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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | Rice Straw-Derived Biochar Properties and Functions as Cu(Ⅱ) and Cyromazine Sorbents as Influenced by Pyrolysis Temperature显示文摘In this study, biochars from rice straw(Oryza sativa L.) were prepared at 200–600?C by oxygen-limited pyrolysis to investigate the changes in properties of rice straw biochars produced at different temperatures, and to examine the adsorption capacities of the biochars for a heavy metal, copper(Ⅱ)(Cu(Ⅱ)), and an organic insecticide of cyromazine, as well as to further reveal the adsorption mechanisms.The results obtained with batch experiments showed that the amount of Cu(Ⅱ) adsorbed varied with the pyrolysis temperatures of rice straw biochar. The biochar produced at 400?C had the largest adsorption capacity for Cu(Ⅱ)(0.37 mol kg-1) among the biochars,with the non-electrostatic adsorption as the main adsorption mechanism. The highest adsorption capacity for cyromazine(156.42 g kg-1) was found in the rice straw biochar produced at 600?C, and cyromazine adsorption was exclusively predominated by surface adsorption. An obvious competitive adsorption was found between 5 mmol L-1Cu(II) and 2 g L-1cyromazine when they were in the binary solute system. Biochar may be used to remediate heavy metal- and organic insecticide-contaminated water, while the pyrolysis temperature of feedstocks for producing biochar should be considered for the restoration of multi-contamination. | JIANG Jun Yongbo PENG YUAN Min HONG Zhineng WANG Dejian XU Renkou | 2015 | Pedosphere2015，25，5： | 7 |
| 3 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 4 | Marine Carbon-Sulfur Biogeochemical Cycles during the Steptoean Positive Carbon Isotope Excursion(SPICE) in the Jiangnan Basin, South China显示文摘Global occurrences of Steptoean Positive Carbon Isotope Excursion(SPICE) during Late Cambrian recorded a significant perturbation in marine carbon cycle, and might have had profound impacts on the biological evolution. In previous studies, SPICE has been reported from the Jiangnan slope belt in South China. To evaluate the bathymetric extent of SPICE, we investigate the limestone samples from the upper Qingxi Formation in the Shaijiang Section in the Jiangnan Basin. Our results show the positive excursions for both carbonate carbon(δ^(13)C) and organic carbon(δ^(13)C_(org)) isotopes, as well as the concurrent positive shifts in sulfur isotopes of carbonate associated sulfate(CAS, δ^(34)S_(CAS)) and pyrite(δ^(34)S_(pyrite)), unequivocally indicating the presence of SPICE in the Jiangnan Basin. A 4‰ increase in δ^(13)C_(carb) of the Qingxi limestone implies the increase of the relative flux of organic carbon burial by a factor of two. Concurrent positive excursions in δ^(34)S_(CAS) and δ^(34)S_(pyrite) have been attributed to the enhanced pyrite burial in oceans with extremely low concentration and spatially heterogeneous isotopic composition of seawater sulfate. Here, we propose that the seawater sulfur isotopic heterogeneity can be generated by volatile organic sulfur compound(VOSC, such as methanethiol and dimethyl sulfide) formation in sulfidic continental margins that were widespread during SPICE. Emission of 32S-enriched VOSC in atmosphere, followed by lateral transportation and aerobic oxidation in atmosphere, and precipitation in open oceans result in a net flux of ^(32)S from continental margins to open oceans, elevating δ^(34)S of seawater sulfate in continental margins. A simple box model indicates that about 35% to 75% of seawater sulfate in continental margins needs to be transported to open oceans via VOSC formation. | Yang Peng Yongbo Peng Xianguo Lang Haoran Ma Kangjun Huang Fangbing Li Bing Shen | 2016 | Journal of Earth Science2016，27，2： | 5 |
