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| 1 | An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. | Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He | 2019 | Cell Research2019，29，5： | 10 |
| 2 | The effect of nanohybrid materials on the pour-point and viscosity depressing of waxy crude oil显示文摘The pipeline transportation of waxy crude oil is a problem both at home and abroad.In this paper,a novel nanohybrid pour-point depressant (PPD) was used to decrease the pour point and viscosity of waxy crude oil.The pour point and apparent viscosity of waxy crude oil was decreased significantly upon addition of the nanohybrid PPD,and the long-term stability of the nanohybrid PPD was superior to that of a conventional ethylene-vinyl acetate copolymer PPD.Polarized optical microscopy and X-ray diffraction were used to study the effect of the nanohybrid PPD on the crystallization of crude oil.Addition of the nanohybrid PPD reduced the amount of wax crystals,prevented their aggregation,and reduced the temperature at which the crude oil started to crystallize.The significant effect of this nanohybrid PPD on the pour point and viscosity depressing of crude oil is of great importance for facilitating the safe,efficient and energy-minimized transportation of waxy crude oil. | WANG Feng ZHANG DongMin DING YanFen ZHANG LiXin YANG MingShu JIANG BaoLiang ZHANG ShiMin AI MuYang LIU GuangWen ZHI ShuJie HUO LianFeng OUYANG Xin LI Li | 2011 | Chinese Science Bulletin2011，56，1： | 9 |
| 3 | Salicyloyl-aspartate synthesized by the acetyl-amido synthetase GH3.5 is a potential activator of plant immunity in Arabidopsis显示文摘水杨酸酸(SA ) 对病原体感染在植物免疫回答起一个关键作用,特别在全身的获得的抵抗的建立。水杨酸盐的另外的形式是否也在植物免疫工作,没被探索。我们的以前的学习揭示了那 salicyloyl-aspartate (SA 毒蛇) ,唯一的报导的内长的 SA 氨基的酸在植物结合,高度在病原体感染以后在 Arabidopsis 标注激活的变异的 gh3.5-1D 被积累。在这研究,我们把了在 Arabidopsis 的 SA 毒蛇生产。在 vitro,生物化学的实验证明 GH3.5 蛋白质能与丁氨二酸酸催化 SA 的变化形式形成 SA 毒蛇。SA 毒蛇没在植物作为一个活动分子被变换成免费 SA 和可能的幕。SA 毒蛇能导致致病相关(PR ) 基因表示和增加疾病抵抗到病原的 Pseudomonas syringae。我们的当前的学习也支持 GH3.5 是在植物荷尔蒙新陈代谢的多功能酶的观点。 | Ying Chen Hui Shen Muyang Wang Qun Li Zuhua He | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 6 |
| 4 | Evaluation of coronary plaque and stent deployment by intravascular optical coherence tomography in elderly patients with unstable angina and non-ST-elevation myocardial infarction显示文摘Objective To evaluate the feasibility and efficacy of intravascular optical coherence tomography (OCT) in the assessment of plaque characteristics and drug eluting stent deployment quality in the elderly patients with unstable angina (UA) and non-ST segment elevation myocardial infarction (NSTEMI). Methods OCT was used in elderly patients undergoing percutaneous coronary interventions. Fifteen patients, 9 males and 6 females with mean age of 72.6±5.3 years (range 67-92 years) were enrolled in the study. Images were obtained before initial balloon dilatation and following stent deployment. The plaque characteristics before dilation, vessel dissection, tissue prolapse, stent apposition and strut distribution after stent implantation were evaluated. Results Fifteen lesions were selected from 32 angiographic lesions as study lesions for OCT imaging after diagnostic coronary angiography. There were 7 lesions in the left anterior descending artery, 5 lesions in the right coronary artery and 3 lesions in the left circumflex coronary artery. Among them, 12 (80.0%) were lipid-rich plaques, and 10 (66.7%) were vulnerable plaques with fibrous cap thickness 54.2±7.3 μm. Seven ruptured culprit plaques (46.7%) were found; 4 in UA patients and 3 in NSTEMI patients. Tissue prolapse was observed in 11 lesions (73.3%). Irregular stent strut distribution was detected in 8 lesions (53.3%). Vessel dissections were found in 5 lesions (33.3%). Incomplete stent apposition was observed in 3 stents (20%) with mean spacing between the struts and the vessel wall 172±96 mm (range 117-436 mm). Conclusions 1) It is safe and feasible to perform intravascular OCT to differentiate vulnerable coronary plaque and monitor stent deployment in elderly patients with UA and USTEMI. 2) Coronary plaques in elderly patients with UA and USTEMI could be divided into acute ruptured plaque, vulnerable plaque, lipid-rich plaque, and stable plaque. 3) Minor or critical plaque rupture is one of the mechanisms of UA in elderly patients. 4) Present drug eluting stent implantation is complicated with multiple tissue prolapses which are associated with irregular strut distributions. 5) The action and significance of tissue prolapse on acute vessel flow and in-stent thrombus and restenosis need to be further studied. | Caiyi LU Shiwen WANG Wei YAN Xingli WU Yuxiao ZHANG Qiao XUE Muyang YAN Peng LIU Rui CHEN Jinyue ZHAI | 2007 | Journal of Geriatric Cardiology2007，4，1： | 3 |
