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| 1 | Change in arterial tumor perfusion is an early biomarker of lenvatinib efficacy in patients with unresectable hepatocellular carcinoma显示文摘BACKGROUND Lenvatinib is one of the first-line tyrosine kinase inhibitors used for unresectable hepatocellular carcinoma(HCC). In the present study, we evaluated the potential of early changes in the time-intensity curve(TIC) of arterial phase on contrastenhanced ultrasound(CEUS) as early imaging biomarkers of lenvatinib efficacy.AIM To evaluate the potential of the early changes in the TIC of CEUS as early imaging biomarkers of lenvatinib efficacy in patients with unresectable HCC.METHODS We analyzed 20 consecutive patients with unresectable HCC treated with lenvatinib from March to November 2018. Tumor response at 8 wk was assessed by computed tomography using the modified Response Evaluation Criteria in Solid Tumors(m RECIST). CEUS was performed at baseline before treatment(Day 0) and on day 7(Day 7), and the images were analyzed in the arterial phase for 20 seconds after the contrast agent arrived at the target tumor. Three perfusion parameters were extracted from the TICs: the slope of wash-in(Slope),time to peak(TTP) intensity, and the total area under the curve(AUC) during wash-in. The rate of change in the TIC parameters between Day 0 and Day 7 was compared between treatment responders and non-responders based on m RECIST.RESULTS The rate of change for all TIC parameters showed significant differences between the responders(n = 9) and non-responders(n = 11)(Slope, P = 0.025; TTP, P =0.004; and AUC, P = 0.0003). The area under the receiver operating curve values for slope, TTP, and AUC for the prediction of responders were 0.805, 0.869, and0.939, respectively.CONCLUSION CEUS may be useful for the early prediction of tumor response to lenvatinib therapy in patients with unresectable HCC. | Hidekatsu Kuorda Tamami Abe Yudai Fujiwara Takuya Okamoto Miki Yonezawa Hiroki Sato Kei Endo Takayoshi Oikawa Kei Sawara Yasuhiro Takikawa | 2019 | World Journal of Gastroenterology2019，25，19： | 8 |
| 2 | A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria*显示文摘 | Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Hiroshi Ogura Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2006 | Critical Care Medicine2006，，3： | 2 |
| 3 | High-power recessed-gate AlGaN-GaN HFET with a field-modulating plate显示文摘 | Yasuhiro Okamoto Yuji Ando Tatsuo Nakayama | 2004 | IEEE Transactions on Electron Devices2004，51，12： | 1 |
| 4 | Improved power performance for a recessed-gate AlGaN-GaN heterojunction FET with a field-modulating plate显示文摘 | Yasuhiro Okamoto Yuji Ando Koji Hataya | 2004 | IEEE Transactions on Microwave Theory and Techniques2004，52，11： | 1 |
| 5 | A male patient with severe acute hepatitis who was domestically infected with a genotype H hepatitis B virus in Iwate, Japan显示文摘 | Ichiro Kumagai Koichi Abe Takayoshi Oikawa Akihiro Sato Shinichiro Sato Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki Tomoyuki Masuda Shigehiko Sainokami Kazunori Endo Masaharu Takahashi Hiroaki Okamoto | 2007 | Journal of Gastroenterology2007，，2： | 1 |
| 6 | Antitumor Activity of Lenvatinib (E7080): An Angiogenesis Inhibitor That Targets Multiple Receptor Tyrosine Kinases in Preclinical Human Thyroid Cancer Models显示文摘 | Osamu Tohyama Junji Matsui Kotaro Kodama Naoko Hata-Sugi Takayuki Kimura Kiyoshi Okamoto Yukinori Minoshima Masao Iwata Yasuhiro Funahashi Giovanni Tallini | 2014 | Journal of Thyroid Research2014，，： | 1 |
