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| 1 | Flight strategy optimization for high-altitude long-endurance solar-powered aircraft based on Gauss pseudo-spectral method显示文摘Solar-powered aircraft have attracted great attention owing to their potential for longendurance flight and wide application prospects.Due to the particularity of energy system,flight strategy optimization is a significant way to enhance the flight performance for solar-powered aircraft.In this study,a flight strategy optimization model for high-altitude long-endurance solar-powered aircraft was proposed.This model consists of three-dimensional kinematic model,aerodynamic model,energy collection model,energy store model and energy loss model.To solve the nonlinear optimal control problem with process constraints and terminal constraints,Gauss pseudo-spectral method was employed to discretize the state equations and constraint equations.Then a typical mission flying from given initial point to given final point within a time interval was considered.Results indicate that proper changes of the attitude angle contribute to increasing the energy gained by photovoltaic cells.Utilization of gravitational potential energy can partly take the role of battery pack.Integrating these two measures,the optimized flight strategy can improve the final state of charge compared with current constant-altitude constant-velocity strategy.The optimized strategy brings more profits on condition of lower sunlight intensity and shorter daytime. | Shaoqi WANG Dongli MA Muqing YANG Liang ZHANG Guanxiong LI | 2019 | Chinese Journal of Aeronautics2019，32，10： | 15 |
| 2 | Orderly Porous Covalent Organic Frameworks-based Materials:Superior Adsorbents for Pollutants Removal from Aqueous Solutions显示文摘Covalent organic frameworks(COFs)are a new type of crystalline porous polymers known for chemical stability,excellent structural regularity,robust framework,and inherent porosity,making them promising materials for capturing various types of pollutants from aqueous solutions.This review thoroughly presents the recent progress and advances of COFs and COF-based materials as superior adsorbents for the efficient removal of toxic heavy metal ions,radionuclides,and organic pollutants.Information about the interaction mechanisms between various pollutants and COF-based materials are summarized from the macroscopic and microscopic standpoints,including batch experiments,theoretical calculations,and advanced spectroscopy analysis.The adsorption properties of various COF-based materials are assessed and compared with other widely used adsorbents.Several commonly used strategies to enhance COF-based materials’adsorption performance and the relationship between structural property and sorption ability are also discussed.Finally,a summary and perspective on the opportunities and challenges of COFs and COF-based materials are proposed to provide some inspiring information on designing and fabricating COFs and COF-based materials for environmental pollution management. | Xiaolu Liu Hongwei Pang Xuewei Liu Qian Li Ning Zhang Liang Mao Muqing Qiu Baowei Hu Hui Yang Xiangke Wang | 2021 | The Innovation2021，2，1： | 12 |
| 3 | Efficacy of chalcopyrite bioleaching using a pure and a mixed bacterium显示文摘To determine the efficacy of chalcopyrite bioleaching using pure cultures of Thiobacillus ferrooxidans or Thiobacillus thiooxidans and a mixed culture composed of Thiobacillus ferrooxidans and Thiobacillus thiooxidans, experiments were carried out in shake flasks with [Fe^(2+)] 4 g.L^(-1) and S 1 g.L^(-1) at pH=1.80, 130 r/min and 30℃. The tests showed that the copper extraction in a mixed culture composed of Thiobacillus ferrooxidans and Thiobacillus thiooxidans is higher than that in a pure culture. On the other hand, an important potential of Thiobacillus thiooxidans to leaching chalcopyrite was indicated. Thiobacillus thiooxidans can prevent jarosites accumulating on the substrate and allow further copper to dissolute through the action of ferric ion. The selection of the suitable pH in a leaching solution would be significant. Thiobacillus thiooxidans and Thiobacillus ferrooxidans play an important role in the bioleaching process. Finally, the mechanism and the reason for iron precipitation were also discussed in detail. | Muqing Qiu Shuiying Xiong Weimin Zhang | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 8 |
