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| 1 | Noninvasive estimation of liver fibrosis and response to interferon therapy by a serum fibrogenesis marker, YKL-40, in patients with HCV-associated liver disease显示文摘AIM: To evaluate the clinical utility of serum fibrosis markers,including YKL-40, in patients with HCV-associated liver disease.METHODS: A total of 109 patients with HCV-associated liver disease were enrolled. We measured serum type Ⅳ collagen, amino-terminal peptide of type Ⅲ procollagen (PⅢP),hyaluronic acid (HA), YKL-40 levels and biochemical.Parameters by RIA or ELISA. Eighty-eight patients underwent liver biopsy, and 67 of 109 patients received interferon (IFN)therapy. We also investigated the relationship between the concentrations of serum fibrosis markers and histological fibrosis scores (METAVIR), and evaluated the changes of the levels of fibrosis markers before and after the IFN therapy.RESULTS: The increase in serum levels of all markers,particularly HA, was correlated with the progression of liver fibrosis (for type Ⅳ collagen, F= 9.076, P<0.0001; for PⅢP,F= 9.636, P<0.0001; for HA, F= 13.128, P<0.0001; and for YKL-40, F= 8.016, P<0.0001). YKL-40 had strong correlation with HA (r= 0.536, P<0.0001). Based on the receiver operating curve (ROC), the ability of serum HA exceeded the abilities of other serum markers to determine fibrosis score 4 from fibrosis score 0-3 (AUC = 0.854). While YKL-40 was superior to other fibrosis markers for predicting severe fibrosis (F2-F4) from mild fibrosis (F0-F1) (YKL-40, AUC = 0.809;HA, AUC = 0.805). After IFN therapy, only YKL-40 values significantly decreased not only in the responder group,but also in the nonresponder group (P = 0.03).CONCLUSION: YKL-40 may be a useful non-invasive serum marker to estimate the degree of liver fibrosis and to evaluate the efficacy of IFN therapies in patients with HCV-associated liver disease. | Yukiko Saitou Katsuya Shiraki Yutaka Yamanaka Yumi Yamaguchi Tomoyuki Kawakita Norihiko Yamamoto Kazushi Sugimoto Kazumoto Murata Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，4： | 21 |
| 2 | Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization显示文摘AIM: To detect the expression of a proliferation-related ligand on human hepatocellular carcinoma (HCC) cell lines (SK-Hep1, HLE and HepG2) and in culture medium.METHODS: APRIL expression was analyzed by Western blotting in HCC cell lines. Effects of APRIL to cell count and angiogenesis were analyzed, too.RESULTS: Recombinant human APRIL (rhAPRIL) increased cell viability of HepG2 cells and, in HUVEC, rhAPRIL provided slight tolerance to cell death from serum starvation. Soluble APRIL (sAPRIL) from HLE cells increased after serum starvation, but did not change in SK-Hep1 or HepG2 cells. These cells showed down-regulation of VEGF after incubation with anti-APRIL antibody.Furthermore, culture medium from the HCC cells treated with anti-APRIL antibody treatment inhibited tube formation of HUVECs.CONCLUSION: Functional expression of APRIL might contribute to neovascularization via an upregulation of VEGF in HCC. | Hiroshi Okano Katsuya Shiraki Yutaka Yamanaka Hidekazu Inoue Tomoyuki Kawakita Yukiko Saitou Yumi Yamaguchi Naoyuki Enokimura Keiichi Ito Norihiko Yamamoto Kazushi Sugimoto Kazumoto Murata Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，30： | 13 |
| 3 | Complications of Partial Splenic Embolization in Cirrhotic Patients显示文摘 | Takahisa Sakai Katsuya Shiraki Hidekazu Inoue Kazushi Sugimoto Shigeru Ohmori Kazumoto Murata Koujiro Takase Takeshi Nakano | 2002 | Digestive Diseases and Sciences2002，，2： | 3 |
| 4 | Relative predictive factors for hepatocellular carcinoma after HBeAg seroconversion in HBV infection显示文摘AIM: To determine the predictive factors forhepatocellular carcinoma (HCC) development in patientsafter spontaneous or therapeutic HBeAg seroconversion.METHODS: In 48 patients who seroconverted to anti-HBe positive during follow-up, the background factors forHCC development were analyzed.RESULTS: HCC was developed in six patients duringfollow-up (average follow-up after HBeAg seroconversion:10.9±5.4 years). The incidence of HCC evaluated byKaplan-Meier analysis was significantly higher in patientswith abnormal aspartate aminotransferase (AST>40 IU/L) level, lower platelet counts (PLT<10×104/μL),lower albumin level (Alb<30 g/L), positive HBV-DNA or older age at seroconversion (>40 years). However, lower platelet count was the only predictive factor for HCC development shown by multivariate proportional-hazard analysis.CONCLUSION: Active hepatitis or advanced hepatitis at HBeAg seroconversion or progressive hepatitis even after HBeAg seroconversion would be the risk factors for HCC development. These predictive factors should be taken into account in determining the frequency of biochemical study or imaging studies for HCC surveillance. | Kazumoto Murata Kazushi Sugimoto Katsuya Shiraki Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，43： | 2 |
