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| 1 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 2 | Inhibitor of fatty acid synthase induced apoptosis in human colonic cancer cells显示文摘INTRODUCTIONThe treatment of human epithelial malignancies islimited by drug resistance and toxic and side effects,which results in the failure in the treatment ofmajority of advanced cancer victims.To seek for anew,and specific antineoplastic therapy willprovide hope for tumor treatment.Althoughdisordered intermediary metabolism in cancer cellshas been known for many years,much of the | Pei Lin Huang Shi Neng Zhu Shi Lun Lu Zhen Sheng Dai Yue Lin Jin | 2000 | World Journal of Gastroenterology2000，6，2： | 13 |
| 3 | Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma显示文摘Celastrol is a triterpene derived from the traditional Chinese medicine Tripterygium wilfordii Hook f,which displays potential anticancer activity.In the present study,we investigated the anticancer effects of celastrol against clear cell renal cell carcinoma(ccRCC)and the underlying mechanisms.Using Cancer Genome Atlas(TCGA)database and genotype-tissue expression(GTEx)database we conducted a bioinformatics analysis,which showed that the mRNA levels of liver-X receptorsα(LXRα)and ATP-binding cassette transporter A1(ABCA1)in ccRCC tissues were significantly lower than those in adjacent normal tissues.This result was confirmed by immunoblotting analysis of 4 ccRCC clinical specimens,which showed that the protein expression of LXRαand ABCA1 was downregulated.Similar results were obtained in a panel of ccRCC cell lines(786-O,A498,SN12C,and OS-RC-2).In 786-O and SN12C cells,treatment with celastrol(0.25–2.0μM)concentration-dependently inhibited the cell proliferation,migration,and invasion as well as the epithelial-mesenchymal transition(EMT)process.Furthermore,we demonstrated that celastrol inhibited the invasion of 786-O cells through reducing lipid accumulation;celastrol concentration-dependently promoted autophagy to reduce lipid storage.Moreover,we revealed that celastrol dramatically activated LXRαsignaling,and degraded lipid droplets by inducing lipophagy in 786-O cells.Finally,celastrol promoted cholesterol efflux from 786-O cells via ABCA1.In high-fat diet-promoted ccRCC cell line 786-O xenograft model,administration of celastrol(0.25,0.5,1.0 mg·kg^(−1)·d^(−1),for 4 weeks,i.p.)dose-dependently inhibited the tumor growth with upregulated LXRαand ABCA1 protein in tumor tissue.In conclusion,this study reveals that celastrol triggers lipophagy in ccRCC by activating LXRα,promotes ABCA1-mediated cholesterol efflux,suppresses EMT progress,and ultimately inhibits cell proliferation,migration,and invasion as well as tumor growth.Thus,our study provides evidence that celastrol can be used as a lipid metabolism-based anticancer therapeutic approach. | Chan-juan Zhang Neng Zhu Jia Long Hong-tao Wu Yu-xiang Wang Bi-yuan Liu Duan-fang Liao Li Qin | 2021 | Acta Pharmacologica Sinica2021，42，9： | 8 |
| 4 | Three-dimensional image of hepatocellular carcinoma under confocal laser scanning microscope显示文摘AIM To investigate the application of confocallaser scanning microscopy(CLSM)in tumorpathology and three-dimensional( 3-D )reconstruction by CLSM in pathologic specimensof hepatocellular carcinoma(HCC).METHODS The 30μm thick sections were cutfrom the paraffin-embedded tissues of HCC,hyperplasia and normal liver,stained with DNAfluorescent probe YOYO-1 iodide and examinedby CLSM to collect optical sections of nuclei and3-D images reconstructed.RESULTS HCC displayed chaotic arrangementof carcinoma cell nuclei,marked pleomorphism,indented and irregular nuclear surface,andirregular and coarse chromatin texture.CONCLUSION The serial optical tomograms ofCLSM can be used to create 3-D reconstruction ofcancer cell nuclei.Such 3-D impressions mightbe helpful or even essential in making anaccurate diagnosis. | Wang Hai Zhang Shi Neng Zhu Shi Lun Lu Ya Lin Huang Peng Zhao | 2000 | World Journal of Gastroenterology2000，6，3： | 7 |
