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| 1 | Antihyperglycemic activity,antihyperlipedemic activity,haematological effects and histopathological analysis of Sapindus mukorossi Gaerten fruits in streptozotocin induced diabetic rats显示文摘Objective:To investigate the antihyperglycemic and antihyperlipidemie properties of hydroalcoholic extract of fruits of Sapindus mukorossi Caerlen and its beneficial effect on haeniatological parameters with histopathological analysis in streptpzotocin induced diabetic rats.Methods:Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and standard drug glybenclamide(0.5 mg/kg body weight) were administered to diabetic rats.Effect of extract on hyperglycemia,hyperlipidemia and hematological parameters was studied in diabetic rats.Histopathological changes in diabetic rat pancreas were also observed after extract and glybenclamide treatment.Results:Daily oral administration of Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and glybenclamide for 20 days showed beneficial effects on blood glucose level(P<0.01) and lipid level.The extract has a favorable effect on the histopathological changes of the pancreas in streptozotocin induced diabetes.Conclusions: These findings reveal that the hydroalcoholic extract of Sapindus mukorossi fruits extract possesses antihyperglycemic and antihyperlipidemie properties.In addition.the extract can prevent various complications of diabetes and improve some haeniatological parameters. | Neeraj Verma G Amresh P K Sahu Neelam Mishra Anil P Singh Ch V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 14 |
| 2 | Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models显示文摘Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(Z.oenoplia) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal models.Methods:Five groups of six rats each were selected for the study.Ethanolic extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated groups.The serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the liver.Result:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of Z.oenoplia roots.Meanwhile,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose dependency.In addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections.Conclusions:The results of this study slrongly indicate that ethanolic extract of Z.oenoplia has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats. | Ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 6 |
| 3 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 4 | Analysis of dichroic dye-doped polymer-dispersed liquid crystal materials for display devices显示文摘 | Kumar P Neeraj Kang S W | 2011 | Thin Solid Films2011，520，1： | 1 |
| 5 | Steady-state and dynamic modeling of gas-phase polypropylene processed using stirred-bed reactors 显示文摘 | Neeraj P Hare K Bruce Lucas | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 6 | Rate control with ivabradine : angina pectoris and beyond 显示文摘 | NEERAJ P BALRAM B | 2011 | Am J Cardiovasc Drug2011，11，1： | 1 |
| 7 | Photooxidative damage to the cyanobacterium Spirulina platensis mediated by singlet oxygen显示文摘 | Singh D P Neeraj S Kavita V | 1995 | Current Microbiol1995，31，1： | 1 |
| 8 | Grain boundary effects on the electrical and magnetic properties of Pr2/3Ba1/3MnO3 and La2/3Ca1/3MnO3 manganites 显示文摘 | NEERAJ P VIKRAM S PANDVA D K AGARAWAL S K | 2007 | Mater Lett2007，61，： | 1 |
| 9 | Synthesis and Structure of the First Open-framework Cadmium Oxalate Possessing Channels 显示文摘 | Prasad P A Neeraj S Natarajan S | 2000 | Chem Commun2000，，14： | 1 |
| 10 | Adult and child malaria mortality in India: a nationally representative mortality survey显示文摘 | Neeraj Dhingra Prabhat Jha Vinod P Sharma Alan A Cohen Raju M Jotkar Peter S Rodriguez Diego G Bassani Wilson Suraweera Ramanan Laxminarayan Richard Peto | 2010 | 2010 (9754)2010，，9754： | 1 |
| 11 | Cost Effective Natural Antioxidants显示文摘 | Dhan P Neeraj K | 2011 | Nutrition and Health2011，，4： | 1 |
| 12 | Development of amphotericin B loaded polymersomes based on(PEG)3-PLA co-polymers:Factors affecting size and in vitro evaluation显示文摘 | JAY P J NEERAJ K | 2010 | Eur J Pharm Sci2010，40，5： | 1 |
| 13 | Map-based Support for Wireless Sen-sor Network Simulation显示文摘 | Szczytowski P Khelil A Neeraj S | 2012 | Journal of Networks(JNW)2012，7，1： | 1 |
| 14 | Steady state and dynamic modeling of gas-phase polypropylene processes using stirred-bed reactors显示文摘 | NEERAJ P K BRUCE L KEVIN C S | 2004 | Industrial Engineering Chem- ical Research2004，43，： | 1 |
| 15 | Human papillomavirus type 16 variant analysis of E6 ,E7 ,and L1 genes and long control region in biopsy samples from cervical cancer patients in North India显示文摘 | Shailja P Neeraj J Bhupesh KIP | 2008 | J Clin Microbio12008，46，3： | 1 |
| 16 | Thermal properties ofLar3Ba1/3(Mn1-xSb,)O3manganites显示文摘 | Vikram Sen Bhalla G L Neeraj P | 2010 | Physica2010，405，： | 1 |
| 17 | Srinivasan Natarajan显示文摘 | Prasad P A Neeraj S Vaidhyanathan R | 2002 | Journal of Solid State Chemistry2002，166，： | 1 |
| 18 | Hedgehog-Gli signaling pathway inhibitors as anti- cancer agents 显示文摘 | NEERAJ M CHANDANAMALI P NAOAKI F | 2009 | J Med Chem2009，52，13： | 1 |
| 19 | Steadystate and dynamic modeling of gas-phase polypropylene processed using stirred-bed reactors显示文摘 | NEERAJ P HARE K BRUCE LUCAS | | 0，，： | 1 |
| 20 | Wind electric power in the world and perspectives of its development in India 显示文摘 | Neeraj Golaita R M Moharilb P S Kulkarnia | 2009 | Renewable and Sustainable Energy Reviews2009，13，1： | 1 |
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