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| 1 | Soil biofilms:microbial interactions,challenges,and advanced techniques for ex-situ characterization显示文摘Soil is inhabited by a myriad of microorganisms,many of which can form supracellular structures,called biofilms,comprised of surface-associated microbial cells embedded in hydrated extracellular polymeric substance that facilitates adhesion and survival.Biofilms enable intensive inter-and intra-species interactions that can increase the degradation efficiency of soil organic matter and materials commonly regarded as toxins.Here,we first discuss organization,dynamics and properties of soil biofilms in the context of traditional approaches to probe the soil microbiome.Social interactions among bacteria,such as cooperation and competition,are discussed.We also summarize different biofilm cultivation devices in combination with optics and fluorescence microscopes as well as sequencing techniques for the study of soil biofilms.Microfluidic platforms,which can be applied to mimic the complex soil environment and study microbial behaviors at the microscale with highthroughput screening and novel measurements,are also highlighted.This review aims to highlight soil biofilm research in order to expand the current limited knowledge about soil microbiomes which until now has mostly ignored biofilms as a dominant growth form. | Peng Cai Xiaojie Sun Yichao Wu Chunhui Gao Monika Mortimer Patricia A.Holden Marc Redmile-Gordon Qiaoyun Huang | 2019 | Soil Ecology Letters2019，1，3： | 4 |
| 2 | Wafer-scale arrayed p-n junctions based on few-layer epitaxial GaTe显示文摘二维(2D ) 材料吸引了实质的注意在电子并且有灵活、透明、高度悦耳的优异优点的 optoelectronic 应用。当时,无差距的 graphene 展出极端宽带、快的 photoresponse 半导体的瞬间 2 和门高展出的 2D 敏感和悦耳的 responsivity 到可见的光。然而,设备收益和重覆性打电话让进一步的改进完成大规模一致性。这里,我们与 28.4 厘米 2/(V0 的高洞活动性报导晶片规模门的 layer-by-layer | Xiang Yuan Lei Tang Peng Wang Zhigang Chen Yichao Zou Xiaofeng Su Cheng Zhang Yanwen Liu Weiyi Wang Cong Liu Fansheng Chen Jin Zou Peng Zhou Weida Hu Faxian Xiu | 2015 | Nano Research2015，8，10： | 4 |
| 3 | Soil phyllosilicate and iron oxide inhibit the quorum sensing of Chromobacterium violaceum显示文摘Microorganisms respond to various adverse environmental conditions and regulate different physiological functions by secreting and sensing signal molecules through quorum sensing(QS)systems.Phyllosilicates and iron oxides present in soils and sediments may have substantial impact on bacterial activity and QS due to their unique reactivity and close association with microorganisms.This research explored the effect of goethite,montmorillonite and kaolinite(0.05–2gL^(–1))on the growth and QS of a bacterial model,Chromobacterium violaceum.The results showed that kaolinite and goethite caused cellular damage at low mineral concentrations.The capacity for violacein production and biofilm formation of C.violaceum were inhibited by the minerals in the order of kaolinite>goethite>montmorillonite.The possible underlying mechanisms for QS inhibition by different minerals were investigated.Specifically,kaolinite repressed QS function through downregulation the expression of signal molecules synthesis gene cviI.Goethite and montmorillonite interfered with QS by adsorption of extracellular signal molecules.This work provides a better understanding of the interactions between bacteria and minerals and proposed that the inhibition of QS system is an ignored mechanism for bacterial toxicity by phyllosilicates and iron oxides. | Shanshan Yang Chenchen Qu Manisha Mukherjee Yichao Wu Qiaoyun Huang Peng Cai | 2021 | Soil Ecology Letters2021，3，1： | 2 |
| 4 | Synthesis and characterization of folate conjugated chitosan and cellular uptake of its nanoparticles in HT-29 cells显示文摘 | Puwang Li Yichao Wang Fanbo Zeng Lijue Chen Zheng Peng Ling Xue Kong | 2011 | Carbohydrate Research2011，，6： | 1 |
| 5 | Optical frequency comb generation based on electro-optical modulation with high-order harmonic of a sine RF signal 显示文摘 | WEI Renjie YAN Juanjuan PENG Yichao | 2013 | Optics Communications(S0030-4018)2013，291，6： | 1 |
| 6 | The Feasibility and Safety of Laparoscopic Splenectomy for Massive Splenomegaly: A Comparative Study显示文摘 | Jin Zhou Zhong Wu Yunqiang Cai Yichao Wang Bing Peng | 2011 | Journal of Surgical Research2011，，1： | 1 |