| 5 | Decontamination of Bacillus subtilis var. niger spores on selected surfaces by chlorine dioxide gas显示文摘Objective:Chlorine dioxide(CD) gas has been used as a fumigant in the disinfection of biosafety labo-ratories.In this study,some experiments were conducted to assess the inactivation of spores inoculated on six ma-terials [stainless steel(SS),painted steel(PS),polyvinyl chlorid(PVC),polyurethane(PU),glass(GS),and cotton cloth(CC)] by CD gas.The main aims of the study were to determine the sporicidal efficacy of CD gas and the effect of prehumidification before decontamination on sporicidal efficacy.Methods:Material coupons(1.2 cm diameter of SS,PS,and PU;1.0 cm×1.0 cm for PVC,GS,and CC) were contaminated with 10 μl of Bacillus subtilis var.niger(ATCC 9372) spore suspension in mixed organic burden and then dried in a biosafety cabinet for 12 h.The spores were recovered by soaking the coupons in 5 ml of extraction liquid for 1 h and then vortexing the liquid for 1 min.Results:The log reductions in spore numbers on inoculated test materials exposed to CD gas [0.080%(volume ratio,v/v) for 3 h] were in the range of from 1.80 to 6.64.Statistically significant differences were found in decontamination efficacies on test material coupons of SS,PS,PU,and CC between with and without a 1-h prehumidification treatment.With the extraction method,there were no statistically significant differences in the recovery ratios between the porous and non-porous materials.Conclusions:The results reported from this study could provide information for developing decontamination technology based on CD gas for targeting surface microbial contamination. | Yan-ju LI Neng ZHU Hai-quan JIA Jin-hui WU Ying YI Jian-cheng QI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，4： | 4 |
| 6 | Relationship between the eating quality and the physico-chemical properties of high grain quality rice in China | CHEN Neng,ZHU Zhiwei,ZHANG Boping,ZHENG Youchuan,and Xie Lihong,CNRRI,Hangzhou 310006,China | 1997 | Chinese Rice Research Newsletter1997，5，1： | 4 |
| 7 | Improving stability of MXenes显示文摘Due to their superior hydrophilicity and conductivity,ultra-high volumetric capacitance,and rich surface-chemistry properties,MXenes exhibit unique and excellent performance in catalysis,energy storage,electromagnetic shielding,and life sciences.Since they are derived from ceramics(MAX phase)through etching,one of the challenges in MXenes preparation is the inevitable exposure of metal atoms on their surface and embedding of anions and cations.Because the as-obtained MXenes are always in a thermodynamically metastable state,they tend to react with trace oxygen or oxygen-containing groups to form metal oxides or degrade,leading to sharply declined activity and impaired performance.Therefore,improving the stability of MXenesbased materials is of practical significance in relevant applications.Unfortunately,there lacks a comprehensive review in the literature on relevant topics.To help promote the wide applications of MXenes,we review from the following aspects:(i)insights into the factors affecting the stability of MXenes-based materials,including oxidation of MXenes flakes,stability of MXenes colloidal solutions,and swelling and degradation of MXenes thin-film,(ii)strategies for enhancing the stability of MXenes-based materials by optimizing MAX phase synthesis and modifying the MXenes preparation,and(iii)techniques for further increasing the stability of freshly prepared MXenes-based materials via controlling the storage conditions,and forming shielding on the surface and/or edge of MXenes flakes.Finally,some outlooks are proposed on the future developments and challenges of highly active and stable MXenes.We aim to provide guidance for the design,preparation,and applications of MXenes-based materials with excellent stability and activity. | Jizhou Jiang Saishuai Bai Jing Zou Song Liu Jyh-Ping Hsu Neng Li Guoyin Zhu Zechao Zhuang Qi Kang Yizhou Zhang | 2022 | Nano Research2022，15，7： | 4 |
| 8 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 9 | Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling显示文摘 | Li QIN Yun-bo YANG Yi-xin YANG Neng ZHU Yong-zhen GONG Cai-ping ZHANG Shun-xiang LI Duan-fang LIAO | 2014 | Acta Pharmacologica Sinica2014，35，9： | 2 |
