|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos显示文摘有类型 II 的最近的进展定期聚类 interspaced 短 palindromic 重复(CRISPR ) 系统诺言染色体编辑的一条改进途径。然而,在模型有机体的这个系统的适用性和效率例如 zebrafish,几乎没被学习。这里,我们报导那指导 RNA 的 Cas9 核酸酶高效地便于染色体以一种简单、柔韧的方式在哺乳动物的房间和 zebrafish 胚胎编辑。当特定的 Cas/gRNA 被用来在 vivo 在 zebrafish 胚胎指向任何一个 etsrp, gata4 或 gata5 时,超过 35% 地点特定的体的变化被发现。Cas9/gRNA 高效地在结果导致了 etsrp 或 gata5 的 biallelic 变换体的房间,在 etsrp 在 fau 异种胚胎或贲门 bifida 显型 > tm236a 异种胚胎。最后,我们成功地完成了 Cas9/gRNA 系统在 zebrafish 胚胎导致的 mloxP 顺序的地点特定的插入。这些结果证明 Cas9/gRNA 系统有为 zebrafish 和另外的模型有机体成为一个简单、柔韧、有效的反向的基因工具的潜力。和另外的染色体工程技术, Cas9 系统为在生物学,农业,环境研究和药的应用是有希望的。 | Nannan Chang Changhong Sun Lu Gao Dan Zhu Xiufei Xu Xiaojun Zhu Jing-Wei Xiong Jianzhong Jeff Xi | 2013 | Cell Research2013，23，4： | 155 |
| 2 | Differential Fault Attack on Camellia显示文摘 | ZHOU Yongbin WU Wenling XU Nannan FENG Dengguo | 2009 | Chinese Journal of Electronics2009，18，1： | 15 |
| 3 | Hierarchical Control of Ride Height System for Electronically Controlled Air Suspension Based on Variable Structure and Fuzzy Control Theory显示文摘The current research of air suspension mainly focuses on the characteristics and design of the air spring. In fact, electronically controlled air suspension(ECAS) has excellent performance in flexible height adjustment during different driving conditions. However, the nonlinearity of the ride height adjusting system and the uneven distribution of payload affect the control accuracy of ride height and the body attitude. Firstly, the three-point measurement system of three height sensors is used to establish the mathematical model of the ride height adjusting system. The decentralized control of ride height and the centralized control of body attitude are presented to design the ride height control system for ECAS. The exact feedback linearization method is adopted for the nonlinear mathematical model of the ride height system. Secondly, according to the hierarchical control theory, the variable structure control(VSC) technique is used to design a controller that is able to adjust the ride height for the quarter-vehicle anywhere, and each quarter-vehicle height control system is independent. Meanwhile, the three-point height signals obtained by three height sensors are tracked to calculate the body pitch and roll attitude over time, and then by calculating the deviation of pitch and roll and its rates, the height control correction is reassigned based on the fuzzy algorithm. Finally, to verify the effectiveness and performance of the proposed combined control strategy, a validating test of ride height control system with and without road disturbance is carried out. Testing results show that the height adjusting time of both lifting and lowering is over 5 s, and the pitch angle and the roll angle of body attitude are less than 0.15?. This research proposes a hierarchical control method that can guarantee the attitude stability, as well as satisfy the ride height tracking system. | XU Xing ZHOU Kongkang ZOU Nannan JIANG Hong CUI Xiaoli | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 13 |
| 4 | Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion显示文摘 | Qinggan Ni Jiahui Chen Xia Li Xiaodong Xu Nannan Zhang Ang Zhou Bin Zhou Qian Lu Zhong Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 9 |
| 5 | Pyrethroid resistance in mosquitoes显示文摘重复的血费用在整个他们的寿命钟声使蚊子成为了许多疾病代理人的理想的传输器。向量控制是为联系蚊子的疾病的控制的当前的全球策略的很重要的部分,杀虫药剂申请是在这个努力的最重要的部件。Pyrethroids,说明 25% 世界杀虫药剂市场,当前是为蚊子的室内的控制的最广泛地使用的杀虫药剂,唯一的化学药品为蚊帐的处理被推荐,为在非洲阻止疟疾的主要工具。然而,忍受蚊子的疾病现在是苏醒的,主要因为在蚊子向量和寄生虫的反寄生虫抗药性发展了的杀虫药剂电阻。这篇论文考察我们在在蚊子带 topyrethroid 电阻的敏感管理新陈代谢的解毒和目标地点的发展的分子的机制的当前的知识。 | NANNAN LIU QIANG XU FANG ZHU LEE ZHANG | 2006 | Insect Science2006，13，3： | 8 |
