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| 1 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 2 | Behavior modeling and verification of movement authority scenario of Chinese Train Control System using AADL显示文摘Train control systems like most digital controllers are, by definition, hybrid systems as they interact with or try to control some aspects of the physical world. Detailed behavior modeling with constraints specification and formal verification, required for reliability prediction, is a great challenge for hybrid system designers.Train control systems further intensify this challenge with extensive interaction between computing units and their physical environment and their mutual dependence on each other. In this paper, we investigate behavior modeling and formal verification of Chinese Train Control System Level 3(CTCS-3) using Architectural Analysis & Design Language(AADL) to cope with this challenge. AADL is an architecture description language for embedded systems and is based on model-based engineering paradigm. Along with structural modeling of embedded systems using the core language constructs, AADL also provides support for language extension through annex sublanguages. In system requirements specification document, the behavior of the CTCS-3 is specified as a set of basic operation scenarios that cooperate with each other to achieve safe and secure functionality of trains.Movement Authority(MA) scenario, explored in this paper, is considered as a basic and most crucial scenario to prevent trains from colliding with each other. The detailed discrete behavior of control system is modeled and verified using the Behavior Language for Embedded Systems with Software(BLESS) annex sublanguage of AADL, and the continuous behavior of train with the cyber–physical interaction(communication between train and control system) is modeled using the Hybrid annex sublanguage. The behavior of the MA scenario at system level is verified using the Hybrid Hoare Logic theorem prover. Behavior constraints are specified as assertions using first-order logic formulas augmented with a simple temporal operator. | AHMAD Ehsan DONG YunWei LARSON Brian Lü JiDong TANG Tao ZHAN NaiJun | 2015 | Science China(Information Sciences)2015，58，11： | 4 |
| 3 | THERMOCHEMISTRY AND MECHANISM ON THE PROCESS OF PREP ARING POWDER OF Bi_2O_3 USING MELT-ATOMIZING-COMBUSTION METHOD显示文摘THERMOCHEMISTRYANDMECHANISMONTHEPROCESSOFPREPARINGPOWDEROFBi2O3USINGMELTATOMIZINGCOMBUSTIONMETHOD①ZhouNaijun,YinZhimin,Chen... | Zhou, Naijun Yin, Zhiminb Chen, Shizhu | 1997 | 中国有色金属学会会刊:英文版1997，7，3： | 3 |
| 4 | Exposure measurement, risk assessment and source identification for exposure of traffic assistants to particle-bound PAHs in Tianjin, China显示文摘To investigate the levels of exposure to particulate-bound polycyclic aromatic hydrocarbon(PAH) and to estimate the risk these levels pose to traffic assistants(TAs) in Tianjin(a megacity in North China), a measurement campaign(33 all-day exposure samples, 25 occupational-exposure samples and 10 indoor samples) was conducted to characterize the TAs' exposure to PAHs, assess the cancer risk and identify the potential sources of exposure. The average total exposure concentration of 14 PAHs was approximately 2871 ± 928 ng/m3(on-duty), and 1622 ± 457 ng/m3(all-day). The indoor PAHs level was 1257 ± 107 ng/m3. After 8000 Monte Carlo simulations, the cancer risk resulting from exposure to PAHs was found to be approximately 1.05 × 10-4. A multivariate analysis was applied to identify the potential sources, and the results showed that, in addition to vehicle exhaust, coal combustion and cooking fumes were also another two important contributors to personal PAH exposure. The diagnostic ratios of PAH compounds agree with the source apportionment results derived from principal component analysis. | Xiaodan Xue Yan You Jianhui Wu Bin Han Zhipeng Bai Naijun Tang Liwen Zhang | 2014 | Journal of Environmental Sciences2014，26，2： | 2 |
| 5 | Oxygen permeation and phase structure properties of partially A-site substituted BaCo_(0.7)Fe_(0.225)Ta_(0.075)O_(3-δ) perovskites显示文摘Ba0.9R0.1Co0.7Fe0.225Ta0.075O3-δ(BRCFT, R = Ca, La or Sr) membranes were synthesized by a solid-state reaction. Metal cation Ca2+,La3+or Sr2+doping on A-site partially substituted Ba2+in BaCo0.7Fe0.225Ta0.075O3-δoxides, and its subsequent effects on phase structure stability, oxygen permeability and oxygen desorption were systematically investigated by XRD, TG-DSC, H2-TPR, O2-TPD techniques and oxygen permeation experiments. The partial substitution with Ca2+, La3+or Sr2+, whose ionic radii are smaller than that of Ba2+, succeeded in stabilizing the cubic perovskite structure without formation of impurity phases, as revealed by XRD analysis. Oxygen-involving experiments showed that BRCFT with A-site fully occupied by Ba2+exhibited good oxygen permeation flux under He flow, reaching about 2.3mL min-1 cm-2at 900 ℃ with 1 mm thickness. Of all the membranes, BLCFT membrane showed better chemical stability in CO2, owing to the reduction in alkalinity of the mixed conductor oxide by La doping. In addition, we also found the stability of the perovskite structure under reducing atmospheres was strengthened by increasing the size of A-site cation(Ba2+>La3+>Sr2+>Ca2+). | Bo Jiang Hongwei Cheng Longfei Luo Xionggang Lu Naijun Zhang Jizhong Liu | 2014 | Journal of Energy Chemistry2014，23，2： | 2 |
