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| 1 | High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis显示文摘BACKGROUND The quantitative faecal immunochemical test for haemoglobin(FIT) has been revealed to be highly accurate for colorectal cancer(CRC) detection not only in a screening setting, but also in the assessment of patients presenting lower bowel symptoms. Therefore, the National Institute for Health and Care Excellence has recommended the adoption of FIT in primary care to guide referral for suspected CRC in low-risk symptomatic patients using a 10 μg Hb/g faeces threshold.Nevertheless, it is unknown whether FIT′s accuracy remains stable throughout the broad spectrum of possible symptoms.AIM To perform a systematic review and meta-analysis to assess FIT accuracy for CRC detection in different clinical settings.METHODS A systematic literature search was performed using MEDLINE and EMBASE databases from inception to May 2018 to conduct a meta-analysis of prospective studies including symptomatic patients that evaluated the diagnostic accuracy of quantitative FIT for CRC detection. Studies were classified on the basis of brand,threshold of faecal haemoglobin concentration for a positive test result,percentage of reported symptoms(solely symptomatic, mixed cohorts) and CRC prevalence(< 2.5%, ≥ 2.5%) to limit heterogeneity and perform subgroup analysis to assess the influence of clinical spectrum on FIT′s accuracy to detect CRC.RESULTS Fifteen cohorts including 13073 patients(CRC prevalence 0.4% to 16.8%) were identified. Pooled estimates of sensitivity for studies using OC-Sensor at 10 μg Hb/g faeces threshold(n = 10400) was 89.6% [95% confidence interval(CI): 82.7%to 94.0%). However, pooled estimates of sensitivity for studies formed solely by symptomatic patients(n = 4035) and mixed cohorts(n = 6365) were 94.1%(95%CI: 90.0% to 96.6%) and 85.5%(95%CI: 76.5% to 91.4%) respectively(P <0.01), while there were no statistically significant differences between pooled sensitivity of studies with CRC prevalence < 2.5%(84.9%, 95%CI: 73.4% to 92.0%)and ≥ 2.5%(91.7%, 95%CI: 83.3% to 96.1%)(P = 0.25). At the same threshold, OCSensor? sensitivity to rule out any significant colonic lesion was 78.6%(95%CI:75.6% to 81.4%). We found substantial heterogeneity especially when assessing specificity.CONCLUSION The results of this meta-analysis confirm that, regardless of CRC prevalence,quantitative FIT is highly sensitive for CRC detection. However, FIT ability to rule out CRC is higher in studies solely including symptomatic patients. | Noel Pin Vieito Sara Zarraqui?os Joaquín Cubiella | 2019 | World Journal of Gastroenterology2019，25，19： | 5 |
| 2 | Determination of drug,excipients and coating distribution in pharmaceutical tablets using NIR-CI显示文摘The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained.In addition,the same NIR-CI allowed the coating thickness and its surface distribution to be quantified.Images were processed to extract the target data and calibration models constructed using the Partial Least Squares (PLS) algorithms.The concentrations of Active Pharmaceutical Ingredient (API) and excipients obtained for uncoated cores were essentially identical to the nominal values of the pharmaceutical formulation.But the predictive ability of the calibration models applied to the coated tablets decreased as the coating thickness increased. | Anna Palou Jordi Cruz Marcelo Blanco Jaume Tomàs Joaquín de los Ríos Manel Alcalà | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 4 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Use of wild trout for PBDE assessment in freshwater environments: Review and summary of critical factors显示文摘Certain wild animals represent sentinels to address issues related to environmental pollution,since they can provide integrative data on both pollutant exposure and biological effects.Despite their technological benefits,PBDEs are considered a threat to environmental health due to their persistence,toxicity,and capacity to be accumulated.These pollutants have been found geographically widespread in fish,particularly in predator species such as trout.The aim of this work is to critically review the applicability and usefulness of wild trout for assessing PBDEs in freshwater environments.Reviewed reports include data from highly industrialized areas as well as areas from remote regions with relatively low human activity,including European and North American great lakes and freshwater environments in Europe,Greenland,subarctic areas and