| 5 | Exposing Cu-rich {110} active facets in PtCu nanostars for boosting electrochemical performance toward multiple liquid fuels electrooxidation显示文摘In catalysis,tuning the structural composition of the metal alloy is known as an efficient way to optimize the catalytic activity.This work presents the synthesis of compositional segregated six-armed PtCu nanostars via a facile solvothermal method and their distinct composition-structure-dependent performances in electrooxidation processes.The alloy is shown to have a unique six arms with a Cu-rich dodecahedral core,mainly composed of {110} facets and exhibit superior catalytic activity toward alcohols electrooxidation compared to the hollow counterpart where Cu was selectively etched.Density functional theory (DFT) calculations suggest that the formation of hydroxyl intermediate (OH^*) is crucial to detoxify CO poisoning during the electrooxidation processes.The addition of Cu is found to effectively adjust the d band location of the alloy catalyst and thus enhance the formation of ^*OH intermediate from water splitting,which decreases the coverage of ^*CO intermediate.Our work demonstrates that the unique compositional anisotropy in alloy catalyst may boost their applications in electrocatalysis and provides a methodology for the design of this type catalyst. | Liping Huang Wei Zhang Peng Li Yongbo Song Hongting Sheng Yuanxin Du Yang-Gang Wang Yuen Wu Xun Hong Yanhuai Ding Xiaoyou Yuan Manzhou Zhu | 2019 | Nano Research2019，12，5： | 4 |
| 6 | Early Cretaceous Climate Changes Recorded in Magnetic Susceptibility and Color Index Variations of the Lower Liupanshan Group, Central China显示文摘This study carried out comprehensive analysis on sedimentology, magnetic susceptibility(χlf) and color data of the continental sediments of the Liupanshan Group in Central China so as to obtain climatic change information during the 129.14–122.98 Ma interval. Based on the results of the ?lf and of the redness(a*), the section can be divided into two segments:(1) 129.14–126.3 Ma, with the lowest ?lf values and strongly variable relatively high values of redness and(2) 126.3–122.98 Ma, with high ?lf values and relatively low redness. Analysis of the lithology and facies as well as the magnetic minerals and their contents points to a detrital origin of the magnetic minerals and this allow us to interpret the relationship between magnetic susceptibility variations and climate changes. Our study shows that the climate was significantly dry and hot during the whole studied interval although the interval between 126.3 Ma and 122.98 was a little bit cooler with increased humidity. | DAI Shuang ZHU Qiang HUANG Yongbo DA SILVA Anne-Christine ZHAO Jie LIU Junwei KONG Li PENG Dongxiang LUO Lingling YAN Ningyun WANG Wenjie ZHANG Xiang | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 3 |
| 7 | Validating the deep time carbonate carbon isotope records: effect of benthic flux on seafloor carbonate显示文摘It is a consensus that marine carbonate archives the isotopic composition of seawater dissolved inorganic carbon(DIC,δ13Csw),the largest active C reservoir in the hydrosphere.Carbonate carbon isotope(δ13Ccarb)excursions have been used to reflect perturbations of the global carbon cycle and related environmental change.However,the deep timeδ13Ccarb records indicate faster and more pronounced perturbations of the carbon cycle compared to the present day.Here,we reportδ13Ccarb and elemental compositions of Late Paleozoic carbonate sections from South China,showing negative correlations betweenδ13-Ccarb and Fe^(2+)content of carbonate(Fecarb).We suggest that,because Late Paleozoic carbonate was mainly produced by benthic carbonate-secreting organisms,δ13Ccarbrecorded the isotopic composition near the seafloor,where benthic flux derived from anaerobic organic matter degradation delivers both Fe2+and 13C-depleted DIC from porewater.The binary mixing between seawater and benthic flux would result in the deviation ofδ13Ccarb fromδ13Csw.The negative correlation implies thatδ13Ccarb is influenced by benthic flux and is affected by the seafloor redox and sedimentation rate.The deep time spatially heterogeneous and temporally oscillatoryδ13Ccarb records in the basin-scale could be alternatively attributed to the variations of local environmental factors rather than aδ13Csw depth-gradient.Thus,the seafloor carbonate precipitation is continuously affected by diagenetic reactions in sediments,suggesting thatδ13Ccarb recording the seawater DIC composition is conditional.Our study urges that the interpretation ofδ13Ccarb should also consider the sedimentary process and depositional environment of marine carbonate. | Weiming Ding Ting Nie Yongbo Peng Yuanlin Sun Jinzhuang Xue Bing Shen | 2021 | Acta Geochimica2021，40，3： | 2 |