| 4 | Genotyping-by-sequencing application on diploid rose and a resulting high-density SNP-based consensus map显示文摘Roses,which have been cultivated for at least 5000 years,are one of the most important ornamental crops in the world.Because of the interspecific nature and high heterozygosity in commercial roses,the genetic resources available for rose are limited.To effectively identify markers associated with QTL controlling important traits,such as disease resistance,abundant markers along the genome and careful phenotyping are required.Utilizing genotyping by sequencing technology and the strawberry genome(Fragaria vesca v2.0.a1)as a reference,we generated thousands of informative single nucleotide polymorphism(SNP)markers.These SNPs along with known bridge simple sequence repeat(SSR)markers allowed us to create the first high-density integrated consensus map for diploid roses.Individual maps were first created for populations J06-20-14-3דLittle Chief”(J14-3×LC),J06-20-14-3דVineyard Song”(J14-3×VS)and“Old Blush”דRed Fairy”(OB×RF)and these maps were linked with 824 SNPs and 13 SSR bridge markers.The anchor SSR markers were used to determine the numbering of the rose linkage groups.The diploid consensus map has seven linkage groups(LGs),a total length of 892.2 cM,and an average distance of 0.25 cM between 3527 markers.By combining three individual populations,the marker density and the reliability of the marker order in the consensus map was improved over a single population map.Extensive synteny between the strawberry and diploid rose genomes was observed.This consensus map will serve as the tool for the discovery of marker–trait associations in rose breeding using pedigree-based analysis.The high level of conservation observed between the strawberry and rose genomes will help further comparative studies within the Rosaceae family and may aid in the identification of candidate genes within QTL regions. | Muqing Yan David H.Byrne Patricia E.Klein Jizhou Yang Qianni Dong Natalie Anderson | 2018 | Horticulture Research2018，5，1： | 6 |
| 5 | Down-regulation of CEACAM1 in breast cancer显示文摘(CEACAM1 ) Carcinoembryonic 抗原相关的粘附分子 1 是一种类型属于 CEA 家庭的 1 transmembrane glycoprotein,它当在身体液体的也可溶的形式或房间上的膜界限形式出现,被发现了存在。异常 CEACAM1 表示与肿瘤前进被联系并且在许多人的恶意被发现了。增加的兴趣在乳癌被奉献给 CEACAM1 的表示,但是大多数这些调查结果是矛盾的。这研究的目的是详细地在乳癌调查 CEACAM1 表示。用染色的 immunohistochemical,我们发现那 CEACAM1 表情与 noncancerous 胸纸巾相比在乳癌纸巾被减少或输。另外,可溶的 CEACAM1 在乳癌房间线的文化媒介铺平是比在一个 nontumorigenic 乳房的那些显著地低的上皮的房间线。Immunofluorescence 分析一致地证明乳癌房间线有膜界限 CEACAM1 的相对低的表示。而且, CEACAM1 mRNA 和蛋白质表示层次在分别地用即时反向的 transcriptase 聚合酶链反应和西方的污点分析测量了的乳癌房间线是下面调整的。一起拿,我们的结果在乳癌表明 CEACAM1 的一条系统的下面规定并且建议恢复 CEACAM1 表示的策略可能对乳癌的治疗有用。 | Changcheng Yang Pingqing He Yiwen Liu Yiqing He Cuixia Yang Yan Du Muqing Zhou Wenjuan Wang Guoliang Zhang Man Wu Feng Gao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 5 |
| 6 | Dynamic simulation of aerial towed decoy system based on tension recurrence algorithm显示文摘Dynamic model of aerial towed decoy system is established and simulations are performed to research the dynamic characteristics of the system. Firstly, Kinetic equations based on spinor are built, where the cable is discretized into a number of rigid segments while the decoy is modeled as a rigid body hinged on the cable. Then tension recurrence algorithm is developed to improve computational efficiency, which makes it possible to predict the dynamic response of aerial towed decoy system rapidly and accurately. Subsequently, the efficiency and validity of this algorithm are verified by comparison with Kane's function and further validated by wind tunnel tests.Simulation results indicate that the distance between the towing point and the decoy's center of gravity is suggested to be 5%–20% of the length of decoy body to ensure the stability of system.In up-risen maneuver process, the value of angular velocity is recommended to be less than0.10 rad/s to protect the cable from the aircraft exhaust jet. During the turning movement of aircraft, the cable's extent of stretching outwards is proportional to the aircraft's angular velocity.Meanwhile, the decoy, aircraft and missile form a triangle, which promotes the decoy's performance. | Ma Dongli Wang Shaoqi Yang Muqing Dong Yongpan | 2016 | Chinese Journal of Aeronautics2016，29，6： | 5 |