| 7 | Intracystic hemorrhage of a simple liver cyst mimicking a biliary cystadenocarcinoma显示文摘 | Yasuhiro Kitajima Yasutaka Okayama Masaaki Hirai Kazuki Hayashi Hideto Imai Tetsu Okamoto Shigeru Aoki Shinji Akita Kazuo Gotoh Hirotaka Ohara Tomoyuki Nomura Takashi Joh Yoshifumi Yokoyama Makoto Itoh | 2003 | Journal of Gastroenterology2003，，2： | 1 |
| 8 | SIRS-ASSOCIATED COAGULOPATHY AND ORGAN DYSFUNCTION IN CRITICALLY ILL PATIENTS WITH THROMBOCYTOPENIA显示文摘 | Hiroshi Ogura Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2007 | Shock2007，，4： | 1 |
| 9 | Development of shape measurement system for hot large forgings 显示文摘 | Akira Okamoto Yasuhiro Wasa Kagawa Y | 2007 | Kobe Steel Engineering Reports2007，57，3： | 1 |
| 10 | Three DOF parallel link mechanism utilizing smooth impact drive mechanism显示文摘 | MORITA Takeshi YOSHIDA Ryuichi OKAMOTO Yasuhiro | 2002 | Journal of the International Societies for Precision Engineering and Nanotechnology2002，26，3： | 1 |
| 11 | Hemodynamic Effects of Combined Therapy Using Partial Splenic Embolization and Transjugular Retrograde Obliteration for Gastric Varices with Gastrorenal Shunt显示文摘 | Fumio Chikamori Atsushi Inoue Hiroshi Okamoto Nobutoshi Kuniyoshi Takahiko Kawashima Yasuhiro Takase | 2010 | World Journal of Surgery2010，，5： | 1 |
| 12 | Abnormalities of cerebral blood flow in multiple sclerosis: A pseudocontinuous arterial spin labeling MRI study显示文摘 | Miho Ota Noriko Sato Yasuhiro Nakata Kimiteru Ito Kouhei Kamiya Norihide Maikusa Masafumi Ogawa Tomoko Okamoto Satoko Obu Takamasa Noda Manabu Araki Takashi Yamamura Hiroshi Kunugi | 2013 | Magnetic Resonance Imaging2013，，6： | 1 |
| 13 | Three DOF parallel link mechanism utilizing smooth impact drive mechanism显示文摘 | MORITA Takeshi YOSHIDA Ryuichi OKAMOTO Yasuhiro | 2002 | Journal of the International Societies for Precision Engineering and Nanotechnology2002，26，3： | 1 |
| 14 | Muscle stiffness sensor to control an assistance device for the disabled显示文摘 | Shunji Moromugi Yasuhiro Koujina Seigo Ariki Akira Okamoto Takayuki Tanaka Maria Q. Feng Takakazu Ishimatsu | 2004 | Artificial Life and Robotics2004，，1： | 1 |
| 15 | Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A显示文摘 | Shigehiko Sainokami Koichi Abe Ichiro Kumagai Akio Miyasaka Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki Hitoshi Mizuo Yoshiki Sugai Yoshihiro Akahane Yoichi Koizumi Yoshiaki Yajima Hiroaki Okamoto | 2004 | Journal of Gastroenterology2004，，7： | 1 |
| 16 | The elimination of the ‘artifact’ in the electrostatic force measurement using a novel noncontact atomic force microscope/electrostatic force microscope显示文摘 | Kenji Okamoto Yasuhiro Sugawara Seizo Morita | 2002 | Applied Surface Science2002，，3： | 1 |
| 17 | Fabri- cation of micro-structure on glass surface using micro-in- dentation and wet etching process显示文摘 | Yasuhiro Saito Shinya Okamoto Atsushi Miki | 2008 | Applied Surface Sci- ence2008，，254： | 1 |
| 18 | Development of Shape Measurement System for Hot Large Forgings 显示文摘 | Akira OKAMOTO Yasuhiro WASA Yasunori KAGAWA | 2007 | Kobe Steel Engineering Reports2007，57，3： | 1 |
| 19 | Variation in fumarolic H,gas and volcanic activity at Nasudake in Japan显示文摘 | YASUHIRO KIYOSU YASUNORI OKAMOTO | 1998 | Journal of Volcanology and Geothermal Research1998，80，： | 1 |
| 20 | Three DOF parallel link mechanism utilizing smooth impact drive mechanism显示文摘 | TAKESHI Morita RYUICHI Yoshida YASUHIRO Okamoto | 2002 | Journal of the International Societies for Precision Engineering and Nanotechnolagy2002，26，3： | 1 |
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