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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 3 | Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials显示文摘 | Peter M Rothwell F Gerald R Fowkes Jill FF Belch Hisao Ogawa Charles P Warlow Tom W Meade | 2011 | The Lancet2011，，9759： | 2 |
| 4 | 纤维增强钛基复合材料界面剪切强度的FEM分析显示文摘用薄试样push-out和push-back试验测试了SCS-6/Timetal834复合材料从室温到530℃温度范围内的峰值载荷和滑动摩擦切应力。用轴对称圆柱有限元模型模拟计算了SiC纤维增强钛基复合材料不同温度下的界面应力沿轴向分布规律和界面脱粘过程。计算表明,push-out试验的界面脱粘过程可以用剪切强度准则描述,对于SCS-6/Timetal834复合材料,当界面单元尺寸L=6.25μm时,其室温下界面剪切强度τm=500MPa,300℃时τm=300MPa,530℃时τm=140MPa。由于应力奇异性的影响,界面剪切强度的值与单元尺寸大小有关。 | 曾卫东 周义刚 P W M Peters | 2002 | 稀有金属材料与工程2002，31，6： | 2 |
| 5 | Capsaicin-evoked brain activation and central sensitization in anaesthetised rats:A functional magnetic resonance imaging study显示文摘 | Ricardo J M G Peter G M Malcolm J W P | 2006 | Pain2006，126，13： | 1 |
| 6 | Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials显示文摘 | Peter M Rothwell Michelle Wilson Carl-Eric Elwin Bo Norrving Ale Algra Charles P Warlow Tom W Meade | 2010 | 2010 (9754)2010，，9754： | 1 |
| 7 | Model uncertainty in claims reserving within Tweedie's com- pound Poisson models显示文摘 | Peters G W Shevchenko P V Wtithrich M V | 2009 | Astin Bulletin2009，39，01： | 1 |
| 8 | Illness severity,viral shedding,and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus显示文摘 | WRIGHT P F GRUBER W C PETERS M | 2002 | Infect Dis2002，185，8： | 1 |
| 9 | Microbial diversit y in hot synthetic compost as revealed by PCR-Amplified rRNA sequences from cultivated isolates and extracted DNA显示文摘 | Peter M Dees P M Ghiorse W C | 2001 | FEMS Microbiology Ecology2001，35，2： | 1 |
| 10 | Endoscopic treatment of high-grade dysplasia and early stage cancer in Barrett's esophagus显示文摘 | PETERS F P KARA M A ROSMOLEN W D | 2005 | Gastrointest Endos2005，61，4： | 1 |
| 11 | High-resolution endoscopy plus chromoendoscopy or narrow-band imaging in Barretts esophagus:a prospective randomized crossover study显示文摘 | Kara M A Peters F P Rosmolen W D | | 0，，10： | 1 |
| 12 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，162，1： | 1 |
| 13 | Identification of a cullin homology region in a subunit of the anaphase-promoting complex显示文摘 | YU H PETERS J M KING R W PAGE A M H IETER P K IRSCHNER M W | 1998 | Science1998，279，5354： | 1 |
| 14 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudineresistant chronic hepatitis B 显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，126，1： | 1 |
| 15 | Adefovir Dipivoxil Alone or in Combination with Lamivudine in Patients with Lamivudine-resistant Chronic Hepatitis B 显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，126，1： | 1 |
| 16 | Studies of the retrogradation process for various starch gels using Ra- man spectroscopy显示文摘 | Fechner P M Siegfried W Peter K | 2005 | Carbohydrate Research2005，340，： | 1 |
| 17 | Prevention and control of cystic echinococcosis显示文摘 | Philip S Craig Donald P McManus Marshall W Lightowlers Jose A Chabalgoity Hector H Garcia Cesar M Gavidia Robert H Gilman Armando E Gonzalez Myriam Lorca Cesar Naquira Alberto Nieto Peter M Schantz | 2007 | The Lancet Infectious Diseases2007，，6： | 1 |
| 18 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 19 | Interracial bond strength and fracture energy at room and elevated temperature in titanium matrix composites (SCS-6/Timetal 834 ) 显示文摘 | Zeng W D Peters P W M Tanaka Y | 2002 | Composites Part A: Applied Science and Manufacturing2002，33，9： | 1 |
| 20 | Protein carbonyls in decidua and placenta of pre eclamptic women as markers for oxidative stress显示文摘 | Zusterzeel P L Rutten H Roelofs H M Peters W H Steegers EA | 2001 | Placenta2001，22，： | 1 |
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