| 7 | Numerical simulation of Gurney flap on SFYT15thick airfoil显示文摘A two-dimensional steady Reynolds-averaged Navier–Stokes(RANS) equation was solved to investigate the effects of a Gurney flap on SFYT15 thick airfoil aerodynamic performance. This airfoil was designed for flight vehicle operating at 20 km altitude with freestream velocity of 25 m/s. The chord length(C) is5 m and the Reynolds number based on chord length is Re = 7.76 × 105. Gurney flaps with the heights ranging from 0.25%C to 3%C were investigated. The shear stress transport(SST) k-ω turbulence model was used to simulate the flow structure around the airfoil. It is showed that Gurney flap can enhance not only the prestall lift but also lift-to-drag ratio in a certain range of angles of attack. Specially, at cruise angle of attack(α = 3°), Gurney flap with 0.5%C height can increase lift-to-drag ratio by 2.7%, and lift coefficient by 12.9%, respectively. Furthermore, the surface pressure distribution, streamlines and trailing-edge flow structure around the airfoil are illustrated, which are helpful to understand the mechanisms of Gurney flap on airfoil aerodynamic performance. Moreover, it is found that the increase of airfoil drag with Gurney flap can be attributed to the increase of pressure drag between the windward and the leeward sides of Gurney flap itself. | Xi He Jinjun Wang Muqing Yang Dongli Ma Chao Yan Peiqing Liu | 2016 | Theoretical & Applied Mechanics Letters2016，6，6： | 5 |
| 8 | A high-quality genome assembly of Morinda officinalis,a famous native southern herb in the Lingnan region of southern China显示文摘Morinda officinalis is a well-known medicinal and edible plant that is widely cultivated in the Lingnan region of southern China.Its dried roots(called bajitian in traditional Chinese medicine)are broadly used to treat various diseases,such as impotence and rheumatism.Here,we report a high-quality chromosome-scale genome assembly of M.officinalis using Nanopore single-molecule sequencing and Hi-C technology.The assembled genome size was 484.85Mb with a scaffold N50 of 40.97 Mb,and 90.77%of the assembled sequences were anchored on eleven pseudochromosomes.The genome includes 27,698 protein-coding genes,and most of the assemblies are repetitive sequences.Genome evolution analysis revealed that M.officinalis underwent core eudicotγgenome triplication events but no recent whole-genome duplication(WGD).Likewise,comparative genomic analysis showed no large-scale structural variation after species divergence between M.officinalis and Coffea canephora.Moreover,gene family analysis indicated that gene families associated with plant–pathogen interactions and sugar metabolism were significantly expanded in M.officinalis.Furthermore,we identified many candidate genes involved in the biosynthesis of major active components such as anthraquinones,iridoids and polysaccharides.In addition,we also found that the DHQS,GGPPS,TPS-Clin,TPS04,sacA,and UGDH gene families—which include the critical genes for active component biosynthesis—were expanded in M.officinalis.This study provides a valuable resource for understanding M.officinalis genome evolution and active component biosynthesis.This work will facilitate genetic improvement and molecular breeding of this commercially important plant. | Jihua Wang Shiqiang Xu Yu Mei Shike Cai Yan Gu Minyang Sun Zhan Liang Yong Xiao Muqing Zhang Shaohai Yang | 2021 | Horticulture Research2021，8，1： | 4 |
| 9 | The progress and prospect of assessment measures of uterine cavity function for infertility patients显示文摘Objective:To explore the progress and prospect of evaluation methods for infertility patients.Methods:From September 2017 to December 2020,199 cases of infertility patients who have accepted mini-hysteroscopy examination in the Department of Gynecological Endocrinology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University.The patients who had primary ovary insufficiency,tubal infertility were excluded;patients with hysteroscopy contradiction,such as acute or sub-acute vaginal tract inflammation,endometrium lesion or endometrium carcinoma,severe cardiovascular,liver or kidney insufficiency were excluded.40 patients were excluded and 15 patients lost follow up,144 patients were eventually included in the analysis.The patient’s age,body mass index,infertility etiology,preoperative and postoperative stimulate ovulation cycle,pregnancy state and pregnancy time were recorded.The effect of mini-hysteroscopy on ovulation induction cycle was analyzed in pregnant patients.Results:The average age of 144 patients was 32.10±4.67 years old.96(66.67%)patients were found to have intrauterine abnormalities,while 48(33.33%)patients were found to have normal intrauterine cavity.48 cases of pregnancy,accounting for 33.33%;the median and interquartile ranges[M(Q1,Q3)]of