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| 1 | Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells显示文摘瞄准:到 investigat 肝炎 B X 交往的效果蛋白质(HBXIP ) oncell proliferation.Methods:对 HBXIP 的兔子抗体是 HBXIP 基因的 generated.The RNA 干扰( RNAi )碎片在编码 HBXIP 基因和 pSilencer-hbxip weretransfected 进人的胸癌 MCF-7 房间, hepatoma H7402 房间,和正常的 pcDNA3-hbxip 的 pSilencer-3.0-H1 向量 termedpSilencer-hbxip.Plasmids 被构造 humanhepatic 房间线 L-O2 ,respectively.3-[ 4,5-dimethylthiazol-2-yl ] -2,5-diphenyltetrazolium 溴化物( MTT )试金和 5-bromo-2-deoxyuridine 加入试金被用于 dete HBXIP 的功能之一是它在房间增长的参与。 | Feng-ze WANG Li SHA Wei-ying ZHANG Lian-ying WU Ling QIAO Nan LI Xiao-dong ZHANG Li-hong YE | 2007 | Acta Pharmacologica Sinica2007，28，3： | 16 |
| 2 | Bushen Qiangjin capsule(补肾强筋胶囊) inhibits the Wnt/β-catenin pathway to ameliorate papain-induced knee osteoarthritis in rats显示文摘OBJECTIVE:To evaluate the molecular mechanism underlying the beneficial effect of Bushen Qiangjin capsule(补肾强筋胶囊,BSQJ),a Traditional Chinese Medicine,on knee osteoarthritis(KOA).METHODS:In the present study,32 female Sprague-Dawley rats were randomly divided into four groups:control,KOA,high-dose BSQJ(H-BSQJ),and low-dose BSQJ(L-BSQJ).After successfully establishing the KOA model by intra-articular injection of papain,H-BSQJ and L-BSQJ groups were intragastrically administered 0.243 and 0.122 g/kg BSQJ,respectively,daily for 6 weeks.At the end of the experiment,knee articular cartilage tissues of rats were collected for evaluation by hematoxylin and eosin staining,Safranin O-Fast Green staining,and terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay.Serum interleukin-1βand tumor necrosis factor-αlevels of rats were detected with an enzyme-linked immunosorbent assay method.Gene expression of Wnt-4,β-catenin,Frizzled-2,glycogen synthase kinase-3β(GSK-3β),cysteinyl aspartate-specific proteinases 3 and 9(caspases 3 and 9),collagen typeⅡalpha 1(Col2 a1),and matrix metalloproteinases 1 and 13(MMP-1 and MMP-3)of rat knee articular cartilage was quantified by reverse transcription-quantitative polymerase chain reaction analysis.Wnt-4,β-catenin,Frizzled-2,GSK-3β,cleaved caspase-3,and cleaved caspase-9 protein expression in rat knee articular cartilage was determined by western blot analysis.RESULTS:BSQJ obviously reduced pathological damage and matrix degradation of articular cartilage in KOA rats.Compared with the KOA group,H-BSQJ rats exhibited downregulated m RNA and protein expression of Wnt-4,β-catenin,Frizzled-2,and caspase-3,as well as upregulated m RNA and protein expression of GSK-3β.In addition,H-BSQJ significantly increased m RNA expression of Col2 a1 and decreased m RNA expression of MMP-1 and MMP-13.CONCLUSION:BSQJ exerted a beneficial effect on KOA by a mechanism involving downregulation of the Wnt/β-catenin pathway,which inhibited both cartilage extracellular matrix degradation and chondrocyte apoptosis to ameliorate KOA in rats. | YAO Nan CHEN Guocai LU Yanyan XU Xuemeng ZHAO Chuanxi HUANG Xuejun LIU Wengang PENG Sha WU Huai | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 5 |
| 3 | Applications and developments of gene therapy drug delivery systems for genetic diseases显示文摘Genetic diseases seriously threaten human health and have always been one of the refractory conditions facing humanity.Currently,gene therapy drugs such as siRNA,shRNA,antisense oligonucleotide,CRISPR/Cas9 system,plasmid DNA and miRNA have shown great potential in biomedical applications.To avoid the degradation of gene therapy drugs in the body and effectively deliver them to target tissues,cells and organelles,the development of excellent drug delivery vehicles is of utmost importance.Viral vectors are the most widely used delivery vehicles for gene therapy in vivo and in vitro due to their high transfection efficiency and stable transgene expression.With the development of nanotechnology,novel nanocarriers are gradually replacing viral vectors,emerging superior performance.This review mainly illuminates the current widely used gene therapy drugs,summarizes the viral vectors and non-viral vectors that deliver gene therapy drugs,and sums up the application of gene therapy to treat genetic diseases.Additionally,the challenges and opportunities of the field are discussed from the perspective of developing an effective nano-delivery system. | Xiuhua Pan Hanitrarimalala Veroniaina Nan Su Kang Sha Fenglin Jiang Zhenghong Wu Xiaole Qi | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 3 |