Patagonia,respectively.A summary of relevant factors were grouped into organism-specific factors(food habits,age,size,lipid content,sex and reproduction,tissue type,mechanism of contaminant uptake and metabolism),and PBDE levels in the surrounding environment(sediment).Five wild trout species[rainbow trout(Oncorhynchus mykiss),brown trout(Salmo trutta),lake trout(Salvelinus namaycush),arctic char(Salvelinus alpinus),and brook trout(Salvelinus fontinalis)],collected worldwide within the 1994 to present time frame,were considered.Multivariate techniques(principal component analysis-PCA)and mapping approach,showed clear differences in geographic distribution patterns of PBDE levels in trout depending on the region studied:wild trout from European and North American great lakes have the highest PBDE loads.This pattern could be due to high industrial activity at these locations.A correlational approach used to explore intraspecific relationships between PBDE levels and morphometry,showed positive relationships only for brown trout.Further,brown trout showed the highest trout-to-sediment ratios,which is suggestive of a relatively greater capacity of this species to accumulate PBDEs in relation to sediment levels.Overall,results suggest that adult wild trout could be useful as a PBDE bioindicator. | Juan M.Ríos Nerina B.Lana Paula Berton Néstor F.Ciocco Jorgelina C.Altamirano | 2015 | Emerging Contaminants2015，1，1： | 2 |
| 5 | Sebaceus naevi:a clinicopathologic study显示文摘 | Mu(n)oz-Pérez MA García-Hernandez MJ Ríos JJ | 2002 | J Eur Acad Dermatol Venereol2002，16，4： | 1 |
| 6 | Spanish and Latin American nursing personnel and deceased organ donation:a study of attitude显示文摘 | A Ríos L Martínez-Alarcón MA Ayala | | 0，，01： | 1 |
| 7 | Heritability of structural brain traits an endophenotype approach to deconstruct schizophrenia显示文摘 | Kaymaz N van Os J | 2009 | Int Rev Neurobiol2009，89，： | 1 |
| 8 | Tau oligomers and aggregation in Alzheimer’s disease显示文摘 | Marco A.Meraz‐Ríos Karla I.Lira‐De León VictoriaCampos‐Pe?a Martha A.De Anda‐Hernández RaúlMena‐López | 2010 | Journal of Neurochemistry2010，，6： | 1 |
| 9 | Chromium retention properties of N -alkyl quaternized poly(4-vinylpyridine)显示文摘 | María Inés Toral Javier González-Navarrete Angel Leiva Hernán E. Ríos Marcela D. Urzúa | 2008 | European Polymer Journal2008，，3： | 1 |
| 10 | Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver isclaemia/reperfusion 显示文摘 | Leon Fema'n OS Ajamieh HH Berlanga J | 2007 | Transplant Intl2007，14，： | 1 |
| 11 | Comparisons of analgesic effects of different doses of morphine and morphine plus methyl prednisolone after knee surgery 显示文摘 | Kizil kaya M Yildirim OS Ezirmik N | 2006 | Eur J Anaesthesio2006，22，8： | 1 |
| 12 | Welsh citizens in South-Eastern Spain:a study of attitude toward organ donation显示文摘 | A Ríos L Martínez-Alarcón J Sánchez | | 0，，05： | 1 |
| 13 | F101 显示文摘 | OS D N V | 2012 | Submarine Pipeline Systems2012，，： | 1 |
| 14 | H e l i c o b a c t e r p y l o r iinfection and the development ofgastric cancer显示文摘 | U e m u r a N O k a m o t o S Y a m a m o t oS e t a l | 2001 | N Engl J Med2001，345，11： | 1 |
| 15 | Phenotypic diversity and association mapping for fruit quality traits in cultivated tomato and related species显示文摘 | Xu J X Nicolas R Mu(n)os S Rolland S Bouchet J P Desplat N Paslier M C Le Liang Y Brunel D Causse M | | 0，，3： | 1 |
| 16 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 17 | Circulating angiogenic factors and urinary prolactin as predictors of adverse outcomes in women with preeclampsia显示文摘 | Lea(n)os MA Campos GI Ramírez V KL | 2013 | Hypertension2013，61，5： | 1 |
| 18 | 2013 Ambulatory Blood Pressure Monitoring Recommendations for the Diagnosis of Adult Hypertension, Assessment of Cardiovascular and other Hypertension-associated Risk, and Attainment of Therapeutic Goals显示文摘 | Ramón C. Hermida Michael H. Smolensky Diana E. Ayala Francesco Portaluppi Juan J. Crespo Fabio Fabbian Erhard Haus Roberto Manfredini Artemio Mojón Ana Moyá Luis Pi?eiro María T. Ríos Alfonso Otero Horia Balan José R. Fernández | 2013 | Chronobiology International2013，，3： | 1 |
| 19 | Alkyl arene sulphonates:the effect of chemical structure on phyis-co2chemical properties显示文摘 | VAN OS N M KOK R BOLSMAN T A B M | 1992 | Tenside Surfactants Detergents1992，29，3： | 1 |
| 20 | Elevated vaso active intestinal peptlde concentrations inpatients with irritable bowel syndrome显示文摘 | Palsso n OS Mo rteau O Bozymski EM | 2004 | Dig Dis Sci2004，49，78： | 1 |
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