ovulation induction cycles before and after surgery were respectively[3(0,5)],[2(1,3)],the difference was statistically significant(P<0.05).Among the 48 pregnant patients,32 of them had no structural lesions in hysteroscopy,the ovulation induction cycle of these patients before and after hysteroscopy were respectively[5(0,9)],[1(0,3)],the difference was statistically significant(P<0.05).Conclusion:Uterine cavity evaluation is important for the assessments of fertility.As an advanced diagnosis instrument,mini-hysteroscopy can not only timely detect the intrauterine abnormalities of patients,hut also with great application value in shorten the ovulation cycle in infertility patients and increase the pregnancy rate. | Luping Zhang Rui Ju Xiangyan Ruan Yinmei Dai Husheng Wang Fengyu Jin Jing Jin Muqing Gu Jiaojiao Cheng Yu Yang Xin Xu Thomas Roemer | 2021 | Global Health Journal2021，5，2： | 3 |
| 10 | Numerical simulation of gurney flaps lift-enhancement on a low reynolds number airfoil显示文摘Two-dimensional steady Reynolds-averaged Navier-Stokes(RANS) equations with transition shear stress transport(SST) model were solved to investigate the effects of Gurney flaps on the aerodynamic performance of a low Reynolds number airfoil. This airfoil was designed for flight vehicles operating at 20 km altitude with freestream velocity of 25 m/s. The chord length(C) of this airfoil is 5 m and the corresponding Reynolds number is 7.76×10~5. Gurney flaps with the heights ranging from 0.25%C to3%C were investigated. It has been shown that Gurney flaps can enhance not only the prestall lift but also lift-to-drag ratio in a certain range of angles of attack. Specially, at cruise angle of attack(3°), Gurney flap with the height of 0.5%C.can increase lift-to-drag ratio and lift coefficient by 1.6% and 12.8%, respectively. Furthermore, the mechanisms of Gurney flaps to improve the aerodynamic performance were illustrated by analyzing the surface pressure distribution, streamlines and trailing-edge flow structure for this low Reynolds number airfoil. Specially, distinguished from some other numerical researches, the flow details such as the laminar separation bubble and transition phenomena for low Reynolds number airfoil with Gurney flaps were investigated and it was found that Gurney flaps can delay the transition onset position at small angles of attack(≤2°). However, with the increase of angles of attack, Gurney flaps will promote the boundary layer transition. | HE Xi WANG JinJun YANG MuQing MA DongLi YAN Chao LIU PeiQing | 2017 | Science China(Technological Sciences)2017，60，10： | 3 |
| 11 | Challenges of organic pollutant photocatalysis by biochar‑based catalysts显示文摘With the fast development of industrialization and urbanization,large amounts of organic pollutants are released into the natural environment.The efficient elimination of organic pollutants is thereby crucial for environmental pollution treatment and human health.In the last decades,photocatalytic degradation of persistent organic pollutants has attracted multidisciplinary interest because of its simple operation on a large scale.However,the whole processes for the photocatalytic degradation of organic pollutants are still unclear.In this perspective,the contribution of reactive species,the contribution of photocatalysts,the analysis of intermediate products,the charge transfer and fast carrier recombination are discussed on biochar-based photocatalysts. | Muqing Qiu Baowei Hu Zhongshan Chen Hui Yang Li Zhuang Xiangke Wang | 2021 | Biochar2021，3，2： | 2 |
| 12 | Adaptive-surrogate-based robust optimization of transonic natural laminar flow nacelle显示文摘Natural Laminar Flow(NLF)technology is very effective for reducing the skin friction drag of aircraft engine nacelle,but the aerodynamic performance of NLF nacelle is highly sensitive to uncertain working conditions.Therefore,it’s imperative to incorporate uncertainties into the design of NLF nacelle.In this study,for a robust optimization of NLF nacelle and for improving its efficiency,an adaptive-surrogate-based robust optimization strategy is established,which is an iterative optimization process where the surrogate model is updated to obtain the real Pareto front of multi-objective optimization problem.A case study is carried out to validate its feasibility and effectiveness.The results show that the optimization increases the favorable pressure gradient region and the volume ratio of the nacelle by increasing its lip radius and reducing its maximum diameter.And the aerodynamic robustness of the NLF nacelle is mainly determined by the lip radius,maximum diameter of nacelle and location of the maximum diameter.Compared to the initial nacelle,the optimized nacelle maintains a wide range of low drag and high laminar flow ratio in the disturbance space,which extends the average laminar flow region to 21.6%and facilitates a decrease of 1.98 counts in the average drag coefficient. | Yuan YAO Dongli MA Muqing YANG Liang ZHANG Yang GUO | 2021 | Chinese Journal of Aeronautics2021，34，10： | 2 |