| 7 | Effects of long-term fencing on soil microbial community structure and function in the desert steppe,China显示文摘One of the goals of grazing management in the desert steppe is to improve its ecosystem.However,relatively little is known about soil microbe communities in the desert steppe ecosystem under grazing management.In this study,we investigated the diversity and aboveground biomass of Caragana korshinskii Kom.shrub communities in long-term fencing and grazing areas,combined with an analysis of soil physical-chemical properties and genomics,with the aim of understanding how fence management affects plant-soil-microbial inter-relationships in the desert steppe,China.The results showed that fence management(exclosure)increased plant diversity and aboveground biomass in C.korshinskii shrub area and effectively enhanced soil organic carbon(233.94%),available nitrogen(87.77%),and available phosphorus(53.67%)contents.As well,the Shannon indices of soil bacteria and fungi were greater in the fenced plot.Plant-soil changes profoundly affected the alpha-and beta-diversity of soil bacteria.Fence management also altered the soil microbial community structure,significantly increasing the relative abundances of Acidobacteriota(5.31%-8.99%),Chloroflexi(3.99%-5.58%),and Glomeromycota(1.37%-3.28%).The soil bacterial-fungal co-occurrence networks under fence management had higher complexity and connectivity.Based on functional predictions,fence management significantly increased the relative abundance of bacteria with nitrification and nitrate reduction functions and decreased the relative abundance of bacteria with nitrate and nitrite respiration functions.The relative abundances of ecologically functional fungi with arbuscular mycorrhizal fungi,ectomycorrhizal fungi,and saprotrophs also significantly increased under fence management.In addition,the differential functional groups of bacteria and fungi were closely related to plant-soil changes.The results of this study have significant positive implications for the ecological restoration and reconstruction of dry desert steppe and similar areas. | PAN Yaqing KANG Peng QU Xuan RAN Yichao LI Xinrong | 2024 | Journal of Arid Land2024，16，3： | 0 |
| 8 | Zooming in to acquire micro-reaction:Application of microfluidics on soil microbiome显示文摘Microfluidics confers unique advantages in microbiological studies as these devices can accurately replicate the micro-and even nano-scale structures of soil to simulate the habitats of bacteria.It not only helps us understand the spatial distribution of bacterial communities(such as biofilms),but also provides mechanistic insights into microbial behaviors including chemotaxis and horizontal gene transfer(HGT).Microfluidics provides a feasible means for real-time,in situ studies and enables indepth exploration of the mechanisms of interactions in the soil microbiome.This review aims to introduce the basic principles of microfluidic technology and summarize the recent progress in microfluidic devices to study bacterial spatial distribution and functions,as well as biological processes,such bacterial chemotaxis,biofilm streamers(BS),quorum sensing(QS),and HGT.The challenges in and future development of microfluidics for soil microbiological studies are also discussed. | Xiongkun Zhang Shan Wu Xiaojie Sun Monika Mortimer Yichao Wu Ming Zhang Qiaoyun Huang Peng Cai | 2022 | Soil Ecology Letters2022，4，3： | 0 |
| 9 | Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway显示文摘Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in HCC.We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues.In addition,overexpression of ZYX in hepatoma cell lines(PLC/PRF/5,HCCLM3)enhanced their proliferation,migration and invasion,whereas ZYX knockdown had the opposite effects(SK HEP-1,Huh-7).Furthermore,the change in the expression levels of ZYX also altered that of proteins related to cell cycle,migration and invasion.Similar results were obtained with xenograft models.The AKT/mTOR signaling pathway is one of the key mediators of cancer development.While ZYX overexpression upregulated the levels of phosphorylated AKT/mTOR proteins,its knockdown had the opposite effect.In addition,the AKT inhibitor MK2206 neutralized the pro-oncogenic effects of ZYX on the HCC cells,whereas the AKT activator SC79 restored the proliferation,migration and invasion of HCC cells with ZYX knockdown.Taken together,ZYX promotes the malignant progression of HCC by activating AKT/mTOR signaling pathway,and is a potential therapeutic target in HCC. | TIANYING CAI JUNJIE BAI PENG TAN ZHIWEI HUANG CHEN LIU ZIMING WU YONGLANG CHENG TONGXI LI YIFAN CHEN JIAN RUAN LIN GAO YICHAO DU WENGUANG FU | 2023 | Oncology Research2023，31，5： | 0 |
