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| 1 | An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. | Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He | 2019 | Cell Research2019，29，5： | 10 |
| 2 | Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes显示文摘As an excitatory transmitter system,the glutamatergic transmitter system controls excitability and conductivity of neurons.Since both cardiomyocytes and neurons are excitable cells,we hypothesized that cardiomyocytes may also be regulated by a similar system. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qiang Ji Qicheng Zou Lingling Wang Yi Liu Dandan Liang Jinfeng Xue Luxin Wang Xueting Gao Xingdong Gu Hongyu Liu r Xiaoyu He Li Li Jian Yang Youming Lu Luying Peng Yi-Han Chen | 2021 | Cell Research2021，31，9： | 5 |
| 3 | Mailuoning prevents high-glucose-mediated human umbilical vein endothelial cells apoptosis显示文摘OBJECTIVE: To investigated the role of Mailuoning in the prevention of high-glucose-mediated ce apoptosis in human umbilical vein endothelial cell (HUVEC) and the mechanisms involved. METHODS: MTT assay was used to investigate ce viability, western blot was used to investigate pro tein expression, and flow cytometric detection technology was used to detect cell apoptosis. RESULTS: Exposure of HUVEC to high glucose (50 mM) significantly suppressed cell viability and increased cell apoptosis compared with normal glu cose (11 mM) (all P<0.05). However, Mailuoning pre vented high-glucose-induced HUVEC apoptosis in dose-dependent manner. Further studies indicatedthat Mailuoning suppressed high-glucose-induced p38 mitogen-activated protein kinase phosphorylation, but had no effect on extracellular signal-regulated kinase 1/2 and Akt phosphorylation. CONCLUSION: Mailuoning can prevent high-glucose-induced HUVEC apoptosis by suppressing p38 activation. | Wei Wang Chao Liu Jie Yang Xueting Cai Wuguang Lu Zhenhua Gu Peng Cao | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 2 |
| 4 | Roles of small RNAs in crop disease resistance显示文摘Small RNAs(sRNAs)are a class of short,non-coding regulatory RNAs that have emerged as critical components of defense regulatory networks across plant kingdoms.Many sRNA-based technologies,such as host-induced gene silencing(HIGS),spray-induced gene silencing(SIGS),virus-induced gene silencing(VIGS),artificial microRNA(amiRNA)and synthetic trans-acting siRNA(syn-tasiRNA)-mediated RNA interference(RNAi),have been developed as disease control strategies in both monocot and dicot plants,particularly in crops.This review aims to highlight our current understanding of the roles of sRNAs including miRNAs,heterochromatic siRNAs(hc-siRNAs),phased,secondary siRNAs(phasiRNAs)and natural antisense siRNAs(nat-siRNAs)in disease resistance,and sRNAs-mediated trade-offs between defense and growth in crops.In particular,we focus on the diverse functions of sRNAs in defense responses to bacterial and fungal pathogens,oomycete and virus in crops.Further,we highlight the application of sRNA-based technologies in protecting crops from pathogens.Further research perspectives are proposed to develop new sRNAs-based efficient strategies to breed non-genetically modified(GMO),diseasetolerant crops for sustainable agriculture. | Jun Tang Xueting Gu Junzhong Liu Zuhua He | 2021 | Stress Biology2021，1，1： | 0 |
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