|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors显示文摘Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4(BSL-4) facilities, which have restricted the development of anti-filovirus vaccines and drugs.An HIV-based pseudovirus cell infection assay is widely used for viral entry studies in BSL-2 conditions. Here,we successfully constructed nine in vitro pseudo-filovirus models covering all filovirus genera and three in vivo pseudo-filovirus-infection mouse models using Ebola virus, Marburg virus, and Lloviu virus as representative viruses. The pseudo-filovirus-infected mice showed visualizing bioluminescence in a dose-dependent manner. A bioluminescence peak in mice was reached on day 5 post-infection for Ebola virus and Marburg virus and on day4 post-infection for Lloviu virus. Two known filovirus entry inhibitors, clomiphene and toremiphene, were used to validate the model. Collectively, our study shows that all genera of filoviruses can be well-pseudotyped and are infectious in vitro. The pseudo-filovirus-infection mouse models can be used for in vivo activity evaluation of anti-filovirus drugs. This sequential in vitro and in vivo evaluation system of filovirus entry inhibitors provides a secure and efficient platform for screening and assessing anti-filovirus agents in BSL-2 facilities. | Qing Chen Ke Tang Xiaoyu Zhang Panpan Chen Ying Guo | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 10 |
| 2 | Virus-induced Phytoene Desaturase(PDS) Gene Silencing Using Tobacco Rattle Virus in Lilium × formolongi显示文摘Gene function analysis is challenging for Lilium due to the lack of an efficient method for stable genetic transformation. Virus-induced gene silencing(VIGS) is an attractive tool for determining gene function in plants. This study reported that Tobacco rattle virus(TRV)-based VIGS of a PHYTOENE DESATURASE(PDS) ortholog(LhPDS) can be achieved in Lilium × formolongi seedlings, with a survival rate of 92%, using the inoculation method of rubbing plus injection. Compared with untreated and mock-treated seedlings, the photobleached leaf phenotype of silenced plants significantly correlates with down-regulation of endogenous LhPDS(P ≤ 0.05). In addition, the silencing phenomenon can be observed in the growing points of plants, indicating that systemic viral infection was achieved using the protocol. The results indicate that TRV-based VIGS can be used to characterize gene function in Lilium × formolongi. This work lays the foundation for gene function analysis and molecular breeding in Lilium spp. | Hua Xu Leifeng Xu Panpan Yang Yuwei Cao Yuchao Tang Guoren He Suxia Yuan Jingyi Lei Jun Ming | 2019 | Horticultural Plant Journal2019，5，1： | 6 |
| 3 | On the similarity/dissimilarity of DNA sequences based on 4D graphical representation显示文摘In this paper,we propose a new 4D graphical representation of DNA primary sequences based on the Z-curve theory.The advantage of our approach is that it has the similar biological significance with the Z-curve,and it does not lose any biological information of the sequence.The geometrical centers of the 4D graphical representation of DNA sequences are used as the numerical characterizations,and the examination of similarities/dissimilarities about the coding sequences of the first exon of β-globin genes of eleven different species shows that this approach can provide satisfactory results. | TANG XiaoChan ZHOU PanPan QIU WenYuan | 2010 | Chinese Science Bulletin2010，55，8： | 5 |
| 4 | HDL impairs osteoclastogenesis and induces osteoclast apoptosis via upregulation of ABCG1 expression显示文摘 | Xinyun Huang Yuan Lv Panpan He Zongbao Wang Fang Xiong Linhao He Xilong Zheng Dawei Zhang Qi Cao Chaoke Tang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 5 | Self-Floating Efficient Solar Steam Generators Constructed Using Super-Hydrophilic N,O Dual-Doped Carbon Foams from Waste Polyester显示文摘Solar evaporation is recognized as a prospective technique to produce freshwater from non-drinkable water using inexhaustible solar energy.However,it remains a challenge to fabricate low-cost solar evaporators with obviously reduced water evaporation enthalpy to achieve high evaporation rates.Herein,N,O dual-doped carbon foam(NCF)is fabricated from the lowtemperature carbonization of poly(ethylene terephthalate)(PET)waste by melamine/molten salts at 340℃.During carbonization,melamine reacts with carboxylic acids of PET degradation products to yield a crosslinking network,and then molten salts catalyze the decarboxylation and dehydration to construct a stable framework.Owing to rich N,O-containing groups,3D interconnected pores,super-hydrophilicity,and ultra-low thermal conductivity(0.0599 W m^(−1) K^(−1)),NCF not only achieves high light absorbance(ca.99%)and solar-to-thermal conversion,but also promotes the formation of water cluster