| 4 | Quantitative detection of ING1 mRNA under different gene regulation based on molecular beacon显示文摘The effects of drug treatment, gene transfection, and p53 RNA interference (RNAi) on level of ING1 mRNA in tumor cells were quantitatively detected with the help of ING1 molecular beacon (MB)/cRNA standard curve based on MB detection technology. Results showed that the level of ING1 mRNA could be upregulated by 5-FU treatment or ING1 transfection in low expression cell line of MCF-7 and be inhibited by silencing p53 with RNAi technology in normal expression cell line of CNE2. The level of ING1 varied from 7.7×10?16 to 53.4× 10?16 mol/μg total RNA of tumor cells. The results not only provided evidence for the regulation effects of gene expression but also were applied to investigat- ing the interaction of multigenes on signal transduc- tion pathway. | LIU Bin1,2,3,4, WANG Kemin1,2,3,4, XIAO Zhiqiang5,6, WANG Wei1,3,4, TAN Weihong1,2,3,4, SUN Yi5,6, TANG Hongxing1,3,4 & YANG Xiaohai1,3,41. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hu- nan University, Changsha 410082, China 2. Life Science and Biotechnology Institute, Hunan University, Chang- sha 410082, China 3. Chemistry and Chemical Engineer College, Hunan University, Changsha 410082, China 4. Hunan Engineering Research Center for Bio-Nanotechnology, Hunan University, Changsha 410082, China 5. Medical Experiment Research Center, Xiangya Hospital, Central South University, Changsha 410008, China 6. Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Changsha 410008, China | 2006 | Chinese Science Bulletin2006，51，17： | 2 |
| 5 | Inhibition of Syk with fostamatinib disodium has significant clinical activity in non- Hodgkin lymphoma and Chronic lymphocytic leukemia显示文摘 | Frie'dberg JW Sha~nan J Sweetenham J | 2010 | Blood2010，115，13： | 1 |
| 6 | The Comparative Study on the Mining Industry Competitiveness of Xinjiang in China显示文摘 | SHA Jinghua MAO Xinxin XIANG Nan | | 0，，05： | 1 |
| 7 | Guidelines on the Diagnosis and Management of Primary Biliary Cholangitis (2021)显示文摘In 2015, the Chinese Society of Hepatology and the Chinese Society of Gastroenterology published a consensus on pri-mary biliary cholangitis (PBC). In the past years, numerous clinical studies have been published in the field of PBC. To guide the clinical diagnosis and management of PBC patients, the Chinese Society of Hepatology invited a panel of experts to assess the new clinical evidence and formulate the current guidelines. | Hong You Weijia Duan Shuxiang Li Tingting Lv Sha Chen Lungen Lu Xiong Ma Ying Han Yuemin Nan Xiaoyuan Xu Zhongping Duan Lai Wei Jidong Jia Hui Zhuang Chinese Society of Hepatology,Chinese Medical Association | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 8 | Dynamic modeling and simulation of water environment management with a focus on water recycling显示文摘 | Xiang Nan Yah Jingjing Sha Jinghua | 2014 | Water2014，，6： | 1 |
| 9 | Perspective of Calcium Imaging Technology Applied to Acupuncture Research显示文摘Acupuncture, a therapeutic treatment defined as the insertion of needles into the body at specific points(ie, acupoints), has growing in popularity world-wide to treat various diseases effectively, especially acute and chronic pain. In parallel, interest in the physiological mechanisms underlying acupuncture analgesia, particularly the neural mechanisms have been increasing. Over the past decades, our understanding of how the central nervous system and peripheral nervous system process signals induced by acupuncture has developed rapidly by using electrophysiological methods. However, with the development of neuroscience, electrophysiology is being challenged by calcium imaging in view field, neuron population and visualization in vivo. Owing to the outstanding spatial resolution, the novel imaging approaches provide opportunities to enrich