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| 1 | 静水压力下功能梯度圆柱壳稳定性研究显示文摘文章研究了静水压力下功能梯度圆柱壳的稳定性特性。该文在Flügge理论的基础上,通过变换轴向波数,先后采用波动法和牛顿迭代法得到不同边界条件下FG圆柱壳的固有频率值。最后利用线性拟合方法得到水下FG圆柱壳的临界压力。在经过与各向同性圆柱壳的分析结果进行对比,验证了文中研究的有效性和正确性的基础上,讨论了水下FG圆柱壳的临界压力。通过算例,分析了材料组分、体积分数、边界条件、壳体尺寸等因素对水下FG圆柱壳临界压力的影响。 | 孟凡深 李戎 梁斌 Noda NAOKI | 2016 | 船舶力学2016，20，1： | 3 |
| 2 | The release and behavior of mercury, sele- nium, and boron in coal combustion 显示文摘 | Naoki Noda Shigeo Ito | 2008 | Powder Technology2008，180，： | 1 |
| 3 | Corrosion characteristics of reduced activation ferritic steel, JLF-1 (8.92Cr–2W) in molten salts Flibe and Flinak显示文摘 | Masatoshi Kondo Takuya Nagasaka Qi Xu Takeo Muroga Akio Sagara Nobuaki Noda Daisuke Ninomiya Masaru Nagura Akihiro Suzuki Takayuki Terai Naoki Fujii | 2009 | Fusion Engineering and Design2009，，7： | 1 |
| 4 | Corrosion characteristics of reduced activation ferritic steel, JLF-1 (8.92Cr–2W) in molten salts Flibe and Flinak显示文摘 | Masatoshi Kondo Takuya Nagasaka Qi Xu Takeo Muroga Akio Sagara Nobuaki Noda Daisuke Ninomiya Masaru Nagura Akihiro Suzuki Takayuki Terai Naoki Fujii | 2009 | Fusion Engineering and Design2009，，7： | 1 |
| 5 | Optically Active N-Acetyldopamine dimers of the Crude Drug 'Zentai' the Cast-off Shell of the Cicada,Cryptotympana sp显示文摘 | Naoki Noda Shinichi Kubota Yoko Miyata | 2000 | Chem Pharm Bull2000，48，11： | 1 |
| 6 | The release and behavior of mercury, selenium, and boron in coal combustion显示文摘 | Naoki Noda S I | 2008 | Powder Technology2008，180，12： | 1 |
| 7 | Mercury emissions from a coal-fired power plant in Japan显示文摘 | Takahisa Yokoyama Kazuo Asakura Hiromitsu Matsuda Shigeo Ito Naoki Noda | 2000 | Science of the Total Environment2000，，1： | 1 |
| 8 | Isolation and Characterization of Some Hydroxy Fatty and Phosphoric Acid Esters of 10-Hydroxy-2-decenoic Acid from the Royal Jelly of Honeybees ( Apis mellifera ) 显示文摘 | Naoki Noda Kazue Umebayashi Takafumi Nakatani | 2005 | Lipids2005，40，8： | 1 |
| 9 | 2,4-Bis(4-hydroxybenzyl) Phenol from Gastrodia elaea显示文摘 | NAOKI NODA YUKIO KOBAYASHI KAZUMOTO MIYAHARAI | | 0，，05： | 1 |
| 10 | Influence of operating temperature on performance of electrostatic precipitator for pulverized coal combustion boiler显示文摘 | NODA Naoki MAKINO Hisao | | 0，，04： | 1 |
| 11 | 2,4-bis ( 4- Hydroxybenzyl) Phenol form Gastrodia Elata 显示文摘 | Naoki Noda Yukio Kobayashi Kazumoto Miyahara | 2000 | Phytochemistry2000，39，5： | 1 |
| 12 | Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors显示文摘Background:Antiangiogenic tyrosine kinase inhibitors(TKIs)provide one of the few therapeutic options for effective treatment of hepatocellular carcinoma(HCC).However,patients with HCC often develop resistance toward antiangiogenic TKIs,and the underlying mechanisms are not understood.The aim of this study was to determine the mechanisms underlying antiangiogenic TKI resistance in HCC.Methods:We used an unbiased proteomic approach to define proteins that were responsible for the resistance to antiangiogenic TKIs in HCC patients.We evaluated the prognosis,therapeutic response,and serum insulin-like growth factor-binding protein-1(IGFBP-1)levels of 31 lenvatinib-treated HCC patients.Based on the array of results,a retrospective clinical study and preclinical experiments using mouse and human hepatoma cells were conducted.Additionally,in vivo genetic and pharmacological gain-and loss-of-function experiments were performed.Results:In the patient cohort,IGFBP-1 was identified as the signaling molecule with the highest expression that was inversely associated with overall survival.Mechanistically,antiangiogenic TKI treatment markedly elevated tumor IGFBP-1 levels via the hypoxia-hypoxia inducible factor signaling.IGFBP-1 stimulated angiogenesis through activation of the integrinα5β1-focal adhesion kinase pathway.Consequently,loss of IGFBP-1 and integrinα5β1 by genetic and pharmacological approaches re-sensitized HCC to lenvatinib treatment.Conclusions:Together,our data shed light onmechanisms underlying acquired resistance of HCC to antiangiogenic TKIs.Antiangiogenic TKIs induced an increase of tumor IGFBP-1,which promoted angiogenesis through activating the IGFBP-1-integrinα5β1 pathway.These data bolster the application of a new therapeutic concept by combining antiangiogenic TKIs with IGFBP-1 inhibitors. | Hiroyuki Suzuki Hideki Iwamoto Takahiro Seki Toru Nakamura Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Yasuko Imamura Takashi Niizeki Masahito Nakano Shigeo Shimose Tomotake Shirono Yu Noda Naoki Kamachi Miwa Sakai Kazutoyo Morita Masamichi Nakayama Tomoharu Yoshizumi Ryoko Kuromatsu Hirohisa Yano Yihai Cao Hironori Koga Takuji Torimura | 2023 | Cancer Communications2023，43，4： | 0 |
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