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	题名	作者	年代	出处	被引量
1	NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD.	Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley	2011	World Journal of Gastroenterology2011，17，23：	2
2	Improved tools for biological sequence comparison 显示文摘	PEARSON W R LIPMAN D J	1988	Proc Natl Acad Sci USA1988，85，：	2
3	The chemical bond in semiconductors显示文摘	Pearson W B	1960	Progress in Semiconductors1960，5，：	1
4	Potential of somatic cell concentration in milk as a sire selection criterion to reduce mastitis in dairy cattle 显示文摘	Coffey E M Vinson W E Pearson R E	1986	J Dairy Sci1986，69，：	1
5	Application of integrated quality management systems to promote CI and learning in R&D organisations 显示文摘	Dilani Jayawarna Alan W Pearson	2003	International Journal of Technology Management2003，，8：	1
6	Development of a tool for measuring and analyzing computer user satisfaction 显示文摘	Bailey J E Pearson S W	1983	Management science1983，，53：	1
7	Metabolic relations to temperatures in the copepods Diaptomus dorsalis and Mesocyclopes edax from North-Central Texas显示文摘	Smith G A Fitzpatrick L C Pearson W D		0，，：	1
8	Drip irrigation with waste stabilization pond effluents-solving the problem of emitter fouling显示文摘	Taylor H D Bastos R K X Pearson H W	1995	Water Science and Technology1995，29，4：	1
9	The applica- tion of laser ablation-inductively coupled plasma-mass spectrometry to in situ U-Pb zircon geochronology显示文摘	Jackson S E Pearson N J Griffin W L	2004	Chemical Geology2004，211，1：	1
10	Progress in semiconductors显示文摘	MOOSER E PEARSON W B GIBSON A F	1960	Johniley & Sons1960，，5：	1
11	Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association 显示文摘	Pearson T A Mensah G A Alexander R W	2003	Circulation2003，107，3：	1
12	Transform coding of images using interleaved blocks 显示文摘	Pearson D E Whybray M W	1984	Communications Radar and Signal Processing of IEE Proceedings1984，131，5：	1
13	Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘	Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N	2010	Lancet Infect Dis2010，10，9：	1
14	The Hf isotopecompositon of cratonic mantle: LA-MC-ICPMS analysis of zir-con megacrysts in kimberlites显示文摘	Griffin W L Pearson N J * Belousova E A	2000	Geochemica et CosmochimicaActa2000，64，：	1
15	Integration of the casebased series in population-orientated prevention into a problembased medical curricu- lum J显示文摘	Pearson T Barker W Fisher S	2003	Am J Prey Med2003，24，4：	1
16	The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain显示文摘	Pearson R B Dennis P B Han J W	1995	EMBO J1995，14，21：	1
17	Fatigue of rubber-modified epoxies:effect of particle size and volume fraction显示文摘	Azimi H R Pearson R A Hertzberg R W	1996	J Mater Sci1996，31，15：	1
18	The application of Ia- set ablation-inductively coupled plasma-mass spectrometry to in si- tu U-Pb zircon geochronology显示文摘	Jackson S E Pearson N J Griffin W L	2004	Chemical Geology2004，211，：	1
19	Fatigue of hybrid epoxy composites: Epoxies containing rubber and hollow glass spheres显示文摘	Azimi H R Pearson R A Hertzberg R W	1996	Polym Eng Sci1996，36，18：	1
20	Markers of inflammation and cardiovascular disease: application to clinical and public health praclice= a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association显示文摘	Pearson TA Mensah GA Alexander W	2000	Circulation2000，107，：	1

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