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| 1 | The Peculiar Existence of Protein-Bound Unconjugated Bile Acid in the Cytoplasmic Fraction of Rat Brain显示文摘 | MANO Nariyasu GOTO Takaaki GOTO Junichi | 2004 | 色谱2004，22，4： | 2 |
| 2 | Preparation of Pt-loaded TiO2 nanofibers by electrospinning and their application for WGS reactions 显示文摘 | Hyeonjae Kim Yeongsoo Choi Nariyasu Kanuka | 2009 | Applied Catalysis A : General2009，352，12： | 1 |
| 3 | Stimulatory effect on the transport mediated by organic anion transporting polypeptide 2B1显示文摘Drug-drug interaction(DDI)is one of causes of adverse drug events and can result in lifethreatening consequences.Organic anion-transporting polypeptide(OATP)2B1 is a major uptake transporter in the intestine and contributes to transport various clinically used therapeutic agents.The intestine has a high risk of DDI,because it has a special propensity to be exposed to a high concentration of drugs.Thus,understanding drug interaction mediated by OATP2B1 in the absorption process is important for the prevention of adverse drug events,including decrease in the therapeutic effect of co-administered drugs.Acute drug interaction occurs through the direct inhibitory effect on transporters,including OATP2B1.Moreover,some compounds such as clinically used drugs and food components have an acute stimulatory effect on transport of co-administered drugs by OATP2B1.This review summarizes the acute stimulatory effect on the transport mediated by OATP2B1 and discusses the mechanisms of the acute stimulatory effects of compounds.There are two types of acute stimulatory effects,substrate-independent and-dependent interactions on OATP2B1 function.The facilitating translocation of OATP2B1 to the plasma membrane is one of causes for the substrate-independent acute stimulatory effect.On the contrary,the substrate-dependent effect is based on the direct binding to the substrate-binding site or allosteric progesterone-binding site of OATP2B1. | Jiro Ogura Hiroaki Yamaguchi Nariyasu Mano | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 1 |
| 4 | Prognostic value of carcinoembryonic antigen and CYFRA21-1 in patients with pathological stage I non- small cell lung cancer显示文摘 | Katsunari Matsuoka Shinichi Sumitomo Nariyasu Nakash- ina | 2007 | Eur J Cardiothorac Surg2007，32，3： | 1 |
| 5 | Intratu- moral Wntl expression affects survivin gene expression in non- small cell lung cancer 显示文摘 | Nariyasu Nakashima Cheng - Long Huang Dage Liu | 2010 | Int J 0ncol2010，37，3： | 1 |
| 6 | Wnt3 gene expression promotes tumor progression in non-small cell lung cancer显示文摘 | Nariyasu Nakashima Dage Liu Cheng-long Huang Masaki Ueno Xia Zhang Hiroyasu Yokomise | 2011 | Lung Cancer2011，，2： | 1 |
| 7 | Acantho-panax senticosus Harms as a prophylactic for MPTP-induced Parkinson's disease in rats 显示文摘 | Takahiko Fujikawa Shinji Miguchi Nariyasu Kanada | 2005 | J Ethnopharmacol2005，97，02： | 1 |
| 8 | Preparation of Pt- loaded TiO2 nanofibers by electrospinning and their application for WGS reactions 显示文摘 | Hyeonjae K Yeongsoo C Nariyasu K | 2009 | Applied Catalysis A : General2009，352，12： | 1 |
| 9 | Development of an automatic classification system for eating, ruminating and resting behavior of cattle using an accelerometer显示文摘 | Nariyasu Watanabe Seiichi Sakanoue Kensuke Kawamura | 2008 | Grassland Science2008，54，4： | 1 |
| 10 | Highly Selective Molecular Recognition of Biologically Active Substances Using Liquid Phase Separation显示文摘The development of new chiral stationary phases has been very important in the a ccurate analysis of drug enantiomers and their metabolites in biological samples during drug discovery and development. New chiral stationary phases have been d eveloped using conalbumin and flavoprotein from chicken egg whites, which have b een applied to a broad range of drug enantiomers. The application and characteri zation of these two chiral columns for high-performance liquid chromatograp hy have been documented. Both specific and non-specific interactions, based on the silica gel surface and linker moiety, influenced retention and chiral separa tion of solutes. Interactions between drug enantiomers and proteins, as a pseudo chiral stationary phase, were investigated with affinity capillary electrophore sis, in order to avoid the effects of non-specific interactions. The chiral dis crimination region for ketoprofen on the flavoprotein surface was concluded to c onsist of an α-helix structure. Studies with chemically modified flavoprot ein indicated that two types of interactions at the chiral discrimination region were required for chiral separation: a π-π interaction between a tryptophan residue and the aromatic ring of ketoprofen, and an ionic interaction between th e carboxyl group of ketoprofen and an amino and carboxyl group of the protein. I n the bod y, drugs and biologically active substances having a carboxyl group have been kn own to transform various metabolites such as acyl glucuronide. The acyl adenylat e has also been noted as a chemically active intermediate of coenzyme A ligation . Both the acyl adenylate and the acyl glucuronide produced protein adducts by r eacting with nucleophilic groups such as amino groups on protein molecules. To c haracterize both active intermediates and protein adducts, analytical techniques conferring highly selective molecular recognition, such as high-performance li quid chromatography and mass spectrometry, were required. | MANO Nariyasu ASAKAWA Naoki GOTO JunichiGraduate School of Pharmaceutical Sciences Tohoku University | 2003 | 色谱2003，21，4： | 0 |
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