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| 1 | Application of the CRISPR-Cas System for Efficient Genome Engineering in Plants显示文摘 | Mao, Yanfei Zhang, Hui Xu, Nanfei Zhang, Botao Gou, Feng Zhu, Jian-Kang | 2013 | Molecular Plant2013，6，6： | 132 |
| 2 | Roles of F-box Proteins in Plant Hormone Responses显示文摘F 盒子蛋白质是 E3 ubiquitin 连接酶 Skp1-Cullin-F-box 蛋白质建筑群的一个重要部件。它为调停 ubiquitin 的解朊作用绑特定的底层。F 盒子蛋白质包含一个签名 F 盒子主题在他们的氨基终点并且在他们的 carboxy 终点的一些蛋白质蛋白质相互作用主题,例如 Trp 毒蛇重复或白氨酸富人重复。许多 F 盒子蛋白质被识别了作为受体或重要中间的部件涉及植物荷尔蒙反应。这些突破调查结果在调整植物开发使我们结构的当前的理解和各种各样的 F 盒子蛋白质,他们表明小径的相关植物荷尔蒙,和他们的角色的功能清楚些。 | Haichuan YU Jiao WU Nanfei XU Ming PENG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 6 |
| 3 | Gamma(ɣ)‑MnO_(2)/rGO Fibered Cathode Fabrication from Wet Spinning and Dip Coating Techniques for Cable‑Shaped Zn‑Ion Batteries显示文摘Cable/fber-shaped Zn-ion batteries are designed to power wearable electronics that require high fexibility to operate on human body.However,one of technical challenges of these devices is the complexity and high cost for manufacturing fbered cathode.In this work,we demonstrated gamma manganese oxide(ɣ-MnO_(2))/reduced graphene oxide(rGO)fbered cathode fabrication using facile and cost-efective fber production and active material coating techniques.Specifcally,rGO fbers were fabricated via wet spinning,followed by chemical reduction with hydroiodic acid(HI).The synthesized rGO fber bundle was then dip-coated with a mixture ofɣ-MnO_(2),carbon black or multi-walled carbon nanotubes,and xanthan gum or polyvinylidene fuoride binder to obtainɣ-MnO_(2)/rGO fbered cathode.We studied the efect of binders and conductive materials on physical properties and electrochemical performance of the fbered cathode.It was found that hydrophobic binder had more benefts than hydrophilic binder by providing higher active material loading,better coating layer homogeneity,and more stable electrochemical performance.Cable-shaped Zn-ion batteries(CSZIBs)were then assembled by using theɣ-MnO_(2)/rGO fbered cathode,Zn wire anode,and xanthan gum polymeric gel electrolyte with 2 M ZnSO_(4) and 0.2 M MnSO_(4) salts without a separator.We investigated the battery assembling procedure on a glass slide(prototype ZIB)and in a plastic tube(cable-shaped ZIB),and evaluated their electrochemical performance.The CSZIB showed promising maximum capacity of~230 mAh/g with moderate cycling stability(80%capacity retention after 200 cycles)and high fexibility by maintaining the potential after consecutive pressing for 200 times under controlled pressing distance,duration,and testing speed.Finally,we explored ion intercalation behaviours and proposed a H^(+)/Zn^(2+)co-intercalation mechanism in ZIB withɣ-MnO_(2) active material. | Nakarin Subjalearndee Nanfei He Hui Cheng Panpanat Tesatchabut Priew Eiamlamai Pimpa Limthongkul Varol Intasanta Wei Gao Xiangwu Zhang | 2022 | Advanced Fiber Materials2022，4，3： | 2 |
| 4 | Ground-layer adaptive optics for the New Vacuum Solar Telescope:Instrument description and first results显示文摘Ground-layer adaptive optics(GLAO)has shown its potential for use in solar observation owing to its wide field-of-view(FOV)correction.A high-order GLAO system that consists of a multiple direction Shack-Hartmann wavefront sensor(WFS),a realtime controller with a multi-CPU processor,and a 151-element deformable mirror was developed for the 1-m New Vacuum Solar Telescope at Yunnan Observatories,Chinese Academy of Sciences.A hexagonal microlens with 9×8 subapertures is employed in the WFS.The detection FOV is 42′′×37′′,in which 9(3×3)guide regions are extracted for multiple direction wavefront sensing with a frame rate of up to 2200 Hz.To our knowledge,this is the first professional solar GLAO system used as a regularly operating instrument for scientific observations.Its installation and adjustment were performed in the summer of 2021.In this article,a detailed account of the GLAO system and its first light results and a comprehensive analysis of the performance of the GLAO system are provided.The results show that this system can effectively improve the imaging quality after compensating for the wavefront aberration due to ground-layer turbulence. | Lanqiang Zhang Hua Bao Xuejun Rao Youming Guo Libo Zhong Xian Ran Nanfei Yan Jinsheng Yang Cheng Wang Jiahui Zhou Ying Yang Yunyao Long Xinlong Fan Zhongyi Feng Donghong Chen Changhui Rao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，6： | 1 |
