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52篇 您的检索式：作者名="Naoki O"

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	题名	作者	年代	出处	被引量
1	Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.	Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi	2016	World Journal of Gastroenterology2016，22，44：	5
2	Tissue velocity imaging of coronary artery by rotating-type intravascular ultrasound显示文摘	Yoshifumi S Akira T Naoki O	2004	Ultrasonics2004，42，19：	1
3	Electrochemistry and structural chemistry of Li O4 (Fd3m) in nonaqueous lithium cells显示文摘	Tsutomu O Koji T Naoki M	2000	J Electrochem Soc2000，147，10：	1
4	Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy显示文摘	Naoki O Tomonori Y Hironori Y	2007	Gastrointest Endosc2007，66，：	1
5	Severity of atrophicgastritis related to antiparietal cell antibody and gastriccarcinogenesis,including p53 mutations显示文摘	Ayumu T Naoki O Akihiro I	2006	J GastroenterolHepatol2006，21，3：	1
6	Endocrine carcinoma of the stomach : clinicopathological analysis of 27 surgically treated cases in a single institute显示文摘	Takeshi K Shigekazu O Naoki H	2012	Gastric Cancer2012，1，5：	1
7	Preparation and mechanical properties of polypropylene-clayhybrids based on modified polypropylene and organophilicclay显示文摘	Naoki H Hirotaka O Makoto K	2000	J of Appl Polym Sci2000，78，1：	1
8	Ultrahigh porosity in metal-organic frameworks 显示文摘	Furukawa Hiroyasu Ko Nakeun Go Yong Bok Aratani Naoki Choi Sang Beom Choi Eunwoo Ozgtir Yazaydin A Snurr Randall Q O'Keeffe Michael Kim Jaheon Yaghi Omar M	2010	Science2010，329，：	1
9	Lowered stimulated emission threshold of zinc oxide by hydro- gen doping with pulsed argon-hydrogen plasma 显示文摘	Naoki O Wang Y-G Takamasa I	2007	Journal of Crystal Growth2007，306，2：	1
10	An inoculum for the aerobic treatment of wastewaters with high concentrations of fats and oils显示文摘	Kwaku T D Seijiro F Naoki O	1999	Bioresource Technology1999，69，2：	1
11	New endoscopic treatment for chronic pancrcatitis, using contrast media containing ulinastatin and prednisolone 显示文摘	MINORU O NAOKI W MASHIRO M	1997	J Gastroenter1997，32，2：	1
12	Low and high frequency acupunctrue stimulations mental stress - induced sweating in humans via different mechanisms 显示文摘	Kihiro O Junichi S Naoki N	2005	Autonomic Neurosci2005，118，12：	1
13	High performance porous silicon nitrides显示文摘	Yoshiaki I Naoki K Tatsuki O		0，，14：	1
14	Evaluation of test re- sults of 1 000 m^3 N/h pilot plant for CO2 absorption using an amine-based solution 显示文摘	Norso A Naoki O Mutsuo Y	1997	Energy Conveys1997，38，1：	1
15	Molecular analysis oforganic-solvent-tolerance in yeast 5accharomyces cerevisiae based on DNA microarray analysis显示文摘	Naoki O Ken M Kouichi K		0，，：	1
16	Cerebral vasospasm after subarachnoid hemorrhage from severe arteriovenous malformation显示文摘	SATORU T KIMIHIRO N NAOKI O		0，，05：	1
17	Importance of rostral ventrolateral medulla neurons in determining efferent sympa- thetic nerve activity and blood pressure显示文摘	Hiroo K Naoki O Tomokazu M	2012	Hypertens Res2012，35，2：	1
18	Serotonin 2A receptor gene polymorphism is not associated with completed suicide显示文摘	Hisae O Osamu S Naoki N	2001	J Psychiatr Res2001，35，3：	1
19	Dielectric properties of sintered aluminum nitride显示文摘	Kume S Masaki Y Naoki O	2005	Int J Refract Met Hard Mater2005，4，23：	1
20	Characterization of transparent and conducting Sn-doped Ga2()3 single crystal after annealing显示文摘	SHIGEO O NORIH1TO S Z K NAOKI A	2008	Thin Solid Films2008，516，17：	1

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