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| 1 | Plant diversity reduces the effect of multiple heavy metal pollution on soil enzyme activities and microbial community structure显示文摘It is unclear whether certain plant species and plant diversity could reduce the impacts of multiple heavy metal pollution on soil microbial structure and soil enzyme activities. Random amplified polymorphic DNA (RAPD) was used to analyze the genetic diversity and microbial similarity in planted and unplanted soil under combined cadmium (Cd) and lead (Pb) pollution. A metal hyper- accumulator, Brassica juncea, and a common plant, Festuca arundinacea Schreb, were used in this research. The results showed that microorganism quantity in planted soil significantly increased, compared with that in unplanted soil with Cd and Pb pollution. The order of microbial community sensitivity in response to Cd and Pb stress was as follows: actinomycetes 〉 bacteria 〉 fungi. Respiration, phosphatase, urease and dehydrogenase activity were significantly inhibited due to Cd and Pb stress. Compared with unplanted soil, planted soils have frequently been reported to have higher rates of microbial activity due to the presence of additional surfaces for microbial colonization and organic compounds released by the plant roots. Two coexisting plants could increase microbe population and the activity of phosphatases, dehydrogenases and, in particular, ureases. Soil enzyme activity was higher in B. juncea phytoremediated soil than in F. arundinacea planted soil in this study. Heavy metal pollution decreased the richness of the soil microbial community, but plant diversity increased DNA sequence diversity and maintained DNA sequence diversity at highlevels. The genetic polymorphism under heavy metal stress was higher in B. juncea phytoremediated soil than in F. arundinacea planted soil. | Yang GAO Chiyuan MIAO Jun XIA Liang MAO Yafeng WANG Pei ZHOU | 2012 | Frontiers of Environmental Science & Engineering2012，6，2： | 14 |
| 2 | Nicotinamide phosphoribosyltransferase aggravates inflammation and promotes atherosclerosis in ApoE knockout mice显示文摘Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme of nicotinamide adenine dinucleotide (NAD) salvage biosynthesis in mammals, and is involved in fundamental physiological processes and pathophysiology of many diseases. Thus far, however, the role of Nampt in atherosclerosis development is still in debate. In this study, we crossed global Nampt transgenic mice (Nampt-Tg) with a well-established atherosclerosis animal model (ApoE knockout mice, ApoE-/-) to generate ApoE-/-;Nampt-Tg mice and investigated the effects of Nampt overexpression on atherosclerosis development in ApoE-/- mice. Both ApoE-/- and ApoE-/-;Nampt-Tg mice were fed with a pro-atherosclerotic high-fat diet (HFD) for 16 weeks. Their serum lipid contents and atherosclerotic lesion were assessed. The results showed that there was no significant difference in body weight or serum levels of glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol between the two strains of mice, but ApoE-/-;Nampt-Tg mice had a significantly higher level of serum non-esterified fatty acid. Compared with ApoE-/- mice, ApoE-/-;Nampt-Tg mice displayed significantly increased atherosclerotic lesion area and thickness, lower collagen content, decreased collagen I/III ratio (collagen immaturation), increased number of apoptotic cells, and enhanced activities of caspase-3, caspase-8, and caspase-9. Moreover, macrophage infiltration (F4/80 staining), tumor necrosis factor signaling, and chemokines expression (ICAM-1 and CXCR-4) were all activated in aortic atherosclerotic plaque of ApoE-/-;Nampt-Tg mice compared with ApoE-/- mice. Our results provide in vivo evidence that Nampt transgene aggravates atherosclerotic inflammation and promotes atherosclerosis development in ApoE-/- mice. | Yuan-yuan Kong Guo-qiang Li Wen-jie Zhang Xia Hua Can-can Zhou Tian-ying Xu Zhi-yong Li Pei Wang Chao-yu Miao | 2019 | Acta Pharmacologica Sinica2019，40，9： | 12 |
| 3 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 4 | Synthesis of a benzoxazine monomer containing maleimide and allyloxy groups显示文摘新奇 benzoxazine 单体 3-(4-allyloxy )phenyl-3,4-dihydro-2H-6-(N-maleimido )-1,3-benzoxazine (AMB ) 被综合,结构被英尺红外证实,(1 ) H NMR。AMB 的热分析(DSC ) 证明烯丙氧基组的介绍减少了熔点并且展出了一扇狭窄、对称的治好的发热的窗户。 | Yan Tang Qing Lai Zhao Ke Zeng Pei Kai Miao Ke Zhou Wen Rui Tang Hong Fei Zhou Tao Liu Yi Peng Wang Gang Yang | 2007 | Chinese Chemical Letters2007，18，8： | 10 |