| 10 | Generation of strong magnetic fields with a laser-driven coil显示文摘As a promising new way to generate a controllable strong magnetic field, laser-driven magnetic coils have attracted interest in many research fields. In 2013, a kilotesla level magnetic field was achieved at the Gekko XⅡ laser facility with a capacitor–coil target. A similar approach has been adopted in a number of laboratories, with a variety of targets of different shapes. The peak strength of the magnetic field varies from a few tesla to kilotesla, with different spatiotemporal ranges. The differences are determined by the target geometry and the parameters of the incident laser. Here we present a review of the results of recent experimental studies of laser-driven magnetic field generation, as well as a discussion of the diagnostic techniques required for such rapidly changing magnetic fields. As an extension of the magnetic field generation, some applications are discussed. | Zhe Zhang Baojun Zhu Yutong Li Weiman Jiang Dawei Yuan Huigang Wei Guiyun Liang Feilu Wang Gang Zhao Jiayong Zhong Bo Han Neng Hua Baoqiang Zhu Jianqiang Zhu Chen Wang Zhiheng Fang Jie Zhang | 2018 | High Power Laser Science and Engineering2018，6，3： | 2 |
| 11 | Comparison and analysis of energy consumption of energy-efficient office buildings in different climate regions in China: case studies显示文摘这份报纸的目的是分析精力消费(EC ) 并且在中国在不同气候地区的典型城市里根据特定的案例研究发现精力有效的办公大楼盒子的决定因素。调查大楼案例位于三个建筑学 thermotechnical 设计地区(冷地区,热夏天和冷冬季地区,热夏天和温暖的冬季地区) 的四个城市(北京, Ningbo,南京和深圳) 。分析显示这四个案例的精力消费索引(ECI ) 从 41.06 ~ 74.23 kW 吗?? | Ke ZHANG Neng ZHU | 2013 | Frontiers in Energy2013，7，3： | 2 |
| 12 | Target alignment in the Shen-Guang Ⅱ Upgrade laser facility显示文摘The Shen-Guang II Upgrade(SG-Ⅱ-U) laser facility consists of eight high-power nanosecond laser beams and one shortpulse picosecond petawatt laser. It is designed for the study of inertial confinement fusion(ICF), especially for conducting fast ignition(FI) research in China and other basic science experiments. To perform FI successfully with hohlraum targets containing a golden cone, the long-pulse beam and cylindrical hohlraum as well as the short-pulse beam and cone target alignment must satisfy tight specifications(30 and 20 μm rms for each case). To explore new ICF ignition targets with six laser entrance holes(LEHs), a rotation sensor was adapted to meet the requirements of a three-dimensional target and correct beam alignment. In this paper, the strategy for aligning the nanosecond beam based on target alignment sensor(TAS) is introduced and improved to meet requirements of the picosecond lasers and the new six LEHs hohlraum targets in the SG-II-U facility. The expected performance of the alignment system is presented, and the alignment error is also discussed. | Lei Ren Ping Shao Dongfeng Zhao Yang Zhou Zhijian Cai Neng Hua Zhaoyang Jiao Lan Xia Zhanfeng Qiao Rong Wu Lailin Ji Dong Liu Lingjie Ju Wei Pan Qiang Li Qiang Ye Mingying Sun Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，1： | 2 |
| 13 | Ulinastatin reduces urinary sepsis?related inflammation by upregulatingIL?10 and downregulating TNF?α levels显示文摘 | Xian Chen Yi Wang Hongmei Luo Zhigang Luo Lisha Liu Wujun Xu Tao Zhang Ning Yang Xiangyang Long Neng Zhu Huang Xie Jun Liu | 2013 | Molecular Medicine Reports2013，，1： | 2 |
| 14 | An abrupt change in the intensity of the East Asian summer monsoon index and its relationship with temperature and precipitation over East China显示文摘 | Shi Neng Zhu Qiangen | 1996 | International Journal of Climatology1996，16，1： | 1 |
| 15 | Preliminary study on aerosol particle addition calibration method for on-line quantitative analysis of airborne radioactive particles with ICP-MS显示文摘 | Yong Yang Su Zhi Ming Li Hong Bo Dong Guo Qing Zhou Li Hua Zhai Jiang Xu Neng Bin Huang Shi Zeng Feng Rong Zhu | 2011 | International Journal of Environmental Analytical Chemistry2011，，5： | 1 |
| 16 | Eutectic mixtures of capric acid and laurie acid applied in building wallboards for heat energy stor- age显示文摘 | Lv Shilei Zhu Neng Feng Guohui | 2006 | Energy and Buildings2006，38，： | 1 |
| 17 | Studies on nylon 6/clay nanocomposites by melt-intercalation process显示文摘 | LIU Li Ming QI Zong Neng ZHU Xiao Guang | 1999 | J Appl Polym Sci1999，71，7： | 1 |
| 18 | Variations and transmission of QTL alleles for yield and fiber qualities in upland cotton cultivars developed in China显示文摘 | Zhang Tianzhen Qian Neng Zhu Xiefei | 2013 | PLoS One2013，8，57： | 1 |
| 19 | Technology Dine and case analysis of heat metering and energy efficiency retrofit of existing residential buildings in northern heating areas of China 显示文摘 | Zhao Jing Zhu Neng Wo Yong | 2009 | Energy Policy2009，37，6： | 1 |
| 20 | Eutectic Mixtures of Capric Acid and Laurie Acid Applied in Building Wallboards for Heat Energy Storage 显示文摘 | LV Shi-lei ZHU Neng FENG Guo-hui | 2006 | Energy and Buildings2006，38，： | 1 |
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