to reduce water evaporation enthalpy by ca.37%.Consequently,NCF exhibits a high evaporation rate(2.4 kg m^(−2) h^(−1)),surpassing the-state-of-the-art solar evaporators,and presents good antiacid/basic abilities,long-term salt-resistance,and self-cleaning ability.Importantly,a large-scale NCF-based outdoor solar desalination device is developed to produce freshwater.The daily freshwater production amount per unit area(6.3 kg)meets the two adults’daily water consumption.The trash-to-treasure strategy will give impetus to the development of low-cost,advanced solar evaporators from waste plastics for addressing the global freshwater shortage. | Huiying Bai Ning Liu Liang Hao Panpan He Changde Ma Ran Niu Jiang Gong Tao Tang | 2022 | Energy & Environmental Materials2022，5，4： | 1 |
| 6 | UAV Laser scanning technology:a potential cost-effective tool for micro-topography detection over wooded areas for archaeological prospection显示文摘Airborne laser scanning(ALS)has recently been identified as a potential tool in topographic mapping for archaeological prospection.However,most existing applications in this field refers to manned ALS systems,for which the high operation and maintenance costs limits its application in small-scale archaeological investigation.In this paper,we conducted an exploratory study on the application of the unmanned aerial vehicle(UAV)laser scanning(ULS)system in ancient micro-topography detection over wooded areas.Compared with manned ALS technology,we analyzed the advantages and potentials of ULS technology for archaeological applications.Then we outlined existing mainstream survey-grade UAV-based laser scanners,data processing and visualization approaches.Furthermore,we performed case studies in three cultural heritage sites in Zhejiang Province,China using two representative mainstream survey-grade ULS systems.Results were then verified by an in-site investigation.Finally,the correct selection of ULS devices,the planning of data acquisition missions and the use of appropriate data processing methods specifically for archaeological prospection were discussed.This paper provides a cost-effective and flexible solution for micro-topography detection in wooded areas.ULS technology,as demonstrated here,can be an important supplement to existing archaeological investigation methods,particularly for small-scale areas,and has promising prospects in archaeological applications. | Wei Zhou Fulong Chen Huadong Guo Mingyuan Hu Qi Li Panpan Tang Wenwu Zheng Jian’an Liu Rupeng Luo Kaikai Yan Ru Li Pilong Shi Sheng Nie | 2020 | International Journal of Digital Earth2020，13，11： | 1 |
| 7 | Permafrost environment monitoring on the Qinghai-Tibet Plateau using time series ASAR images显示文摘The permafrost in Qinghai-Tibet Plateau(QTP)has long been the focus of many researchers.In this study,we first use the method that integrates synthetic aperture radar(SAR)intensity and phase information to monitor permafrost environment in the Beiluhe Region,using time series advanced SAR images.The backscattering coefficients(σ^(0))and deformation were extracted for the main features,and the influences of meteorological conditions to them were also quantified.The results show that both the change inσ^(0)and surface deformation are closely related to the active layer,and the deformation is also affected by the permafrost table.First,over meadow and sparse vegetation regions,σ^(0)rose about 6.9 and 4 dB from the freezing to thawing period,respectively,which can be mainly attributed to the thaw of the active layer and increased precipitation.Second,seasonal deformation,derived from the freeze-thaw cycle of the active layer,was characteristic of frost heave and thaw settlement and exhibited a negative correlation with air temperature.Its magnitude was larger than 1 cm in a seasonal cycle.Last,significant secular settlement was observed,with rates ranging from-16 to 2 mm/a,and it was primarily due to the thaw of the permafrost table caused by climate warming. | Zhen Li Panpan Tang Jianmin Zhou Bangsen Tian Quan Chen Sitao Fu | 2015 | International Journal of Digital Earth2015，8，10： | 1 |
