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| 1 | Prognostic factors of primary gastrointestinal stromal tumors: a cohort study based on high-volume centers显示文摘Objective: We aimed to evaluate the clinicopathologic characteristics, immunohistochemical expression and prognostic factors of patients with primary gastrointestinal stromal tumors(GISTs).Methods: Data from 2,570 consecutive GIST patients from four medical centers in China(January2001–December 2015) were reviewed. Survival curves were constructed by the Kaplan-Meier method, and Cox regression models were used to identify independent prognostic factors.Results: Of the included patients, 1,375(53.5%) were male, and the patient age range was 18 to 95(median, 58)years. The tumors were mostly found in the stomach(64.5%), small intestine(25.1%) and colorectal region(5.1%).At the time of diagnosis, the median tumor size was 4.0(range: 0.1–55.0) cm, and the median mitotic index per 50 high power fields(HPFs) was 3(range: 0–254). Of the 2,168 resected patients, 2,009(92.7%) received curative resection. According to the modified National Institutes of Health(NIH) classification, 21.9%, 28.9%, 14.1% and35.1% were very low-, low-, intermediate-and high-risk tumors, respectively. The rate of positivity was 96.4% for c-Kit, 87.1% for CD34, 96.9% for delay of germination 1(DOG-1), 8.0% for S-100, 31.0% for smooth muscle actin(SMA) and 5.1% for desmin. However, the prognostic value of each was limited. Multivariate analysis showed that age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors. Furthermore, we found that high-risk patients benefited significantly from postoperative imatinib(P<0.001), whereas intermediate-risk patients did not(P=0.954).Conclusions: Age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors in patients with GISTs. Moreover, determining whether intermediate-risk patients can benefit from adjuvant imatinib would be of considerable interest in future studies. | Xuechao Liu Haibo Qiu Peng Zhang Xingyu Feng Tao Chen Yong Li Kaixiong Tao Guoxin Li Xiaowei Sun Zhiwei Zhou | 2018 | Chinese Journal of Cancer Research2018，30，1： | 14 |
| 2 | Dongsha erosive channel on northern South China Sea Shelf and its induced Kuroshio South China Sea Branch显示文摘Based on a data base of multi-channel seismic profiles covered over Dongsha plateau of the northern South China Sea margin, we found that the sea bed morphology of northern South China Sea margin had been changed dramatically after Dongsha uplifting, that sedimentary layer since Miocene age had been eroded with maximum eroded thickness more than 1000 m, and that an erosive channel had been formed of 20 km in width and 200 km in length and several hundreds meters in depth on the outer shelf of northern South China Sea. The erosive channel is parallel to the 600 m isobath line, stretching from northeast to the southwest north of Dongsha uplift. The Kuroshio intrudes the South China Sea through Luzon Strait both in winter time and summer time, and in the northern South China Sea margin area, the intruded Kuroshio Branch takes the form of Pacific-Indian Ocean Through Flow (PITH) in winter time, while the Luzon Strait Subsurface Inflow (LSSIF) in summer time, the routes of both PITH and LSSIF coincide well with the distribution of the erosive channel. After climbing from the northern slope up to the northern shelf, and after joined by the southward flow from the middle northern shelf of South China Sea, the Kuroshio Branch is strengthened and thus is able to erode the sea floor, and the shape of the erosive channel is a result of the long-term interaction between the Kuroshio South China Sea Branch and the Dongsha outer shelf sea floor. | LUAN XiWu ZHANG Liang PENG XueChao | 2012 | Science China Earth Sciences2012，55，1： | 11 |
| 3 | Modeling investigation of geometric size effect on pervaporation dehydration through scaled-up hollow fiber NaA zeolite membranes显示文摘A mass transfer model in consideration of multi-layer resistances through Na A zeolite membrane and lumen pressure drop in the permeate side was developed to describe pervaporation dehydration through scaled-up hollow fiber supported NaA zeolite membrane. It was found that the transfer resistance in the lumen of the permeate side is strongly related with geometric size of hollow fiber zeolite membrane, which could not be neglected. The effect of geometric size on pervaporation dehydration could be more significant under higher vacuum pressure in the permeate side. The transfer resistance in the lumen increases with the hollow fiber length but decreases with lumen diameter. The geometric structure could be optimized in terms of the ratio of lumen diameter to membrane length. A critical value of dI/L(R_c) to achieve high permeation flux was empirically correlated with extraction pressure in the permeate side. Typically, for a hollow fiber supported Na A zeolite membrane with length of0.40 m, the lumen diameter should be larger than 2.0 mm under the extraction pressure of 1500 Pa. | Jiacheng Wang Peng Ye Xuechao Gao Yuting Zhang Xuehong Gu | 2018 | Chinese Journal of Chemical Engineering2018，26，7： | 4 |
