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| 1 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘 | Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M | 2008 | Lancet Oncology2008，，3： | 12 |
| 2 | Phase Ⅱ study of protracted irinotecan infusion and a low-dose cisplatin for metastatic gastric cancer显示文摘AIM: To test protracted irinotecan infusion plus a low-dose cisplatin in this Phase Ⅱ trial to decrease its toxic-ity. METHODS: The eligibility criteria were: (1) histologi-cally proven measurable gastric cancer; (2) performance status of 0 or 1; (3) no prior chemotherapy or comple-tion of prior therapy at least 4 wk before enrollment; (4) adequate function of major organs; (5) no other active malignancy; and (6) written informed consent. The regi-men consisted of irinotecan (60 mg/m2) on d 1 and 15 by 24-h infusion and cisplatin (10 mg/m2) on d 1, 2, 3, 15, 16, and 17. Treatment was repeated every 4 wk. RESULTS: Thirty-one patients were registered between April 2000 and January 2001. The response rate for all 31 patients, 20 patients without prior chemotherapy, and 11 patients with prior chemotherapy was 52% (16/31), 60% (12/20), and 36% (4/11), respectively. The median survival time was 378 d. The median number of courses given to all patients was 2. Grade 4 neutropenia oc-curred in 11 (35%) patients, while grade 3 to 4 diarrhea or nausea occurred in 1 (3%) and 3 (10%) patients, respectively. Fatigue was minimal as grade 1 fatigue was found only in 3 (10%) patients. Other adverse events were mild and no treatment-related deaths occurred.CONCLUSION: This regimen showed a high level of ac-tivity and acceptable toxicity in patients with metastatic gastric cancer. | Hiroshi Imamura Masataka Ikeda Hiroshi Furukawa Toshimasa Tsujinaka Kazumasa Fujitani Kenji Kobayashi Hiroyuki Narahara Michio Kato Haruhiko Imamoto Arimichi Takabayashi Hideaki Tsukuma | 2006 | World Journal of Gastroenterology2006，12，40： | 7 |
| 3 | A novel videoendoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers <ce:link locator='fx1'/>显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Takuya Yamada Hideharu Ogiyama Kazuho Imanaka Naotoshi Sugimoto Koji Higashino Ryu Ishihara Hiroyuki Narahara Shingo Ishiguro | 2005 | Gastrointestinal Endoscopy2005，，4： | 2 |
| 4 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘 | Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M | 2008 | Lancet Oncology2008，，3： | 2 |
| 5 | Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan显示文摘 | Ryu Ishihara Hiroyasu Iishi Noriya Uedo Yoji Takeuchi Sachiko Yamamoto Takuya Yamada Eriko Masuda Koji Higashino Motohiko Kato Hiroyuki Narahara Masaharu Tatsuta | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 6 | Combination of fluvastatin with pegylated interferon/ribavirin therapy reduces viral relapse in chronic hepatitis C infected with HCV genotype 1b显示文摘 | Masanori Atsukawa Akihito Tsubota Chisa Kondo Norio Itokawa Yoshiyuki Narahara Katsuhisa Nakatsuka Satomi Hashimoto Takeshi Fukuda Yoko Matsushita Hideko Kidokoro Tamaki Kobayashi Hidenori Kanazawa Choitsu Sakamoto | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 7 | Kawasaki disease in an 8-day-old neonate 显示文摘 | Nakagawa N Yoshida M Narahara K | 2008 | Pediatr Cardiol2008，，： | 1 |
| 8 | Role of chemokines in the pathogenesis of Endometriosis显示文摘 | Nishida M Nasu K Narahara H | 2011 | Front Biosci2011，3，13： | 1 |
| 9 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer ( SPIRITS trial) :a phase III tria显示文摘 | Koizumi W Narahara H Hara T | 2008 | Lancet Oncol2008，9，： | 1 |
| 10 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gas-tric cancer (SPIRITS trial): a phase III trial显示文摘 | Koizumi W Narahara H Hara T | 2008 | Lancet Oncol2008，9，3： | 1 |
| 11 | A novel videoendoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers <ce:link locator='fx1'/>显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Takuya Yamada Hideharu Ogiyama Kazuho Imanaka Naotoshi Sugimoto Koji Higashino Ryu Ishihara Hiroyuki Narahara Shingo Ishiguro | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 12 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase Ⅲ trial 显示文摘 | Koizumi W Narahara H Hara T | 2008 | Lancet Oncol2008，9，3： | 1 |
| 13 | S - 1 plus cisplatin versus S - 1 alone for first-line treatment of advanced gastric cancer ( SPIRITS trial) : a phase Ⅲ trial 显示文摘 | Koizumi W Narahara H Hara T | 2008 | Lancet Oncol2008，9，3： | 1 |
| 14 | Growth and enayme production in a solid-state culture of Aspergillus oryzae显示文摘 | Narahara H Koyama Y Yoshida T | 1982 | J Ferment Technol1982，69，： | 1 |
| 15 | Production of Interleukin (IL)-6 and IL-8 by a Choriocarcinoma Cell Line, BeWo显示文摘 | K. Fujisawa K. Nasu K. Arima T. Sugano H. Narahara I. Miyakawa | 2000 | Placenta2000，，4： | 1 |
| 16 | Effects of transjugular intrahepatic portosystemic shunt on changes in the small bowel mucosa of cirrhotic patients with portal hypertension显示文摘 | Yoko Matsushita Yoshiyuki Narahara Shunji Fujimori Hidenori Kanazawa Norio Itokawa Takeshi Fukuda Yoko Takahashi Chisa Kondo Hideko Kidokoro Masanori Atsukawa Katsuhisa Nakatsuka Choitsu Sakamoto | 2013 | Journal of Gastroenterology2013，，5： | 1 |
| 17 | S-l plus cisplatin versus S-l alone for first-line treatment of advanced gastric cancer(SPlRITS trial):A phase Ⅲ trial显示文摘 | Koizumi W Narahara H Hara T | 2008 | Lancet Oncol2008，9，3： | 1 |
| 18 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIPITS trial): a phase Ill trial显示文摘 | Koizumi W Narahara H Hara T | 2008 | Lancet Oncol2008，9，3： | 1 |
| 19 | Platelet activating factor acetylhydrolade activity in human follicular fluid显示文摘 | Narahara H Tanaka Y Kawano Y | 1996 | Adv Exp Med Biol1996，416，： | 1 |
| 20 | Insulin responsiveness to glucose and tissue responsiveness to insulin during lactation in dairy cows显示文摘 | Sano H Narahara S Kondo T | 1993 | Domest Anim Endocrinol1993，10，： | 1 |
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