mixture of high/low molecular weight branched polyethylenimine-polyethylene glycol-reduced graphene oxide(mBPEI-PEG-rGO) using reduced graphene oxide as matrix. A model drug of doxorubicin(DOX) was loaded on the nanocomposites with the efficiency of 81% and the release rate of more than 50% at acidic environment. In vitro experiments indicated that mBPEI-PEG-rGO-DOX with enhanced stability and biocompatibility efficiently delivered and released DOX into cells mainly through micropinocytosis and killed SMMC-7721 cells by inducing reactive oxygen species(ROS) and cell apoptosis. Furthermore, in vivo experiments indicated that the combination of intratumoral injection of mBPEI-PEG-rGO-DOX and local laser irradiation nearly ablated hepatocarcinoma. In conclusion, this new drug delivery system provided an alternative for combinational photothermal and chemotherapy against hepatocarcinoma. | Chunyi Tong Xizhi Zhang Jialong Fan Bin Li Bin Liu Muhammad Daniyal Wei Wang | 2018 | Science Bulletin2018，63，14： | 6 |
| 4 | Dialdehyde starch nanoparticles: Preparation and application in drug carrier显示文摘Dialdehyde starch nanoparticles (DASNP) were prepared by the redox reaction of NaIO4 and starch in water-in-oil microemulsion. IR spectrum showed that DASNP had aldehyde groups, and quantitative alkali consumption showed that its dialdehyde content was about (50±5)%. The average diameter of DASNP determined by SEM was about 100 nm. TGA-DTA showed that its thermal stability was better than starch nanoparticle (StNP) and dialdehyde starch (DAS). Its low biological toxicity was detected by cell experiment. Also the best mass ratio of doxorubicin (DOX) to combined DASNP detected by UV-VIS was 15 : 1, and the product was effective for controlled release of DOX. The cell experiment showed that the drug-carrier particle (DOX-DASNP) can release DOX for a long time and strengthened the effect of the anticancer drug. This work demonstrates that the DASNP, which has good thermal stability, small particle size, low biological toxicity, and slowly anticancer drug-releasing to strengthen drug effect, is a potentially useful carrier for anticancer drug. | YU DanMi XIAO SuYao TONG ChunYi CHEN Lin LIU XuanMing | 2007 | Chinese Science Bulletin2007，52，21： | 5 |
| 5 | Development and application of tumor-targeting magnetic nanoparticles FA-StNP@Fe_2O_3 for hyperthermia显示文摘Modified magnetic starch nanoparticles (FA-StNP@Fe2O3) were synthesized by conjugating folic acid (FA-PEG-NH2) onto the surface of magnetic starch nanoparticles (StNP@Fe2O3) prepared by reverse microemulsion method. The synthesized FA-StNP@Fe2O3 was investigated by transmission electron microscopy and zeta potential analysis. The average size of its well dispersed particles was 250 nm. The iron concentration of 2 mg/g was detected by phenanthroline method. Placing FA-StNP@Fe2O3 nanoparticles in the alternating magnetic field for 30 min resulted in an increase in the suspension temperature from ambient temperature (37℃) to a value between 42℃ and 43℃. Co-cultured nanoparticles and Hela cell line or normal HUEC-12 cell line, and the biological effects at the cellular level were investigated in the alternating magnetic field using MTT assay, Hochest-PI double staining and flow cytometry analysis. Experimental results showed that FA-StNP@Fe2O3 within acertain concentration range has no obvious effect on cell proliferation. When treated in the magnetic field, apoptosis rate on Hela induced by FA-StNP@Fe2O3 was 13.4%. Prussian blue staining analysis confirmed that the nanoparticles modified with folic acid had improved ability in tumor cell-targeting, and therefore, potential applications in biomedical and magnetocaloric areas. It is expected be applied in tumor targeting therapy in the near future. | ZHENG YuanQing TONG ChunYi WANG Bei XIE Ying LIAO HongDong LI Dan LIU XuanMing | 2009 | Chinese Science Bulletin2009，54，17： | 3 |
| 6 | Dialdehyde starch nanoparticles as antitumor drug delivery system:An in vitro,in vivo,and immunohistological evaluation显示文摘Sustaining the release of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner is a potentially powerful technology. A new drug carrier-dialdehyde starch nanoparticle (DASNP) that can sustain the loading and release of 5-fluorouracil (5-Fu) antitumor drug is reported in this study. IR spectrophotometer and 1H NMR confirmed the formation of aldehyde groups, and scan electron microscope determinations showed that the dialdehyde starch nanoparticles obtained had an average diameter of 90 nm. 5-Fu, the model drug, was conjugated into nanoparticles by aldehyde groups. These 5-Fu-binding nanoparticles significantly enhanced breast cancer cell (MCF-7) inhibition in vitro compared with free 5-Fu. After subcutaneous 0 injection in the breast tumor-loaded rats, 5-Fu-DASNP exhibited remarkable tumor-inhibitory efficacy determined by measuring tumor weight in vivo. The tumor inhibition of 5-Fu-DASNP was 61%±6%, whereas that of free 5-Fu was only 42%±4%. Bcl-2/Bax immunohistochem-istry studies indicated that 5-Fu-DASNP remarkably induced tumor tissue necrosis. These results demonstrated that the DASNP prepared in this work is a potentially effective drug carrier. | XIAO SuYao LIU XuanMing TONG ChunYi ZHAO LiChao LIU XiaoJuan ZHOU AiMei CAO Yong | 2012 | Chinese Science Bulletin2012，57，24： | 3 |