| 5 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 6 | Supersymmetric microring laser arrays显示文摘A coherent combination of emission power from an array of coupled semiconductor lasers operating on the same chip is of fundamental and technological importance. In general, the nonlinear competition among the array supermodes can entail incoherence and spectral broadening, leading to a spatiotemporally unstable and multimode emission pattern and thus poor beam quality. Here, by harnessing notions from supersymmetric(SUSY)quantum mechanics, we report that the strategic coupling between a class III-V semiconductor microring laser array with its dissipative superpartner can be used to limit the number of supermodes available for laser actions to one. We introduce a novel approach based on second-order SUSY transformation in order to drastically simplify the superpartner array engineering. Compared to a conventional laser array, which has a multimode spectrum, a SUSY laser array is observed to be capable of operating in a single(transverse) supermode. Enhancement of the peak output intensity of the SUSY laser array has been demonstrated with high efficiency and lower lasing threshold, compared with a single laser and a conventional laser array. Our experimental findings pave the way towards broad-area and high-power light generation in a scalable and stable fashion. | BIKASHKALI MIDYA HAN ZHAO XINGDU QIAO PEI MIAO WIKTOR WALASIK ZHIFENG ZHANG NATALIA M.LITCHINITSER LIANG FENG | 2019 | Photonics Research2019，7，3： | 4 |
| 7 | Genesis of the Gold Deposit in the Indus-Yarlung Tsangpo Suture Zone,Southern Tibet:Evidence from Geological and Geochemical Data显示文摘The Nianzha gold deposit,located in the central section of the Indus-Yarlung Tsangpo suture(IYS) zone in southern Tibet,is a large gold deposit(Au reserves of 25 tons with average grade of 3.08 g/t) controlled by a E-W striking fault that developed during the main stage of Indo-Asian collision(~65-41 Ma).The main orebody is 1760 m long and 5.15 m thick,and occurs in a fracture zone bordered by Cretaceous diorite in the hanging wall to the north and the Renbu tectonic melange in the footwall to the south.High-grade mineralization occurs in a fracture zone between diorite and ultramafic rock in the Renbu tectonic melange.The wall-rock alteration is characterized by silicification in the fracture zone,serpentinization and the formation of talc and magnesite in the ultramafic unit,and chloritization and the formation of epidote and calcite in diorite.Quartz veins associated with Au mineralization can be divided into three stages.Fluid inclusion data indicate that the deposit formed from H_2O-NaCl-organic gas fluids that homogenize at temperatures of 203℃-347℃ and have salinities of 0.35wt%-17.17wt%NaCl equivalent.The quartz veins yield δ^(18)O_(fluid) values of 0.15‰-10.45‰,low δD_(V-SMOW)values(-173‰ to-96‰),and the δ^(13)C values of-17.6‰ to-4.7‰,indicating the ore-forming fluids were a mix of metamorphic and sedimentary orogenic fluids with the addition of some meteoric and mantle-derived fluids.The pyrite within the diorite has δ^(34)S_(V-CDT) values of-2.9‰-1.9‰(average-1.1‰),^(206)Pb/^(204)Pb values of 18.47-18.64,^(207)Pb/^(204)Pb values of 15.64-15.74,and ^(208)Pb/^(204)Pb values of 38.71-39.27,all of which are indicative of the derivation of S and other ore-forming elements from deep in the mantle.The presence of the Nianzha,Bangbu,and Mayum gold deposits within the IYS zone indicates that this area is highly prospective for large orogenic gold deposits.We identified three types of mineralization within the IYS,namely Bangbu-type accretionary,Mayum-type microcontinent,and Nianzha-type ophiolite-associated orogenic Au deposits.The three types formed at different depths in an accretionary orogenic tectonic setting.The Bangbu type was formed at the deepest level and the Nianzha type at the shallowest. | ZHANG Xiong DENG Xueguo YANG Zhusen HOU Zengqian ZHENG Yuanchuan LIU Yingchao ZHAO Xiaoyan XU Bo PEI Yingru ZHOU Jinsheng ZHAO Miao YUAN Jianfei | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 4 |
