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| 1 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 2 | Progress in researches about focal adhesion kinase in gastrointestinal tract显示文摘Focal adhesion kinase(FAK)is a 125-kDa non-receptor protein tyrosine.Growth factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein tyrosine kinases,resulting in the phosphorylation of Tyr-576 and Tyr-577 in the FAK activation loop and full catalytic FAK activation.FAK plays a critical role in the biological processes of normal and cancer cells including the gastrointestinal tract.FAK also plays an important role in the restitution,cell survival and apoptosis and carcinogenesis of the gastrointestinal tract.FAK is over-expressed in cancer cells and its over-expression and elevated activities are associated with motility and invasion of cancer cells.FAK has been proposed as a potential target in cancer therapy.Small molecule inhibitors effectively inhibit the kinase activity of FAK and show a potent inhibitory effect for the proliferation and migration of tumor cells,indicating a high potential for application in cancer therapy. | Hui Fang Hao Yoshio Naomoto Xiao-Hong Bao Nobuyuki Watanabe Kazufumi Sakurama Kazuhiro Noma Yasuko Tomono Takuya Fukazawa Yasuhiro Shirakawa Tomoki Yamatsuji Junji Matsuoka Munenori Takaoka | 2009 | World Journal of Gastroenterology2009，15，47： | 8 |
| 3 | Progress towards onchocerciasis elimination in the participating countries of the African Programme for Onchocerciasis Control: epidemiological evaluation results显示文摘Background:The African Programme for Onchocerciasis Control(APOC)was created in 1995 to establish community-directed treatment with ivermectin(CDTi)in order to control onchocerciasis as a public health problem in 20 African countries that had 80%of the global disease burden.When research showed that CDTi may ultimately eliminate onchocerciasis infection,APOC was given in 2008 the additional objective to determine when and where treatment can be safely stopped.We report the results of epidemiological evaluations undertaken from 2008 to 2014 to assess progress towards elimination in CDTi areas with≥6 years treatment.Methods:Skin snip surveys were undertaken in samples of first-line villages to determine the prevalence of O.volvulus microfilariae.There were two evaluation phases.The decline in prevalence was evaluated in phase 1A.Observed and model-predicted prevalences were compared after correcting for endemicity level and treatment coverage.Bayesian statistics and Monte Carlo simulation were used to classify the decline in prevalence as faster than predicted,on track or delayed.Where the prevalence approached elimination levels,phase 1B was launched to determine if treatment could be safely stopped.Village sampling was extended to the whole CDTi area.Survey data were analysed within a Bayesian framework to determine if stopping criteria(overall prevalence<1.4%and maximum stratum prevalence<5%)were met.Results:In phase 1A 127665 people from 639 villages in 54 areas were examined.The prevalence had fallen dramatically.The decline in prevalence was faster than predicted in 23 areas,on track in another 23 and delayed in eight areas.In phase 1B 108636 people in 392 villages were examined in 22 areas of which 13 met the epidemiological criteria for stopping treatment.Overall,32 areas(25.4 million people)had reached or were close to elimination,18 areas(17.4 million)were on track but required more years treatment,and in eight areas(10.4 million)progress was unsatisfactory.Conclusions:Onchocerciasis has been largely controlled as a public health problem.Great progress has been made towards elimination which already appears to have been achieved for millions of people.For most APOC countries,nationwide onchocerciasis elimination is within reach. | Afework H.Tekle Honorath G.M.Zouré Mounkaila Noma Michel Boussinesq Luc E.Coffeng Wilma A.Stolk Jan H.F.Remme | 2016 | Infectious Diseases of Poverty2016，5，1： | 6 |
| 4 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 5 | Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer显示文摘 | Hiroshi Kurahara Hiroyuki Shinchi Yuko Mataki Kousei Maemura Hidetoshi Noma Fumitake Kubo Masahiko Sakoda Shinichi Ueno Shoji Natsugoe Sonshin Takao | 2011 | Journal of Surgical Research2011，，2： | 3 |
| 6 | 糖尿病患者的房水细胞因子水平与玻璃体细胞因子水平及糖尿病视网膜病变的进展相关 | Funatsu H. Yamashita H. Noma H. 张磊 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，6： | 3 |