| 7 | Highly emissive coordination polymer derived from tetraphenylethylene-tetrazole chromophore:Synthesis,characterization and piezochromic luminescent behavior显示文摘Solid-state materials that exhibit pressure stimulus-response characteristics in a manner of emission signal,known as piezochromic luminescence(PCL),demonstrate great potential in photoelectric devices.The weakened luminescence and insignificant color change in the aggregation state,however,hampers their practical applications.Herein,a highly emissive coordination polymer,[Zn2(H4TTPE)(H2O)4]·H2O(CUST-805),is successfully constructed by employing an AIE-active chromophore as the building block.The structural characterization and photophysical properties are systematically studied.Owing to intrinsic twisted conformation and AIE feature of tetraphenylethylene-tetrazole ligand,CUST-805 achieves the visible and reversible PCL from blue to green switched by different external stimuli.The transformation between crystalline and amorphous states is proved to be the origin of present PCL behavior.Moreover,on basis of electron and energy transfer quenching mechanism,the highly selective and sensitive sensor based on CUST-805 is realized,showing the low detection limit of 0.29 ppm towards 2,4,6-trinitrophenol. | Xu Han Jialin Tong Guanyu Ding Chunyi Sun Xinlong Wang Zhongmin Su Jing Sun Li-Li Wen Guo-Gang Shan | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 8 | Novel sulfhydryl functionalized covalent organic frameworks for ultra-trace Hg^(2+) removal from aqueous solution显示文摘Two kinds of novel sulfhydryl functionalized covalent organic frameworks were fabricated as adsorbents for the removal of ultra-trace concentrations of Hg^(2+)from water.The two kinds of sulfhydryl functionalized covalent organic frameworks were obtained via a thiol-ene click reaction between the thiol groups of trithiocyanuric acid(TTC)or bismuththiol(BMT)and vinyl groups on the surface of covalent organic frameworks.The material structure was characterized by XRD,SEM,EDS,FT-IR,BET,and TG analysis.Due to their rich sulfur content,both adsorbents(COF-SH-1 and COF-SH-2)exhibited a high level of selective Hg^(2+)removal from aqueous solution with maximum adsorption capacities of 763.4 mg g^(-1) and526.3 mg g^(-1),respectively.Furthermore,in the presence of ultra-low concentrations of Hg^(2+)both materials exhibited excellent performance,achieving rapid Hg^(2+)removal at concentrations from 10μg L^(-1) to less than 0.02 ng L^(-1).Analysis of the adsorption mechanism indicates that the sulfur containing chelating groups exhibit a strong binding capacity for Hg^(2+).Results show that the structure determines the performance,with the amount of adsorption sites being related to the adsorption capacity.Therefore,as sulfhydryl functionalized covalent organic frameworks contain an abundance of adsorption sites,these materials can effectively achieve the removal of ultra-low trace Hg^(2+)concentrations and have promising future application potential for the environmental detection of heavy metals. | Fei Pan Chunyi Tong Zhaoyang Wang Fenghua Xu Xiaofei Wang Baicheng Weng Dawei Pan Rilong Zhu | 2021 | Journal of Materials Science & Technology2021，，34： | 2 |
| 9 | Numerical Study of the Effect of Imaginary Circle Diameter and Initial Flow Field on the Aerodynamic Field in a Tangentially Fired Furnace显示文摘In this paper, the effect of the imaginary circle diameter opi and the initial flow field on the aerodynamic field in a tangentially fired furnace was studied by numerical simulation and experiments in the cold model. Results show that merely reducing the imaginary circle diameter rki can not significantly reduce the rotatiollal diameter op in the range considered. The flow still rotates coullter-clockwise stably and does not change rotation direction when the direction of all jet axes are defiected suddenly to the opposite rotation direction by up to 5.4' in a countereclockwise llow field. It is the first time that the numerical sAnulation results were obtained which agreed quite well with this experimental