our knowledge about the neurophysiological mechanisms of acupuncture analgesia at subcellular, cellular, and circuit levels in combination with new labeling, genetic and circuit tracing techniques. Therefore, this review will introduce the principle and the method of calcium imaging applied to acupuncture research. We will also review the current findings in pain research using calcium imaging from in vitro to in vivo experiments and discuss the potential methodological considerations in studying acupuncture analgesia. | LI Sha LIU Yun ZHANG Nan LI Wang XU Wen-jie XU Yi-qian CHEN Yi-yuan CUI Xiang ZHU Bing GAO Xin-yan | 2024 | Chinese Journal of Integrative Medicine2024，30，1： | 1 |
| 10 | A two-year(2020–2021)observation of marine phycotoxins in phytoplankton in typical mariculture areas of East China Sea显示文摘To learn the marine phycotoxins(MPTs)contamination status in mariculture areas in the East China Sea(ECS),from May 2020 to October 2021,80 net-concentrated phytoplankton samples were collected from 12 stations in three typical areas with high incidence of red tides,namely,Gouqi Island,Sandu’ao-Lianjiang,and Zhangzhou-Dongshan Island in ECS,and MPTs of the samples were detected.Six types of toxins were detected in 24 samples from 9 stations.Lipophilic marine toxins(LMTs)were more common and diverse in these areas.Pectenotoxin 2(PTX2)was the main lipophilic marine toxin(LMT)in the concentrated phytoplankton samples and the occurrence showed seasonal differences from north to south.According to the potential risks of pectenotoxin(PTXs)to seafood safety,it is suggested to execute regular monitoring on PTXs in ECS and a mandatory standard should be formulated based on the comprehensive analysis of in-situ monitoring and lab research.Meanwhile,contamination risks of cyclic imine toxins in the north and domoic acid(DA)in the south of ECS should also be paid with attention to.Only 2 paralytic shellfish toxins(PSTs),N-sulfocarbamoyl toxin C2(C2),and decarbamoyl gonyatoxin 3(dcGTX3),were found from spring samples in the north of ECS.As the biggest mussel culture county of China,Gouqi Island showed higher toxin diversity and the toxin detection rate was higher than the other two areas.In Gouqi Island area,PSTs were a serious potential threat in spring,and LMTs instead of PSTs became the main risk in summer-autumn seasons.To ensure the safety of seafood and marine environmental health,it is recommended to conduct long-term targeted tracking and monitoring of MPTs in this and similar mariculture areas. | Xiaoqing TIAN Chengqi FAN Yunyu TANG Haiyan ZHANG Wei KANG Sha CHEN Chongbin LI Ya’nan LU | 2022 | Journal of Oceanology and Limnology2022，40，6： | 1 |
| 11 | Association between Macroscopic-factors and Identified HIV/AIDS Cases among Injecting Drug Users: An Analysis Using Geographically Weighted Regression Model显示文摘Drug use(DU),particularly injecting drug use(IDU)has been the main route of transmission and spread of Human Immunodeficiency Virus(HIV)/Acquired Immune Deficiency Syndrome(AIDS) | XING Jian Nan GUO Wei QIAN Sha Sha DING Zheng Wei CHEN Fang Fang PENG Zhi Hang QIN Qian Qian WANG Lu | 2014 | Biomedical and Environmental Sciences2014，27，4： | 1 |
| 12 | Unprotected Sex with Casual Partners: A Neglected Source of HIV Transmission among Members of the Yi Minority in Southwestern China显示文摘The Yi are the largest and most disadvantaged ethnic minority population in southwestern China.This region contains over eight million Yi,with approximately 2.4 million living in the Liangshan Yi Autonomous Prefecture(Liangshan)in Sichuan Province.Liangshan is located along one of the | QIN Si LI A Sha MA Ming Ju LUO Qi WANG Xiao Lin NAN Lei ZENG Can XIAO Lin LI Qiao Qiao ZUO Jian Bing CHEN Dan Dan CUI Xin Yu LUAN Rong Sheng | 2014 | Biomedical and Environmental Sciences2014，27，10： | 0 |