| 7 | Partial stent-in-stent placement of biliary metallic stents using a short double-balloon enteroscopy显示文摘Endoscopic intervention is less invasive than percutaneous or surgical approaches and should be considered the primary drainage procedure in most cases with obstructive jaundice.Recently,therapeutic endoscopic retrograde cholangiopancreatography(ERCP) using double-balloon enteroscopy(DBE) has been shown to be feasible and effective,even in patients with surgically altered anatomies.On the other hand,endoscopic partial stent-in-stent(PSIS) placement of selfexpandable metallic stents(SEMSs) for malignant hilar biliary obstruction in conventional ERCP has also been shown to be feasible,safe and effective.We performed PSIS placement of SEMSs for malignant hilar biliary obstruction due to liver metastasis using a short DBE in a patient with Roux-en-Y anastomosis and achieved technical and clinical success.This procedure can result in quick relief from obstructive jaundice in a single session and with short-term hospitalization,even in patients with surgically altered anatomies. | Koichiro Tsutsumi Hironari Kato Takeshi Tomoda Kazuyuki Matsumoto Ichiro Sakakihara Naoki Yamamoto Yasuhiro Noma Takayuki Sonoyama Hiroyuki Okada Kazuhide Yamamoto | 2012 | World Journal of Gastroenterology2012，18，45： | 3 |
| 8 | Successful biliary drainage using a metal stent through the gastric stoma显示文摘We report a case of biliary drainage for malignant stricture using a metal stent with an ultrathin endoscope through the gastric stoma. A 78-year-old female was referred to our hospital for jaundice and fever. She had undergone percutaneous endoscopic gastrostomy(PEG) for esophageal obstruction after radiation therapy for cancer of the pharynx. Abdominal contrast-enhanced computed tomography showed a 3-cm enhanced mass in the middle bile duct and dilatation of the intrahepatic bile duct. We initially performed endoscopic retrograde cholangiopancreatography(ERCP) with a trans-oral approach. However, neither the side-viewing endoscope nor the ultrathin endoscope passed through the esophageal orifice. Thus, we eventually performed ERCP via the PEG stoma using an ultrathin endoscope. We performed biliary drainage with a 6F introducer selfexpanding metal stent. The cytology findings obtained by brush cytology showed malignancy. Her laboratory results were restored to normal levels after drainage and no complication occurred. | Kazuyuki Matsumoto Hironari Kato Koichiro Tsutsumi Yutaka Akimoto Daisuke Uchida Takeshi Tomoda Naoki Yamamoto Yasuhiro Noma Shigeru Horiguchi Hiroyuki Okada Kazuhide Yamamoto | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 9 | Efficacy of Endoscopic Over 3-branched Partial Stent-in-Stent Drainage Using Self-expandable Metallic Stents in Patients With Unresectable Hilar Biliary Carcinoma显示文摘 | Daisuke Uchida Hironari Kato Shinichiro Muro Yasuhiro Noma Naoki Yamamoto Shigeru Horiguchi Ryo Harada Koichiro Tsutsumi Hirofumi Kawamoto Hiroyuki Okada Kazuhide Yamamoto | 2015 | Journal of Clinical Gastroenterology2015，，6： | 2 |
| 10 | Hand-Sewn Versus Mechanical Esophagogastric Anastomosis After Esophagectomy: A Systematic Review and Meta-Analysis显示文摘 | Michitaka Honda Akira Kuriyama Hisashi Noma Souya Nunobe Toshi A Furukawa | 2013 | Annals of Surgery2013，，2： | 2 |
| 11 | Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema显示文摘 | Hideharu Funatsu Hidetoshi Yamashita Hidetaka Noma Tatsuya Mimura Tetsuji Yamashita Sadao Hori | 2002 | American Journal of Ophthalmology2002，，1： | 2 |
| 12 | Establishment and maintenance of a heterochromatin domain显示文摘 | HAIL I M SHANKARANARAYANA G D NOMA K I | 2002 | Science2002，297，5590： | 1 |
| 13 | Autologous bone-marrow mononuclear cell implantation improves endothelium dependent vasodilation in patients with limb ischemia显示文摘 | Higashi Y Kimura M Hara K Noma K Jitsuiki D Nakagawa K | 2004 | Cirvulation2004，109，10： | 1 |
| 14 | Endothelial function and oxidative stress in cardiovascular diseases 显示文摘 | Higashi Y Noma K Yoshizumi M | 2009 | Circ J2009，73，： | 1 |
| 15 | Length and quality of survival after external-beam radiotherapy with concurrent continuous 5-fluorouracil infusion for locally unresectabal pancreatic cancer显示文摘 | Shinchi H Takao S Noma H | 2002 | IntJ Radiat Oncol Biol Phys2002，53，1： | 1 |
| 16 | Photolysis studies of technical decabromodiphenyl ether (DecaBDE) and ethane (DeBDethane) in plastics under natural sunlight显示文摘 | KAJIWARA N NOMA Y TAKIGAMI H | 2008 | Environ- mental Science & Technology2008，42，： | 1 |
| 17 | Repetitive facilitative exercise under continuous electrical stimulation for severe arm im- pairment after sub-acute stroke : a randomized controlled pilot study 显示文摘 | Shimodozono M Noma T Matsumoto S | 2014 | Brain Inj2014，28，2： | 1 |
| 18 | KITS acts in cis to promote RNA interference - mediated transcriptional and post - transcriptional silencing 显示文摘 | Noma K Sugiyama T Cam H | 2004 | Nat Genet2004，36，11： | 1 |
| 19 | A case of mutinous cystadenocarcinoma of the appendix penetrating the urinary bladder显示文摘 | Mori N Noma M Yamaguchi S | 2002 | Acta Urol Jpn2002，48，： | 1 |
| 20 | Identification of Na^+/Ca^2+ exchanger current in single ventricular cells of guinea-pig显示文摘 | Kimura J Miyamae S Noma A | 1989 | J Gen Physiol1989，93，： | 1 |
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