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| 1 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 2 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 3 | cytoplasmic domain of tissue factor promotes liver fibrosis in mice显示文摘AIM To evaluate the role of tissue factor(TF) and protease activated receptor(PAR)-2 in liver fibrosis.METHODS Using CCl4 administration for eight weeks, we induced hepatic fibrosis in wild-type C57BL/6 mice and in mice with deletion of the cytoplasmic signalling domain of TF(TF§CT/§CT), deletion of PAR-2(PAR-2-/-) and combined deletion of TF signalling domain and PAR-2(TF§CT/§CT/PAR-2-/-). Hepatic fibrosis area was assessed by quantitative imaging of picrosirius red staining. Hepatic collagen content was assessed by hydroxyproline levels. Hepatic stellate cells(αSMA positive) and hepatic macrophages(CD68 positive) were identified by immunohistochemistry. Hepatic gene expression was determined by PCR and liver TGFβ1 content by ELISA.RESULTS CCl4 treated mice with deletion of the PAR-2 gene(PAR-2-/-) and the cytoplasmic domain of TF(TF§CT/§CT) developed significantly less hepatic fibrosis, characterised by reduced liver fibrosis area and hydroxyproline content, compared to control wildtype mice treated with CCl4. The observed reduction in histological fibrosis was accompanied by a significant decrease in the hepatic content of TGFβ, the prototypic fibrogenic cytokine, as well as fewer activated hepatic stellate cells and hepatic macrophages. Deletion of the TF cytoplasmic signalling domain reduced hepatic fibrosis to levels similar to thoseobserved in mice lacking PAR-2 signalling but combined deletion provided no added protection against fibrosis indicating a lack of mutual modulating effects that have been observed in other contexts such as angiogenic responses.CONCLUSION Tissue factor cytoplasmic domain is involved in TF-PAR-2 signalling initiating hepatic fibrosis and is a potential therapeutic target, as its deletion would not impact coagulation. | Virginia Knight Dinushka Lourensz Jorge Tchongue Jeanne Correia Peter Tipping William Sievert | 2017 | World Journal of Gastroenterology2017，23，31： | 3 |
| 4 | Geological uncertainty and risk:implications for the viability of mining projects显示文摘Computerized geological models are the basis of modern mine design,planning and production.A sound,validated geological model is essential to the success of a min- ing project.However,due to the complexity of geology surrounding deposits,geological models inherit uncertainty,or error.This geological uncertainty may significantly affect the risk profile of a mining project during its design and operational phases.Methodologies for quantifying geological uncertainty and risk have been developed by CRC Mining and the University of Queensland,Australia and successfully applied to case studies.This paper discussed the implications of geological uncertainty and risk to a coal mining project,and presents advances for quantifying geological/geotechnical uncertainty and risk.A case study is presented to demonstrate the application of the technology developed. | 李树兴 Peter Knights Doug Dunn | 2008 | Journal of Coal Science & Engineering(China)2008，14，2： | 2 |
| 5 | Employability Through the Curriculum显示文摘 | Peter T. Knight Mantz Yorke | 2002 | Tertiary Education and Management2002，，4： | 2 |
| 6 | Integration of real options into short-term mine planning and production scheduling显示文摘Commodity prices have fallen sharply due to the global financial crisis. This has adversely affected the viability of some mining projects, including leading to the possibility of bankruptcy for some companies. These price falls reflect uncertainties and risks associated with mining projects. In recent years, much work has been published related to the application of real options pricing theory to value life-of-mine plans in response to long term financial uncertainty and risk. However, there are uncertainties and risks associated with medium/short-term mining operations. Real options theory can also be applied to tactical decisions involving uncertainties and risks. This paper will investigate the application of real options in the mining industry and present a methodology developed at University of Queensland, Australia, for integrating real options into medium/short-term mine planning and production scheduling. A case study will demonstrate the validity and usefulness of the methodology and techniques developed. | KNIGHTS Peter | 2009 | Mining Science and Technology2009，19，5： | 2 |
| 7 | Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors显示文摘 | Edward Sausville Patricia LoRusso Michael Carducci Judith Carter Mary F. Quinn Lisa Malburg Nilofer Azad David Cosgrove Richard Knight Peter Barker Sonya Zabludoff Felix Agbo Patricia Oakes Adrian Senderowicz | 2014 | Cancer Chemotherapy and Pharmacology2014，，3： | 1 |
| 8 | Product design for manufacture and assembly显示文摘 | Geoffrey Boothroyd Peter Dewhurst winston Knight | | 0，，： | 1 |
| 9 | Rubidium- and caesium-doped silicotungstic acid catalysts supported on alumina for the catalytic dehydration of glycerol to acrolein显示文摘 | Muhammad H. Haider Nicholas F. Dummer Dazhi Zhang Peter Miedziak Thomas E. Davies Stuart H. Taylor David J. Willock David W. Knight David Chadwick Graham J. Hutchings | 2011 | Journal of Catalysis2011，，： | 1 |
| 10 | The Effect of Preservation Solutions for Storage of Liver Allografts on Transplant Outcomes: A Systematic Review and Meta-Analysis显示文摘 | John M. O?Callaghan Robert D. Morgan Simon R. Knight Peter J. Morris | 2014 | Annals of Surgery2014，，1： | 1 |
| 11 | Product design for manufacture and assembly显示文摘 | BOOTHROYD Geoffrey DEWHURST Peter KNIGHT Winston A | 1994 | Computer-Aided Design1994，26，7： | 1 |
| 12 | Information internalization and hurdle rates in small and medium enterprise internationalization 显示文摘 | Liesch Peter W Gary A Knight | 1999 | Journal al of International Business Studies1999，30，1： | 1 |
| 13 | Employability Through the Curriculum显示文摘 | Peter T. Knight Mantz Yorke | 2002 | Tertiary Education and Management2002，，4： | 1 |
| 14 | Aqueous phase biodegradation kinetics of 10 PAH compounds显示文摘 | KNIGHTES C D PETERS C A | 2003 | Environmental Engineering Science2003，20，3： | 1 |
| 15 | The Undergraduate Curriculum and Employability 显示文摘 | Mantz Yorke Peter Knight | 2005 | Ninth Quality in Higher Education International Seminar in collaboration with ESECT and The Independent2005，，9： | 1 |
| 16 | p73 induces apoptosis by different mechanisms显示文摘 | Saafa Ramadan Alessandro Terrinoni Maria Valeria Catani A. Emre Sayan Richard A. Knight Martina Mueller Peter H. Krammer Gerry Melino Eleonora Candi | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 17 | Simple Wind Energy Controller for an Expanded Operating Range 显示文摘 | Knight A M Peters G E | 2005 | IEEE Transactions on Energy Conversion2005，20，2： | 1 |
| 18 | Coming to Know in Higher Education: theorising faculty entry to new work contexts显示文摘 | Paul Trowler Peter T. Knight | 2000 | Higher Education Research & Development2000，，1： | 1 |
| 19 | Transforming Work Experience in Higher Education显示文摘 | Alison Blackwell Lindsey Bowes Lee Harvey Anthony J. Hesketh Peter T. Knight | 2001 | British Educational Research Journal2001，，3： | 1 |
| 20 | A systemic approach to professional develop- ment: learning as practice 显示文摘 | Peter Knight | 2002 | Teaching and Teacher Educa- tion2002，18，3： | 1 |
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