| 8 | Sulfur and Oxygen Isotopes of Sulfate Extracted from Early Cambrian Phosphorite Nodules: Implications for Marine Redox Evolution in the Yangtze Platform显示文摘Phosphorite nodule beds are discovered in the black shale of basal Niutitang Formation throughout the Yangtze Platform in South China, recording an important phosphorite-generation event. Platform-wide phosphorite precipitation requires special oceanographic and geochemical conditions, thus the origin of the Niutitang phosphorite nodules may provide valuable information about the ocean chemistry in the Early Cambrian. In this study, we measured sulfur and oxygen isotopic compositions of sulfate extracted from phosphorite nodules collected from the basal Niutitang Formation. Phosphorite associated sulfate(PAS) is a trace amount of sulfate that incorporates into crystal lattice during phosphorite precipitation, accordingly PAS records the geochemical signals during phosphorite nodule formation. Sulfur isotopic composition of PAS(δ^(34)S_(PAS)) ranges from-1.16‰ to +24.48‰(mean=+8.19‰, n=11), and oxygen isotopic value(δ^(18)O_(PAS)) varies between-5.3‰ and +26.3‰(mean=+7.0‰, n=8). Most phosphorite nodules have low δ^(34)SPAS and low δ^(18)O_(PAS) values, suggesting PAS mainly derived from anaerobic oxidation of H_2S within suboxic sediment porewater. We propose that phosphate was delivered to the Yangtze Platform by a series of upwelling events, and was scavenged from seawater with the precipitation of FeOOH. The absorbed phosphate was released into suboxic porewater by the reduction of FeOOH at the oxic-suboxic redox boundary in sediments, and phosphorite nodule precipitated by the reaction of phosphate with Ca^(2+) diffused from the overlying seawater. The platform-wide deposition of phosphorite nodules in the basal Niutitang Formation implies the bottom water might be suboxic or even oxic, at least sporadically, in Early Cambrian. We speculate that the intensified ocean circulation as evident with frequent occurrences of upwelling events might be the primary reason for the episodic oxidation of the Yangtze Platform in Early Cambrian. | Wenlang Qiao Xianguo Lang Yongbo Peng Kaiyuan Jiang Wu Chen Kangjun Huang Bing Shen | 2016 | Journal of Earth Science2016，27，2： | 2 |
| 9 | A Great late Ediacaran ice age显示文摘The emergence of the Ediacara biota soon after the Gaskiers glaciation ca.580 million years ago(Ma)implies a possible glacial fuse for the evolution of animals.However,the timing of Ediacaran glaciation remains controversial because of poor age constraints on the∼30 Ediacaran glacial deposits known worldwide.In addition,paleomagnetic constraints and a lack of convincing Snowball-like cap carbonates indicate that Ediacaran glaciations likely did not occur at low latitudes.Thus,reconciling the global occurrences without global glaciation remains a paradox.Here,we report that the large amplitude,globally synchronous ca.571–562 Ma Shuram carbon isotope excursion occurs below the Ediacaran Hankalchough glacial deposit in Tarim,confirming a post-Shuram glaciation.Leveraging paleomagnetic evidence for a∼90°reorientation of all continents due to true polar wander,and a non-Snowball condition that rules out low-latitude glaciations,we use paleogeographic reconstructions to further constrain glacial ages.Our results depict a‘Great Ediacaran Glaciation’occurring diachronously but continuously from ca.580–560 Ma as different continents migrated through polar–temperate latitudes.The succession of radiation,turnover and extinction of the Ediacara biota strongly reflects glacial–deglacial dynamics. | Ruimin Wang Bing Shen Xianguo Lang Bin Wen Ross N.Mitchell Haoran Ma Zongjun Yin Yongbo Peng Yonggang Liu Chuanming Zhou | 2023 | National Science Review2023，10，8： | 2 |
| 10 | Advances of the probability density evolution method for nonlinear stochastic systems显示文摘 | Jie Li Jianbing Chen Weiling Sun Yongbo Peng | 2011 | Probabilistic Engineering Mechanics2011，，： | 2 |