| 13 | Secure Transmission in Satellite-UAV Integrated System Against Eavesdropping and Jamming:A Two-Level Stackelberg Game Model显示文摘Aiming at the physical layer security(PLS)secure transmission existing in the information backhaul link of the satellite-UAV integrated(SUI)network,a two-layer Stackelberg game model(TSGM)that can resist full-duplex(FD)eavesdropping and jamming attacks is proposed.The confrontation relationship between the UAV network and the attacker is established as the first layer Stackelberg game.The source UAV adjusts its own transmission power strategy according to the attacker’s jamming strategy to resist malicious jamming attacks.The internal competition and cooperation relationship in UAV network is modeled as the second layer Stackelberg game,and the optimal cooperative UAV transmits jamming signal to the attacker to resist malicious eavesdropping attacks.Aiming at the“selfishness”of UAV nodes,a price incentive mechanism is established to encourage UAV to actively participate in cooperation,so as to maximize the advantages of cooperative communication.For the proposed TSGM,we construct the utility function and analyze the closed equilibrium solution of the game model,and design a three-stage optimal response iterative(TORI)algorithm to solve the game equilibrium.The simulation results show that the proposed TSGM can effectively increase the utility of the source UAV and improve the enthusiasm of cooperation compared with other power control models. | Chengjian Liao Kui Xu Hongpeng Zhu Xiaochen Xia Qiao Su Nan Sha | 2022 | China Communications2022，19，7： | 0 |
| 14 | Multistimuli-Responsive Fluorescent Organometallic Assemblies Based on Mesoionic Carbene-Decorated Tetraphenylethene Ligands and Their Applications in Cell Imaging显示文摘The controllable construction of light-emitting organometallic supramolecular materials integrating stimulus responses and biological applications is still a major challenge today.In this work,emissive organometallic assemblies based on AgI/AuI and mesoionic carbene-decorated tetraphenylethene(MIC-TPE)ligands have been synthesized and characterized.Photophysical studies showed that these organometallic assemblies[M_(4)(2)_(2)](OTf)_(4) not only fluoresce in various dilute solutions,resulting from the rigidification of MIC-TPE ligands upon complexation,but also show tunable fluorescence wavelengths and intensity behaviors in mixed solvent systems and at varying temperatures while in solution,and mechanical pressure stimulus-responsive fluorescent features in the solid state.Furthermore,the organometallic cages[M_(4)(2)_(2)](OTf)_(4)(M=Ag and Au)were successfully employed for cell imaging and showed the potential of anticancer activity,making them promising candidates for cancer theranostics.This work provides a simple and efficient method to prepare highly emissive and stimulus-responsive organometallic materials and paves the way for related biological applications such as cancer cell imaging and targeted therapy. | Yang Li Tianfeng Yang Nan Li Sha Bai Xin Li Li-Li Ma Kai Wang Yanmin Zhang Ying-Feng Han | 2022 | CCS Chemistry2022，4，2： | 0 |
| 15 | Insights into varicella-zoster virus assembly from the B-and C-capsid at near-atomic resolution structures显示文摘Varicella-zoster is a highly communicable virus that can be transmitted through the airborne route.About one quarter of people are infected with this virus.Previous studies have described the structure of A-capsid and a blurred reconstruction of the C-capsid with icosahedral symmetry.In this study,we have determined the more precise detailed structures of the varicella-zoster virus(VZV)B-and C-capsid in icosahedral symmetry using a combination of block-based reconstruction and symmetry relaxation strategies.In addition,we are reporting structural details of the portal vertex reconstructions in five-fold symmetry and portal reconstructions in twelve-fold symmetry.The structures unveil the basis for the high thermal stability of the VZV capsid.The conformational flexibility of structural elements of the capsid plays a role in the assembly of the capsid and drives processes critical for the viral life cycle.The results of the study open up new avenues for the development of drugs against a highly prevalent and contagious pathogen. | Lei Cao Nan Wang Zhe Lv Wenyuan Chen Zhonghao Chen Lifei Song Xueyan Sha Guiqiang Wang Yaling Hu Xiaojun Lian Guoliang Cui Jinyan Fan Yaru Quan Hongrong Liu Hai Hou Xiangxi Wang | 2024 | hLife2024，2，2： | 0 |