| 6 | Characteristics of size distributions and sources of water-soluble ions in Lhasa during monsoon and non-monsoon seasons显示文摘To understand the physical and chemical characteristics, particle size distribution and sources of size-separated aerosols in Lhasa, which is located on the Tibetan Plateau(TP), six sizes of aerosol samples were collected in Lhasa in 2014. Ca^(2+), NH_4^+, NO_3^-,SO_4^(2-)and Cl-were the dominant ions. The ratio of cation equivalents(CE) to anion equivalents(AE) for each particle size segment indicated that the atmospheric aerosols in Lhasa were alkaline. SO_4^(2-)and NO_3^-could be neutralized by Ca^(2+), but could not be neutralized by NH_4^+, according to the [NH_4^+]/[NO_3^-+ SO_4^(2-)] and [Ca^(2+)]/[NO_3^-+ SO_4^(2-)] ratios. Mobile sources were dominant in PM_(0.95-1.5),PM_(1.5-3) and PM_(3-7.2), while stationary sources were dominant in the other three size fractions according to the [NO_3^-]/[SO_4^(2-)] ratios. The particle size distribution of all watersoluble ions during monsoon and non-monsoon periods was characterized by a bimodal distribution due to the different sources and formation mechanisms, and it was revealed that different ions had different sources in different seasons and different particle size segments by combining particle size distribution with correlation analysis. Source analysis of aerosols in Lhasa was performed using the Principal component analysis(PCA) for the first time, which revealed that combustion sources, motor vehicle exhaust, photochemical reaction sources and various types of dust were the main sources of Lhasa aerosols.Furthermore, Lhasa's air quality was also affected by long-distance transmission, expressed as pollutants from South Asia and West Asia, which were transmitted to Lhasa according to backward trajectory analysis. | Nannan Wei Zhiyou Xu Junwen Liu Guanghua Wang Wei Liu Deqing Zhuoga Detao Xiao Jian Yao | 2019 | Journal of Environmental Sciences2019，31，8： | 7 |
| 7 | Synthesis of chain-like MoS_2 nanoparticles in W/O reverse microemulsion and application in photocatalysis显示文摘Chain-like MoS2assemblies consisting of hexagonal MoS2nanoparticles(20-60 nm) have been successfully synthesized in a Triton X-100/cyclohexane/hexanol/water W/O reverse microemulsion in the presence of(NH 4)2MoS 4 as the molybdenum source and NH2OH·HCl as the reducing agent.The products were characterized by X-ray powder diffraction(XRD),transmission electron microscopy(TEM) and UV-vis diffuse reflectance absorption spectra.The influence of synthetic parameters such as acidity,water/oil ratio(0),aging time and annealing temperature on the formation of MoS2assemblies was investigated.TEM analysis showed that these synthetic factors played important roles in controlling the size of MoS2nanoparticles and the length of the chain-like MoS2assemblies.XRD analysis indicated that the well-crystallized MoS2nanoparticles could be obtained by annealing the precursors at 700 C for2h under a flow of N2atmosphere.In addition,the as-prepared chain-like MoS2nanoparticles exhibited excellent photocatalytic H2activity in Ru(bpy) 3 2+-MoS2-H2A three-component molecular systems under visible light irradiation. | LIU MeiYing LI XiaoQian XU ZhiLing LI BoNa CHEN LinLin SHAN NanNan | 2012 | Chinese Science Bulletin2012，57，30： | 6 |
| 8 | Investigation of black phosphorus as a nano-optical polarization element by polarized Raman spectroscopy显示文摘 | Nannan Mao Shishu Zhang Jinxiong Wu Huihui Tian Juanxia Wu Hua Xu Hailin Peng Lianming Tong Jin Zhang | 2018 | Nano Research2018，11，6： | 4 |
| 9 | Carbazole-endcapped Spiro[fluorene-9,9'-xanthene] with Large Steric Hindrance as Hole-transporting Host for Heavily-doped and High Performance OLEDs显示文摘 | Xianghua Zhao Yukun Wu Nannan Shi Xiaoyu Li Yi Zhao Mingli Sun Dongxue Ding Hui Xu Linghai Xie | 2015 | Chinese Journal of Chemistry2015，33，8： | 3 |
| 10 | Rice Chitin Receptor OsCEBiP Is Not a Transmembrane Protein but Targets the Plasma Membrane via a GPI Anchor显示文摘 | Gong, Ben-Qiang Xue, Jiao Zhang, Nannan Xu, Lahong Yao, Xinran Yang, Qiu-Jiao Yu, Yang Wang, Hong-Bin Zhang, Dandan Li, Jian-Feng | 2017 | Molecular Plant2017，10，5： | 3 |
| 11 | A novel Cu-doped high entropy alloy with excellent comprehensive performances for marine application显示文摘High entropy alloy(HEA)has attracted great interests as one of the promising multifunctional materials in marine applications.However,Cu as an effective biocide tends to form segregation in HEA,which could deteriorate corrosion and induce brittle fracture.Herein,we report a strategy to tailor the existing form of Cu in HEA from undesired large-scale segregation to uniform distribution with dispersed nanoscale precipitation,while retaining the unique structure characteristics of HEA.Eliminating Cu segregation improves toughness and avoids serious corrosion in the grain boundary.Uniform distribution with dispersed nanoscale precipitation of Cu further enhances the antifouling and lubricating abilities of Cu-doped HEA.Tailored AlCoCrFeNiCu_(0.5)HEA in this work has excellent comprehensive properties combining good mechanical properties,outstanding antifouling abilities,superior resistance to corrosion and wear.Furthermore,the corresponded mechanisms are discussed in terms of Cu-segregation-eliminated,nanoscale-Cu-precipitate-forming and comprehensive properties. | Yuan Yu Nannan Xu Shengyu Zhu Zhuhui Qjao Jianbin Zhang Jun Yang Weimin Liu | 2021 | Journal of Materials Science & Technology2021，，10： | 3 |