| 13 | RPL Based on Triangle Module Operator for AMI Networks显示文摘the routing protocol for low-power and lossy networks(RPL) has been used in advanced metering infrastructure(AMI)which could provide two-way communication between smart meters and city utilities.To improve the network performance of AMI networks, this paper proposed an improved algorithm of RPL based on triangle module operator(IAR-TMO). IAR-TMO proposes membership functions of the following five typical routing metrics: end-to-end delay, number of hops, expected transmission count(ETX),node remaining energy, and child node count.Moreover, IAR-TMO uses triangle module operator to fuse membership functions of these routing metrics. Then, IAR-TMO selects preferred parents(the next hop) based on the triangle module operator. Theoretical analysis and simulation results show that IAR-TMO has a great improvement when compared with two recent representative algorithms: ETXOF(ETX Objective Function) and OF-FL(Objective Function based on Fuzzy Logic), in terms of network lifetime, average end-to-end delay,etc. Consequently, the network performances of AMI networks can be improved effectively. | Yanan Cao Muqing Wu | 2018 | China Communications2018，15，5： | 2 |
| 14 | Chemical functionalization of 2D black phosphorus显示文摘As an emerging two-dimensional material,black phosphorus(BP)has fascinating structure and electronic properties,affording broad applications in fieldeffect transistors,optoelectronic devices,energy devices,and biomedicines.However,the lone pair electrons of phosphorus atoms readily react with oxygen,so few-layer BP is easily oxidized and degraded when exposed to air.Therefore,the ambient stability of BP needs to be enhanced for its potential application.Chemical functionalization is one of the most effective methods for improving the ambient stability of few-layer BP.In this review,we provide a comprehensive overview of the chemical functionalization of BP,focusing on covalent and noncovalent functionalization and surface coordination.The influence of the functionalization pattern on the electronic properties and ambient stability of BP is summarized.Finally,the challenges and future development of chemical functionalization of BP are discussed. | Yajuan Liu Muqing Chen Shangfeng Yang | 2021 | InfoMat2021，3，3： | 2 |
| 15 | Biochar for the removal of contaminants from soil and water:a review显示文摘Biochar shows significant potential to serve as a globally applicable material to remediate water and soil owing to the extensive availability of feedstocks and conducive physio-chemical surface characteristics.This review aims to highlight biochar production technologies,characteristics of biochar,and the latest advancements in immobilizing and eliminating heavy metal ions and organic pollutants in soil and water.Pyrolysis temperature,heat transfer rate,residence time,and type of feedstock are critical influential parameters.Biochar’s efficacy in managing contaminants relies on the pore size distribution,surface groups,and ion-exchange capacity.The molecular composition and physical architecture of biochar may be crucial when practically applied to water and soil.In general,biochar produced at relatively high pyrolysis temperatures can effectively manage organic pollutants via increasing surface area,hydrophobicity and microporosity.Biochar generated at lower temperatures is deemed to be more suitable for removing polar organic and inorganic pollutants through oxygen-containing functional groups,precipitation and electrostatic attraction.This review also presents the existing obstacles and future research direction related to biochar-based materials in immobilizing organic contaminants and heavy metal ions in effluents and soil. | Muqing Qiu Lijie Liu Qian Ling Yawen Cai Shujun Yu Shuqin Wang Dong Fu Baowei Hu Xiangke Wang | 2022 | Biochar2022，4，1： | 2 |