| 11 | Safety Analysis for Thread Pair Clearance of Safety Mechanism of Three Gorges Project Ship Lift显示文摘The Three Gorges Project(TGP) ship lift employs 4 safety mechanisms, of which one consists of a rotary locking screw and a nut jaw column. The thread pair clearance(TPC) of safety mechanisms is set at 60 mm. Owing to influential factors,the TPC changes randomly in the upward/downward-stroke of the ship chamber. If it diminished to 0, the safety mechanism would be jammed, thus resulting in disastrous accidents. By the bearing test of the drive system, 7 influential factors have been studied; 15 other influential factors(including 8 factors of manufacture and installation deviation, 3 factors of chamber offset, 2 factors of external load and 2 factors of wear) have been analyzed based on the design data. Results by the limit superposition reveal that the TPC change varies from -43.8 mm to +48.4 mm when the water level of the chamber ranges from 3.4 m to 3.6 m. According to the Gaussian distribution, the probability of the TPC change varied from -53.7 mm to +58.8 mm in the most detrimental status is99.74%, therefore, the TPC remains in a safe condition. This paper puts forward that two-phase operation of the drive system should be adopted so as to reduce the maximum TPC change to -44.6 mm. | SHI Duanwei CHENG Shuxiao ZHAO Tiezhu PENG Hui WANG Yongbo | 2014 | Wuhan University Journal of Natural Sciences2014，19，6： | 2 |
| 12 | Quantifying the carbon source of pedogenic calcite veins in weathered limestone: implications for the terrestrial carbon cycle显示文摘The continent is the second largest carbon sink on Earth’s surface.With the diversification of vascular land plants in the late Paleozoic,terrestrial organic carbon burial is represented by massive coal formation,while the development of soil profiles would account for both organic and inorganic carbon burial.As compared with soil organic carbon,inorganic carbon burial,collectively known as the soil carbonate,would have a greater impact on the long-term carbon cycle.Soil carbonate would have multiple carbon sources,including dissolution of host calcareous rocks,dissolved inorganic carbon from freshwater,and oxidation of organic matter,but the host calcareous rock dissolution would not cause atmospheric CO2drawdown.Thus,to evaluate the potential effect of soil carbonate formation on the atmospheric p CO2level,different carbon sources of soil carbonate should be quantitatively differentiated.In this study,we analyzed the carbon and magnesium isotopes of pedogenic calcite veins developed in a heavily weathered outcrop,consisting of limestone of the early Paleogene Guanzhuang Group in North China.Based on the C and Mg isotope data,we developed a numerical model to quantify the carbon source of calcite veins.The modeling results indicate that4–37 wt%of carbon in these calcite veins was derived from atmospheric CO2.The low contribution from atmospheric CO2might be attributed to the host limestone that might have diluted the atmospheric CO2sink.Nevertheless,taking this value into consideration,it is estimated that soil carbonate formation would lower 1 ppm atmospheric CO2within 2000 years,i.e.,soil carbonate alone would sequester all atmospheric CO2within 1 million years.Finally,our study suggests the C–Mg isotope system might be a better tool in quantifying the carbon source of soil carbonate. | Lin Zou Lin Dong Meng Ning Kangjun Huang Yongbo Peng Shujian Qin Honglin Yuan Bing Shen | 2019 | Acta Geochimica2019，38，4： | 2 |
| 13 | Cracking the superheavy pyrite enigma:possible roles of volatile organosulfur compound emission显示文摘The global deposition of superheavy pyrite(pyrite isotopically heavier than coeval seawater sulfate in the Neoproterozoic Era and particularly in the Cryogenian Period)defies explanation using the canonical marine sulfur cycle system.Here we report petrographic and sulfur isotopic data(δ^(34)Spy)of superheavy pyrite from the Cryogenian Datangpo Formation(660–650 Ma)in South China.Our data indicate a syndepositional/early diagenetic origin of the Datangpo superheavy pyrite,with ^(34)S-enriched H_(2)S supplied from sulfidic(H_(2)S rich)seawater.Instructed by a novel sulfur-cycling model,we propose that the emission of ^(34)S-depleted volatile organosulfur compounds(VOSC)that were generated via sulfide methylation may have contributed to the formation of ^(34)S-enriched sulfidic seawater and superheavy pyrite.The global emission of VOSC may be attributed to enhanced organic matter production after the Sturtian glaciation in the context of widespread sulfidic conditions.These findings demonstrate that VOSC cycling is an important component of the sulfur cycle in Proterozoic oceans. | Xianguo Lang Zhouqiao Zhao Haoran Ma Kangjun Huang Songzhuo Li Chuanming Zhou Shuhai Xiao Yongbo Peng Yonggang Liu Wenbo Tang Bing Shen | 2021 | National Science Review2021，8，10： | 2 |