| 8 | A Novel Fluorescence Tool for Monitoring Agricultural Industry Chain Based on AIEgens显示文摘With the development of the global economy,the safety of agricultural production has attracted intense attention.To minimize the risk of harmful ingredients in the whole industry chain,it is very necessary to cover the entire process of safety inspections from planting to production to environmental management.Fluorescence sensing as a promising and powerful screening tool is widely used for the detection of ions,toxic gases,biological molecules and so on.However,traditional fluorescent probes often suffer from aggregation-induced quenching(ACQ)effects,which limits their practical applications.In this regard,aggregation-induced emission luminogens(AIEgens)can perfectly address this notorious issue and have shown great potential in agricultural safety analysis.In this review,we briefly summarize their applications in agricultural safety monitoring,including the fabrication of agricultural film,agricultural sewage treatment and selective detection of harmful residues in agricultural products.The challenge and future development of AIEgens in this field are also discussed and highlighted.Hopefully,this review can inspire more researchers to participate in this fascinating area. | CHEN Mingyu XIANG Song LV Panpan Ql Chunxuan FENG Hai-Tao TANG Ben Zhong | 2021 | Chemical Research in Chinese Universities2021，37，1： | 0 |
| 9 | Near-infrared emissive AIE nanoparticles for biomedical applications:From the perspective of different nanocarriers显示文摘Fluorescent imaging based on near-infrared(NIR)fluorophores has revolutionized the techniques employed for detecting biological events in depth owing to their advantages referring to diminished photon scattering,high signal-to-noise ratio and better light transparence through tissue.As for conventional luminogens,the nanofabrication of those innately hydrophobicπ-conjugated architectures into water-dispersible nanoparticles(NPs)may result in attenuated fluorescent intensity deriving from the detrimental distribution ofπ-πinteractions in the confined space.Oppositely,chromophores possessing aggregation-induced emission(AIE)characteristics emit boosted brightness at aggregate level according to the mechanism of restriction of intramolecular motion(RIM).In this review,we summarize the recent progresses of NIR emissive AIE NPs for multifarious biomedical applications from the viewpoint of different fabricated manners,mainly covering self-assembly and matrices assisted approaches.Furthermore,the current challenges and future research directions of NIR AIE NPs are briefly discussed. | Dingyuan Yan Yi Qin Saisai Yan Panpan Sun Yuanwei Wang Dong Wang Ben Zhong Tang | 2023 | Particuology2023，，3： | 0 |
| 10 | The SUPER reporting guideline suggested for reporting of surgical technique显示文摘Background:Existing reporting guidelines pay insufficient attention to the detail and comprehensiveness reporting of surgical technique.The Surgical techniqUe rePorting chEcklist and standaRds(SUPER)aims to address this gap by defining reporting standards for surgical technique.The SUPER guideline intends to apply to articles that encompass surgical technique in any study design,surgical discipline,and stage of surgical innovation.Methods:Following the EQUATOR(Enhancing the QUAlity and Transparency Of health Research)Network approach,16 surgeons,journal editors,and methodologists reviewed existing reporting guidelines relating to surgical technique,reviewed papers from 15 top journals,and brainstormed to draft initial items for the SUPER.The initial items were revised through a three-round Delphi survey from 21 multidisciplinary Delphi panel experts from 13 countries and regions.The final SUPER items were formed after an online consensus meeting to resolve disagreements and a three-round wording refinement by all 16 SUPER working group members and five SUPER consultants.Results:The SUPER reporting guideline includes 22 items that are considered essential for good and informative surgical technique reporting.The items are divided into six sections:background,rationale,and objectives(items 1 to 5);preoperative preparations and requirements(items 6 to 9);surgical technique details(items 10 to 15);postoperative considerations and tasks(items 16 to 19);summary and prospect(items 20 and 21);and other information(item 22).Conclusions:The SUPER reporting guideline has the potential to guide detailed,comprehensive,and transparent surgical technique reporting for surgeons.It may also assist journal editors,peer reviewers,systematic reviewers,and guideline developers in the evaluation of surgical technique papers and help practitioners to better understand and reproduce surgical technique. | Kaiping Zhang Yanfang Ma Jinlin Wu Qianling Shi Leandro Cardoso Barchi Marco Scarci Rene Horsleben Petersen Calvin S.H.Ng Steven Hochwald Ryuichi Waseda Fabio Davoli Robert Fruscio Giovanni Battista Levi Sandri Michel Gonzalez Benjamin Wei Guillaume Piessen Jianfei Shen Xianzhuo Zhang Panpan Jiao Yulong He Nuria M.Novoa Benedetta Bedetti Sebastien Gilbert Alan D.L.Sihoe Alper Toker Alfonso Fiorelli Marcelo F.Jimenez Toni Lerut Aung Y.Oo Grace S.Li Xueqin Tang Yawen Lu Hussein Elkhayat Tomaz Stupnik Tanel Laisaar Firas Abu Akar Diego Gonzalez-Rivas Zhanhao Su Bin Qiu Stephen D.Wang Yaolong Chen Shugeng Gao | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
