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| 1 | Epstein-Barr病毒相关疾病的IgG/Z抗体检测显示文摘血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7%和84%。50%的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z抗原与EBV复制相关,故IgG/Z抗体对鼻咽癌不仅有诊断意义,还可能有预后的意义。 | 曾毅 Jean-claude Nicolas Guy Schwaab Guy de The Bernard Clausse Thomas Tursz Irene Joab | 1992 | 病毒学报1992，8，3： | 11 |
| 2 | Comparing outcomes for endoscopic submucosal dissection between Eastern and Western countries:A systematic review and meta-analysis显示文摘AIM To compare endoscopic submucosal dissection(ESD) outcomes between Eastern and Western countries.METHODS A systematic review and meta-analysis was performed using Pub Med,MEDLINE,Web of Science,CINAHL and EBM reviews to identify studies published between 1990 and February 2016. The primary outcome was the efficacy of ESD based on information about either curative resection,en bloc or R0 resection rates. Secondary outcomes were complication rates,local recurrence rates and procedure times. RESULTS Overall,238 publications including 84318 patients and 89512 gastrointestinal lesions resected using ESD were identified. 90% of the identified studies reporting ESDon 87296 lesions were conducted in Eastern countries and 10% of the identified studies reporting ESD outcomes in 2216 lesions were from Western countries. Meta-analyses showed higher pooled percentage of curative,en bloc,and R0 resection in the Eastern studies; 82%(CI: 81%-84%),95%(CI: 94%-96%) and 89%(CI: 88%-91%) compared to Western studies; 71%(CI: 61%-81%),85%(CI: 81%-89%) and 74%(CI: 67%-81%) respectively. The percentage of perforation requiring surgery was significantly greater in the Western countries(0.53%; CI: 0.10-1.16) compared to Eastern countries(0.01%; CI: 0%-0.05%). ESD procedure times were longer in Western countries(110 min vs 77 min).CONCLUSION Eastern countries show better ESD outcomes compared to Western countries. Availability of local ESD expertise and regional outcomes should be considered for decision making to treat gastrointestinal lesions with ESD. | Dane Christina Daoud Nicolas Suter Madeleine Durand Mickael Bouin Bernard Faulques Daniel von Renteln | 2018 | World Journal of Gastroenterology2018，24，23： | 8 |
| 3 | Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis显示文摘 | Bernard Uzzan Régis Cohen Patrick Nicolas Michel Cucherat Gérard-Yves Perret | 2006 | Critical Care Medicine2006，，7： | 2 |
| 4 | Fluoride removal from brackish water by electrodialysis显示文摘 | Zakia Amor Bernard Bariou Nabil Mameri Mohamed Taky Stephan Nicolas Azzedine Elmidaoui | 2001 | Desalination2001，，3： | 2 |
| 5 | 基于混合有限元解析法的永磁同步电机永磁体电涡流损耗估计显示文摘永磁同步电机永磁体受限于热约束,无法在温度较高的环境下运行,故需减少永磁体上的电涡流损耗,从而降低永磁体上的温度。针对使用有限元法对永磁体电涡流损耗估算时间较长,以及使用解析法估算时难以达到与有限元法相同的精度,采用混合有限元解析法估算永磁体上的电涡流损耗。结合电涡流的反作用,在模拟电机旋转时,无需重复划分三角形区域;使用MATLAB软件仿真模拟,将混合有限元解析法与Galerkin有限元法对比,减少三角形区域划分的个数。由此验证了永磁体上电涡流损耗符合端部效应以及集肤效应的特征,在保证精度的同时,减少了仿真的时间。 | 冯页帆 王天真 谢卫 Huu Kien BUI Nicolas BERNARD | 2019 | 电机与控制应用2019，46，5： | 2 |
| 6 | Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial显示文摘 | Bernard Escudier Anna Pluzanska Piotr Koralewski Alain Ravaud Sergio Bracarda Cezary Szczylik Christine Chevreau Marek Filipek Bohuslav Melichar Emilio Bajetta Vera Gorbunova Jacques-Olivier Bay Istvan Bodrogi Agnieszka Jagiello-Gruszfeld Nicola Moore | 2007 | The Lancet . 2007 (9605)2007，，： | 2 |
| 7 | Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa显示文摘Autophagy is invoIved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged organelles.Cryptorchidism is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in ejaculates.The aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid patients.Semen samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron microscopy.Autophagy protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm cells.LC3 was also detected in the midpiece of cryptorchid sperm tail.Autophagy substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid ones.Transmission electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid samples.Partly degraded mitochondria were frequently discerned in autophagic vacuoles.In conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to control.Our work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological conditions.Thus,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men. | Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 8 | Spleen-preserving Distal Pancreatectomy with Excision of Splenic Artery and Vein: A Case-matched Comparison with Conventional Distal Pancreatectomy with Splenectomy显示文摘 | Nicolas Carrère MD Skander Abid MD Charles Henri Julio MD Eric Bloom MD Bernard Pradère MD | 2007 | World Journal of Surgery2007，，2： | 2 |