| 5 | Analysis of risk of delay of highway construction显示文摘 | Pan Nanfei | 2005 | Journal of Technology2005，20，3： | 1 |
| 6 | Pechinin synthesis and luminescence properties of Y3Ga5O12(YGG):Tb thin film 显示文摘 | ZHU Nanfei LI Yongxiang YU Xiaofeng | 2008 | Mater Lett2008，62，15： | 1 |
| 7 | Application of Time Series Hyperspectral Imaging (TS-HSI) for Determining Water Distribution Within Beef and Spectral Kinetic Analysis During Dehydration显示文摘 | Di Wu Songjing Wang Nanfei Wang Pengcheng Nie Yong He Da-Wen Sun Jiansong Yao | 2013 | Food and Bioprocess Technology2013，，11： | 1 |
| 8 | Crosstalk between IL-15Rα^(+)tumor-associated macrophages and breast cancer cells reduces CD8+T cell recruitment显示文摘Background:Interleukin-15(IL-15)is a promising immunotherapeutic agent owing to its powerful immune-activating effects.However,the clinical benefits of these treatments are limited.Crosstalk between tumor cells and immune cells plays an important role in immune escape and immunotherapy drug resistance.Herein,this study aimed to obtain in-depth understanding of crosstalk in the tumor microenvironment for providing potential therapeutic strategies to prevent tumor progression.Methods:T-cell killing assays and co-culture models were developed to determine the role of crosstalk between macrophages and tumor cells in breast cancer resistant to IL-15.Western blotting,histological analysis,CRISPR-Cas9 knockout,multi-parameter flow cytometry,and tumor cell-macrophage co-injection mouse models were developed to examine the mechanism by which IL-15Rα^(+)tumor-associated macrophages(TAMs)regulate breast cancer cell resistance to IL-15.Results:We found thatmacrophages contributed to the resistance of tumor cells to IL-15,and tumor cells induced macrophages to express high levels of theαsubunit of the IL-15 receptor(IL-15Rα).Further investigation showed that IL-15Rα^(+)TAMs reduced the protein levels of chemokine CX3C chemokine ligand 1(CX3CL1)in tumor cells to inhibit the recruitment of CD8^(+)T cells by releasing the IL-15/IL-15Rαcomplex(IL-15Rc).Administration of an IL-15Rc blocking peptide markedly suppressed breast tumor growth and overcame the resistance of cancer cells to anti-programmed cell death protein 1(PD-1)antibody immunotherapy.Interestingly,Granulocyte-macrophage colony-stimulating factor(GMCSF)inducedγchain(γc)expression to promote tumor cell-macrophage crosstalk,which facilitated tumor resistance to IL-15.Additionally,we observed that the non-transcriptional regulatory function of hypoxia inducible factor-1alpha(HIF-1α)was essential for IL-15Rc to regulateCX3CL1 expression in tumor cells.Conclusions:The IL-15Rc-HIF-1α-CX3CL1 signaling pathway serves as a crosstalk between macrophages and tumor cells in the tumormicroenvironment of breast cancer.Targeting this pathway may provide a potential therapeutic strategy for enhancing the efficacy of cancer immunotherapy. | Wenlong Zhang Qing Zhang Nanfei Yang Qian Shi Huifang Su Tingsheng Lin Zhonglei He Wenxin Wang Hongqian Guo Pingping Shen | 2022 | Cancer Communications2022，42，6： | 0 |
| 9 | Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages显示文摘Dear Editor,Tumor-associated macrophages(TAMs)are critical pro-tumor immunocytes and depletion of TAMs has been exploited for cancer therapy.1 However,the phenotypes and functions of TAMs are plastic,TAMs can also be effector cells by engulfing tumor cells and recruiting cytotoxic T cells,thus shaping the actions of TAMs is more scientific rational than depleting them indiscriminately.2 To promote the entry of reorienting TAMs into the clinical treatments of tumors,it is essential to explore the underline mechanisms controlling the anti-and pro-tumor activities of TAMs. | Yuxin