| 11 | Archeological crop marks identified from Cosmo-SkyMed time series: the case of Han-Wei capital city, Luoyang, China显示文摘The development of spaceborne Synthetic Aperture Radar(SAR)technology declares that the golden era of SAR remote sensing in archeology is approaching;however,nowadays its methodology framework is still lacking due to the inadequate case studies validated by ground-truths.In this study,we investigated the crop marks using multi-temporal Cosmo-SkyMed data acquired in 2013 by applying a twostep decision-tree classifier in conjunction with a spatial analysis in an area of archeological interest nearby the archeological site of Han-Wei capital city(1900–1500 BP),in Luoyang,China.The time-series backscattering anomalies related to the wheat growth cycle were identified and then further validated in two zones by geophysical investigations(Ground Penetration Radar and electrical measurements)and in a third zone by archeological excavations made after the SAR data acquisition.This study provides a new approach for the relic detection,shallowly buried and covered by the crop vegetation,by temporal crop marks on spaceborne SAR images.We also emphasize the necessity to establish a satellite-to-ground methodology framework for the promotion of remote-sensing technology in archeology. | Aihui Jiang Fulong Chen Nicola Masini Luigi Capozzoli Gerardo Romano Maria Sileo Ruixia Yang Panpan Tang Panpan Chen Rosa Lasaponara Guolin Liu | 2017 | International Journal of Digital Earth2017，10，8： | 0 |
| 12 | Functional data analysis: An application to COVID-19 data in the United States in 2020显示文摘Background: In this paper, we conduct an analysis of the COVID-19 data in the United States in 2020 via functional data analysis methods. Through this research, we investigate the effectiveness of the practice of public health measures, and assess the correlation between infections and deaths caused by the COVID-19. Additionally, we look into the relationship between COVID-19 spread and geographical locations, and propose a forecasting method to predict the total number of confirmed cases nationwide.Methods: The functional data analysis methods include functional principal analysis methods, functional canonical correlation analysis methods, an expectation-maximization (EM) based clustering algorithm and a functional time series model used for forecasting.Results: It is evident that the practice of public health measures helps to reduce the growth rate of the epidemic outbreak over the nation. We have observed a high canonical correlation between confirmed and death cases. States that are geographically close to the hot spots are likely to be clustered together, and population density appears to be a critical factor affecting the cluster structure. The proposed functional time series model gives more reliable and accurate predictions of the total number of confirmed cases than standard time series methods.Conclusions: The results obtained by applying the functional data analysis methods provide new insights into the COVID-19 data in the United States. With our results and recommendations, the health professionals can make better decisions to reduce the spread of the epidemic, and mitigate its negative effects to the national public health. | Chen Tang Tiandong Wang Panpan Zhang | 2022 | Quantitative Biology2022，10，2： | 0 |
| 13 | Comparison and assessment of NDVI time series for seasonal wetland classification显示文摘Satellite-based wetland mapping faces challenges due to the high spatial heterogeneity and dynamic characteristics of seasonal wetlands.Although normalized difference vegetation index(NDVI)time series(NTS)shows great potential in land cover mapping and crop classification,the effectiveness of various NTS with different spatial and temporal resolution has not been evaluated for seasonal wetland classification.To address this issue,we conducted comparisons of those NTS,including the moderate-resolution imaging spectroradiometer(MODIS)NTS with 500 m resolution,NTS fused with MODIS and Landsat data(MOD_LC8-NTS),and HJ-1 NDVI compositions(HJ-1-NTS)with finer resolution,for wetland classification of Poyang Lake.Results showed the following:(1)the NTS with finer resolution was more effective in the classification of seasonal wetlands than that of the MODIS-NTS with 500-m resolution and(2)generally,the HJ-1-NTS performed better than that of the fused NTS,with an overall accuracy of 88.12%for HJ-1-NTS and 83.09%for the MOD_LC8-NTS.Future work should focus on the construction of satellite image time series oriented to highly dynamic characteristics of seasonal wetlands.This study will provide useful guidance for seasonal wetland classification,and benefit the improvements of spatiotemporal fusion models. | Panpan Xu Zhenguo Niu Ping Tang | 2018 | International Journal of Digital Earth2018，11，11： | 0 |
