|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of antibiotics for treatment of inflammatory boweldisease显示文摘Inflammatory bowel disease is thought to be caused by an aberrant immune response to gut bacteria in a genetically susceptible host. The gut microbiota plays an important role in the pathogenesis and complications of the two main inflammatory bowel diseases: Crohn's disease(CD) and ulcerative colitis. Alterations in gut microbiota, and specifically reduced intestinal microbial diversity, have been found to be associated with chronic gut inflammation in these disorders. Specific bacterial pathogens, such as virulent Escherichia coli strains, Bacteroides spp, and Mycobacterium avium subspecies paratuberculosis, have been linked to the pathogenesis of inflammatory bowel disease. Antibiotics may influence the course of these diseases by decreasing concentrations of bacteria in the gut lumen and altering the composition of intestinal microbiota. Different antibiotics, including ciprofloxacin, metronidazole, the combination of both, rifaximin, and anti-tuberculous regimens have been evaluated in clinical trials for the treatment of inflammatory bowel disease. For the treatment of active luminal CD, antibiotics may have a modest effect in decreasing disease activity and achieving remission, and are more effective in patients with disease involving the colon. Rifamixin, a non absorbable rifamycin has shown promising results. Treatment of suppurative complications of CD such as abscesses and fistulas, includes drainage and antibiotic therapy, most often ciprofloxacin, metronidazole, or a combination of both. Antibiotics might also play a role in maintenance of remission and prevention of post operative recurrence of CD. Data is more sparse for ulcerative colitis, and mostly consists of small trials evaluating ciprofloxacin, metronidazole and rifaximin. Most trials did not show a benefit for the treatment of active ulcerative colitis with antibiotics, though 2 meta-analyses concluded that antibiotic therapy is associated with a modest improvement in clinical symptoms. Antibiotics show a clinical benefit when used for the treatment of pouchitis. The downsides of antibiotic treatment, especially with recurrent or prolonged courses such as used in inflammatory bowel disease, are significant side effects that often cause intolerance to treatment, Clostridium dificile infection, and increasing antibiotic resistance. More studies are needed to define the exact role of antibiotics in inflammatory bowel diseases. | Orna Nitzan Mazen Elias Avi Peretz Walid Saliba | 2016 | World Journal of Gastroenterology2016，22，3： | 14 |
| 2 | Clostridium difficile and inflammatory bowel disease: Role in pathogenesis and implications in treatment显示文摘Clostridium difficile(C.difficile)is the leading cause of antibiotic associated colitis and nosocomial diarrhea.Patients with inflammatory bowel disease(IBD)are at increased risk of developing C.difficile infection(CDI),have worse outcomes of CDI-including higher rates of colectomy and death,and experience higher rates of recurrence.However,it is still not clear whether C.difficile is a cause of IBD or a consequence of the inflammatory state in the intestinal environment.The burden of CDI has increased dramatically over the past decade,with severe outbreaks described in many countries,which have been attributed to a new and more virulent strain.A parallel rise in the incidence of CDI has been noted in patients with IBD.IBD patients with CDI tend be younger,have less prior antibiotic exposure,and most cases of CDI in these patients represent outpatient acquired infections.The clinical presentation of CDI in these patients can be unique-including diversion colitis,enteritis and pouchitis,and typical findings on colonoscopy are often absent.Due to the high prevalence of CDI in patients hospitalized with an IBD exacerbation,and the prognostic implications of CDI in these patients,it is recommended to test all IBD patients hospitalized with a disease flare for C.difficile.Treatment includes general measures such as supportive care and infection control measures.Antibiotic therapy with either oral metronidazole,vancomycin,or the novel antibiotic-fidaxomicin,should be initiated as soon as possible.Fecal macrobiota transplantation constitutes another optional treatment for severe/recurrent CDI.The aim of this paper is to review recent data on CDI in IBD:role in pathogenesis,diagnostic methods,optional treatments,and outcomes of these patients. | Orna Nitzan Mazen Elias Bibiana Chazan Raul Raz Walid Saliba | 2013 | World Journal of Gastroenterology2013，19，43： | 12 |
