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| 1 | MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer显示文摘Colorectal cancer(CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC(mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the monoclonal antibodies bevacizumab, cetuximab and panitumumab as well as the protein-trap aflibercept and the smallmolecule multi-kinase inhibitor regorafenib. One of the major problems for the management of CRC is the inherent or acquired resistance to therapeutic approaches. The discovery of microRNAs(miRNAs), a class of small, endogenous, non-coding, single-stranded RNAs that play a role as post-transcriptional regulators, has added new dimensions to the diagnosis and treatment of cancer. Because miRNAs are important regulators of carcinogenesis, progression, invasion, angiogenesis and metastases in CRC, they might serve as potential predictive and prognostic factors and even as therapeutic targets themselves. Several miRNAs are already known to be dysregulated in CRCs and have been linked to biological processes involved in tumor progression and response to anti-cancer therapies. This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients. | Verena Stiegelbauer Samantha Perakis Alexander Deutsch Hui Ling Armin Gerger Martin Pichler | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 2 | DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination显示文摘 | Weihua Qin Patricia Wolf Nan Liu Stephanie Link Martha Smets Federica La Mastra Ignasi Forne Garwin Pichler David Horl Karin Fellinger Fabio Spada Ian Marc Bonapace Axel Imhof Hartmann Harz Heinrich Leonhardt | 2015 | Cell Research2015，25，8： | 5 |
| 3 | Protecting kidneys in liver transplant patients:A pathway to preventive interventions显示文摘Acute kidney injury(AKI) is a frequent postoperative complication after liver transplantation. The etiology is multifactorial,including perioperative renal status,surgery related events,and postoperative immunosuppression therapy. The role of renal hypoperfusion and hepatic ischemia-reperfusion injury as causes of early AKI are now being increasingly recognized. Further studies should focus on therapies that would attenuate this injury. | Lena Sibulesky Scott W Biggins Raimund Pichler | 2018 | World Journal of Hepatology2018，10，9： | 2 |
| 4 | Scintillation Crystals Coupled to New Large Area APDs Compared to LSO and BGO显示文摘 | Pichler B J Rafecas M Schlosshauer M et al LGSO | 1999 | IEEE Trans Nucl Sci1999，46，3： | 1 |
| 5 | Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept显示文摘 | Pichler WJ | 2002 | Curr Opin Allergy Clin Immunol2002，2，4： | 1 |
| 6 | The risk of iatrogenic injury to the deep peroneal nerve in minimally invasive osteosynthesis of the tibia with the less invasive stabilisation system : acadaver study 显示文摘 | Pichler W Grechenig W Tesch N P | 2009 | J Bone Joint Surg Br2009，91，3： | 1 |
| 7 | Effect of noise in the probability matrix used for statistical reconstruction of PET data显示文摘 | Pichler B J Lorenz E Schwaiger M | 2004 | IEEE Transactions on Nuclear Science2004，51，1： | 1 |
| 8 | Pharmacological interaction of drugs with immune receptors:the p-i concept 显示文摘 | Pichler WJ Beeler A Keller M | 2006 | Allergol Int2006，55，1： | 1 |
| 9 | A prototype high-resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals显示文摘 | Sibylle I. Ziegler Bernd J. Pichler Guido Boening Magdalena Rafecas Wendelin Pimpl Eckart Lorenz Norbert Schmitz Markus Schwaiger | 2001 | European Journal of Nuclear Medicine and Molecular Imaging2001，，2： | 1 |
| 10 | Premature newborns with fatal intrauterine herpes simplex virus-1infection:first report of twins and review of the literature显示文摘 | Pichler M Staffler A Bonometti N | 2015 | J Eur Acad Dermatol Venereol2015，29，6： | 1 |
| 11 | The SUMO E3 ligase RanBP2 promotes modifica- tion of the HDAC4 deacetylase 显示文摘 | Kirsh O Seeler J S Pichler A Gast A Mtiller S Mis- ka E | 2002 | EMBO J2002，21，： | 1 |
| 12 | Localized and delocalized electronic states in single-wall carbon nanotubes显示文摘 | KNUPFER M el al | 1998 | Phys Rev Lett1998，80，5： | 1 |
| 13 | Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo显示文摘 | Hugo CP Pichler RP Schulze-Lohoff E | 1999 | Kidney Int1999，55，6： | 1 |
| 14 | Markers of myocardial ischemia after minimally invasive and conventional coronary operation显示文摘 | Kilger E Pichler B Veis F | 2000 | Ann Thorac Surg2000，70，6： | 1 |
| 15 | Allergen-specific T cell reactivity in cordblood:the inflkuence of maternal cytokine production显示文摘 | Kopp MV Zehle C Pichler J | 2001 | Clin Exp Allergy2001，31，： | 1 |
| 16 | Osteopontin expression in ansiotensin-induced tubulointerstitial nephritis显示文摘 | Giachelli CM Pichler R Lombardi D | 1994 | Kidney Int1994，45，2： | 1 |
| 17 | Direct T-cell stimulations by drugs--bypassing the innate immune system显示文摘 | Pichler WJ | 2005 | Toxicology2005，209，2： | 1 |
| 18 | The Doping of Carbon Nanotubes with Nitrogen and Their Potential Applications 显示文摘 | Ayala P &renal R Ruemmeli M Rubio A Pichler T | 2010 | Carbon2010，48，3： | 1 |
| 19 | Quality-aware service-oriented data inte- gration: requirements,state of the art and open challenges 显示文摘 | DUSTDAR S PICHLER R | 2012 | ACM $1GMOD Record2012，41，1： | 1 |
| 20 | A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients显示文摘 | Absenger G Szkandera J Pichler M | 2013 | Br J Cancer2013，109，2： | 1 |
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