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| 1 | Human ICE/CED-3 Protease Nomenclature显示文摘 | Emad S Alnemri David J Livingston Donald W Nicholson Guy Salvesen Nancy A Thornberry Winnie W Wong Junying Yuan | 1996 | Cell1996，，2： | 2 |
| 2 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 3 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 4 | Optimization of diagnostic micro array for application in analyzing landfill methanotroph communities under different plant covers显示文摘 | NANCY S P ANGELA S WEILHARTER A | 2004 | Environmental Microbiology2004，6，4： | 1 |
| 5 | Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer显示文摘AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma.METHODS From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after high-dose [59.4 Gy(RBE)] proton radiotherapy with a high rate of local control,acceptable surgical morbidity,and a median survival of 24 mo. | Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven J Hughes John A Stauffer Scott A Celinski Elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg | 2017 | World Journal of Gastrointestinal Surgery2017，9，4： | 1 |
| 6 | HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium显示文摘BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.AIM To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) cells.METHODS Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional modeling.RESULTS HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium cells.Immunogold technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS cells.Bioinformatics analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein to the external environment. The programs also showed a similarity with the Tip-alpha protein of H. pylori. Tip-alpha is an exotoxin that penetrates cells and induces tumor necrosis factor alpha production, and HP0953 could have a similar function as posttranslational modification sites were found;modifications in turn require enzymes located in eukaryotic cells. Thus, to be functional, HP0953 may necessarily need to be translocated inside the cell where it can trigger different mechanisms producing cellular damage.CONCLUSION The location of HP0953 around infected cells, the probable posttranslational modifications, and its similarity to an exotoxin suggest that this protein is a virulence factor. | Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 7 | The untapped potential of genetically-engineered mouse models in chemoprevention research:Opportunities and challenges显示文摘 | CORY A S POWEL H B NANCY H C | 2008 | Cancer Prev Res2008，1，3： | 1 |
| 8 | Physiological and Biochemical Effects of the Myeotoxin Patulin on Chang Liver Cell Cultures显示文摘 | Warren I S Nancy E S Patricia A P | 1975 | In Vitro Cell DevPl1975，11，2： | 1 |
| 9 | Air rage : Choice of law for inten- tional torts occurring in flight over international waters 显示文摘 | NANCY L F KIMBERLY A S | 1999 | Alba- ny Law Review1999，，9： | 1 |
| 10 | Nitrogen and phosphorus budgets for the Yucatdn littoral: an approach for groundwater management显示文摘 | NANCY A C FRANCISCO C JORGE H S | 2010 | Environmental Monitoring and Assessment2010，172，14： | 1 |
| 11 | Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘 | Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang | 2012 | Lancet Oncology2012，，2： | 1 |
| 12 | The impacts of combustion emissions onair quality andclimate:from coal to biofuels and beyond显示文摘 | JEFFREY S G NANCY A M | 2009 | Atmos Environ2009，43，1： | 1 |
| 13 | Development of a monoclonal antibody based enzyme-linked immunosorbent assay to quantify soluble β-glucans in oats and barley显示文摘 | Christof R Nancy A Joanne S | 2003 | Journal of Agricultural and Chemistry2003，51，： | 1 |
| 14 | Identification of theHPV-16 E6 protein from transformed mouse cells and humancervical carcinoma cell lines 显示文摘 | Elliot J A Nancy L H John T S | 1987 | The EMBO Journal1987，6，4： | 1 |
| 15 | Reducing organic chloride contaminats in polyamide polyamines epichlorohydrin wet-strength resins显示文摘 | Danidl Nancy S C Stephen A F | 1991 | TAPPI1991，74，12： | 1 |
| 16 | Development of a rapid assimilable organic carbon method for water 显示文摘 | Lechevallier M W Nancy S Shaw Louis A Kaplan | 1993 | Appl Environ Microbiol1993，59，5： | 1 |
| 17 | High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial显示文摘 | John F Tisdale Daniel E Dunn Nancy Geller Michelle Plante Olga Nunez Cynthia E Dunbar A John Barrett Thomas J Walsh Stephen J Rosenfeld Neal S Young | 2000 | 2000 (9241)2000，，9241： | 1 |
| 18 | American Associa- tion of Neuroscience Nurses Scope and Standards of Prac- tice for Neuroscience Advanced Practice Nurses显示文摘 | Chris S A Nancy V Rossi S R | 2010 | J Neu- rosci Nurs2010，42，3： | 1 |
| 19 | γ-Globulin treatment of acute myocarditis in the pediatric population 显示文摘 | Nancy A D Colan S D Lewis A B | 1994 | Circulation1994，89，1： | 1 |
| 20 | Uhrastructural immtmodetection of osteopontin and osteocalcin as major matrix components of renal calculi 显示文摘 | MCKEE M D NANCI A KHAN S R | 1995 | J Bone Miner Res1995，10，12： | 1 |
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