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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 3 | Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels显示文摘 | Franz K Ralphiel SP Norbert R | 2004 | Brain Research2004，1021，5： | 1 |
| 4 | What makes a fragrance substantive? 显示文摘 | PETER M M NORBERT N J FRANZ E | 1993 | Perfumer& Havorist1993，18，4： | 1 |
| 5 | In- fluence of Coatings and Surface Improvements on the Li- fetime of Gears 显示文摘 | Franz Joachim Norbert Kurz Bernhard Glatthaar | 2004 | Gear Technology2004，，78： | 1 |
| 6 | Familial Chilblain Lupus, a Monogenic Form of Cutaneous Lupus Erythematosus, Maps to Chromosome 3p显示文摘 | Min Ae Lee-Kirsch Maolian Gong Herbert Schulz Franz Rüschendorf Annette Stein Christiane Pfeiffer Annalisa Ballarini Manfred Gahr Norbert Hubner Maja Linné | 2006 | The American Journal of Human Genetics2006，，： | 1 |
| 7 | PTHR1 Loss-of-Function Mutations in Familial, Nonsyndromic Primary Failure of Tooth Eruption显示文摘 | Eva Decker Angelika Stellzig-Eisenhauer Britta S. Fiebig Christiane Rau Wolfram Kress Kathrin Saar Franz Rüschendorf Norbert Hubner Tiemo Grimm Bernhard H.F. Weber | 2008 | The American Journal of Human Genetics2008，，6： | 1 |
| 8 | Class II major histocompatibility complex molecules of murine dendritic cells: Synthesis, sialylation of invariant chain and antigen processing capacity are down-regulated upon culture 显示文摘 | Eekhart K Norbert K Franz K | 1991 | Proc Nati Acad Sci Immunology USA1991，88，： | 1 |
| 9 | Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning显示文摘 | Horst Thiermann Dirk Steinritz Franz Worek Maria Radtke Peter Eyer Florian Eyer Norbert Felgenhauer Thomas Zilker | 2011 | Toxicology Letters2011，，1： | 1 |
| 10 | 镀层和表面改进对齿轮寿命的影响显示文摘表面镀层或精加工过程是改善硬齿面齿轮承载能力的未来技术。通过基础试验,测试了不同镀层和精加工过程对抗磨损性能、耐磨损性、微点蚀、点蚀倾向和效率的影响。而且还获得了各种不同变速器镀层齿轮的使用报告。总体而言,变速器镀层齿轮可看作是一种改善薄弱环节的'修补方法'。该项技术的进一步应用主要取决于其可接受程度或/和成本效益关系及试验要素、设计数据等。 | Franz Joachim Norbert Kurz Bernhard Glathaar | 2007 | 传动技术2007，21，3： | 1 |
| 11 | Proteases of psychrotrophic bacteria isolated from glaciers显示文摘 | Rosa Margesin Norbert Paima Franz Knauseder | 1991 | Journal of Basic Microbiology1991，31，5： | 1 |
| 12 | Analysis of tissues specific gene dilevery by recombinant adenoviruses containing cardiac-specific promoters显示文摘 | Thomas Rothmann Norbert Frey | 1997 | Cardiovas Res1997，35，3： | 1 |
| 13 | Influence of coatings and surface improvements on the lifetime of gears显示文摘 | FRANZ J NORBERT K BERNHARD G | 2004 | Gear technology2004，，4： | 1 |
| 14 | In situ grazing-incidence small-angle X-ray scattering observation of block-copolymer templated formation of magnetic nanodot arrays and their magnetic properties显示文摘bit-patterned 媒介(BPM ) 的制造为硬盘驱动器的新类型是关键的。为 BPM 的生产的方法的发展很快正在进行。常规平版印刷术活动范围关于侧面的分辨率的限制,和新线路被需要。在这研究,我们主要在蚀刻持续时间的 Ar +-ion 上集中于尺寸的依赖和磁性的 nanodots 的形状,用象面具的硅石点。二维(2D ) 磁性的 nanostructures 的数组作为模板用充满硅石的 diblock 共聚物微粒被创造。在以后进 2D 的微粒自己组装六角形的数组,聚合物壳被移开,并且 SiO 2 核心被利用把形态学转变成一(公司 / 磅) 经由离子在正常下面蚀刻的 2-multilayer 发生。准备步的数字被使尽可能低简化 nanostructure 数组的形成。在 situ 放牧发生高分辨率散布的小角度的 X 光检查(GISAXS ) 调查在蚀刻监视并且控制制造进程的 Ar +-ion 期间被执行。在里面 situ 调查提供蚀刻的条件怎么能为进一步的前 situ 实验被改进的信息。GISAXS 模式与模拟相比。我们观察到点在形状变化从对圆柱在蚀刻的过程期间圆锥形。磁性的行为被利用磁电机眼的克尔效果学习。公司 / 磅点展出取决于他们的尺寸, interparticle 距离,和蚀刻的时间的不同磁性的行为。他们与对这部电影垂直的磁化的容易的轴显示出强磁性。coercivity 的系统的依赖准时地,尺寸被观察。 | Andreas Meyer Norbert Franz Hans Peter Oepen Jan Perlich Gerardina Carbone Till Hartmut Metzger | 2017 | Nano Research2017，10，2： | 1 |
| 15 | C-Reactive Protein, Carotid Atherosclerosis, and Cerebral Small-Vessel Disease: Results of the Austrian Stroke Prevention Study显示文摘 | Reinhold Schmidt Helena Schmidt Martin Pichler Christian Enzinger Katja Petrovic Kurt Niederkorn Susanna Horner Stefan Ropele Norbert Watzinger Martin Schumacher Andrea Berghold Gerhard M. Kostner Franz Fazekas | 2006 | Stroke2006，，12： | 1 |
| 16 | 影响铁矿石烧结矿粒度的因素显示文摘引言现在,人们习惯于用一个指数来描述成品烧结矿的粒度。在欧洲,多用HS50或HS80毫米来作指数,而在远东。 | Norbert Magedanz Franz Oeters Fred Cappel 柳鸣 | 1985 | 烧结球团1985，13，5： | 0 |
| 17 | 冻干机的最佳改造时机显示文摘对于某些工艺来说,并不一定总是需要全新的设备,尤其是冷冻干燥设备,其技术改造同样是非常有价值的。本文将介绍有关冻干设备技术改造的评估和决策指南,有助于使用者了解对设备进行技术改造的合适时间。 | Norbert Franz | 2012 | 流程工业2012，，21： | 0 |
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