| 6 | Numerical simulation of electrolyte two-phase flow induced by anode bubbles in an aluminum reduction cell显示文摘 | ZHOU Naijun XUE Yuqing Chen J J J | 2007 | Chemical Product and Process Modeling2007，11，2： | 1 |
| 7 | Effect of compound Guizhu capsule on phosphate and tension homology deleted on chromsome ten and murine double mimute 2 gene expression in lung cancer of mice显示文摘OBJECTIVE: To observe the inhibitory effect of the Chinese herbal compound Guizhu capsule(CGZC)on lung cancer and explore the possible mechanism underlying its actions by evaluating its effects on the expression of phosphate and tension homology deleted on chromsome ten(PTEN) and murine double mimute 2(MDM2) in lung cancer model mice.METHODS: A mouse model of transplanted lung cancer was established by subcutaneous inoculation of cancer cells into the axillae of mice. Twenty-four hours later, the mice were weighed and randomly divided into the model control group, cisplatin group(DDP group), and high, moderate and low dosage CGZC groups, with ten mice in each group. The control mice received an equal volume of distilled water. DDP was intraperitoneally injected at 1 mg/kg in the DDP group, once a day for 3days. CGZC diluted with distilled water was admin-istered at 20 g/kg(10 times the clinical adult dosage) in the high-dose group, 10 g/kg(5 times the clinical adult dosage) in the moderate-dose group and 5 g/kg(2.5 times the clinical adult dosage) in the low-dose group once a day for 10 days. On the11 th day, the mice were weighed and killed. The tumor tissues were weighed and the tumor inhibition rate was calculated. PTEN and MDM2 protein expression were detected by immunohistochemical analysis of tumor tissues.RESULTS: The CGZC high-and moderate-dose groups showed a significant inhibitory effect on tumor growth(P < 0.05); there was no significant difference between the high dose group and the DDP group(P > 0.05). The CGZC high-dose group also showed enhanced expression of PTEN protein(P <0.01) and decreased expression of MDM2 protein(P < 0.01) in lung cancer cells of the mice. There was no significant difference between the high dose group and the DDP group.CONCLUSION: CGZC has a significant inhibitory effect on transplanted lung cancer in mice. The mechanism may involve reducing expression of PTEN and decreasing the expression of MDM2 in the lung cancer tissues of the mice. | Cao Yong Zhang Shuyong Zhang Ge Zhang Na Zhang Lixia Huang Yuanliang Yuan Naijun Tang Xiaojuan Du Jiajin Fang Jiuyun | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 1 |
| 8 | FLUID KINETICS PRINCIPLE AND DESIGN CRITERIA OF ATOMIZER显示文摘FLUIDKINETICSPRINCIPLEANDDESIGNCRITERIAOFATOMIZER￥ChenShizhu;ZhouNaiJun;YinZhimin(DepartmentofMaterialsScienceandEngineering,... | Chen Shizhu Zhou NaiJun Yin Zhimin(Department of Materials Science and Engineering,Central South University of Technology, Changsha 410083) | 1996 | 中国有色金属学会会刊:英文版1996，6，3： | 1 |
| 9 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor显示文摘Emerging evidence showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) could induce expression of certain reactivation-associated genes in astrocytes, however, the consequent cellular effects and molecular mechanisms are still unclear. During the process of astrocyte reactivation, migration is a critical cellular event. In the present study, we employed woundhealing assay and Transwell? motility assay to explore the effects of TCDD on cell migration in primary cultured rat cortical astrocytes. We found that upon TCDD treatments at relative low concentrations(10^(-10) and/or 10^(-9) mol/L), the ability of primary astrocytes to migrate horizontally and vertically was promoted. In line with this cellular effect, the mR NA expression of two promigratory genes, including cell division cycle 42(CDC42) and matrix metalloproteinase 2(MMP2)was induced by TCDD treatment. Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor(AhR) pathway. So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191. We found that application of CH223191 significantly reversed the pro-migratory effects of TCDD. Interestingly, the basal ability of horizontal migration as well as basal levels of CDC42 and MMP2 expression were dramatically reduced suggesting a possible physiological role of AhR in maintaining the endogenous migration ability of the primary astrocytes. These findings support the notion that dioxin promotes astrocyte reactivation at molecular and cellular levels. | Yangsheng Chen Rui Sha Li Xu Yingjie Xia Yiyun Liu Xuejun Li Heidi Qunhui Xie Naijun Tang Bin Zhao | 2019 | Journal of Environmental Sciences2019，31，2： | 1 |