| 8 | Gallic Acid: A Potential Anti-Cancer Agent显示文摘Cancer is one of the most devastating diseases worldwide and definitive therapeutics for treating cancer are not yet available despite extensive research efforts. The key challenges include limiting factors connected with traditional chemotherapeutics, primarily drug resistance, low response rates, and adverse side-effects. Therefore, there is a high demand for novel anti-cancer drugs that are both potent and safe for cancer prevention and treatment. Gallic acid(GA), a natural botanic phenolic compound, can mediate various therapeutic properties that are involved in anti-inflammation, anti-obesity, and anti-cancer activities. More recently, GA has been shown to exert anti-cancer activities via several biological pathways that include migration, metastasis, apoptosis, cell cycle arrest, angiogenesis, and oncogene expression. This review discusses two aspects, one is the anti-cancer potential of GA against different types of cancer and the underlying molecular mechanisms, the other is the bibliometric analysis of GA in cancer and tumor research. The results indicated that lung cancer, prostate cancer, stomach cancer, and colon adenocarcinoma may become a hot topic in further research. Overall, this review provides evidence that GA represents a promising novel, potent, and safe anti-cancer drug candidate for treating cancer. | JIANG Yuan PEI Jin ZHENG Yan MIAO Yu-jing DUAN Bao-zhong HUANG Lin-fang | 2022 | Chinese Journal of Integrative Medicine2022，28，7： | 4 |
| 9 | Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma显示文摘AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CRC) development.METHODS:Tissue microarrays were prepared from archival paraffin embedded tissue,including 51 colorectal carcinomas,25 tubular adenomas (TA) and 26 HPs,each with matched normal colonic epithelium.Immunohistochemistry was performed using antibodies against TIF1γ,Smad4 and TGFβ RⅡ.The levels of expression were scored semi-quantitatively (score 0-3 or loss and retention for Smad4).RESULTS:Overexpression of TIF1γ was detected in 5/26 (19%) HP;however,it was seen in a significantly higher proportion of neoplasms,15/25 (60%) TAs and 24/51 (47%) CRCs (P<0.05).Normal colonic mucosa,HP,and TAs showed strong Smad4 expression,while its expression was absent in 22/51 (43%) CRCs.Over-expression of TGFβ RⅡ was more commonly seen in neoplasms,13/25 (52%) TAs and 29/51 (57%) CRCs compared to 9/26 (35%) HP (P<0.05).Furthermore,there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value=0.35,P<0.05).The levels of TIF1γ overexpression were significantly higher in stage Ⅲ than in stage Ⅰ and Ⅱ CRC (P<0.05).CONCLUSION:The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis,is inversely related with Smad4 loss,and may be a prognostic indicator for poor outcome. | Shilpa Jain Shashideep Singhal Franto Francis Cristina Hajdu Jin-Hua Wang Arief Suriawinata Yin-Quan wang Miao Zhang Elizabeth H Weinshel Fritz Francois Zhi-Heng Pei Peng Lee Ru-Liang Xu | 2011 | World Journal of Gastroenterology2011，17，35： | 3 |
| 10 | ZrO2 nanoparticles anchored on nitrogen-doped carbon nanosheets as efficient catalyst for electrochemical CO2 reduction显示文摘Electrochemical reduction of CO2 to produce value-added feedstock chemicals using high-performance electrocatalysts is a promising protocol to address the excessive CO2 in the atmosphere and the energy crisis. However, the high overpotential, low current density, and poor product selectivity for CO2 electroreduction greatly impede their practical applications. In this work, we develop an efficient catalyst for CO2 reduction to CO consisting of well-dispersed ZrO2 nanoparticles tightly anchored on nitrogendoped carbon nanosheets(ZrO2/N-C) for the first time. Importantly, the ZrO2 nanoparticles possess oxygen vacancies and defects, which regulate the electronic structure of catalyst and thus greatly enhance the electrocatalytic activity. Specifically, ZrO2/N-C demonstrates a high CO Faradaic efficiency(FE) of 64% at-0.4 V vs. the reversible hydrogen electrode(RHE) and a respectable current density of ~2.6 m A cm-2 in CO2-saturated 0.5 M KHCO 3 solution. This work opens a new avenue for developing excellent catalysts for CO2 electroreduction with metal oxide/heteroatom-doped carbon composite structure. | Zhengpei Miao Pei Hu Chuanye Nie Huan Xie Wenli Fu Qing Li | 2019 | Journal of Energy Chemistry2019，28，11： | 3 |