| 5 | Axillary lymph node dissection can be avoided in women with breast cancer with intraoperative, false-negative sentinel lymph node biopsies显示文摘 | Hiroyuki Takei Masafumi Kurosumi Takashi Yoshida Yuko Ishikawa Yuji Hayashi Jun Ninomiya Katsunori Tozuka Hanako Oba Kenichi Inoue Shigenori Nagai Yoshihiro Saito Tomoko Kazumoto Jun-ichi Saitoh Toshio Tabei | 2010 | Breast Cancer2010，，1： | 2 |
| 6 | Sensitization of photocatalytic activity of S- or N-doped TiO 2 particles by adsorbing Fe 3+ cations显示文摘 | Teruhisa Ohno Zenta Miyamoto Kazumoto Nishijima Hidekazu Kanemitsu Feng Xueyuan | 2005 | Applied Catalysis A, General2005，，： | 1 |
| 7 | First Japanese case of Pierson syndrome with mutations in LAMB2显示文摘 | Hiroko Togawa Koichi Nakanishi Hironobu Mukaiyama Taketsugu Hama Yuko Shima Masaru Nakano Naoya Fujita Kazumoto Iijima Norishige Yoshikawa | 2013 | Pediatrics International2013，，2： | 1 |
| 8 | Therapeutic effect of linac- based stereotactic radiotherapy with a micro-multileaf collimator for the treatment of patients with brain metastases from lung cancer显示文摘 | Saitoh J Saito Y Kazumoto T | 2010 | Jpn J Clin Onco12010，40，： | 1 |
| 9 | Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosisin human hepatocellular carcinoma cells显示文摘 | Hidekazu Inoue Katsuya Shiraki Kazumoto Murata Kazushi Sugimoto Tomoyuki Kawakita Yumi Yamaguchi Yukiko Saitou Naoyuki Enokimura Norihiko Yamamoto Yutaka Yamanaka Takeshi Nakano | 2004 | International Journal of Molecular Medicine2004，，2： | 1 |
| 10 | Muhi-instutional study of radiation therapy for isolated para-aortic lymph node re-currence in uterine cervical carcinoma: 84 subjects of a population of more than 5 000显示文摘 | Niibe Y KenjoM Kazumoto T | 2006 | lnt J Radiat Oncol Biol phys2006，66，： | 1 |
| 11 | Role of p38 MAP kinase pathway in a toxin-induced model of hemolytic uremic syndrome显示文摘 | Xue Jun Fu Kazumoto Iijima Kandai Nozu Kiyoshi Hamahira Ryojiro Tanaka Tatsuya Oda Norishige Yoshikawa Masafumi Matsuo | 2004 | Pediatric Nephrology2004，，8： | 1 |
| 12 | Multiple brain metastases from adenoid cystic carcinoma of the parotid gland显示文摘 | Kazumoto K Hayase N Kurosumi I | 1998 | Surg Neurol1998，50，5： | 1 |
| 13 | Polysaccharide K induces Mn superoxide dismutase (Mn-SOD)in tumor tissues and inhibits malignant progression of QR-32 tumor cells显示文摘 | HASEM H FUTOSHI O KAZUMOTO N | 1998 | Cancer Immunology Immunotherap1998，46，6： | 1 |
| 14 | Multi institutional study of radiation therapy for isolated para aortic lymph node recur- rence in uterine cervical carcinoma: 84 subjects of a population of more than 5,000显示文摘 | Niibe Y Kenjo M Kazumoto T | 2006 | Int J Radiat Oncol Biol Phys2006，66，5： | 1 |
| 15 | Pathophysiology and treatment of IgA nephropathy in children显示文摘 | N. Yoshikawa Ryojiro Tanaka Kazumoto Iijima | 2001 | Pediatric Nephrology2001，，5： | 1 |
| 16 | Multi-instutional study of radiation therapy for isolated para-aortic lymph node recurrence in uterine cervical carcinoma:84 subjects of a population of more than 5,000显示文摘 | Niibe Y Kenjo M Kazumoto T | 2006 | Int J Radiat Oncol Biol Phys2006，66，： | 1 |
| 17 | Survey of rituximab treatment for childhood-onset refractory nephrotic syndrome显示文摘 | Shuichi Ito Koichi Kamei Masao Ogura Tomohiro Udagawa Shuichiro Fujinaga Mari Saito Mayumi Sako Kazumoto Iijima | 2013 | Pediatric Nephrology2013，，2： | 1 |
| 18 | Frequency and characteristics of isolated paraaortic lymph node recurrence in patients with uterine cervical carcinoma in Japan A multi-institutional study 显示文摘 | NIIBE Y KAZUMOTO T TOITA | 2006 | Gynecol Oncol2006，103，4： | 1 |
| 19 | Pathophysiology and treatment of IgA nephropathy in children显示文摘 | Norishige Y Ryojiro T Kazumoto I | 2001 | Pediatr Nephrol2001，16，： | 1 |
| 20 | Pulmonary tumor thrombot- ic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor显示文摘 | Chinen K Kazumoto T Ohkura Y | 2005 | Pathol Int2005，55，1： | 1 |
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