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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Outcome of oculomotor nerve palsy from posterioa communicating atery aneurysm:comparison of clipping and coiling显示文摘 | Peng RC Sepideh AH Felipe CA | 2006 | Neurosurgy2006，58，： | 1 |
| 3 | The role of angiotensin receptor blocks and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular disease:meta-analysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 4 | Cyclosporine and tacrolimus- associated thrombotic microangiopathy 显示文摘 | Pham PT Peng A Wilkinson AH | 2000 | Am J Kidney Dis2000，36，4： | 1 |
| 5 | The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases:meta-analysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 6 | The role of angiotensin receptor blockers and or angiotensinconverting enzyme inhibitors in the prevent- ion of atriafibrillation in patient with cardiovascular disease metaanalysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electr ophysio 12004，27，10： | 1 |
| 7 | Outcome of oculomo tor nerve palsy from posterioa communicating atery aneu rysm:comparison of clipping and coiling显示文摘 | Peng RC Sepideh AH Fekipe CA | 2006 | Neurosurgy2006，58，： | 1 |
| 8 | The role of angiotensin receptor blockers and or angiotensin converting enzyme inhibitors in the prevention of atria fibrillation in patient with cardiovascular disease meta-analysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 9 | The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases:meta-analysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 10 | The role of angiotensin receptor blockers and/or angiutensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases: meta-analysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，： | 1 |
| 11 | Cyclosporine and tacrolimus - a,ssociated thrombotic microangiopathy显示文摘 | Pham PT Peng A Wilkinson AH | 2000 | Am J Kidney Dis2000，36，4： | 1 |
| 12 | The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases:meta-analysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 13 | Molecular imprinting polymer coated BAW bio-mimic sensor for direct determination of epinephrine显示文摘 | Liang CD Peng H Zhuo AH | 2000 | Anal Chim Acta2000，415，： | 1 |
| 14 | The gennme of the mesopolyploid crop species Brassica rapa 显示文摘 | Wang X Wang H Wang J Sun R Wu J Liu S Bai Y Mun JH Bancroft I Cheng F Huang S Li X Hua W Wang J Wang X Freeling M Pires JC Paterson AH Chalhoub B Wang B Hayward A Sharpe AG Park BS Weisshaar B Liu B Li B Liu B Tong C Song C Duran C Peng C Geng C Koh C Lin C Edwards D Mu D Shen D Soumpourou E Li F Fraser F Conant G Lassalle G King G J Bonnema G Tang H Wang H Belcram H Zhou H Hirakawa H Abe I-I Guo H Wang H Jin H Parkin IA Batley J Kim JS Just J l i J Xu J Deng J Kim JA Li J Yu J Meng J Wang J Min J Poulain J Wang J Hatakeyama K Wu K Wang L Fang L Trick M Links MG Zhao M Jin M Ramchiary N Drou N Berkman PJ Cai Q Huang Q Li R Tabata S Cheng S Zhang S Zhang S Huang S Sato S Sun S Kwon SJ Choi SR Lee TH Fan W Zhao X Tan X Xu X Wang Y Qiu Y Yin Y l i Y Du Y Liao Y Lira Y Narusaka Y Wang Y Wang Z Li Z Wang Z Xiong Z Zhang Z Brassica rapa Genome Sequencing Project Consortium | 2011 | Nature Genetics2011，43，10： | 1 |
| 15 | Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA显示文摘 | Yin AH Peng CF Zhao X | 2015 | Proc Natl Acad S ci U S A2015，112，14： | 1 |
| 16 | Pharmacological effects of Niancian Milian Chuanbei Pipa Gao显示文摘 | Li ZL Dai BQ Liang AH Li GQ Yang Q Peng BY 1994 | 1994 | China Journal of Chinese Materia Medica1994，19，9： | 1 |
| 17 | The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases: meta-analysis of randomized controlled clinical trials 显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 18 | The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases:meta-analysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 19 | The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases : meta-analysis of randomized controlled clinical trials 显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 20 | The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases:meta analysis of randomized controlled clinical trials显示文摘 | Madrid AH Peng J Zamora J | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
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