| 10 | Machine vision based path planning for a robotic golf club head welding system 显示文摘 | Ming J Tsai Lee Hongwen Ann Naijun | 2011 | Robotics and Computer-Integrated Manufacturing2011，27，： | 1 |
| 11 | Generating Semi-Algebraic Invariants for Non-Autonomous Polynomial Hybrid Systems显示文摘Hybrid systems are dynamical systems with interacting discrete computation and continuous physical processes, which have become more common, more indispensable, and more complicated in our modern life. Particularly, many of them are safety-critical, and therefore are required to meet a critical safety standard. Invariant generation plays a central role in the verification and synthesis of hybrid systems. In the previous work, the fourth author and his coauthors gave a necessary and sufficient condition for a semi-algebraic set being an invariant of a polynomial autonomous dynamical system, which gave a confirmative answer to the open problem. In addition, based on which a complete algorithm for generating all semi-algebraic invariants of a given polynomial autonomous hybrid system with the given shape was proposed. This paper considers how to extend their work to non-autonomous dynamical and hybrid systems. Non-autonomous dynamical and hybrid systems are with inputs, which are very common in practice; in contrast, autonomous ones are without inputs. Furthermore, the authors present a sound and complete algorithm to verify semi-algebraic invariants for non-autonomous polynomial hybrid systems. Based on which, the authors propose a sound and complete algorithm to generate all invariants with a pre-defined template. | WANG Qiuye LI Yangjia XIA Bican ZHAN Naijun | 2017 | Journal of Systems Science & Complexity2017，30，1： | 1 |
| 12 | Numerical simulation of aluminum holding furnace with fluid-solid coupled heat transfer 显示文摘 | Zhou Naijun Zhou Shanhong Zhang Jiaqi | 2010 | Journal of Central South University of Technology (English Edition)2010，17，6： | 1 |
| 13 | Combustion and energy balance, of aluminum holding furnace with bottom porous brick purging system 显示文摘 | Zhang Jiaqi Zhou Naijun Zhou Shanhong | 2012 | Journal of Central South University of Technology (English Edition)2012，19，1： | 1 |
| 14 | The Real Old-Age Dependency Ratio and the Inadequacy of Public Pension Finance in China显示文摘 | Naijun Hu&Yansui Yang | 2012 | JournalofPopulation Ageing2012，，5： | 1 |
| 15 | Symbolic decision procedure for termination of linear programs显示文摘 | Bican Xia Lu Yang Naijun Zhan | 2011 | Formal Aspects of Computing2011，23，2： | 1 |
| 16 | Practical comparison of 2.7<ce:hsp sp='0.25'/>μm fused-core silica particles and porous sub-2<ce:hsp sp='0.25'/>μm particles for fast separations in pharmaceutical process development显示文摘 | Ahmed Abrahim Mohammad Al-Sayah Peter Skrdla Yuri Bereznitski Yadan Chen Naijun Wu | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，，1： | 1 |
| 17 | Fluidselection and parametric optimization of organic Rankinecycle using low temperature waste heat显示文摘 | WANG Zhiqi ZHOU Naijun GUO Jing | 2012 | Energy2012，37，40： | 1 |
| 18 | Recent advances in program verification through computer algebra显示文摘 | Lu Yang Chaochen Zhou Naijun Zhan Bican Xia | 2010 | Frontiers of Computer Science in China2010，，1： | 1 |
| 19 | From model to implementation: a network algorithm programming language显示文摘Software-defined networking(SDN) is a revolutionary technology that facilitates network management and enables programmatically efficient network configuration,thereby improving network performance and flexibility.However,as the application programming interfaces(APIs) of SDN are low-level or functionality-restricted,SDN programmers cannot easily keep pace with the ever-changing devices,topologies,and demands of SDN.By deriving motivation from industry practice,we define a novel network algorithm programming language(NAPL) that enhances the SDN framework with a rapid programming flow from topology-based network models to C++ implementations,thus bridging the gap between the limited capability of existing SDN APIs and the reality of practical network management.In contrast to several state-of-the-art languages,NAPL provides a range of critical high-level network programming features:(1) topology-based network modeling and visualization;(2) fast abstraction and expansion of network devices and constraints;(3) a declarative paradigm for the fast design of forwarding policies;(4) a built-in library for complex algorithm implementation;(5) full compatibility with C++ programming;and(6) userfriendly debugging support when compiling NAPL into highly readable C++ codes.The expressiveness and performance of NAPL are demonstrated in various industrial scenarios originating from practical network management. | Jian WANG Jie AN Mingshuai CHEN Naijun ZHAN Lulin WANG Miaomiao ZHANG Ting GAN | 2020 | Science China(Information Sciences)2020，63，7： | 1 |
| 20 | Recent advances in program verification through computer algebra 显示文摘 | Yang Lu Zhou Chaochen Zhan Naijun | 2010 | Front Computer Science2010，4，1： | 1 |
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