| 3 | Humus-Rich Compost Increases Lettuce Growth, Nutrient Uptake, Mycorrhizal Colonisation, and Soil Fertility显示文摘Sandy soils, typical of Australia's west, either have little or no habitat protection for microbes including arbuscular mycorrhizal(AM) fungi, which are essential for nutrient cycling. To minimize this problem, the application of organic matter, such as humus-rich composts, is necessary during vegetable crop production. This study aimed at determining the effects of humus-rich composts on either indigenous or inoculated AM fungal colonisation in roots, lettuce(Lactuca sativa L. var. Quechua) growth, and soil fertility improvement. Four different humus-rich composts with varying humus contents were applied at the same standard rate to lettuce grown under glasshouse conditions for 10 weeks after sowing and compared with two low-humus composts and non-amended soil(control). Humus-rich composts significantly increased lettuce shoot growth, root growth, and AM fungal colonisation in roots. Humus contents in the composts were also correlated with lettuce shoot and root growth. Soil dissolved organic carbon, microbial biomass carbon, and fertility were increased with the application of humus-rich composts. These humus-rich composts, especially the compost of higher humic acid with and without AM inoculation, might have a significant role in sustainable vegetable production, for example lettuce growth. Overall, the results indicate that supplementation with humus-rich compost is highly beneficial to enhance soil fertility and potentially maintain the sustainability of vegetable production. | Zakaria M.SOLAIMAN Hongjun YANG Deb ARCHDEACON Orna TIPPETT Michaela TIBI Andrew S.WHITELEY | 2019 | Pedosphere2019，29，2： | 3 |
| 4 | 原花青素拮抗砷诱导人肺上皮细胞氧化损伤的研究显示文摘目的探讨原花青素拮抗砷诱导支气管上皮细胞氧化损伤作用,为揭示原花青素拮抗砷毒性作用提供参考。方法以BEAS-2B细胞为研究对象,分别给予不同剂量As_2O_3(0、5、10和20μmol/L)、葡萄紫原花青素(GSPE)(0、25和50 mg/L)在24和48 h时,利用试剂盒检测氧化应激相关指标[活性氧(ROS)、脂质过氧化物(LPO)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、谷胱甘肽(GSH)、巯基(-SH)、超氧化物气化酶(SOD)、过氧化氢酶(CAT)和总抗氧化能力(T-AOC)]的表达。采用一般线性模型分析原花青素拮抗砷效应的交互作用。结果与砷染毒组相比,在24和48 h均发现As_2O_3+GSPE50 mg/L组的ROS、MDA和LPO的水平降低(P<0.05),T-AOC、GSH、GSH-Px、CAT、-SH、SOD活性和水平增加(P<0.05),As_2O_3+GSPE25 mg/L组的GSH、T-AOC和SOD升高(P<0.05)。结论在一定浓度范围内,GSPE可以有效地拮抗砷所致的氧化损伤,且随着剂量增加,抗氧化损伤效果提高。 | 魏猛 徐孟川 李述刚 Orna Baron-Epel 丁玉松 马儒林 牛强 徐上知 宋关玲 王海霞 | 2018 | 毒理学杂志2018，32，1： | 3 |
| 5 | Preconception Screening for Cytomegalovirus: An Effective Preventive Approach显示文摘 | Orna Reichman Ian Miskin Limor Sharoni Talia Eldar-Geva Doron Goldberg Avi Tsafrir Michael Gal Everett Magann | 2014 | BioMed Research International2014，，： | 1 |
| 6 | Extra- cellular S100A4 (mtsl) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity 显示文摘 | Schmidt-Hansen B Ornas D Grigorian M | 2004 | Oncogene2004，32，： | 1 |
| 7 | Extracellular S100A4(mts1)stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity显示文摘 | Schmidt HB Ornas D Grigorian M | | 0，，32： | 1 |
| 8 | Extracellular S100h4(mtsl ) stimulates invasive growth of mouse endothelial ceils and modulates MMP-I3 matrix metalloproteinase activity显示文摘 | SCHMIDTHANSEN B ORNAS D GRIGORIAN M | 2004 | Oncogene2004，23，32： | 1 |
| 9 | Extracellular S100A4 ( mtsl ) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity 显示文摘 | Schmidt-Hansen B Ornas D Grigorian M | 2004 | Oncogene2004，23，32： | 1 |
| 10 | Extracellular S100A4 ( mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity显示文摘 | SCHMIDT-HANSEN B ORNAS D GRIGORIAN M | 2004 | Oncogene2004，23，32： | 1 |
| 11 | The effect of immobilized RGD peptide in alginate scaffolds on cardiac tissue engineering 显示文摘 | Michal Shachar Orna Tsur-Gang Tal Dvir et al | 2011 | Acta Biomaterialia2011，7，1： | 1 |
| 12 | Effect of physical therapy on muscle strength, respiratory muscles aJd funeliona] parameters Jn palJents wib J- tensive care unit- acquired weakness显示文摘 | Orna Yosef - Brauner Nimrod Adi Tamar Ben Shahar Ester Ye- hezkel Eli Carmeli | 2015 | The Clinical Respirato- ry Juurnal2015，9，1： | 1 |
| 13 | Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia显示文摘 | Reut Fallach Asher Shainberg Orna Avlas Michael Fainblut Yelena Chepurko Eyal Porat Edith Hochhauser | 2010 | Journal of Molecular and Cellular Cardiology2010，，6： | 1 |
| 14 | Are blood cultures necessary in the management of women with complicated pyelonephritis?显示文摘 | Yael Chen Orna Nitzan Walid Saliba Bibiana Chazan Raul Colodner Raul Raz | 2005 | Journal of Infection2005，，： | 1 |
| 15 | Indole acetic acid distribution coincides with vascular differentiation pattern during Arabidopsis leaf ontogeny显示文摘 | ORNA A K CHENG J C CHEN L J | 2002 | Plant Physiology2002，130，： | 1 |
| 16 | Sorption of Sulfonamides and Tetracyclines to Montmorillonite Clay显示文摘 | Dror Avisar Orna Primor Igal Gozlan Hadas Mamane | 2010 | Water Air & Soil Pollution (-)2010，，1： | 1 |
| 17 | The making and breaking of sister chromatid cohesion 显示文摘 | | 2001 | Cell2001，106，2： | 1 |
| 18 | Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia显示文摘 | Reut F Asher S Orna A | 2010 | J Molecul Cellul Cardiol2010，48，6： | 1 |
| 19 | Functional and oncological outcomes of open nephron-sparing surgery for complex renal masses显示文摘 | Zaher Bahouth Sarel Halachmi Itamar Getzler Orna Caspin Boaz Moskovitz Ofer Nativ | 2015 | Urologic Oncology: Seminars and Original Investig2015，，： | 1 |
| 20 | Refractive surgery in Israel Defense Forces recruits显示文摘 | Josepha Horowitz Eedy Mezer Tzippora Shochat Yossi Mandel Gila Buckman Adi Sasson Orna Geyer | 2008 | Journal of Cataract & Refractive Surgery2008，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员