| 14 | Investigation of the on-state behaviors of the variation of lateral width LDMOS device by simulation显示文摘In this paper, the main content revolves round the on-state characteristics of the variation of a lateral width(VLW) LDMOS device. A three-dimensional numerical analysis is performed to investigate the specific onresistance of the VLW LDMOS device, the simulation results are in good agreement with the analytical calculation results combined with device dimensions. This provides a theoretical basis for the design of devices in the future. Then the self-heating effect of the VLW structure with a silicon-on-oxide(SOI) substrate is compared with that of a silicon carbide(SiC) substrate by 3 D thermoelectric simulation. The electrical characteristic and temperature distribution indicate that taking into account the SiC as the substrate can mitigate the self-heating penalty effectively, alleviating the self heating effect and improving reliability. | Panpan Tang Ying Wang Xiongfei Meng Sufen Cui | 2018 | Journal of Semiconductors2018，39，11： | 0 |
| 15 | Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma显示文摘Metastasis and recurrence account for 95%of deaths from nasopharyngeal carcinoma(NPC).Cancer stem cells(CSCs)are regarded as one of the main reasons for tumor cell resistance to clinical therapy,and cancer metastasis or recurrence,while little is known about CSCs in NPC.The present study uncovers a subpopulation of cells labeled as CD45 EPCAM PROCR4 in NPC biopsy samples that exhibit stem cell-like characteristics.A relatively low number of these cells initiate xenograft tumors in mice. | Panpan Zhang Qiuping He Yaqin Wang Guanqun Zhou Yupei Chen Linglong Tang Yuan Zhang Xiaohong Hong Yanping Mao Qingmei He Xiaojing Yang Na Liu Jun Ma | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 16 | Integrating thermal energy storage and microwave absorption in phase change material-encapsulated core-sheath MoS_(2)@CNTs显示文摘Developing advanced nanocomposite integrating solar-driven thermal energy storage and thermal management functional microwave absorption can facilitate the cutting-edge application of phase change materials(PCMs).To conquer this goal,herein,two-dimensional MoS_(2) nanosheets are grown in situ on the surface of one-dimensional CNTs to prepare core-sheath MoS_(2)@CNTs for the encapsulation of paraffin wax(PW).Benefiting from the synergistic enhancement photothermal effect of MoS_(2) and CNTs,MoS_(2)@CNTs is capable of efficiently trapping photons and quickly transporting phonons,thus yielding a high solar-thermal energy conversion and storage efficiency of 94.97%.Meanwhile,PW/MoS_(2)@CNTs composite PCMs exhibit a high phase change enthalpy of 101.60 J/g and excellent lo ng-term thermal storage durability after undergoing multiple heating-cooling cycles.More attractively,PW/MoS_(2)@CNTs composite PCMs realize thermal management functional microwave absorption in heat-related electronic application scenarios,which is superior to the single microwave absorption of traditional materials.The minimum reflection loss(RL) for PW/MoS_(2)@CNTs is-28 dB at 12.91 GHz with a 2.0 mm thickness.This functional integration design provides some insightful references on developing advanced microwave absorbing composite PCMs,holding great potential towards high-efficiency solar energy utilization and thermally managed microwave absorption fields. | Panpan Liu Yang Li Zhaodi Tang Junjun Lv Piao Cheng Xuemei Diao Yu Jiang Xiao Chen Ge Wang | 2023 | Journal of Energy Chemistry2023，，9： | 0 |
| 17 | Enantioselective recognition based on aggregation-induced emission显示文摘Chirality is one of the most important features of the nature.The recognition of enantiomers plays significant roles in the field of life science,pharmaceutical analysis and food chemistry.Among various recognition methods,fluorescence spectrometry has attracted much attention of researchers thanks to its high sensitivity and easy operation.Compared with traditional fluorescent probes,chiral molecules with aggregation-induced emission(AIE)have drawn increasing interests due to their huge potential in high-efficiency chemo/biosensors and solid emitters.Chiral AIE luminogens(AIEgens)can not only discriminate two enantiomers with excellent enantioselectivity,but also show general applicability for many chiral analytes,such as chiral acids,amino acids,amines,alcohols.In this review,we mainly summarized the recent development of chiral probes with AIE properties,including chiral tetraphenylethylene(TPE)derivatives,α-cyanostilbene derivatives,Schiff base derivatives and other AIEgens.Their synthetic routes,recognition capabilities and possible working mechanisms were well discussed.It is envisioned that the present review can give some significant guidance for design and synthesis of chiral AIEgens with good enantioselectivity and inspire more readers to join the research