| 10 | Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system显示文摘Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis. | Kai Li Zhanpeng Feng Zhiwei Xiong Jun Pan Mingfeng Zhou Weizhao Li Yichao Ou Guangsen Wu Mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng | 2024 | Neural Regeneration Research2024，19，10： | 0 |
| 11 | Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors显示文摘Pituitary neuroendocrine tumor(PitNET)is one of the most common intracranial tumors.Due to its extensive tumor heterogeneity and the lack of high-quality tissues for biomarker discovery,the causative molecular mechanisms are far from being fully defined.Therefore,more studies are needed to improve the current clinicopathological classification system,and advanced treatment strategies such as targeted therapy and immunotherapy are yet to be explored.Here,we performed the largest integrative genomics,transcriptomics,proteomics,and phosphoproteomics analysis reported to date for a cohort of 200 PitNET patients.Genomics data indicate that GNAS copy number gain can serve as a reliable diagnostic marker for hyperproliferation of the PIT1 lineage.Proteomics-based classification of PitNETs identified 7 clusters,among which,tumors overexpressing epithelial-mesenchymal transition(EMT)markers clustered into a more invasive subgroup.Further analysis identified potential therapeutic targets,including CDK6,TWIST1,EGFR,and VEGFR2,for different clusters.Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1-PDL1 axis and immune exhaustion,and between changes in the JAK3-STAT6-FOS/JUN axis and immune infiltration.These identified molecular markers and alternations in various clusters/subtypes were further confirmed in an independent cohort of 750 PitNET patients.This proteogenomic analysis across traditional histological boundaries improves our current understanding of PitNET pathophysiology and suggests novel therapeutic targets and strategies. | Fan Zhang Qilin Zhang Jiajun Zhu Boyuan Yao Chi Ma Nidan Qiao Shiman He Zhao Ye Yunzhi Wang Rui Han Jinwen Feng Yongfei Wang Zhaoyu Qin Zengyi Ma Kai Li Yichao Zhang Sha Tian Zhengyuan Chen Subei Tan Yue Wu Peng Ran Ye Wang Chen Ding Yao Zhao | 2022 | Cell Research2022，32，12： | 0 |
| 12 | Clinical Signifi cance of Angiographically Detectable Neovascularity in Patients with Cardiac Myxoma显示文摘Background:Myxomas are the most common primary cardiac tumors.Angiographically detectable neovascularity(ADN)of myxoma is increasingly being reported as a result of the use of coronary angiography(CAG)to detect coronary artery disease.However,the clinical signifi cance of these fi ndings is not fully understood.Methods:We enrolled 59 patients with cardiac myxoma who also underwent CAG between January 2013 and October 2018.Patients were followed up for a mean of 28.9 months(range 1-69 months).The clinical features,echocardiography measurements,pathological examination fi ndings,CAG results,and outcomes during follow-up were compared between patients with ADN and patients without ADN.Results:ADN was found in 25 patients(42.4%).The arteries feeding the ADN included the right coronary artery(n=15),the left circumfl ex coronary artery(n=7),and both arteries(n=3).The patients with ADN had a higher proportion of eosinophils(3.2%vs.2.2%,P=0.03)and higher low-density lipoprotein cholesterol level(2.7 mmol/L vs.2.2 mmol/L,P=0.02).Myxoma pedicles were more likely to be located in the interatrial septum in patients with ADN(96%vs.73.5%,P=0.02).No signifi cant correlation was observed between the groups in clinical manifestations,atrial arrhythmia,myxoma size,cardiac chamber size,left ventricular ejection fraction,and the prevalence of complication with coronary artery disease[16%in the ADN group(n=4)vs.20.6%in the non-ADN group(n=7),P=0.66].However,patients with ADN tended to have a lower incidence of major adverse cardiac and cerebrovascular events on long-term follow-up(0%vs.14.7%,P=0.07).Conclusion:CAG-detected ADN in patients with cardiac myxoma is associated with a borderline lower rate of major adverse cardiac and cerebrovascular events. | Xiaofan Peng Yichao Xiao Yanan Guo Zhaowei Zhu Liyan Liao Xiaobo Liao Xinqun Hu Zhenfei Fang Xuping Li Shenghua Zhou | 2021 | Cardiovascular Innovations and Applications2021，，4： | 0 |
| 13 | Response to Letter to the Editor-“Soil biofilms”:Misleading description of the spatial distribution of microbial biomass in soils显示文摘Thank you for the interest in the article of soil biofilms.We are happy to discuss this topic.Firstly,we should clarify something crucial:at no point has the term“soil biofilm”been used to describe the soil microbial biomass.We have always maintained that biofilms comprise microbial biomass and EPS as distinct pools.Therefore,the title of the above article,“Soil biofilms”:Misleading description of microbial biomass,is itself misleading. | Peng Cai Yichao Wu Marc Redmile-Gordon | 2020 | Soil Ecology Letters2020，2，1： | 0 |
