|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Telomerase activity: An attractive target for cancer therapeutics显示文摘Telomeres are non-coding tandem repeats of 1000-2000 TTAGGG nucleotide DNA sequences on the 3' termini of human chromosomes where they serve as protective 'caps' from degradation and loss of genes. The 'cap' at the end of chromosome required to protect its integrity is a 150-200 nucleotide-long single stranded G-rich 3' overhang that forms two higher order structures, a T-loop with Sheltering complex, or a G-quadruplex complex. Telomerase is a human ribonucleoprotein reverse transcriptase that continually added single stranded TTAGGG DNA sequences onto the single strand 3' of telomere in the 5' to 3' direction. Telomerase activity is detected in male germ line cells, proliferative cells of renewal tissues, some adult pluripotent stem cells, embryonic cells, but in most somatic cells is not detected. Re-expression or up-regulation of telomerase in tumours cells is considered as a critical step in cell tumorigenesis and telomerase is widely considered as a tumour marker and a target for anticancer drugs. Different approaches have been used in anticancer therapeutics targeting telomerase. Telomerase inhibitors can block directly Human TElomerase Reverse Transcriptase(h TERT) or Human TElomerase RNA telomerase subunits activity, or G-quadruplex and Sheltering com-plex components, shortening telomeres and inhibiting cell proliferation. Telomerase can become an immune target and GV1001, Vx-001, I540 are the most widespread vaccines used with encouraging results. Another method is to use h TERT promoter to drive suicide gene expression or to control a lytic virus replication. Recently telomerase activity was used to activate pro-drugs such as Acycloguanosyl 5'-thymidyltriphosphate, a synthetic ACV-derived molecule when it is activated by telomerase it does not require any virus or host active immune response to induce suicide gene therapy. Advantage of all these therapies is that target only neoplastic cells without any effects in normal cells, avoiding toxicity and adverse effects of the current chemotherapy. However, as not all the approaches are equally efficient, further studies will be necessary. | Lucia Picariello Cecilia Grappone Simone Polvani Andrea Galli | 2014 | World Journal of Pharmacology2014，3，4： | 3 |
| 2 | Evaluation of acid–base balance in ST-elevation myocardial infarction in the early phase: a prognostic tool?显示文摘 | Chiara Lazzeri Serafina Valente Marco Chiostri Claudio Picariello Gian Franco Gensini | 2010 | Coronary Artery Disease2010，，5： | 1 |
| 3 | Proteomic a- nalysis of water soluble and myofibrillar protein changes occurring in dry-cured hams 显示文摘 | Luccia A D Picariello G Cacace G | 2005 | Meat Science2005，69，： | 1 |
| 4 | Acid–base imbalance in uncomplicated ST-elevation myocardial infarction: the clinical role of tissue acidosis显示文摘 | Chiara Lazzeri Serafina Valente Marco Chiostri Claudio Picariello Gian Franco Gensini | 2010 | Internal and Emergency Medicine2010，，1： | 1 |
| 5 | Analysis of food proteins and peptides by mass spectrometry- based techniques 显示文摘 | Mamone G Picariello G Caira S | 2009 | Journal of Chromatography A2009，1216，43： | 1 |
| 6 | Using Renyi's information and wavelets for target detection:an application to mammo- grams显示文摘 | Boccignone G Chianese A Picariello A | 2000 | Pattern Analysis & Applications2000，3，： | 1 |
| 7 | The glucose dysmetabolism in the acute phase of non-diabetic ST-elevation myocardial infarction: from insulin resistance to hyperglycemia显示文摘 | Chiara Lazzeri Serafina Valente Marco Chiostri Paola Attanà Claudio Picariello Gian Franco Gensini | 2013 | Acta Diabetologica2013，，3： | 1 |
| 8 | DNA and nuclear aggregates of polyamines显示文摘 | Giuseppe Iacomino Gianluca Picariello Luciano D’Agostino | 2012 | BBA - Molecular Cell Research2012，，10： | 1 |
| 9 | A compar ison of methods for the analysis of low abundance proteins in desmoid tumor cells 显示文摘 | Picariello L Carbonell Sala S Martineti V etal | 2006 | Anal Biochem2006，354，2： | 1 |
| 10 | Impact of hypertension on short- and long-term prognoses in patients with ST elevation myocardial infarction and without previously known diabetes显示文摘 | Chiara Lazzeri Serafina Valente Marco Chiostri Paola Attanà Claudio Picariello Gian Gensini | 2012 | Heart and Vessels2012，，4： | 1 |
| 11 | Identification of N–linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry显示文摘 | Picariello G Ferranti P Mamone G | 2008 | Proteomics2008，8，38： | 1 |
| 12 | Protein digestomics:Integrated platforms to study food-protein digestion and derived functional and active peptides显示文摘 | PICARIELLO G MAMONE G NITRIDE C | 2013 | Tr AC Trends in Analytical Chemistry2013，52，： | 1 |
| 13 | Casein proteolysis in human milk:Tracing the pattern of casein breakdown and the formation of potential bioactive peptides显示文摘 | Ferranti P Traisci M V Picariello G | 2004 | Journal of Dairy Research2004，71，： | 1 |
| 14 | Prote- omic analysis in allergy and intolerance to wheat products 显示文摘 | Mamone G Picariello G Addeo F | 2011 | Expert Review of Proteo- mics2011，8，1： | 1 |
| 15 | Functional Estrogen Receptor β in Colon Cancer Cells显示文摘 | Gianna Fiorelli Lucia Picariello Valentina Martineti Francesco Tonelli Maria Luisa Brandi | 1999 | Biochemical and Biophysical Research Communications1999，，2： | 1 |
| 16 | Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts:effect of N-acetylcysteine and curcumin 显示文摘 | Fontani F Marcucci T Picariello L | 2014 | Exp Cell Res2014，323，1： | 1 |
| 17 | Estrogen metabolism in human colorectal cancer cells显示文摘 | Fiorelli G Picariello L Martinrti V | 2002 | J steroid Biochem Mol Biol2002，81，3： | 1 |
| 18 | Kinetic of procalcitonin in patients with cardiogenic shock following acute myocardial in- farction: preliminary data显示文摘 | Picariello C Lazzeri C Chiostri M | 2010 | HSR Proc Intensive Care Cardio- vasc Anesth2010，2，3： | 1 |
| 19 | Evaluation of gamma rays influence on some biochemical and microbiological aspects in black truffles显示文摘 | Nazzaro F Fratianni F Picariello G | 2007 | Food Chemistry2007，，103： | 1 |
| 20 | Preliminary data显示文摘 | Picariello C Lazzeri C Valente S Kinetics of procalcitonin in cardiogenie shock and in septic shock | 2010 | Acute Card Care2010，12，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员