| 5 | Benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids:Design,synthesis and in vitro anti-mycobacterial activity evaluation显示文摘A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H_(37)Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents. | Yaohuan Zhang Ruo Wang Tesen Zhang Weitao Yan Yihong Chen Yanping Zhang Muyang Zhou | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 6 | Impact of great gerbils(Rhombomys opimus) on desert plant communities显示文摘Great gerbil(Rhombomys opimus) colonies, with bare soil and herbaceous plants, are conspicuous to the background environment throughout their range area. In order to quantify the engineer role of great gerbils, we investigated the plant communities of 20 active colonies in the Junggar Basin, Xinjiang, China. In areas without disturbance, desert plant communities were dominated by the shrubs with low level species richness. In burrow areas and surrounding intermediate areas, which were disturbed by great gerbils, the shrubs were suppressed with the decrease of vegetation cover and aboveground biomass. As a result, 'niche gaps' were created in disturbed areas and worked as a refuge for herbaceous annuals and perennials. So the existence of great gerbils increased the overall species richness of the desert. Furthermore, herbaceous annuals and perennials are the major food source for great gerbils in spring, indicating that great gerbils have a mutually beneficial relationship with herbaceous plants. | XU Wenxuan LIU Wei YANG Weikang WANG Muyang XU Feng David BLANK | 2015 | Journal of Arid Land2015，7，6： | 2 |
| 7 | Diet characteristics of wild sheep(Ovis ammon darwini) in the Mengluoke Mountains,Xinjiang,China显示文摘In most arid and semi-arid regions of the world, domestic livestock and native wildlife share pastures, and their competition for forage and habitat is thought to be a serious conservation issue. Moreover, unmanaged grazing by livestock can cause the population decline in wild ungulates. The diet of an animal species is a determining aspect of its ecological niche, and investigating its diet has been one of the initial steps in basic ecology study of a new species. To get an approximate understanding of the interspecific food relationships of argali(Ovis ammon darwini) between sexes, and sympatric domestic sheep and goats, we compared the diet compositions and diet-overlaps among these herbivores, i.e., male argali, female argali, domestic sheep, and domestic goats in the Mengluoke Mountains of Xinjiang, China by using micro-histological fecal analysis. Female argali, male argali, domestic sheep and domestic goat primarily consumed forbs(43.31%±4.86%), grass(36.02%±9.32%), forbs(41.01%±9.18%), and forbs(36.22%±10.61%), respectively in warm season. All these animals consumed mostly shrubs(female argali: 36.47%±7.56%; male argali: 47.28%±10.75%; domestic sheep: 40.46%±9.56%; and domestic goats: 42.88%±9.34%, respectively) in cold season. The diet-overlaps were relatively high among all species in cold season with values ranging from 0.88 to 0.94. Furthermore, Schoener's index measured between each possible pair of 4 herbivores increased from the warm season to the cold season. The results illustrate that the high degree of diet-overlap of argali and domestic livestock(sheep and goat) may pose a threat to the survival of the argali in cold season. From the viewpoint of rangeland management and conservation of the endangered argali, the numbers of domestic sheep and goats should be limited in cold season to reduce food competition. | LI Bang XU Wenxuan David A BLANK WANG Muyang YANG Weikang | 2018 | Journal of Arid Land2018，10，3： | 1 |
| 8 | Feasibility and safety of combined interventional procedures in elderly patients with complex cardiovascular diseases:experience of a single medical center显示文摘Objectives:To report the clinical experience of combined interventional procedures in the treatment of elderly patients with coexisting two or more cardiovascular diseases in our medical center, and to assess the feasibility, safety and therapeutic efficacy of this management strategy. Methods : Patients were selected to the study if: 1) age >65 years; 2) with coexistence of two or more cardiovascular diseases which are indications for interventional therapy; 3) patients' general condition and organ functions allow the performance of combined multiple procedures; 4) the predicted procedure time is within 150 min; 5) the predicted contrast medium dosage is within 300 ml. The criteria we analyzed included procedural type, rocedural time, fluoroscopy time, dosage of contrast medium, success rates of the procedures, complications and in-hospital mortality. All patients were followed up for 30.4 ± 9.3 months,to determine the all-cause mortality, recurrence rates and adverse cardiac events. Results : From January 2000 to December 2004,combined interventional procedures were performed on 136 patients, with 2 procedures on 134 patients and 3 procedures on 2 patients.The mean procedure time was 115.4±11.6 min, the mean fluoroscopy time was 35.7±9.3 min, and the mean dosage of contrast medium used was 183.6±19.4 ml. Procedural success rate was 100%, no procedure related death or major complications occurred.Conclusion: Performed by a competent team, combined interventional procedures in elderly patients with multiple cardiovascular diseases were feasible and relatively safe. | Caiyi LU Shiwen WANG Xinli WU Qiao XUE Taohong HU Muyang YAN Rui CHEN Zhongren ZHAO Haiyun WU | 2005 | Journal of Geriatric Cardiology2005，2，3： | 1 |
