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| 1 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 2 | Electroanatomic versus fluoroscopic mapping for catheter ablation procedures:A prospective randomized study显示文摘 | Sporton S Earley M Nat han A | 2004 | J Cardiovasc Electrophysiol2004，15，： | 1 |
| 3 | P1site-specific recombination:nucleotide sequence of recombining sites显示文摘 | RONALD H H MARCIA Z NAT S | 1982 | Proc Natl Acad Sci USA1982，79，： | 1 |
| 4 | Studies on the properties of p1 site-specific recombination;Evidence for topologically unlinked products following recombination显示文摘 | KEN A RON H NAT S | 1983 | Cell1983，32，： | 1 |
| 5 | Clinical impact of intratu-moralnatural killer cell and dendritic cell infiltration in gastric cancer显示文摘 | Nat sugoe S Tokuda K Nakajo A | 2000 | Cancer Lett2000，159，1： | 1 |
| 6 | Identification of differentially expressed non-coding RNAs in embryonic stem cell neural differentiation显示文摘 | Skreka K Schafferer S Nat IR | | 0，，13： | 1 |
| 7 | Activity of phenolic compounds from plant origin against Candida species显示文摘 | Natália Martins Lillian Barros Mariana Henriques Sónia Silva Isabel C.F.R. Ferreira | 2015 | Industrial Crops & Products2015，，： | 1 |
| 8 | Laparoscopic cardiomyotomy forachalas ia显示文摘 | Shimi S Nat hanson LK Cu schieriA | 1991 | JR Coll Surg Ed inb1991，36，3： | 1 |
| 9 | Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma显示文摘 | Takatori H Nat sugoe S Okumura H | 2008 | Eur J Surg Oncol2008，34，4： | 1 |
| 10 | Exposure to p,p'-DDE or dieldrin during the\sreproductive season alters hepatic CYP expression in largemouth bass(Micropterus salmoides)显示文摘 | Barber David S Mc Nally Alex J Garcia-Reyero Natàlia | 2007 | Aquatic Toxicology(Amsterdam Netherlands)2007，81，1： | 1 |
| 11 | Wear in cast titanium carbide reinforced ferrous composites under dry sliding显示文摘 | Rai V K Srivastava R Nat h S K | 1999 | Wear1999，231，2： | 1 |
| 12 | 查看详情显示文摘 | Kateˇrina Trtkov′a Lenka Paˇskov′a Nat′alie Matijeˇsˇcukov′a | | 0，，02： | 1 |
| 13 | Analysis of six fungicides and one acaricide in still and fortified wines using solid-phase microextraction-gas chromatography/tandem mass spectrometry显示文摘 | Joana Martins Cristina Esteves Ana Limpo-Faria Paulo Barros Natália Ribeiro Tomás Sim?es Manuela Correia Cristina Delerue-Matos | 2011 | Food Chemistry2011，，1： | 1 |
| 14 | The role of fibrin glue in the treat- ment of high and low fistulas in ano 显示文摘 | Mishra A Shah S Nat AS | 2013 | J Clin Diagn Res2013，7，5： | 1 |
| 15 | Reducing the semantic gap in content-based image retrieval in mammography with relevance feedback and inclusion of expert knowledge显示文摘 | Paulo Mazzoncini de Azevedo-Marques Natália Abdala Rosa Agma Juci Machado Traina Caetano Traina Sérgio Koodi Kinoshita Rangaraj Mandayam Rangayyan | 2008 | International Journal of Computer Assisted Radiology and Surgery2008，，1： | 1 |
| 16 | Reactoge nicity of infant whole cell pertussis combination vaccine corn pared with a cellular pertussis vaccines with or without si mtd-- taneous pneumococcal vaccine in Netherlands 显示文摘 | David S Vermeer-de Bondt PE van der Maas NAT | 2008 | Vaccine2008，26，46： | 1 |
| 17 | Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from marine sponge Erylus nobilis显示文摘 | Takada K Nakao Y Nat sunaga S | 2002 | J Nat Prod2002，65，： | 1 |
| 18 | Corticatic acids D and E, polyacetylenic geranylgeranyl transferase type Ⅰ inhibitor, from the marine sponge Petrosia corticata 显示文摘 | S Nat sunaga S Shibazaki M | 2002 | J Nat Prod2002，65，： | 1 |
| 19 | Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures显示文摘 | Nat R Nilbratt M Narkilahti S | 2007 | GGa2007，55，4： | 1 |
| 20 | Scientific co-opera- tion in Europe and the citation of multinationally au- thored papers显示文摘 | Nat'in F Stevens K Whitlow E S | 1991 | Scientometrics1991，21，3： | 1 |
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