phenomena qualitatively. The experimental data, i.e., the rotational diameter & and the maximum velocity on the syrnmetric central line of fUrnace Vm, are only a bit larger than the simulation results. It is shown that the initial flow field has an important influence on the aerodynamic field in the furnace. Other measures have to be taken as wel1 in order to reduce & to resist slagging and high temperature corrosion of furnace tubes. Moreover, a new kind of grid arrangement was proposed in this paper, which can reduce effectively the false diffosion at the exit zone of burner. | Zhu Tong Sun Shaozeng Xia Chunyi An Baizeng Wu Shaohua Qin Yukun(School of Energy Science and Engineering, Harbin Institute of Technology, 150001, Harbin, China)Ma Xichen(Haxbin Boiler Works) | 1997 | Journal of Thermal Science1997，6，2： | 1 |
| 10 | Genetic mapping of folate QTLs using a segregated population in maizeFA显示文摘As essential B vitamin for humans, folates accumulation in edible parts of crops, such as maize kernels, Is of great importance for human health. But its breeding is always limited by the prohibitive cost of folate profiling. The molecular breeding is a more executable and efficient way for folate fortification, but is limited by the molecular knowledge of folate regulation. Here we report the genetic mapping of folate quantitative trait loci (QTLs) using a segregated population crossed by two maize lines, one high in folate (GEMS31) and the other low in folate (DAN3130). Two folate QTLs on chromosome 5 were obtained by the combination of F2 whole-exome sequencing and F3 kernel-folate profiling. These two QTLs had been confirmed by bulk segregant analysis using F6 pooled DNA and F7 kernel-folate profiling, and were overlapped with QTLs identified by another segregated population. These two QTLs contributed 41.6% of phenotypic variation of 5-formyltetrahydrofolate, the most abundant storage form among folate derivatives in dry maize grains, in the GEMS31×DAN3130 population. Their fine mapping and functional analysis will reveal details of folate metabolism, and provide a basis for marker-assisted breeding aimed at the enrichment of folates in maize kernels. | Wenzhu Guo Tong Lian Baobao Wang Jiantao Guan Dong Yuan Huan Wang Fardous Mohammad Safiul Azam Xing Wan Weixuan Wang Qiuju Liang Haiyang Wang Jinxing Tu Chunyi Zhang Ling Jiang | 2019 | Journal of Integrative Plant Biology2019，61，6： | 1 |
| 11 | Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells(ESPCs)-mediated articular cartilage repair显示文摘As a highly specialized shock-absorbing connective tissue,articular cartilage(AC)has very limited self-repair capacity after traumatic injuries,posing a heavy socioeconomic burden.Common clinical therapies for small-to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies,including microfracture,mosaicplasty,autologous chondrocyte implantation(ACI),and matrix-induced ACI(MACI).However,these treatments frequently result in mechanically inferior fibrocartilage,low cost-effectiveness,donor site morbidity,and short-term durability.It prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyaline-like cartilage with similar biomechanical and biochemical properties as healthy native AC.Acellular regenerative biomaterials can create a favorable local environment for AC repair without causing relevant regulatory and scientific concerns from cell-based treatments.A deeper understanding of the mechanism of endogenous cartilage healing is furthering the(bio)design and application of these scaffolds.Currently,the utilization of regenerative biomaterials to magnify the repairing effect of joint-resident endogenous stem/progenitor cells(ESPCs)presents an evolving improvement for cartilage repair.This review starts by briefly summarizing the current understanding of endogenous AC repair and the vital roles of ESPCs and chemoattractants for cartilage regeneration.Then several intrinsic hurdles for regenerative biomaterials-based AC repair are discussed.The recent advances in novel(bio)design and application regarding regenerative biomaterials with favorable biochemical cues to provide an instructive extracellular microenvironment and to guide the ESPCs(e.g.adhesion,migration,proliferation,differentiation,matrix production,and remodeling)for cartilage repair are summarized.Finally,this review outlines the future directions of engineering the next-generation regenerative biomaterials toward ultimate clinical translation. | Liangbin Zhou Jietao Xu Andrea Schwa Wenxue Tong Jiankun Xu Lizhen Zheng Ye Li Zhuo Li Shunxiang Xu Ziyi Chen Li Zou Xin Zhao Gerjo J.V.Mvan Osch Chunyi Wen Ling Qin | 2023 | Bioactive Materials2023，，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员