| 9 | Fabric-substrated capacitive biopotential sensors enhanced by dielectric nanoparticles显示文摘Wearable biopotential sensing devices are essential to long-term and real-time monitoring of human health.Non-contact,capacitive sensing electrodes prevent potential skin iritations,and are thus beneficial for long-term monitoring.Existing capacitive electrodes are either connected to a separate control circuit via external wires or have limited sensing capacitances,which leads to low signal qualities.This study demonstrates a stretchable capacitive sensing device with integrated electrodes and control electronics,with enhanced signal qualities.The electrodes and the control electronics are fabricated on a common fabric substrate for breathability and strain-limiting protection.The stretchable electrodes are based on an island-bridge design with a stretchability as high as-100%,and an area ratio as high as-80%.By using a dielectric calcium copper titanate(CCTO)composite as the adhesive layer,the electrode capacitance can be increased,yielding an enhanced signal-to-noise ratio(SNR)in the acquired biopotentials.This device offers a convenient and comfortable approach for long-term non-contact monitoring of biopotential signals. | Xiangjun Chen Xiaoxiang Gao Akihiro Nomoto Keren Shi Muyang Lin Hongjie Hu Yue Gu Yangzhi Zhu Zhuohong Wu Xue Chen Xinyu Wang Baiyan Qi Sai Zhou Hong Ding Sheng Xu | 2021 | Nano Research2021，14，9： | 1 |
| 10 | Effects of Simvastatin on Endoplasmic Reticulum Stress-Mediated Apoptosis in Atherosclerotic Calcification显示文摘Objective:The effectiveness of statins in reducing atherosclerotic calcification remains controversial.The aim of this study was to confirm that simvastatin reduces atherosclerotic calcification and stabilizes plaque by restricting endoplasmic reticulum stress(ERS)-mediated apoptosis.Methods:Twenty-four 8-week-old male apolipoprotein E(ApoE)-/-mice(C57BL/6J genetic background)were selected and randomly divided into model(n=12)and simvastatin(n=12)groups.Twelve male C57BL/6J mice were selected as control group(n=12).The mice were adaptively fed for 2 weeks and were put on a high-fat diet thereafter.After 9 weeks,they were treated with simvastatin(20 mg/kg)or phosphate-buffered saline daily for 8 weeks.Aortic sinus samples were obtained from ApoE-/-and C57BL/6J mice for hematoxylin and eosin,von Kossa,alizarin Red S,terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling,and immunohistochemical staining after in vivo treatment with simvastatin.In addition,mouse vascular smooth muscle cells were analyzed after exposure to simvastatin in vitro.Results:Administration of simvastatin in vivo drastically attenuated the atherosclerosis,calcification,and apoptosis,and decreased the serum levels of triglycerides,total cholesterol,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol.The expression levels of glucose-regulated protein,78 kDa(GRP78),C/EBP homologous protein(CHOP),and caspase 12(CASP12)in the aortic sinus decreased in the simvastatin group compared with the model group.In vitro,simvastatin or simvastatin plus ERS inhibitor(taurine)attenuated calcification and apoptosis,and reduced the expression of ERS-related proteins GRP78,CHOP,and CASP12.Conclusion:Treatment with simvastatin suppressed atherosclerotic calcification.This effect may be mediated through the inhibition of ERS-related apoptosis. | Jianhua Li Libo Zhao Zhe Zhou Lin Liu Xiao Zou Weihao Xu Li Fan Muyang Yan Shengqi Wang | 2022 | Cardiology Discovery2022，2，4： | 0 |
| 11 | Scutellaria baicalensis:a promising natural source of antiviral compounds for the treatment of viral diseases显示文摘Viruses,the smallest microorganisms,continue to present an escalating threat to human health,being the leading cause of mortality worldwide.Over the decades,although significant progress has been made in the development of therapies and vaccines against viral diseases,the need for effective antiviral interventions remains urgent.This urgency stems from the lack of effective vaccines,the severe side effects associated with current drugs,and the emergence of drug-resistant viral strains.Natural plants,particularly traditionally-used herbs,are often considered an excellent source of medicinal drugs with potent antiviral efficacy,as well as a substantial safety profile.Scutellaria baicalensis,a traditional Chinese medicine,has garnered considerable attention due to its extensive investigation across diverse therapeutic areas and its demonstrated efficacy in both preclinical and clinical trials.In this review,we mainly focused on the potential antiviral activities of ingredients in Scutellaria baicalensis,shedding light on their underlying mechanisms of action and therapeutic applications in the treatment of viral infections. | HUANG Qiuju WANG Muyang WANG Min LU Yuhui WANG Xiaohua CHEN Xin YANG Xin GUO Hongwei HE Rongrong LUO Zhuo | 2023 | Chinese Journal of Natural Medicines2023，21，8： | 0 |
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