Shu Nanfei Yang Nan Cheng Zhengyun Zou\Wenlong Zhang Yuncheng Bei Qian Shi Menghao Qin Wei-Guo Zhu Pingping Shen | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 10 | A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy显示文摘Currently the main treatment of acute myeloid leukemia(AML)is chemotherapy combining hematopoietic stem cell transplantation.However,the unbearable side effect of chemotherapy and the high risk of life-threatening infections and disease relapse following hematopoietic stem cell transplantation restrict its application in clinical practice.Thus,there is an urgent need to develop alternative therapeutic tactics with significant efficacy and attenuated adverse effects.Here,we revealed that umbilical cord-derived mesenchymal stem cells(UC-MSC)efficiently induced AML cell differentiation by shuttling the neutrophil elastase(NE)-packaged extracellular vesicles(EVs)into AML cells.Interestingly,the generation and release of NE-packaged EVs could be dramatically increased by vitamin D receptor(VDR)activation in UC-MSC.Chemical activation of VDR by using its agonist 1a,25-dihydroxyvitamin D3 efficiently enhanced the pro-differentiation capacity of UC-MSC and then alleviated malignant burden in AML mouse model.Based on these discoveries,to evade the risk of hypercalcemia,we synthetized and identified sw-22,a novel non-steroidal VDR agonist,which exerted a synergistic prodifferentiation function with UC-MSC on mitigating the progress of AML.Collectively,our findings provided a non-gene editing MSC-based therapeutic regimen to overcome the differentiation blockade in AML. | Luchen Sun Nanfei Yang Bing Chen Yuncheng Bei Zisheng Kang Can Zhang Nan Zhang Peipei Xu Wei Yang Jia Wei Jiangqiong Ke Weijian Sun Xiaokun Li Pingping Shen | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 11 | Separator threads in yarn-shaped supercapacitors to avoid short-circuiting upon length显示文摘Yarn-shaped supercapacitors(YSCs)are becoming promising energy-supply units with decent mechanical flexibility to be integrated into e-textiles in various shapes and locations.However,a robust YSC configuration that can provide long-term and reliable power output,especially after rigorous weaving and knitting processes,as well as all kinds of end uses,is yet to be established.Most YSCs today still suffer from short-circuiting upon length,primarily due to the structure failure of gel electrolyte that also works as the separator.Herein,we report the incorporation of separator threads in a twisted YSC,to withstand repetitive mechanical deformations.Separator threads are wrapped outside of yarn electrodes as a scaffold to accommodate gel electrolyte,while chemistry and wrapping density of these threads are investigated.With processing parameters optimized,we present an YSC configuration that can bear mechanical deformations along almost all directions,leading to reliable power units in woven or knit fabrics. | Nanfei He Junhua Song Jinyun Liao Feng Zhao Wei Gao | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 12 | Solar adaptive optics systems for the New Vacuum Solar Telescope at the Fuxian Lake Solar Observatory显示文摘Adaptive optics(AO)is essential for high-quality ground-based observations with large telescopes because it counters the impact of wavefront aberrations caused by atmospheric turbulence.The new vacuum solar telescope(NVST)is one of the most important high-resolution solar observation instruments in the world.Three sets of solar adaptive optics systems have been developed and installed on this telescope:conventional adaptive optics,ground layer adaptive optics,and multi-conjugate adaptive optics.These have been in operation from 2018 to 2023.This paper details the development and application of solar adaptive optics on the NVST and discusses the newest instrumentation. | Lanqiang Zhang Xuejun Rao Hua Bao Youming Guo Jinsheng Yang Nanfei Yan Xian Ran Dingkang Tong Xinlong Fan Zhongyi Feng Changhui Rao | 2024 | Astronomical Techniques and Instruments2024，1，2： | 0 |
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