| 11 | Circ-Smad5 retards the G1/S transition of cell cycle via inhibiting the activity of wnt/lef/cyclind1 signaling in JB6 cells显示文摘Circular RNAs are a large class of noncoding RNAs.Smad5 functions in cell differentiation,cell proliferation and metastasis.It has been reported that lnc-Smad5 can inhibit the proliferation of diffuse large B cell lymphoma.However,the function of circ-Smad5 has not yet been reported.Lentivirus vectors were constructed to establish circ-Smad5 upregulated and circ-Smad5 downregulated cell models.A CCK-8 assay was used to detect the proliferation of JB6 cells.FACS was used to analyze the cell cycle in the cell models.Western blot,immunofluorescence staining and TOP/FOP flash dual luciferase activity assays were used to determine the activity of the Wnt signaling pathway.The results revealed that the expression level of circ-Smad5 in JB6 cells was significantly lower than the expression level of linearizedSmad5.Compared with the control group,the percentage of S phase cells and the expression level of cyclin D1 protein were significantly higher in the sh-circ-Smad5 group.In the sh-circSmad5 group,b-catenin and LEF-1 were significantly increased,p-b-catenin was significantly decreased,and the relative activity of the TOP/FOP reporter gene was higher compared to the control group levels.These phenomena could be reversed by treating with Wnt signaling inhibitor PNU-74654.We conclude that the circ-Smad5 retards the proliferation and the cell cycle progression of JB6 cells.Thus,circ-Smad5 may function by inhibiting the activation of Wnt/b-catenin/Lef 1 signaling,which inhibits the expression of cyclin D1.To the best of our knowledge,we are the first to report the function of circ-Smad5. | Xiaogen Ma Fei Xiang Zhuo Pei Jiafeng Miao Pan Wu Xiaofeng Song Yuhong Li Yiming Zhang | 2021 | Genes & Diseases2021，8，3： | 3 |
| 12 | Advances in Urban Meteorological Research in China显示文摘Over the past decades,a large number of studies have been carried out in the field of urban meteorology in China.This paper summarizes the main progress in urban meteorology research from four aspects:urban meteorological observation network and field campaign,multi-scale model of urban meteorology,interaction between urban meteorology and atmospheric environment,and the impacts of urbanization on weather and climate.Major advances are as follows.China’s major cities have established or are improving comprehensive urban meteorological observation networks characterized by multi-platform,multi-variable,multi-scale,multi-link,and multi-function.Beijing,Nanjing,Shanghai,and other cities carried out urban meteorological field campaigns,which were included in the WMO research demonstration project.Wind tunnel experiments and scale-model outdoor experiments were successfully conducted.Multi-scale urban meteorological and air quality prediction numerical model systems have been developed and put into operational use.The urban heat island effect;urban impacts on precipitation,regional climate,and air quality;urban planning;and interaction between urban meteorology and atmospheric environment are extensively investigated.Finally,efforts to improve observational technology,data assimilation,and urban system modeling,to explore the impacts of urbanization on environment and human health,and to provide integrated urban hydro-meteorological climate and environmental services are planned ahead. | Shiguang MIAO Weimei JIANG Ping LIANG Hongnian LIU Xuemei WANG Jianguo TAN Ning ZHANG Ju LI Wupeng DU Lin PEI | 2020 | Journal of Meteorological Research2020，34，2： | 2 |
| 13 | Development and characterization of new allohexaploid resistant to web blotch in peanut显示文摘Peanut diseases seriously threaten peanut production, creating disease-resistant materials via interspecific hybridization is an effective way to deal with this problem. In this study, the embryo of an interspecific F1 hybrid was obtained by crossing the Silihong(Slh) cultivar with Arachis duranensis(ZW55), a diploid wild species. Seedlings were generated by embryo rescue and tissue culture. A true interspecific hybrid was then confirmed by cytological methods and molecular markers. After treating seedlings with colchicine during in vitro multiplication, the established interspecific F1 hybrid produced seeds which were named as Am1210. With oligonucleotide fluorescence in situ hybridization(Oligo FISH), molecular marker evaluations, morphological and web blotch resistance characterization, we found that: 1) Am1210 was an allohexaploid between Slh and ZW55;2) the traits of spreading lateral branches, single-seeded or double-seeded pods and red seed coats were observed to be dominant compared to the erect type, multiple-seeded pods and brown seed coats;3) the web blotch resistance of Am1210 was significantly improved than that of Slh, indicating the contribution of the web blotch resistance from the wild parent A. duranensis. In addition, 69 dominant and co-dominant molecular markers were developed which could be both used to verify the hybrid in this study and to identify translocation or introgression lines with A. duranensis chromosome fragments in future studies as well. | WANG Si-yu LI Li-na FU Liu-yang LIU Hua QIN Li CUI Cai-hong MIAO Li-juan ZHANG Zhong-xin GAO Wei DONG Wen-zhao HUANG Bing-yan ZHENG Zheng TANG Feng-shou ZHANG Xin-you DU Pei | 2021 | Journal of Integrative Agriculture2021，20，1： | 2 |