| 16 | VOC emission caps constrained by air quality targets based on response surface model:A case study in the Pearl River Delta Region,China显示文摘Because of the recent growth in ground-level ozone and increased emission of volatile organic compounds(VOCs),VOC emission control has become a major concern in China.In response,emission caps to control VOC have been stipulated in recent policies,but few of them were constrained by the co-control target of PM_(2.5)and ozone,and discussed the factor that influence the emission cap formulation.Herein,we proposed a framework for quantification of VOC emission caps constrained by targets for PM_(2.5)and ozone via a new response surface modeling(RSM)technique,achieving 50%computational cost savings of the quantification.In the Pearl River Delta(PRD)region,the VOC emission caps constrained by air quality targets varied greatly with the NOxemission reduction level.If control measures in the surrounding areas of the PRD region were not considered,there could be two feasible strategies for VOC emission caps to meet air quality targets(160μg/m^(3)for the maximum 8-hr-average 90th-percentile(MDA8-90%)ozone and 25μg/m^(3)for the annual average of PM_(2.5)):a moderate VOC emission cap with<20%NOxemission reductions or a notable VOC emission cap with>60%NOxemission reductions.If the ozone concentration target were reduced to 155μg/m^(3),deep NOxemission reductions is the only feasible ozone control measure in PRD.Optimization of seasonal VOC emission caps based on the Monte Carlo simulation could allow us to gain higher ozone benefits or greater VOC emission reductions.If VOC emissions were further reduced in autumn,MDA8-90%ozone could be lowered by 0.3-1.5μg/m^(3),equaling the ozone benefits of 10%VOC emission reduction measures.The method for VOC emission cap quantification and optimization proposed in this study could provide scientific guidance for coordinated control of regional PM_(2.5)and O_(3)pollution in China. | Ya’nan Hu Bowen Shi Xin Yuan Chuanzeng Zheng Qing’e Sha Yufan Yu Zhijiong Huang Junyu Zheng | 2023 | Journal of Environmental Sciences2023，，1： | 0 |
| 17 | Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications显示文摘Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases(HATs)advance our understandings in the regulation of histone modifications.However,the molecular basis of HATs selecting acyl coenzyme A(acyl-CoA)substrates for histone modification is less known.We here report that lysine acetyltransferase 2A(KAT2A)as an illustrative instance of HATs can selectively utilize acetyl-CoA,propionyl-CoA,butyryl-CoA,and succinyl-CoA to directly deposit 18 histone acylation hallmarks in nucleosome.By analyzing the co-crystal structures of the catalytic domain of KAT2A in complex with acetyl-CoA,propionyl-CoA,butyryl-CoA,malonyl-CoA,succinyl-CoA,and glutaryl-CoA,we conclude that the alternative substrate-binding pocket of KAT2A and the length and electrostatic features of the acyl chain cooperatively determine the selection of the acyl-CoA substrates by KAT2A.This study reveals the molecular basis underlying the pluripotency of HATs that selectively install acylation hallmarks in nucleosomes,which might serve as instrumental mechanism to precisely regulate histone acylation profiles in cells. | Sha Li Nan Li Jie He Runxin Zhou Zhimin Lu Yizhi Jane Tao Yusong R.Guo Yugang Wang | 2023 | Research2023，，4： | 0 |
| 18 | Decentralized Heterogeneous Federal Distillation Learning Based on Blockchain显示文摘Load forecasting is a crucial aspect of intelligent Virtual Power Plant(VPP)management and ameans of balancing the relationship between distributed power grids and traditional power grids.However,due to the continuous emergence of power consumption peaks,the power supply quality of the power grid cannot be guaranteed.Therefore,an intelligent calculation method is required to effectively predict the load,enabling better power grid dispatching and ensuring the stable operation of the power grid.This paper proposes a decentralized heterogeneous federated distillation learning algorithm(DHFDL)to promote trusted federated learning(FL)between different federates in