| 12 | Sodium channel gene expression in mosquitoes, Aeries albopictus (S.)显示文摘 | NANNAN LIU QIANG XU LEE ZHANG | 2006 | Insect Science2006，13，6： | 2 |
| 13 | Numerical Simulation of Solidification of Work Roll in Centrifugal Casting Process显示文摘A program on the solidification process of horizontal centrifugal casting coupled with eutectic carbides segregation has been developed in this paper.Due to the geometrical features of work roll,a cylindrical coordinate system was used.The temperature field of the outer layer at the end of filling process was imported as the initial temperature condition for the solidification process.The model of eutectic carbides segregation caused by different densities between eutectic MC and the molten steel was coupled in the program.The temperature field of the outer layer of work roll during horizontal centrifugal casting process was investigated.Results show that the outer layer has a 'sandwich shape' solid fraction manner.Results also indicate that the segregation of eutectic MC is quite severe during centrifugal casting process.It forms four zones of different content of carbides in radial direction.The simulated results of MC carbides segregation phenomenon agree with the experimental observations. | Nannan Song Yikun Luan Yunlong Bai Z.A. Xu Xiuhong Kang Dianzhong Li | 2012 | Journal of Materials Science & Technology2012，28，2： | 2 |
| 14 | Review of Parameter Identification and Sensorless Control Methods for Synchronous Reluctance Machines显示文摘Synchronous reluctance machines(SynRMs)have drawn increasing attention in recent years owing to their advantages such as low cost,simple structure,ease of manufacture,and high robustness.The main obstacle to the promotion of SynRMs is severe parameter nonlinearity,which deteriorates drive performance.Sensorless control methods for SynRMs are critical technologies that can broaden the industrial applications of SynRMs.Various methods of parameter identification and sensorless control strategies are reviewed and discussed,including self-commissioning,which is analyzed in detail.Furthermore,sensorless control strategies that can improve the industrial application of SynRMs are described.Finally,future research trends concerning SynRMs are analyzed and discussed. | Chengrui Li Gaolin Wang Guoqiang Zhang Nannan Zhao Dianguo Xu | 2020 | Chinese Journal of Electrical Engineering2020，6，2： | 2 |
| 15 | Effect of high-nitrogen fertilizer on gliadin and glutenin subproteomes during kernel development in wheat(Triticum aestivum L.)显示文摘Nitrogen(N),a macronutrient essential for plant growth and development,is needed for biosynthesis of protein and starch,which affect grain yield and quality.Application of high-N fertilizer increases plant growth,grain yield,and flour quality.In this study,we performed the first comparative analysis of gliadin and glutenin subproteomes during kernel development in the elite Chinese wheat cultivar Zhongmai 175 under high-N conditions by reversed-phase ultra-performance liquid chromatography and twodimensional difference gel electrophoresis(2D-DIGE).Application of high-N fertilizer led to significant increases in gluten macropolymer content,total gliadin and glutenin content,and the accumulation of individual storage protein components.Of 126 differentially accumulated proteins(DAPs)induced by high-N conditions,24 gliadins,12 high-molecularweight glutenins,and 27 low-molecular-weight glutenins were significantly upregulated.DAPs during five kernel developmental stages displayed multiple patterns of accumulation.In particular,gliadins and glutenins showed respectively five and six accumulation patterns.The accumulation of storage proteins under high-N conditions may lead to improved dough properties and bread quality. | Shoumin Zhen Xiong Deng Xuexin Xu Nannan Liu Dong Zhu Zhimin Wang Yueming Yan | 2020 | The Crop Journal2020，8，1： | 2 |