| 16 | Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance显示文摘 | Muqing Zhou Zhiming Jin Yiwen Liu Yiqing He Yan Du Cuixia Yang Yingzhi Wang Jiajie Hu Lian Cui Feng Gao Manlin Cao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 2 |
| 17 | Optimization and analysis of winglet configuration for solar aircraft显示文摘Installing winglets can notably improve the aerodynamic performance of solar aircraft.This paper proposes a multi-constraints optimization method of winglets for solar aircraft,aiming to enhance the corresponding uninterrupted cruising capability.An optimization objective function is formed and is separately studied in aerodynamic and structural terms.Qualitative analysis shows that the winglet design parameters are restricted by four special constraints(geometry,aerodynamics,energy and stability)of solar aircraft.The optimization process is constructed on the basis of a multi-island genetic algorithm,and carried out for a 15 m wingspan solar aircraft.Although the designed winglet is not as good as the traditional winglet in terms of drag and structural weight,the designed winglet provides a better 24 h cruising capability.The sensitivity between the objective function and the design parameters is investigated,and the winglet effects vary with respect to the wing aspect ratio(AR=10,15,19.6).The effect of the constraints is analysed quantitatively,and some basic laws are obtained.Moreover,the feasible design region and the possible optimal design parameters of winglets for different wing configurations are explored.The calculation results show that when the aspect ratio exceeds a certain value,the winglets will not benefit the aircraft. | Liang ZHANG Dongli MA Muqing YANG Shaoqi WANG | 2020 | Chinese Journal of Aeronautics2020，33，12： | 2 |
| 18 | Optimizing conditions for bacterial leaching of copper from discarded mines显示文摘The effect of process parameters (pH, pulp density, inoculum volume, ferrous content, particle size) on the rate of coppersolubilization was analyzed respectively through bioleaching tests with mixed bacteria in shake flasks. These results show that theoptimal process parameters are: pH, 1.50-1.80; pulp density, 5wt%; inoculum volume, 10vol%; ferrous content, 2g?L?1; particle size,<0.076 mm. Furthermore, when the pH value is below 1.50 in leaching solution, the iron precipitated can be reduced to a great extent,but it shows low bacterial activity at this pH. Finally, it is emphasized that the optimal parameters are also determined by economicalbenefit. | Muqing Qiu Genxuan Wang Weimin Zhang Shuiying Xiong | 2006 | Journal of University of Science and Technology Beijing2006，13，2： | 1 |
| 19 | Reclaiming the Efficiency of Opportunistic Routing in Wireless Multi-Hop Networks显示文摘Opportunistic routing(OR) is an effective way to guarantee transmission reliability in wireless multi-hop networks.However,little research focuses on transmission efficiency.Thus,an analytical model based on open queuing network with Markov chains was proposed to evaluate the efficiency.By analyzing two typical ORs,we find duplicate transmission and collision avoidance overhead are the root reasons behind inefficiency.Therefore,a new scheme called dual priority cooperative opportunistic routing(DPCOR) was proposed.In DPCOR,forwarding candidates are configured with dual priority,which enables the network to classify forwarding candidates more effectively so as to reduce the back-off time and obtain more diversity gain.Theoretical analysis and simulation results show DPCOR achieves significant performance improvement with less time overhead compared with traditional routings and typical ORs. | WANG Dongyang WU Muqing WANG Hengyou LAI Xiaoyang LV Bo | 2014 | China Communications2014，11，8： | 1 |
| 20 | Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment显示文摘F1Fo-ATP synthase 原来是思维只在线粒体的内部膜定位。然而,最近的研究在房间膜的外面上证明宫外的 F1Fo-ATP synthase 的存在。宫外的 ATP synthase 为肿瘤目标治疗作为一个标记被建议。不过,宫外的 ATP synthase 的蛋白质运输机制仍然是不清楚的。关于肿瘤,因为它的普遍表示,宫外的 ATP synthase 的特性被询问。在当前的学习,我们构造了绿色荧光灯 protein-ATP5B 熔化蛋白质并且介绍了它进 HepG2 房间学习 ATP synthase 的本地化。ATP5B 的表示与不同恶意在六根房间线被分析。这些房间是有教养的在正常、像肿瘤酸并且 hypoxic 条件。结果建议 ATP synthase 的宫外的表示是从线粒体的 translocation 的后果。表示和宫外的 ATP synthase 的催化活动作为在不太恶意的房间的表面上在恶意的房间的表面上是类似的。有趣地,宫外的 ATP synthase 的表示不是起来调整的在像肿瘤酸并且 hypoxic 微型环境。然而,宫外的 ATP synthase 的催化活动在像肿瘤的微型环境是起来调整的。因此,为肿瘤目标治疗的宫外的 ATP synthase 的特性依靠被观察在的催化活动的高水平酸并且在肿瘤纸巾的 hypoxic 微型环境。 | Zhan Ma Manlin Cao Yiwen Liu Yiqing He Yingzhi Wang Cuixia Yang Wenjuan Wang Yan Du Muqing Zhou Feng Gao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 1 |
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