the blockchain.The algorithm comprises two stages:common knowledge accumulation and personalized training.In the first stage,each federate on the blockchain is treated as ameta-distribution.After aggregating the knowledge of each federate circularly,the model is uploaded to the blockchain.In the second stage,other federates on the blockchain download the trained model for personalized training,both of which are based on knowledge distillation.Experimental results demonstrate that the DHFDL algorithmproposed in this paper can resist a higher proportion of malicious code compared to FedAvg and a Blockchain-based Federated Learning framework with Committee consensus(BFLC).Additionally,by combining asynchronous consensus with the FL model training process,the DHFDL training time is the shortest,and the training efficiency of decentralized FL is improved. | Hong Zhu Lisha Gao Yitian Sha Nan Xiang Yue Wu Shuo Han | 2023 | Computers, Materials & Continua2023，76，9： | 0 |
| 19 | Mild synthesis of N'-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent显示文摘Formamidine derivatives could be used as the building blocks for substituted heterocyclic compounds with various biological activities.N'-Aryl-N,N-dimethylformamidinium chlorides have been synthesized in high yields by reaction of aromatic primary amines with Vilsmeier-Haack reagent at room temperature.The structures of all the new compounds were identified by ESI-MS,IR and NMR spectra.The steric structures of some of these compounds were clarified by X-ray single crystal analysis. | Ge Meng Yao Wu Sha Rui Zhang Nan Bai | 2011 | Chinese Chemical Letters2011，22，9： | 0 |
| 20 | Inhibition of self-renewal and differentiation of HT-29 cells-derived cancer stem-like cells by scutellarin via Hedgehog signaling pathway显示文摘OBJECTIVE To investigate the inhibitory effect of scutellarin on the self-renewal and differentiation of HT-29 cells-derived cancer stem-like cells(HT-29CSC)in vitro and in vivo,and to explore its mechanism.METHODS The effect of scutellarin on the growth of HT-29CSC was determined by 3D Culture assay.The effect of scutellarin on growth and transformation of HT-29CSC was probed by soft agar colony formation assay.The effect of scutellarin on the differentiation of HT-29CSC was determined by serum induction differentiation assay in vitro.The effects of scutellarin on the expressions of marker gene Lgr5,target gene c-Myc,proliferation gene CK20 and Nanog gene were measured by quantitative real-time RT-PCR.Investigate the effect of scutellarin on the expression of c-Myc,Gli1,and Lgr5 protein by Western blotting.A subcutaneous xenograft model of colon cancer in nude mice was established and administered by intraperitoneal injection.The change of body weight and tumor size of nude mice were observed every two days.Investi⁃gate the effects of scutellarin on the growth of xenograft tumors in nude mice.The expression of CD133,Lgr5,Gli1,Ptch1,c-Myc,Ki67,CK20,Nanog gene in tumors were measured by quantitative real-time RT-PCR.The expression of c-Myc,Gli1,Lgr5,CD133,Ki67 protein were measured by Western blotting.RESULTS Scutellarin can inhibit the growth of HT-29CSC in 3D culture.Compared with the solvent control group,scutellarin can significantly inhibit the growth and transformation and differentiation of HT-29CSC in vitro(P<0.01).The expression levels of marker genes Lgr5,target gene c-Myc,proliferation gene CK20 and Nanog in HT-29CSC were down-regulated by scutellarin.Scutellarin can reduce the expression of c-Myc,Gli1,and Lgr5 protein in HT-29CSC.Scutellarin can inhibit the growth of colon cancer xenografts,lower CD133,Lgr5,Gli1,Ptch1,c-Myc,Ki67,CK20,and Nanog mRNA level of xenograft tumors,reduce the expression of c-Myc,Gli1,Lgr5,CD133,and Ki67 protein of xenograft tumors in nude mice.CONCLUSION Scutellarin,which is the main component of scutellaria barbata,can inhibit the differentiation of HT-29CSC and the mechanism is to inhibit the activity of Hedgehog signaling pathway. | LEI Nan XIONG Si-hui TAN Li HE Man ZHANG Meng SUN Qiang ZENG Sha CHEN Li XU Hai-bo | 2019 | 中国药理学与毒理学杂志2019，33，9： | 0 |
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