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| 1 | Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy显示文摘Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in patients.Independent of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,known as diabetic cardiomyopathy(DCM).Four decades of research in experimental animal models and advances in clinical imaging techniques suggest that DCM is a progressive disease,beginning early after the onset of type 1 and type 2 diabetes,ahead of left ventricular remodeling and overt diastolic dysfunction.Although the molecular pathogenesis of early DCM still remains largely unclear,activation of protein kinase C appears to be central in driving the oxidative stress dependent and independent pathways in the development of contractile dysfunction.Multiple subcellular alterations to the cardiomyocyte are now being highlighted as critical events in the early changes to the rate of force development,relaxation and stability under pathophysiological stresses.These changes include perturbed calcium handling,suppressed activity of aerobic energy producing enzymes,altered transcriptional and posttranslational modification of membrane and sarcomeric cytoskeletal proteins,reduced actin-myosin cross-bridge cycling and dynamics,and changed myofilament calcium sensitivity.In this review,we will present and discuss novel aspects of the molecular pathogenesis of early DCM,with a special focus on the sarcomeric contractile apparatus. | Mark T Waddingham Amanda J Edgley Hirotsugu Tsuchimochi Darren J Kelly Mikiyasu Shirai James T Pearson | 2015 | World Journal of Diabetes2015，6，7： | 10 |
| 2 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Active control of helicopter vibration 显示文摘 | Pearson J T Goodall R M Lyndon I | 1994 | Computing & Control Engineering Journal1994，5，6： | 1 |
| 5 | 显示文摘 | Takai T Halicioglu T | 1984 | J Cryst Growth1984，70，： | 1 |
| 6 | cDNA and deduced amino acid sequences of a peritrophic membrane glycoprotein,'peritrophin-48',from the larvae of Lucilia cuprina显示文摘 | Schorderet S Pearson R D Vuocolo T | 1998 | Insect Biochemistry and Molecular Biology1998，28，： | 1 |
| 7 | Tissue culture of the enteric nervous system from equine Ileum 显示文摘 | Hudson N P H Pearson G T Mayhew I G | 2000 | Veterinary Research Communications2000，24，： | 1 |
| 8 | Detection of pollution effects on marine macrobenthos further evaluation of the species abundance biomass method显示文摘 | WARWICK R M PEARSON T H ROSWAHYUMI | 1987 | Marine Biology1987，95，： | 1 |
| 9 | Nanotechnology:awareness and societal concerns显示文摘 | Sheetz T Vidal J Pearson TD | 2005 | Technology in Society2005，27，3： | 1 |
| 10 | Critical pathways as a strategy for improving care:Problems and potential显示文摘 | Pearson S D Goulart-Fisher D Lee T H | 1995 | Annals of internal medicine1995，123，12： | 1 |
| 11 | Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sin-like protein 显示文摘 | Schumacher MA Pearson RF Moller T | 2002 | EMBO J2002，21，13： | 1 |
| 12 | Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association 显示文摘 | Pearson T A Mensah G A Alexander R W | 2003 | Circulation2003，107，3： | 1 |
| 13 | Verbesserungen bei der Vorbehandlung von Aluminium als Substraffuerdie Galvanische Abscheidung 显示文摘 | Pearson T Wake S | 2000 | Galvanotechnik2000，91，11： | 1 |
| 14 | Development of a calibration to predict maize seed composition using single kernel near infrared spectroscopy显示文摘 | Baye T M Pearson T C Settles A M | 2006 | Journal of Cereal Science2006，43，： | 1 |
| 15 | Food as a form of destination identity: A tourism destination brand perspective 显示文摘 | Lin Y C Pearson T E Cai L P | 2011 | Tourism and Hospitality Research2011，1，1： | 1 |
| 16 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 17 | Detecting aflatoxin in single corn kernels by transmittance and reflectance spectroscopy显示文摘 | Pearson T C Wicklow D T Maghirang E B | 2001 | Transactions-american Society of Agricultural Engineers2001，44，5： | 1 |
| 18 | Integration of the casebased series in population-orientated prevention into a problembased medical curricu- lum J显示文摘 | Pearson T Barker W Fisher S | 2003 | Am J Prey Med2003，24，4： | 1 |
| 19 | An experiment of Nb and Ta partitioning between Ti-rich minerals and silicate liquids at high pressure and temperature显示文摘 | Green T H Pearson N J | 1987 | Geochim Cosochim Acta1987，51，： | 1 |
| 20 | Mitogen-activated protein (MAP) kinase pathway:regulation and physiological funcdons显示文摘 | Pearson G Robinson F Beers Gibson T | 2001 | Endocr Rev2001，22，： | 1 |
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