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| 1 | CaMKII in cerebral ischemia显示文摘神经原上的 Ischemic 侮辱触发引起 Ca 导致 neuronal 房间死亡(excitotoxicity ) 的 2+ 超载的过多的、病理学的 glutamate 版本。Ca 2+/calmodulin (凸轮) 依赖者蛋白质 kinase II (CaMKII ) 是位于 neuronal 粘性下面并且学习的生理的有刺激性的 glutamate 信号的一个主要调停人。Glutamate 刺激在 T286 触发 CaMKII 的 autophosphorylation,使 kinase 成为 “ 的一个过程; autonomous”(从 Ca 2+ 刺激的部分活跃的独立人士) 并且那为 synaptic 的形式被要求粘性。最近的研究为侮辱以后的 neuroprotection 作为潜在的药目标也建议了自治 CaMKII 活动,在在 neuronal 文化的 glutamate 侮辱以后并且在在 vivo 的焦点的服的局部缺血以后。然而, CaMKII 和凸轮 kinase 家庭的另外的成员在 neuronal 死亡和幸存的规定被含有。这里,我们在 excitotoxicity 和服的局部缺血讨论过去的调查结果和凸轮 kinase 功能的可能的机制,与 CaMKII 和它的规定的一个焦点。 | Steven J COULTRAP Rebekah S VEST Nicole M ASHPOLE Andy HUDMON K Ulrich BAYEF | 2011 | Acta Pharmacologica Sinica2011，32，7： | 6 |
| 2 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 3 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 4 | Potential Use of a Poultry Manure Digestate as a Biofertiliser:Evaluation of Soil Properties and Lactuca sativa Growth显示文摘Anaerobic digestion is a process that is widely used for the treatment of organic wastes. The digestate can be used as a soil amendment or crop fertiliser. The aims of our work were to evaluate 1) the physicochemical composition and pathogen content in a digestate from poultry manure, according to international regulations, and 2) the effect of its soil application on the major chemical and biological soil properties and on the growth of Lactuca sativa. The experiment consisted of two groups of pots(with and without crop). Treatments applied to each group were as follows: low and high doses of digestate and inorganic fertiliser, and no application(control)(low dose: 70 kg nitrogen(N) ha^(-1) and 21 kg phosphorus(P) ha^(-1); high dose: 210 kg N ha^(-1) and 63 kg P ha^(-1)). Soil samples were taken 7 and 34 d(harvest) after treatment applications. Heavy metal and pathogen contents in the digestate were below the upper limit values. Despite the high pH and electrical conductivity values of the digestate, both soil parameters presented acceptable values for crop growth. Although there were no initial increases in total inorganic N and available P in soil with digestate application, an increase in the fresh weight of crop was observed with the high dose application. This is probably associated with the slow nutrient release from the digestate during the development of the crop. Changes in the microbial community were temporary and occurred at the initial sampling stage of the experiment. | Natalia MóRTOLA Romina ROMANIUK Vanina COSENTINO Maximiliano EIZA Patricia CARFAGNO Pedro RIZZO Patricia BRES Nicolás RIERA Marcos ROBA Mariano BUTTI Daiana SAINZ Lucrecia BRUTTI | 2019 | Pedosphere2019，29，1： | 2 |
| 5 | Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study显示文摘 | Maarten J Titulaer Lindsey McCracken I?igo Gabilondo Thaís Armangué Carol Glaser Takahiro Iizuka Lawrence S Honig Susanne M Benseler Izumi Kawachi Eugenia Martinez-Hernandez Esther Aguilar Núria Gresa-Arribas Nicole Ryan-Florance Abiguei Torrents Albert S | 2013 | Lancet Neurology2013，，2： | 2 |
| 6 | Fluid Stochastic Petri Nets: Theory, Applications and Solution 显示文摘 | G Horton V G Kulkami D M Nicol K S Trivedi | 1998 | European Journal of Operations Research (S0377-2217)1998，105，1： | 1 |
| 7 | Structural features of prolactins and growth hormones that can be related to their biological properties显示文摘 | Nicoll C S Mayer G L Russell S M | 1986 | Endocr Rev1986，7，： | 1 |
| 8 | Oxidant stress, im mune dysregulation, and vascular function in type I diabetes显示文摘 | NICOLLS M R HASKINS K FLORES S C | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 9 | Multi-electrode recordings: the next steps显示文摘 | Nicolelis M A Ribeiro S | 2002 | Curr Opin Neurobiol2002，12，5： | 1 |
| 10 | Differential expression of protein and mRNAs from border cells and root tips of pea显示文摘 | BRIGHAM L A WOO H H NICOLL S M | 1995 | Plant Physiol1995，109，： | 1 |
| 11 | Environmental and stomatal control of transpiration, canopy conductance and decoupling coefficient in young lemon trees under shading net显示文摘 | Nicol 6 s E Barradas V L Ortuno M F Navarro A Torrecilla S A Alarcon J J | 2008 | Environmental and Experimental Botany2008，63，13： | 1 |
| 12 | Ancient signals: comparative genomics of plant MAPK and MAPKK gene families 显示文摘 | Hamel L P Nicole M C Sritubtim S | 2006 | Trends Plant Sci2006，11，4： | 1 |
| 13 | Cathodic processes in the leaching and electrochemistry of covellite in mixed sulfate-chloride media显示文摘 | LEE M S NICOL M J BASSON P | 2008 | Journal of Applied Electrochemistry2008，38，3： | 1 |
| 14 | Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside显示文摘 | Araceli Sala M.Carmen Recio Guillermo R Schinella Salvador Má?ez Rosa M Giner Miguel Cerdá-Nicolás José-Luis R??os | 2003 | European Journal of Pharmacology2003，，1： | 1 |
| 15 | Saturation of wave-packet interferences:direct observation of spin precession in potassium atoms显示文摘 | NICOLE C BOUCHENE M A ZAMITH S | 1999 | Physical Review1999，60，3： | 1 |
| 16 | Kinetics of the dissolution of il-menite in sulfuric acid solutions under reducing conditions 显示文摘 | ZHANG S C NICOL M J | 2010 | Hydrometallurgy2010，103，： | 1 |
| 17 | Simvastatin inhibits the migration and adhesion of monocytic cells and disorganizes the cytoskeleton of activated endothelial cells显示文摘 | Pozo M de Nicolás R Egido J | 2006 | Eur J Pharmacol2006，548，123： | 1 |
| 18 | Raman spectra of TiO2-Ⅱ,TiO2-Ⅲ,SnO2,and GeO2 at high pressure 显示文摘 | Mammone J F Nicol M Sharma S K | 1981 | J Phys Chem Solids1981，42，5： | 1 |
| 19 | OXidant stress, immunedysregulation, and vascular function in type I diabetes 显示文摘 | NICOLLS M R HASKINS K FLORES S C | 2011 | AntioXid RedoX Signal2011，9，7： | 1 |
| 20 | Ice krill under the Amery ice shelf, east Antarctica显示文摘 | Craven M Carsey F Nicol S | 2006 | Antarctic Science2006，18，1： | 1 |
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