| 9 | Coracoid graft osteolysis after the Latarjet procedure for anteroinferior shoulder instability: a computed tomography scan study of twenty-six patients显示文摘 | Giovanni Di Giacomo Alberto Costantini Nicola de Gasperis Andrea De Vita Bernard K.H. Lin Marco Francone Mario A. Rojas Beccaglia Marco Mastantuono | 2011 | Journal of Shoulder and Elbow Surgery2011，，6： | 1 |
| 10 | Multiple Organ Dysfunction Score: A reliable descriptor of a complex clinical outcome显示文摘 | John C. Marshall Deborah J. Cook Nicolas V. Christou Gordon R. Bernard Charles L. Sprung William J. Sibbald | 1995 | Critical Care Medicine1995，，10： | 1 |
| 11 | Molecular adaptation in plant hemoglobin,a duplicated gene involved in plant bacteria symbiosis 显示文摘 | Emilie G Bernard G Nicolas G | 2004 | Journal of Molecular Evolution2004，59，： | 1 |
| 12 | Lack of progressive arteriopathy and stroke recurrence among children with cryptogenic stroke显示文摘 | Stephane Darteyre Stephane Chabrier Emilie Presles Alain Bonafé Agathe Roubertie Bernard Echenne Nicolas Leboucq Francois Rivier | 2012 | Neurology2012，，24： | 1 |
| 13 | External validation of the RENAL nephrometry score in renal tumours treated by partial nephrectomy显示文摘 | Jean‐Alexandre Long Valentin Arnoux Gaelle Fiard Riccardo Autorino Jean‐Luc Descotes Jean‐Jacques Rambeaud Bernard Boillot Nicolas Terrier Alexis Arvin‐Berod Alexandre Moreau‐Gaudry | 2012 | BJU Int2012，，： | 1 |
| 14 | Spleen-preserving Distal Pancreatectomy with Excision of Splenic Artery and Vein: A Case-matched Comparison with Conventional Distal Pancreatectomy with Splenectomy显示文摘 | Nicolas Carrère MD Skander Abid MD Charles Henri Julio MD Eric Bloom MD Bernard Pradère MD | 2007 | World Journal of Surgery2007，，2： | 1 |
| 15 | Characterization of an Antigen That Is Recognized on a Melanoma Showing Partial HLA Loss by CTL Expressing an NK Inhibitory Receptor显示文摘 | Hideyuki Ikeda Bernard Lethé Frédéric Lehmann Nicolas Van Baren Jean-Fran?ois Baurain Charles De Smet Hervé Chambost Massimo Vitale Alessandro Moretta Thierry Boon Pierre G Coulie | 1997 | Immunity1997，，2： | 1 |
| 16 | X-ray microtomography:application to microstructure analysis of a cementitious material during leaching process显示文摘 | Dominique Bernard Chen Da | 2006 | Cement and Concrete Research2006，36，2： | 1 |
| 17 | Aortic valve repair by cusp extension with the use of fresh autologous pericardium in children with rheumatic aortic insufficiency显示文摘 | Afksendiyos Kalangos Maurice Beghetti Ary Baldovinos Dominique Vala Thierry Bichel Bernadette Mermillod Nicolas Murith Ingrid Oberhansli Beat Friedli Bernard Faidutti | 1999 | The Journal of Thoracic and Cardiovascular Surgery1999，，2： | 1 |
| 18 | Multiple Organ Dysfunction Score: A reliable descriptor of a complex clinical outcome显示文摘 | John C. Marshall Deborah J. Cook Nicolas V. Christou Gordon R. Bernard Charles L. Sprung William J. Sibbald | 1995 | Critical Care Medicine1995，，10： | 1 |
| 19 | Endoluminal surgical triangulation: overcoming challenges of colonic endoscopic submucosal dissections using a novel flexible endoscopic surgical platform: feasibility study in a porcine model显示文摘 | Michele Diana Hyunsoo Chung Keng-Hao Liu Bernard Dallemagne Nicolas Demartines Didier Mutter Jacques Marescaux | 2013 | Surgical Endoscopy2013，，11： | 1 |
| 20 | Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial显示文摘 | Bernard Escudier Anna Pluzanska Piotr Koralewski Alain Ravaud Sergio Bracarda Cezary Szczylik Christine Chevreau Marek Filipek Bohuslav Melichar Emilio Bajetta Vera Gorbunova Jacques-Olivier Bay Istvan Bodrogi Agnieszka Jagiello-Gruszfeld Nicola Moore | 2007 | The Lancet2007，，9605： | 1 |
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