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| 1 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013，19，35： | 26 |
| 2 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 3 | Conservative management of placenta accreta and unruptured interstitial cornual pregnancy using methotrexate显示文摘 | Savita Lalchandani Michael Geary Colm O’Herlihy Orla Sheil | 2002 | European Journal of Obstetrics and Gynecology2002，，1： | 1 |
| 4 | How Scientists Commercialise New Knowledge via Entrepreneurship显示文摘 | Colm O' Gorman Orla Byrne Dipti Pandya | 2008 | Journal of Technology Transfer2008，，1： | 1 |
| 5 | A Prospective Trial of Low-Dose Abdominal Computerised Tomography (CT) With Iterative Reconstruction vs Conventional CT in Crohn’s Disease显示文摘 | Orla F. Craig Siobhan B. O’Neill Sum Leong Fiona O’Neill Owen J. O’Connor Michael M. Maher Fergus Shanahan | 2011 | Gastroenterology2011，，： | 1 |
| 6 | High prevalence of overweight and obesity in adults with Crohn’s disease: Associations with disease and lifestyle factors显示文摘 | Treasa Nic Suibhne Tara C. Raftery Orla McMahon Cathal Walsh Colm O’Morain Maria O’Sullivan | 2013 | Journal of Crohn’s and Colitis2013，，7： | 1 |
| 7 | Compari- son of two next-generation sequencing technologies for re- solving highly complex microbiota composition using tandem variable 16S rRNA gene regions显示文摘 | Marcus J Claesson Wang Q Orla O Sullivan | 2010 | Nucleic Acids Research2010，38，22： | 1 |
| 8 | A comprehensive study of metal distribution in three main classes of seaweed 显示文摘 | Siobhan R Peter M Orla O | 2012 | Environmental Pollution2012，167，： | 1 |
| 9 | Diagnostic Accuracy of Computed Tomography Using Lower Doses of Radiation for Patients With Crohn’s Disease显示文摘 | Orla Craig Siobhan O’Neill Fiona O’Neill Patrick McLaughlin AnneMarie McGarrigle Sebastian McWilliams Owen O’Connor Alan Desmond Elizabeth Kenny Walsh Max Ryan Michael Maher Fergus Shanahan | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 10 | The Effect of dietary supplementation with spent cider yeast on the swine distal gut microbiome显示文摘 | Aditya Upadrasta Lisa O' Sullivan Orla O' Sullivan | 2013 | PLOS ONE2013，8，75： | 1 |
| 11 | Identification of a novel DNA probe for strain typing Myeobaeterium bovis by restriction fragement length polymorphism analysis 显示文摘 | Brien R O Orla F Eamon C | 2000 | J Clin Microbiol2000，38，5： | 1 |
| 12 | Localization of urea transporter B in the developing bovine rumen显示文摘Urea nitrogen secreted from blood to rumen is a crucial factor shaping the symbiotic relationship between host ruminants and their microbial populations.Passage of urea across rumen epithelia is facilitated by urea transporter B(UT-B),but the long-term regulation of these proteins remains unclear.As ruminal function develops over a period of months,the developing rumen is an excellent model with which to investigate this regulation.Using rumen epithelium samples of calves from birth to 96 d of age,this study performed immunolocalization studies to localize and semi-quantify UT-B protein development.As expected,preliminary experiments confirmed that ruminal monocarboxylate transporter 1(MCT1)short chain fatty acid transporter protein abundance increased with age(P<0.01,n=4).Further investigation revealed that ruminal UT-B was present in the first few weeks of life and initially detected in the basolateral membrane of stratum basale cells.Over the next 2 months,UT-B staining spread to other epithelial layers and semi-quantification indicated that UT-B abundance significantly increased with age(P<0.01,n=4 or 6).These changes were in line with the development of rumen function after the advent of solid feed intake and weaning,exhibiting a similar pattern to both MCT1 transporters and papillae growth.This study therefore confirmed age-dependent changes of in situ ruminal UT-B protein,adding to our understanding of the long-term regulation of ruminal urea transporters. | Chongliang Zhong Tamsin Lyons Orla Heussaff Evelyn Doyle Eoin O'Hara Sinead M.Waters David Kenny Gavin S.Stewart | 2022 | Animal Nutrition2022，，3： | 1 |
| 13 | The effect of integrator leak in ∑-△ modulation 显示文摘 | Feely Orla Chua Leon O | 1991 | IEEE Transaction on Circuits and Systems1991，38，11： | 1 |
| 14 | The effect of integrator leak in Σ-A modulation显示文摘 | Orla Feely Leon O C hua | 1991 | IEEE Transaction on Circuits and Systems1991，38，11： | 1 |
| 15 | High-throughput se-quence-based analysis of the bacterial composition of kefir and an as- sociated kefir grain显示文摘 | ALLESON D ORLA O PAUL D | 2011 | FEMS Microbiology Letters2011，320，1： | 1 |
| 16 | Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin显示文摘 | Stephen Beatty John Nolan Heather Kavanagh Orla O’Donovan | 2004 | Archives of Biochemistry and Biophysics2004，，1： | 1 |
| 17 | 治疗学 控制不佳的哮喘治疗显示文摘一名35岁男性,既往诊断轻度哮喘,他告知家庭医生,在过去3个月中他间断在夜间咳醒或因气短而憋醒。他是一名厨师,现在已经感到难以完成轮班工作。长期以来,他每天吸入2次倍氯米松200μg,由于持续发作的症状,他询问是否需要改变治疗。控制不佳的哮喘或中度哮喘是指患者每天有哮喘症状。 | Orla O′Carroll Cormac McCarthy Marcus W Butler 王颖(译) 施焕中(校) | 2022 | 英国医学杂志中文版2022，25，1： | 0 |
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