| 14 | PTMD: A Database of Human Disease-associated Post-translational Modifications显示文摘Various posttranslational modifications(PTMs) participate in nearly all aspects of biological processes by regulating protein functions, and aberrant states of PTMs are frequently implicated in human diseases. Therefore, an integral resource of PTM–disease associations(PDAs)would be a great help for both academic research and clinical use. In this work, we reported PTMD,a well-curated database containing PTMs that are associated with human diseases. We manually collected 1950 known PDAs in 749 proteins for 23 types of PTMs and 275 types of diseases from the literature. Database analyses show that phosphorylation has the largest number of disease associations, whereas neurologic diseases have the largest number of PTM associations. We classified all known PDAs into six classes according to the PTM status in diseases and demonstrated that the upregulation and presence of PTM events account for a predominant proportion of diseaseassociated PTM events. By reconstructing a disease–gene network, we observed that breast cancershave the largest number of associated PTMs and AKT1 has the largest number of PTMs connected to diseases. Finally, the PTMD database was developed with detailed annotations and can be a useful resource for further analyzing the relations between PTMs and human diseases. PTMD is freely accessible at http://gffzz7d3e84778ac14081hwxb66oc955ov6fun.ffgz.tsg.suse.edu.cn. | Haodong Xu Yongbo Wang Shaofeng Lin Wankun Deng Di Peng Qinghua Cui Yu Xue | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 2 |
| 15 | A nerve graft constructed with xenogeneic acellular nerve matrix and autologous adipose-derived mesenchymal stem cells显示文摘 | Yongjie Zhang Hailang Luo Ziqiang Zhang Yongbo Lu Xinhui Huang Lu Yang Jiajie Xu Wei Yang Xiaoju Fan Bing Du Peng Gao Gang Hu Yan Jin | 2010 | Biomaterials2010，，20： | 1 |
| 16 | Dynamic response and reliability analysis of tall buildings subject to wind loading显示文摘 | Zhang Linlin Li Jie Peng Yongbo | 2008 | Journal of Wind EngineeringandlndustrialAerdynamics2008，，96： | 1 |
| 17 | Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo显示文摘 | Yongbo Zhao Peng Luo Qindong Guo Sanzhong Li Lei Zhang Mingming Zhao Haoxiang Xu Yuefan Yang Waisang Poon Zhou Fei | 2012 | Experimental Neurology2012，，2： | 1 |
| 18 | Triple oxygen isotope constraints on the origin of ocean island basalts显示文摘Understanding the origin of ocean island basalts(OIB) has important bearings on Earth's deep mantle.Although it is widely accepted that subducted oceanic crust, as a consequence of plate tectonics, contributes material to OIB's formation, its exact fraction in OIB's mantle source remains ambiguous largely due to uncertainties associated with existing geochemical proxies. Here we show, through theoretical calculation, that unlike many known proxies, triple oxygen isotope compositions(i.e.D^(17 )O) in olivine samples are not affected by crystallization and partial melting. This unique feature, therefore, allows olivine D^(17 )O values to identify subducted oceanic crusts in OIB's mantle source. Furthermore, the fractions of subducted ocean sediments and hydrothermally altered oceanic crust in OIB's mantle source can be quantified using their characteristic D^(17 )O values. Based on published D^(17 )O data, we estimated the fraction of subducted oceanic crust to be as high as 22.3% in certain OIB, but the affected region in the respective mantle plume is likely to be limited. | Xiaobin Cao Huiming Bao Caihong Gao Yun Liu Fang Huang Yongbo Peng Yining Zhang | 2019 | Acta Geochimica2019，38，3： | 1 |
| 19 | The cryoprotec-tive effect of different konjac glucomannan (KGM) hydrolysateson the grass carp (Ctenopharyngodon idella) myofibrillar duringfrozen storage 显示文摘 | Wang Lan Xiong Guangquan Peng Yongbo | 2014 | Food and Bioprocess Technology2014，7，12： | 1 |
| 20 | Dynamic response and reliability analysis of tall buildings subject to wind loading显示文摘 | Zhang Linlin Li Jie Peng Yongbo | 2008 | Journal of Wind Engineering and Industrial Aerdynamics2008，96，1： | 1 |
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