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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function显示文摘 | Belloni L Pollicino T De Nicola F Guerrieri F Raffa G Fanciulli M | | Proceedings of the National Academy of Sciences(USA)0，，： | 1 |
| 3 | Effect of turgor on micromechanical and structural properties of apple tissue: A quantitative analysis显示文摘 | OEY M L VANSTREELS E DE BAERDEMAEKER J RAMON H HERTOG M L A T M NICOLA B | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 4 | Nuclear HBx binds the HBV mini chromosome and modifies the epigenetic regulation of cccDNA function显示文摘 | Belloni L Pollici no T De Nicola F | 2009 | Proc Natl Acad Sci USA2009，106，19： | 1 |
| 5 | Nuclear HBx binds the HBV minichromosome and modifies the epi- genetic regulation of cccDNA function 显示文摘 | BELLONI L POLLICINO T de NICOLA F | 2009 | Proc Natl Acad Sci U S A2009，，19： | 1 |
| 6 | Oncogene-in- duced Nrf2 transcription promotes ROS detoxification and tumori- genesis显示文摘 | De Nicola G M Karreth F A Humpton T J | 2011 | Nature2011，475，7354： | 1 |
| 7 | The remaining service time upon reaching a high level in M/G/1 queues显示文摘 | de Boer P T Nicola V F van Ommeren J C W | 2001 | Queueing Systems2001，39，： | 1 |
| 8 | Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function显示文摘 | Belloni L Pollicino T De Nicola F | 2009 | Proc Natl Acad Sci USA2009，106，19： | 1 |
| 9 | Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function显示文摘 | Belloni L Pollicino T de Nicola F | 2009 | Proc Natl Acad Sci U S A2009，106，19： | 1 |
| 10 | Che - 1 phosphoryla-tion by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint显示文摘 | BRUNO T DE NICOLA F IEZZI S | 2006 | Cancer Cell2006，10，6： | 1 |
| 11 | Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and G2/M checkpoint 显示文摘 | Bruno T De Nicola F | 2006 | Cancer Cell2006，12，10： | 1 |
| 12 | Arachidonylethanolamide Induces Apoptosis of Human Glioma Cells through Vanilloid Receptor-1显示文摘 | Emmanuel C Rick W Mirna T Belkouch MC Valérie S Nicolas de T | 2004 | J Neuropathol Exp Neurol2004，63，： | 1 |
| 13 | Che - 1 ar- rests huroan colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter 显示文摘 | DI PADOVA M BRUNO T DE NICOLA F | 2003 | J Biol Chem2003，278，36： | 1 |
| 14 | Defective recovery of QT dispersion following transcatheter aortic valve implantation: frequency, predictors and prognosis显示文摘BackgroundCorrected QT 分散(cQTD ) 与不一致的室的 repolarisation 被相关并且增加了死亡。在有大动脉的狭窄的病人, cQTD 被显示出在大动脉的阀门培植(TAVI ) 是的 transcatheter 的外科的阀门代替,而是效果以后改善了未知。因此,在 222 个病人全部的 TAVI.MethodsA 与在 2005 年 11 月和 2012 年 1 月之间的 Medtronic-CoreValve 系统经历了 TAVI 以后,我们寻求了在 6 个月探索频率,预言者和有缺点的 cQTD 恢复的预示的效果。或谁在一级或 III antiarrhythmics 上或在长期的血液透析上的病人发达 atrial 纤维性颤动,新捆分支块或在 TAVI 被排除以后,成为了依赖的心律调整器。作为结果, pre- , up 以后和后续 ECG (中部:6 个月) 分析在 45 个合格病人是可得到的。有缺点的 cQTD 恢复在 6 months.ResultsIn 在基线 cQTD 以外被定义为任何前进 45 个病人,吝啬的 cQTD 是 47 ±在基线的 23 ms, 45 ±17 ms 立即在 TAVI 和 40 ± 以后;在 6 个月的 16 ms (15% 减小, P = 0.049 ) 。比作基线,而有缺点的 cQTD 恢复在 40% 是在场的,在 6 个月的 cQTD 在 60% 病人被改进。cQTD 增加立即在 TAVI 以后是在 6 个月的有缺点的 cQTD 恢复的一个独立预言者(每 10 ms 增加;或:1.89, 95% CI:1.15-3.12 ) 。由 univariable 分析,有缺点的 cQTD 恢复与迟了的死亡被联系(HR:1.52, 95% CI:1.05-2.17 ).ConclusionsDespite 在 TAVI 以后的 cQTD 的渐渐的减小, 40% 病人在与迟了的死亡被联系的 6 个月有有缺点的恢复。在 TAVI 以后的更多的详细 ECG 分析可以帮助避免迟了的死亡。 | Rutger-Jan Nuis Gokhan Turgut Robert M van der Boon Nicolas M van Mieghem Sjoerd T Nauta Patrick W Serruys Ron T van Domburg Giulio Zuchelli Luc Jordaens Peter P de Jaegere | 2015 | Journal of Geriatric Cardiology2015，12，5： | 1 |
| 15 | Inflammatory effects of peritoneal dialysis:evidence of systemic monocyte activation显示文摘 | Libetta C De Nicola L Rampino T | | 0，，： | 1 |
| 16 | Nuclear HBx binds the HBV minichromosome and modifies the epigenetie regulation of cceDNA function显示文摘 | Belloni L Pollicino T De Nicola F | 2009 | Proc Natl Acad Sci U S A2009，106，19： | 1 |
| 17 | The remaining service time upon reaching a high level in M/G/1 queues显示文摘 | de Boer P T Nicola V F van Ommeren J C M | | 0，，： | 1 |
| 18 | Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function显示文摘 | Belloni L Pollicino T De Nicola F Guerrieri F Raffa G Fanciulli M Raimondo G Levrero M | 2009 | PNAS2009，106，19： | 1 |
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