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| 1 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 2 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 3 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 4 | 厚皮拉伸盐构造运动中上覆层构造影响因素分析显示文摘理论分析表明 ,盐撤量与拉伸造成的空间之间的平衡是决定拆离滑脱形变完全与否的控制因素。当盐撤量大于同期形成的拉伸空间时 ,上覆层发生完全拆离滑脱形变 ;反之 ,则发生非完全拆离滑脱形变。分析模拟表明 ,盐层越厚、岩盐粘滞度越小及上覆前构造层越厚 ,盐撤量就越大 ,完全拆离滑脱形变过程持续得也越久 ;区域拉伸和基底断层位移速率越大及基底断层下降盘越长 。 | 戈红星 Bruno C Vendeville Martin P A Jackson | 2003 | 石油学报2003，24，5： | 3 |
| 5 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 6 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 2 |
| 7 | In vitro antibacterial effects of antilipopolysaccharide DNA aptamer-C1 qrs complexes 显示文摘 | Bruno J G Carrillo M P Phillips T | 2008 | Folia Microbiol(Praha)2008，53，4： | 1 |
| 8 | Post-transplant renal artery stenosis:the hemodynamic response to revascularization显示文摘 | Mosconi L Bruno S | 2001 | Kidney Int2001，60，1： | 1 |
| 9 | mTOR:a protein kinase switching between life and death显示文摘 | Asnaghi L Bruno P Priulla M | 2004 | Pharmacol Res2004，50，6： | 1 |
| 10 | Geometrically constrained magnetic wall显示文摘 | Bruno P | 1999 | Phys Rev Lett1999，83，12： | 1 |
| 11 | Control centers evolve with agent technology显示文摘 | Azevedo Gilberto P Feijo Bruno Costa Monica | 2000 | IEEE Computer Applications in Power2000，13，3： | 1 |
| 12 | The impact of public R&D expenditure on business R&D 显示文摘 | Dominique G Bruno P | 2003 | Economics of Innovation and New Technology2003，，12： | 1 |
| 13 | Transplant renal artery stenosis显示文摘 | Bruno S Remuzzi G Ruggenenti P | 2004 | J Am Soc Nephrol2004，15，13： | 1 |
| 14 | Isolation of a cDNA Encoding a β-1,4 endoglucanase in the root knot nematode Meloidogyne incognita and expression analysis during plant parasitism显示文摘 | MARIE N R BRUNO F CHRISTINE P | 1999 | Mol Plant-Microbe Interact1999，12，7： | 1 |
| 15 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 16 | Does leptin play a cytokine-like role within the airways of COPD patients显示文摘 | Bruno A Chanez P Chiappara G | | 0，，： | 1 |
| 17 | Adverse events following immunization attributable to measles vaccine are rare 显示文摘 | Araki D Bruno J Salama P Sadeed A | 2006 | Disasters2006，30，2： | 1 |
| 18 | Serum tryptase in allergic rhinitis: effect of cetirizine and fluticasone propionate treatment显示文摘 | Andreozzi P Bracchitta S | 2001 | Clin Ter2001，152，5： | 1 |
| 19 | Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulationg factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients: European Group for Blood and Marrow Transplantation(EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italiano Trapianti di Midolio Osseo(GITMO) 显示文摘 | Bacigalupo A Bruno B Saracco P | 2000 | Blood2000，95，： | 1 |
| 20 | ALK1 signaling inhibits angio-genesis by cooperating with the Notch pathway 显示文摘 | BRUNO L CLAUDIA P | 2012 | DevCell2012，22，： | 1 |
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