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| 1 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
| 2 | Primary hepatic carcinosarcoma显示文摘BACKGROUND:Primary hepatic carcinosarcoma is a rare malignant tumor containing an intimate mixture of carci- nomatous and sarcomatous elements.Reports on risk factors, epidemiology,and pathogenesis of the tumor as well as the experience in its treatment are limited. METHOD:We present a case of primary carcinosarcoma of the liver in a 69-year-old man who complained of right hypochondrial pain and weight loss for two months. RESULTS:Magnetic resonance imaging revealed a 14×12 cm mass in segments 7-8 and 4 of the liver with vena hepatica invasion.An ultrasonography-guided biopsy showed osteoid tissue without osteoblastic rimming.Vascular structures accompanied the osteoid tissue.The patient underwent surgery after a diagnosis of hemangioma.Intraoperative frozen sections revealed a carcinosarcoma associated with an osteosarcoma and cholangiocellular carcinoma components. CONCLUSIONS:Preoperative diagnosis of this rare primary hepatic malignant tumor may be difficult by biopsy owing to intratumoral heterogeneity.Highly mature areas of the osteosarcomatous component may lead to misdiagnosis of metaplastic bone tissue.Clinicopathologic features of this rare entity are discussed. | Mehmet elikbilek Kemal Deniz Edip Torun Tarιk Artιs Ersin zaslan kkes brahim Karahan Tahir Ercan Patιroglu mer zbakιr | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，1： | 2 |
| 3 | EGb761blocks MPP+-induced lipid peroxidat ion in mouse corpus striatum显示文摘 | Pat ricia R Belen C Carolina R | 2001 | Neuro-chemical Research2001，26，11： | 1 |
| 4 | Low-risk palpable breast masses removed using a vacuum assisted hang-held device显示文摘 | Fine R E Pat W Whitworth J A | 2003 | Am J Surg2003，186，4： | 1 |
| 5 | Effect of alternate aerobic and an aerobicconditions on redox potential, organic matter decom posit ion and nitrogen loss in a flooded soil显示文摘 | Reddy K R Pat rick W H | 1975 | Soil Bioliochem1975，7，： | 1 |
| 6 | Development of cytoplasmic CD3+/T cell receptor negative cells in the peripheral lymphoid tissues of chickens显示文摘 | Pat B R Chen C I H | | 0，，06： | 1 |
| 7 | Central role of Toll-like reeceptor 4 signaling and host defense in experimental pneumonia caused by gramngative bacteria 显示文摘 | Jill R Schurr Erana Y Pat Byme | 2005 | Infection & Immunity2005，，1： | 1 |
| 8 | Low-risk palpable breast masses removed using a vacuum-assisted hand-held device显示文摘 | Fine R E Pat W Whitworth J A | 2003 | Am J Surg2003，186，4： | 1 |
| 9 | Low-risk palpable beast masses removed using a vacuum-assisted hand-held device显示文摘 | FINE R E PAT W WHITWORTH J A | 2003 | Am J Surg2003，186，4： | 1 |
| 10 | Flavor analysis of Greek white wine by solid-phase microextraction-capillary gas chromatography-mass spectrometry显示文摘 | Jan C R Demyttenaere Cynthia Cagher Pat Sandra | 2003 | Journal of Chromatography A2003，985，： | 1 |
| 11 | Low risk palpable breastmasses removed using a vacuum assisted handheld device显示文摘 | Fine R E Pat W Whitworth J A | 2003 | Am J Surg2003，186，36： | 1 |
| 12 | Antigenic feat ures offoot-and-mouth disease virus serotype Asial as re- vealed by monoclonal antibodies and neut ralization-es- cape mutants显示文摘 | Sanyal A Venkataramanan R Pat tnaik B | 1997 | Virus Research1997，，4： | 1 |
| 13 | On cluster validity for the fuzzy c-means model显示文摘 | Pat N R Bezdek J C | 1995 | IEEE Transactions on Fuzzy Systems1995，3，3： | 1 |
| 14 | Low-risk palpable breast masses removed using a vacuum-assisted hand-held device显示文摘 | Fine R E Pat W Whitworth J A | 2003 | Am J Surg2003，186，4： | 1 |
| 15 | An improved dark-object subtraction technique for atmopheric scattering correction of multispectral data显示文摘 | PAT S Chavez J R | 1988 | Remote Sensing Environment1988，24，3： | 1 |
| 16 | Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John C Mathers Mohammad Movahedi Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diana Eccles Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm Dunlop Judy WC Ho Shirley Hodgson Annika Lindblom Jan Lubinski Pat | 2012 | Lancet Oncology2012，，12： | 1 |
| 17 | Diverse roles of metformin during peri-implantation development:revisiting novel molecular meehanisms underlying clinical implications显示文摘 | Banerjee P Bhonde R R Pat R | 2013 | Stem Cells Dev2013，22，22： | 1 |
| 18 | Review of the psychometric properties of the Diabetes Self - Efficacy Scale: Australian longitudinal study显示文摘 | Pat R Anne P Mike P | 2003 | Nursing and Health Sciences2003，5，： | 1 |
| 19 | Probabilistic risk analysis for the NASA space shuttle:a brief history and current work显示文摘 | Paté -Cornell E Dillon R | 2001 | Reliability Engineering and System Safety2001，74，3： | 1 |
| 20 | A method for representing and developing process models显示文摘 | Stuart R Borrett Will Bridewell Pat Langley | 2007 | Ecological Complexity2007，4，1： | 1 |
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