| 14 | A Giant Right Atrial Myxoma with Blood Supply from the Left and Right Coronary Arteries:Once in a Blue Moon显示文摘Cardiac myxomas,the commonest primary benign cardiac tumors,are extremely rare,with an incidence ranging from 0.0017 to 0.19%and only about one-fi fth of them originating from the right chambers of the heart.A 60-year-old woman was admitted because of recurrent attacks of chest tightness and shortness of breath.Transthoracic echocardiography detected a giant mass in the right atrium;myxoma was indicated by[18 F]fl uorodeoxyglucose PET/CT.Preoperative selective coronary angiography was performed to assess the extent and severity of coronary stenosis,and showed a strongly neovascularized right atrial mass supplied by two feeding vessels with multiple branches from the left and right coronary arteries.The myxoma was successfully excised with open heart surgery and the patient was free of myxoma recurrence during the 3-year follow-up. | Yichao Xiao Zhenfei Fang Xinqun Hu Qiming Liu Zhaowei Zhu Na Liu Xiaofan Peng Shenghua Zhou | 2020 | Cardiovascular Innovations and Applications2020，，1： | 0 |
| 15 | Global multifaceted biodiversity patterns,centers,and conservation needs in angiosperms显示文摘The Convention on Biological Diversity seeks to conserve at least 30%of global land and water areas by 2030,which is a challenge but also an opportunity to better preserve biodiversity,including flowering plants(angiosperms).Herein,we compiled a large database on distributions of over 300,000 angiosperm species and the key functional traits of 67,024 species.Using this database,we constructed biodiversity-environment models to predict global patterns of taxonomic,phylogenetic,and functional diversity in terrestrial angiosperms and provide a comprehensive mapping of the three diversity facets.We further evaluated the current protection status of the biodiversity centers of these diversity facets.Our results showed that geographical patterns of the three facets of plant diversity exhibited substantial spatial mismatches and nonoverlapping conservation priorities.Idiosyncratic centers of functional diversity,particularly of herbaceous species,were primarily distributed in temperate regions and under weaker protection compared with other biodiversity centers of taxonomic and phylogenetic facets.Our global assessment of multifaceted biodiversity patterns and centers highlights the insufficiency and unbalanced conservation among the three diversity facets and the two growth forms(woody vs.herbaceous),thus providing directions for guiding the future conservation of global plant diversity. | Ao Luo Yaoqi Li Nawal Shrestha Xiaoting Xu Xiangyan Su Yichao Li Tong Lyu Kilara Waris Zhiyao Tang Xiaojuan Liu Luxiang Lin Yongsheng Chen Kuiling Zu Wenqi Song Shijia Peng Niklaus E.Zimmermann Loïc Pellissier Zhiheng Wang | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 16 | Synthesis and application of non- bioaccumulable fluorinated surfactants: a review显示文摘Due to negative effects of conventional fluorinated surfactants with long perfluorocarbon chain(C_(x)F_(2x+1),x≥7)like perfluorooctanoic acid(PFOA)and perfluorooctane sulfonate(PFOS),these conventional long perfluorocarbon chain surfactants have been restricted in many industrial applications.Nowadays,their potential non-bioaccumulable alternatives have been developed to meet the requirements of environmental sustainable development.In this paper,the recent advances of potential non-bioaccumulable fluorinated surfactants with different fluorocarbon chain structures,including the short perfluorocarbon chain,the branched fluorocarbon chain,and the fluorocarbon chain with weak points,are reviewed from the aspects of synthesis processes,properties,and structure-activity relationships.And their applications in emulsion polymerization of fluorinated olefins,handling membrane proteins,and leather manufacture also are summarized.Furthermore,the challenges embedded in the current non-bioaccumulable fluorinated surfactants are also highlighted and discussed with the hope to provide a valuable reference for the prosperous development of fluorinated surfactants. | Rong Zhou Yong Jin Yichao Shen Peng Zhao Yutang Zhou | 2021 | Journal of Leather Science and Engineering2021，3，1： | 0 |
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