of chiral AIE. | Pu Chen Panpan Lv Chang-Sheng Guo Rui-Peng Wang Xiaolong Su Hai-Tao Feng Ben Zhong Tang | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 18 | Aggregation-enhanced theranostics:AIE sparkles in biomedical field显示文摘Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized and precision medicine.By virtue of the good biocompatibility,outstanding fluorescence property,easy processability and functionalization,promoted photosensitizing efficiency,as well as facile construction of multi-modality theranostics,fluorophores with aggregation-induced emission(AIE)characteristics exhibit inexhaustible and vigorous vitality in the field of theranostics.Numerous significant breakthroughs and state-of-the-art progression have been witnessed in the past few years.This review highlights the tremendous aggregation-enhanced superiorities of AIE luminogens(AIEgens)in disease theranostics mainly involving diagnostic imaging(fluorescence and room temperature phosphorescence),therapeutic intervention(photodynamic therapy),and feasibility in construction of multi-modality theranostics based on the experimental measurements and theoretical simulations.Additionally,the latest and advanced developments of AIEgens in disease theranostics in the aspect of corresponding strategies to design highly effective AIE-active theranostics through triggering aggregation formation are comprehensively summarized.Moreover,a brief conclusion with the discussion of current challenges and future perspectives in this area is further presented. | Miaomiao Kang Zhijun Zhang Nan Song Meng Li Panpan Sun Xiaohui Chen Dong Wang Ben Zhong Tang | 2020 | Aggregate2020，1，1： | 0 |
| 19 | Tightened1D/3Dcarbonheterostructure infiltratingphase change materials for solar-thermoelectric energy harvesting:Faster and better显示文摘Extensive use of thermal energy in daily life is ideal for reducing carbon emissions to achieve carbon neutrality;however,the effective collection of thermal energy is a major hurdle.Thermoelectric(TE)conversion technology based on the Seebeck effect and thermal energy storage technology based on phase change materials(PCMs)represent smart,feasible,and research-worthy approaches to overcome this hurdle.However,the integration of multiple thermal energy sources freely existing in the environment for storage and output of thermal and electrical energy simultaneously still remains a huge challenge.Herein,three-dimensional(3D)nanostructured metal-organic frameworks(MOFs)are in situ nucleated and grown onto carbon nanotubes(CNTs)via coordination bonding.After calcination,the prepared core-shell structural CNTs@MOFs are transformed into tightened 1D/3D carbon heterostructure loading Co nanoparticles for efficient solar-thermoelectric energy harvesting.Surprisingly,the corresponding composite PCMs show a record-breaking solar-thermal conversion efficiency of 98.1%due to the tightened carbon heterostructure and the local surface plasmon resonance effect of Co nanoparticles.Moreover,our designed all-in-one composite PCMs are also capable of creating an electrical potential of 0.5 mV based on the Seebeck effect without a TE generator.This promising approach can store thermal and electrical energy simultaneously,providing a new direction in the design of advanced all-in-one multifunctional PCMs for thermal energy storage and utilization. | Zhaodi Tang Piao Cheng Panpan Liu Yan Gao Xiao Chen Ge Wang | 2023 | Carbon Energy2023，5，6： | 0 |
| 20 | Dynamic micelles with detachable PEGylation at tumoral extracellular pH for enhanced chemotherapy显示文摘Although surface PEGylation of nanomedicines can decrease serum protein adsorption in vivo,it also blocks uptake by tumor cells.This dilemma could be overcome by employing detachably PEGylated strategy at tumoral extracellular microenvironment to achieve improved cellular uptake while prolonged circulation times.Herein,the amphiphilic graft copolymers with p H-sensitive ortho ester-linked m PEG in side chains and polyurethanes in backbone,can self-assemble into the free and doxorubicin(DOX)-loaded micelles.The p H-sensitive micelles could undergo several characteristics as follows:(i)PEGylated shells for stability in sodium dodecyl sulfonate(SDS)solution;(ii)De PEGylation via degradation of ortho ester linkages at tumoral extracellular pH(6.5)for gradually dynamic size changes and effective release of DOX;and(iii)enhanced cellular uptake and cytotoxicity via positive DOX.Moreover,the dynamic micelles with detachable PEGylation could quickly penetrate the centers of SH-SY5 Y multicellular spheroids(MCs)and strongly inhibit tumor growth in vitro and in vivo,and might be considered as promising and effective drug carriers in tumor therapy. | Guoqing Yan Panpan Zhang Jun Wang Xin Wang Rupei Tang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员