| 4 | Role of humidity on the structures and properties of regenerated silk fibers显示文摘Silk fiber was processed from highly concentrated spinning dope to solid fibers along with water removal. To understand the mechanism of water removal during silk fiber spinning process, a microfluidic chip was designed and applied to investigate the structures and mechanical properties of two kinds of regenerated silk fibroin fibers dry-spun at different relative humidity. The experimental results showed that the diameters of the fibers spun at 40% RH are always larger than the fibers spun at 50% RH due to different removal rates of water. The fibers spun at low humidity contain more β-sheet structure and lower degree of chain orientation and crystalline orientation. These results indicate that the fast phase transition of silk fibroin from sol–gel to silk fiber undergoes with rapid water removal and higher fiber orientation relates to more residue water and drawing force. | Qingfa Peng Huili Shao Xuechao Hu Yaopeng Zhang | 2015 | Progress in Natural Science:Materials International2015，25，5： | 3 |
| 5 | Origin of Taiwan Canyon and its effects on deepwater sediment显示文摘The continental slope of the Taiwan Shoal, which has cultivated numerous submarine canyons, is located in a passive continental margin environment. However, the trend of the Taiwan Canyon, with its 45° intersection angle, is obviously different from that of the erosion valley downward along the continental slope. A distinct break is present in the lower segment of the Taiwan Canyon, which then extends from west to east parallel to the continental slope until finally joining the Manila Trench. By utilizing multiple-beam water depth data, high-resolution seismic data, and sediment cores, this study describes the topographic characteristics of the Taiwan Canyon and provides a preliminary discussion on the origin of the Taiwan Canyon and its effect on deepwater sediment. The terrain, landform, and sediment of the Taiwan Canyon exhibit segmentation characteristics. The upper segment is characterized primarily by erosion, downward cutting with a V shape, and wide development of sliding, slumping, and other gravity flow types. The middle segment is characterized mostly by U-shaped erosion-sedimentation transition and development of an inner levee. The lower segment is characterized primarily by sedimentation and development of a sediment wave. The bottom current has a significant reworking effect on the interior sediments of the canyon and forms reworked sands. The formation and evolution of the Taiwan Canyon is closely related to sediment supply, gravity sliding(slumping), faulting activities, and submarine impaling. Given the sufficient terrigenous clastic supply, the sediments along the continental shelf edge continuously proceed seaward; gliding and slumping in the front edge provide driving forces for the formation of the canyon. Faulting activities result in stratum crushing, and the gravity flow takes priority in eroding the relatively fragile stratum. Thus, the direction of the extension of the canyon crosses the surrounding erosion valley obliquely. Seamounts are formed through submarine impaling. Owing to seamount blocking, the lower segment of the canyon is turned toward the east–west direction. Large amounts of sediments overflow at the turning, forming sediment waves. | XU Shang WANG YingMin PENG XueChao ZOU HuaYao QIU Yan GONG ChengLin ZHUO HaiTeng | 2014 | Science China Earth Sciences2014，57，11： | 2 |
| 6 | Lyocell fibers as the precursor of carbon fiber显示文摘 | Peng Shunjin Shao Huili Hu Xuechao | 2003 | Journal of Applied Polymer Science2003，90，7： | 1 |
| 7 | Sedi- ment waves on the South China Sea Slope off southwestern Taiwan Implications {or the intrusion of the Northern Pacific Deep Water into the South China Sea 显示文摘 | Gong Chenglin Wang Yingmin Peng Xuechao | 2012 | Marine and Petro- leum Geology2012，32，： | 1 |
| 8 | Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2显示文摘Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic mutations.Because of the paradoxical activation induced by a single use of BRAF or MEK inhibitors,dual-target RAF and MEK treatment is thought to be a promising strategy.In this work,we evaluated erianin is a novel inhibitor of CRAF and MEK1/2 kinases,thus suppressing constitutive activation of the MAPK signaling pathway induced by BRAF V600E or RAS mutations.KinaseProfiler enzyme profiling,surface plasmon resonance(SPR),isothermal titration calorimetry(ITC),cellular thermal shift assay,computational docking,and molecular dynamics simulations were utilized to screen and identify erianin binding to CRAF and MEK1/2.Kinase assay,luminescent ADP detection assay,and enzyme kinetics assay were investigated to identify the efficiency of erianin in CRAF and MEK1/2 kinase activity.Notably,erianin suppressed BRAF V600E or RAS mutant melanoma and colorectal cancer cell by inhibiting MEK1/2 and CRAF but not BRAF kinase activity.Moreover,erianin attenuated melanoma and colorectal cancer in vivo.Overall,we provide a promising leading compound for BRAF V600E or RAS mutant melanoma and colorectal cancer through dual targeting of CRAF and MEK1/2. | Penglei Wang Xuechao Jia Bingbing Lu Han Huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 9 | Sediment waves on the South China Sea Slope off southwestern Taiwan:Implications for the intrusion of the Northern Pacific Deep Water into the South China Sea显示文摘 | Chenglin Gong Yingmin Wang Xuechao Peng | 2012 | Marine and Petroleum Geology2012，32，： | 1 |
