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| 1 | Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review显示文摘BACKGROUND Desmoid tumors(DT) are locally advanced but histologically benign monoclonal neoplasms that can occur from any musculoaponeurotic structure. The aim of this report is to analyze a rare clinical case of an aggressive intra-abdominal DT successfully treated with sorafenib.CASE SUMMARY A 36-year-old man presented with increasing colicky abdominal pain and a selfpalpable mass in his left abdomen. Fourteen years earlier he was diagnosed with a large intra-abdominal tumor, which adhered to the left colonic flexure, part of the major gastric curvature and the spleen. Subsequent exploratory laparotomy revealed a voluminous mass in the epigastrium, arising from the posterior surface of the stomach and invading the superior mesenteric vessels, transverse mesocolon and the small bowel mesentery. As the tumor was unresectable, a jejunojejunal bypass was performed. Traditional therapeutic interventions proved insufficient, and the patient was started on sorafenib with a subsequent fulldisease response.CONCLUSIONDT's pathogenesis has been associated with mutations in the adenomatous polyposis coli(APC) gene or beta-catenin gene CTNNB1, sex steroids or previous surgical trauma. Local treatment modalities, such as surgery or radiotherapy, are implemented in aggressively progressing or symptomatic patients. Sorafenib is a hopeful therapeutic option against DTs, while several pharmacological agents have been successfully used. | Aikaterini Mastoraki Dimitrios Schizas Chrysovalantis Vergadis Leon Naar Alexios Strimpakos Michail G Vailas Natasha Hasemaki George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos | 2019 | World Journal of Clinical Oncology2019，10，4： | 4 |
| 2 | The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair显示文摘Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical repair.Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele.This study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and postoperatively.The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate.There were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two groups.The NTA group had a higher preoperative DFI than the TA group.Both groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and DFI.The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA group.Both TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA group.However,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group. | Parviz K Kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen Keikhosrow M Kavoussi Amy Esqueda J David Wininger Shahryar K Kavoussi | 2021 | Asian Journal of Andrology2021，23，2： | 2 |
| 3 | Lipid peroxidation,stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis显示文摘 | Jacob G Natasha P Nghi P Isabelle L Jing YH Geoffrey F | 2003 | J Hepatol2003，39，： | 1 |
| 4 | Iron perchlorophthalogyanion and tetrasulfophthalocyanine catalysed oxidation of cyclohexane using hydrogen peroxide,chloroperoxybenzoic acid and tert-butylhydroperoxide as oxidants显示文摘 | NATASHA G TEBELLO N | 2002 | J Mol Cat A:Chem2002，179，12： | 1 |
| 5 | Val- proate and spinal muscular atrophy (review) 显示文摘 | Natasha G Brandom KG Young EC | 2008 | Mol Med Rep2008，1，2： | 1 |
| 6 | Choline Acetyltransferase Activity in Vascular Dementia and Stroke显示文摘 | Sharp Sally I Francis Paul T Elliott Mark S J Kalaria Rajesh N Bajic Natasha Hortobagyi Tibor Ballard Clive G | 2009 | Dementia and Geriatric Cognitive Disorders2009，，3： | 1 |
| 7 | Symptomatic toxicities experienced during anticancer treatment:Agreement between patient and physician reporting in three randomized trials 显示文摘 | Massimo DM Ciro G Natasha B | 2015 | Journal of Clinical Oncology2015，26，： | 1 |
| 8 | Photoluminescent properties of nanocrystallized zinc borosilicate glasses显示文摘 | CHEN G R NIKL M NATASHA S ALENA B RAO J H YANG Y X ZHANG Y H JIANG X W ZHU C S | 2004 | Radiation Measurements2004，，38： | 1 |
| 9 | The disappearing nutrient显示文摘 | Natasha G | | 0，，： | 1 |
| 10 | Induction of micronuclei and binuclei in blood, gill and liver cells of fishes subchronically exposed to cadmium chloride and copper sulphate显示文摘 | TOLGA C NATASHA N G VICTOR V A | 2005 | Food and Chemical Toxicology2005，43，4： | 1 |
| 11 | Environment: The disappearing nutrient 显示文摘 | Natasha G | 2009 | Nature2009，461，7265： | 1 |
| 12 | Intracranial arteriovenous malformation with maternal carbamazepine use 显示文摘 | Narang M Shah D Natasha G | 2007 | Indian J Pediatr2007，74，1： | 1 |
| 13 | Management of cervical esopha- geal injury after spinal surgery显示文摘 | Natasha R Darcy S Shawn G | 2010 | Ann Thorac Surg2010，90，： | 1 |
| 14 | B5-deficient vaccinia virus as a vaccine vector for the expression of a foreign antigen in vaccinia immune animals显示文摘 | Kendra MV Natasha G Heesun K | 2007 | Virology2007，361，2： | 1 |
| 15 | Basic-genetic algorithm for engineering problems solution显示文摘 | Elisaveta G Shopova Natasha G | 2006 | Computers & Chemical Engineering2006，30，1： | 1 |
| 16 | Activation function-1 domain of estrogen regulates the agonists and antagonistic actions of Tamoxifen显示文摘 | Selina G Natasha A Changqing Z | 2006 | Molecular Endocrinol2006，20，5： | 1 |
| 17 | A Genetic Algorithm for Engineering Problems Solution 显示文摘 | Elisaveta G Shopova Natasha G Vaklieva-Bancheva | 2006 | Computers & Chemical Engineering2006，30，8： | 1 |
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