| 16 | The effects of water depth on the growth and reproduction of Potamogeton crispus in an in situ experiment显示文摘Aims Water level is one of the most important determinants of the distri-bution and composition of submersed aquatic vegetation in shal-low lakes.Without changes in nutrient loading,large-scale declines in submerged macrophytes in shallow lakes are largely attributed to strong external or internal forces,including changes in water level.As a winter-active submerged macrophyte,Potamogeton crispus has important functions in aquatic ecosystem.The objec-tives of our study were to reveal the effects of water depths on the germination,growth,reproduction and morphological changes of P.crispus under natural environmental conditions;identify the optimum water depth range for colonization of P.crispus;and pre-dict the succession course for P.crispus in Lake Taihu.Methods A long-term in situ experiment was performed to study the effects of water depth on the growth and morphology of P.crispus across the entire life cycle.Plants were grown in the improved cross type of rhizotrons for 30 weeks at three different water depths(60,120 and 200 cm)in Dongtaihu Bay of Lake Taihu.We measured the plant height,root length,the length and width of leaves and counted the numbers of leaves,ramets,turion spikes and roots of each plant on each observation day during the experiment.Important Findings Water depths ranging from 60 to 120 cm were favourable for above-ground vegetation growth,root tissue growth and the reproductive ability of P.crispus.At water depth of 200 cm or beyond,the distri-bution of P.crispus will be limited in the following year because of the lack of turion formation and the severe inhibition of ramet pro-duction.The relationship between above-ground biomass and growth time at three different water depths fits a logistic growth curve well(P<0.001).The rapid growth and distribution with high density of P.crispus at water depth near 60 cm during the reproductive stage is not favourable for growth of other submerged species.So a continuous water depth of~60-120 cm is the optimum growth depth range for the conservation and restoration of P.crispus in Lake Taihu.In addi-tion,the morphological parameters values acquired can replace or provide the ranges for the value of GmaxSB(the maximum growth rate of submerged plants,in the unit of d^(−1))obtained via calibration in the control equations of submerged plant growth in the Eco-Taihu model,which is a three-dimensional ecological model of Lake Taihu. | Nannan Zhou Weiping Hu Jiancai Deng Jinge Zhu Weiwei Xu Xin Liu | 2017 | Journal of Plant Ecology2017，10，3： | 2 |
| 17 | Occurrence and fate of chlorinated methylsiloxanes in surrounding aqueous systems of Shengli oilfield, China显示文摘Mono-chlorinated products of cyclic volatile methylsiloxanes(cVMS),i.e.,Monochlormethylheptamethylcyclotetrasiloxane[D3D(CH_(2)Cl)],monochlormethylnonamethylcyclopentasiloxane[D4D(CH_(2)Cl)],and monochlormethylundemethylcyclohexasiloxane[D5D(CH_(2)Cl)],were detected in water[ | Nannan Liu Jie Zhang Xudan He Lin Xu Yaqi Cai | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 18 | The impact of government’s fundings and tax incentives on industrial R&D investments—Empirical evidences from industrial sectors in Shanghai显示文摘 | Pingfang ZHU Weimin XU Nannan LUNDIN | 2005 | China Economic Review2005，，1： | 1 |
| 19 | The limitation of collimating for aspheric lens 显示文摘 | ZHONG XING SHAO | 2002 | Proc SPIE2002，4927，： | 1 |
| 20 | Susceptibility of male and female Japanese medaka (Oryzias latipes) to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes显示文摘2,4,6-trichlorophenol (2,4,6-TCP) is a wide- spread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micro- nucleus assay was conducted on medaka (Oryzias latipes) after a 28-day exposure to 2,4,6-TCE In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCE More- over, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 ~tg-L-1. This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP in vivo exposure. | Nannan LIU Mei MA Yiping XU Jinmiao ZHA Kaifeng RAO Zijian WANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员