| 10 | Sediment waves on the South China Sea Slope off southwestern Taiwan:Implications for the intrusion of the Northern Pacific Deep Water into the South China Sea显示文摘 | Chenglin Gong Yingmin Wang Xuechao Peng | 2012 | Marine and Petroleum Geology2012，32，： | 1 |
| 11 | Behavior of flame spread downward over thick wood sheets and heat transfer analysis显示文摘 | Chen Peng Sun Jinhua He Xuechao | 2007 | Journal of Fire Sciences2007，25，1： | 1 |
| 12 | Tough silk fibers prepared in air using a biomimetic microfluidic chip显示文摘 | Jie Luo Lele Zhang Qingfa Peng Mengjie Sun Yaopeng Zhang Huili Shao Xuechao Hu | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 13 | Influence of opening ratios and directions of windows on natural smoke exhaust effect in atrium buildings显示文摘In this paper,the influence of different opening ratios and different opening directions of the windows on the natural smoke exhaust was studied through a series of real fire experiments and simulation analysis.Increasing the open area of the window could effectively improve the overall smoke exhaust effect.When the top windows were open and the opening ratio increased from 19.2%to 24.3%,the optical density was decreased by 12.4%.The average smoke exhaust rate per unit area of the window did not change significantly.Increasing the area of the natural smoke exhaust window could effectively increase the smoke exhaust rate and improve the overall effect of smoke extraction.When the top windows were open,the temperature rise on the top floor was 30.8%-47.5%lower while the visibility was 16.8%-21.9%higher than that when the side windows were open. | Peng Wang Xiankun Wang Keheng Chen Hongyu Wei Qianhang Feng Yuanyi Xie Xuechao He Yanqiu Chen | 2022 | Building Simulation2022，15，4： | 1 |
| 14 | Sediment waves on the South China Sea Slope off southwestern Taiwan:implications for the intrusion of the Northern Pacific deep water into the South China Sea显示文摘 | Gong Chenglin Wang Yingmin Peng Xuechao | 2012 | Marine and Petroleum Geology2012，32，1： | 1 |
| 15 | Temporal shifts in the explanatory power and relative importance of litter traits in regulating litter decomposition显示文摘Background:Litter traits critically affect litter decomposition from local to global scales.However,our understanding of the temporal dynamics of litter trait-decomposition linkages,especially their dependence on plant functional type remains limited.Methods:We decomposed the leaf litter of 203 tree species that belong to two different functional types(deciduous and evergreen)for 2 years in a subtropical forest in China.The Weibull residence model was used to describe the different stages of litter decomposition by calculating the time to 10%,25%and 50%mass loss(Weibull t_(1/10),t_(1/4),and t_(1/2)respectively)and litter mean residence time(Weibull MRT).The resulting model parameters were used to explore the control of litter traits(e.g.,N,P,condensed tannins and tensile strength)over leaf litter decomposition across different decomposition stages.Results:The litter traits we measured had lower explanatory power for the early stages(Weibull t_(1/10)and t_(1/4))than for the later stages(Weibull t_(1/2)and MRT)of decomposition.The relative importance of different types of litter traits in influencing decomposition changed dramatically during decomposition,with physical traits exerting predominant control for the stages of Weibull t_(1/10)and MRT and nutrient-related traits for the stages of Weibull t_(1/4),and t_(1/2).Moreover,we found that litter decomposition of the early three stages(Weibull t_(1/10),t_(1/4),and t_(1/2))of the two functional types was controlled by different types of litter traits;that is,the litter decomposition rates of deciduous species were predominately controlled by nutrient-related traits,while the litter decomposition rates of evergreen species were mainly controlled by carbon-related traits.Conclusions:This study suggests that litter trait-decomposition linkages vary with decomposition stages and are strongly mediated by plant functional type,highlighting the necessity to consider their temporal dynamics and plant functional types for improving predictions of litter decomposition. | Zhaolin Sun Peng Tian Xuechao Zhao Yanping Wang Shunzhong Wang Xiangmin Fang Qingkui Wang Shengen Liu | 2022 | Forest Ecosystems2022，9，6： | 0 |
| 16 | Direct transformation of n-alkane into all-trans conjugated polyene via cascade dehydrogenation显示文摘Selective C(sp^(3))-H activation is of fundamental importance in processing alkane feedstocks to produce high-value-added chemical products.By virtue of an on-surface synthesis strategy,we report selective cascade dehydrogenation of n-alkane molecules under surface constraints,which yields monodispersed all-trans conjugated polyenes with unprecedented length controllability.We are also able to demonstrate the generality of this concept for alkyl-substituted molecules with programmable lengths and diverse functionalities,and more importantly its promising potential in molecular wiring. | Xuechao Li Kaifeng Niu Junjie Zhang Xiaojuan Yu Haiming Zhang Yuemin Wang Qing Guo Pengdong Wang Fangsen Li Zhengming Hao Chaojie Xu Yanning Tang Zhichao Xu Shuai Lu Peng Liu Guigu Xue Yen Wei Lifeng Chi | 2021 | National Science Review2021，8，10： | 0 |
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