| 14 | Finely Tuned Electron/Hole Transport Preference of Thiazoloisoindigo-based Conjugated Polymers by Incorporation of Heavy Chalcogenophenes显示文摘A series of copolymers of thiazoloisoindigo (Tzll) with different chalcogenophene trimers were synthesized to systematicllyinvestigate the chalcogen effect on their charge transport propertes.When only the middlethiophene ring of terthiphene(T-T-T)is replaced byheavier chalcogenophenes,a preference(expressed by the ratio of μe/μh)towards electron transport was observed descending from T-T-Tto T-Se-Tthen to T-Te-T(Se and Te stand for selenophene and tellurophene,respectively).On the other hand,with the increased number of heavierchalcogenophenes,a preference toward hole transport was observed descending from Se-T-Se to Se-Se-se then to Se-Te-Se.This phenomenon iswellexplained by the balance between the aromatic resonance energy of the chalcogenophenes and the electronegativity of the chalcogens.Specifically,P(TZll-T-Se-T)displayed relatively balanced ambipolar property(μh^(max)andμe^(max) of 3.77 and 1.59 cm^(2)·v^(-1)·s^(-1)with aμe/μh of 0.42).while P(Tll-Se-Te-Se)exhibited the best preference to hole transfer with a u.u,of 0.09.P(Tzll-T-Te-T)exhibited the best preference to electrontransfer with aμe/μl,of 16 and theμe^(max)of 0.64 cm^(2)·v^(-).s^(-1)which is the highest electron mobility among the known conjugated polymerscontaining tellurophenes. | Chen-Chen Li Miao Xiong Jia-Wei Peng Jie-Yu Wang Huan-Rui Zhang You-Bing Mu Jian Pei Xiao-Bo Wan | 2021 | Chinese Journal of Polymer Science2021，39，7： | 2 |
| 15 | Antitumor activity of polysaceha- rides from Lepista sordida against laryngocarcinoma in vitro and in vivo显示文摘 | Miao S Mao X Pei R | 2013 | Int J Biol Macromol2013，60，： | 1 |
| 16 | Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE显示文摘Dear Editor,Previous studies have proved that regulatory T cell(Treg)insufficiency contributed to the development of autoimmune conditions including systemic lupus erythematosus(SLE).Conventional immunosuppressive treatment was reported to downregulate beneficial Tregs together with pathogenic effector immune cells,which may impede a rapid achievement of optimal therapeutic effects. | Haotian Zhou Xiaozhen Zhao Ruijun Zhang Miao Miao Wenwen Pei Zijun Li Yimin Li Jing He Zhanguo Li Xiaolin Sun | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 17 | From soft sets to information systems显示文摘 | Pei D Miao D | 2005 | Proc of Granular Computing IEEE2005，2，： | 1 |
| 18 | Molecular Detection and Identification of Candidatus Ehrlichia Hainanensis,A Novel Ehrlichia Species in Rodents from Hainan Province,China显示文摘Ehrlichia(Anaplasmataceae family)are obligatory intracellular bacteria that infect humans and animals.They are hosted by mammals such as canines,bovines and wild rodents,and are vectored by ticks.In this study,we collected 121 rodent samples comprising 67 Niviventer fulvescens,27 Rattus tanezumi,24 Chiromyscus sp.,2 Rattus nitidus and 1 Leopoldamys edwardsi from Hainan province,which includes the second largest island in China.The presence and genetic diversity of Ehrlichia species was evaluated and characterized by amplification and sequencing of 16S rRNA,groEL and gltA genes.An Ehrlichia species was detected in 5 of the 67 Niviventer fulvescens samples(7.46%).The 16S rRNA,groEL and gltA genes showed the highest identity to known Ehrlichia sequences(99.20%,89.87%and 83.86%,respectively).In the phylogenetic trees they formed a cluster distinct from all other species.We propose that this species is a putative novel Ehrlichia species,which we suggest be named Candidatus Ehrlichia hainanensis.Its pathogenicity to humans remains to be further researched,and molecular surveillance in local populations is needed. | ZHAO Hong Qing LIU Pei Pei XUE Feng LU Miao QIN Xin Cheng LI Kun | 2021 | Biomedical and Environmental Sciences2021，34，12： | 1 |
| 19 | Predictive factors for different subgroups of central lymph node metastasis in unilateral papillary thyroid carcinoma显示文摘 | Miao SS Mao SH Pei R | 2013 | ORL J Otorhinolaryngol Relat Spec2013，75，5： | 1 |
| 20 | Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N -methyl-D-aspartate receptor-mediated Akt1 activation显示文摘 | Miao B Yin X H Pei D S | 2005 | J Biol Chem2005，280，21： | 1 |
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