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| 1 | MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer显示文摘Colorectal cancer(CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC(mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the monoclonal antibodies bevacizumab, cetuximab and panitumumab as well as the protein-trap aflibercept and the smallmolecule multi-kinase inhibitor regorafenib. One of the major problems for the management of CRC is the inherent or acquired resistance to therapeutic approaches. The discovery of microRNAs(miRNAs), a class of small, endogenous, non-coding, single-stranded RNAs that play a role as post-transcriptional regulators, has added new dimensions to the diagnosis and treatment of cancer. Because miRNAs are important regulators of carcinogenesis, progression, invasion, angiogenesis and metastases in CRC, they might serve as potential predictive and prognostic factors and even as therapeutic targets themselves. Several miRNAs are already known to be dysregulated in CRCs and have been linked to biological processes involved in tumor progression and response to anti-cancer therapies. This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients. | Verena Stiegelbauer Samantha Perakis Alexander Deutsch Hui Ling Armin Gerger Martin Pichler | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 2 | Assess- ment of vision - related quality of life in patients with central retinal artery occlusion 显示文摘 | Martin wager MD tamara pichler MS gabriele h franke PHD | 2014 | The journal of retinal and vitreous diseases2014，34，3： | 1 |
| 3 | Geochemistry of hydrothermal fluids from the PACMANUS, Northeast Pual and Vienna Woods hydrothermal fields, Manus Basin, Papua New Guinea显示文摘 | Eoghan P. Reeves Jeffrey S. Seewald Peter Saccocia Wolfgang Bach Paul R. Craddock Wayne C. Shanks Sean P. Sylva Emily Walsh Thomas Pichler Martin Rosner | 2010 | Geochimica et Cosmochimica Acta2010，，4： | 1 |
| 4 | External Validation of the Leibovich Prognosis Score for Nonmetastatic Clear Cell Renal Cell Carcinoma at a Single European Center Applying Routine Pathology显示文摘 | Martin Pichler Georg C. Hutterer Thomas F. Chromecki Johanna Jesche Karin Kampel-Kettner Peter Rehak Karl Pummer Richard Zigeuner | 2011 | The Journal of Urology2011，，5： | 1 |
| 5 | Clinical and laboratory profiles of a large co- hort of patients with different grades of varicocele显示文摘 | Badereddin Mohamad A1 - Ali Rany Shamloul Martin Pichler | 2013 | Cent European J Urol2013，66，1： | 1 |
| 6 | The role of polycomb repressive complexes in biliary tract cancer显示文摘 | Christian Mayr Daniel Neureiter Andrej Wagner Martin Pichler Tobias Kiesslich | 2015 | Expert Opinion on Therapeutic Targets2015，，： | 1 |
| 7 | Cytotoxic effects of chemokine receptor 4 inhibition by AMD3100 in biliarytract cancer cells: Potential drug synergism with gemcitabine显示文摘 | Christian Mayr Daniel Neureiter Martin Pichler Frieder Berr Andrej Wagner Tobias Kiesslich Konrad Namberger | 2015 | Molecular Medicine Reports2015，，： | 1 |
| 8 | Some parameters of negative upward-initiated lightning to the Gaisberg tower (2000 -2007) 显示文摘 | Gerhard Diendorfer Hannes Pichler Martin Mair | 2009 | IEEE Transactions on Electromag netic Compatibility2009，50，3： | 1 |
| 9 | Comprehensive analysis of alterations in the miRNome in response to photodynamic treatment显示文摘 | Doris Bach Julia Fuereder Michael Karbiener Marcel Scheideler Anna Lena Ress Daniel Neureiter Ralf Kemmerling Otto Dietze Markus Wiederstein Frieder Berr Kristjan Plaetzer Tobias Kiesslich Martin Pichler | 2013 | Journal of Photochemistry & Photobiology B: Biology2013，，： | 1 |
| 10 | C-Reactive Protein, Carotid Atherosclerosis, and Cerebral Small-Vessel Disease: Results of the Austrian Stroke Prevention Study显示文摘 | Reinhold Schmidt Helena Schmidt Martin Pichler Christian Enzinger Katja Petrovic Kurt Niederkorn Susanna Horner Stefan Ropele Norbert Watzinger Martin Schumacher Andrea Berghold Gerhard M. Kostner Franz Fazekas | 2006 | Stroke2006，，12： | 1 |
| 11 | Mapping the clinical practice of traditional,complementary and integrative medicine in oncology in Western countries:A multinational cross-sectional survey显示文摘Background Many cancer patients seek adjunctive therapies to biomedical cancer treatments at some point of their disease trajectory.While acupuncture is increasingly recommended by leading oncological associations,limited evidence exists concerning the evidence-informed practice and adherence to current guidelines of traditional complementary and integrative medicine(TCIM)practitioners treating cancer patients.Methods An international online-survey assessed the demographical data,clinical practice,and sources of information used by TCIM practitioners in Austria,Germany,United States of America,Australia,and New Zealand.Results In total,404 respondents completed the survey,of which 254(62.9%)treated cancer patients.Most practitioners were acupuncturists and herbalists(57.1%),had(16.8±9.9)years of clinical experience and see a median of 2(1,4)cancer patients per week.Breast cancer(61.8%)is the most common cancer type seen in TCIM clinics.Adjunctive TCIM treatments are frequently concurrent with the patient’s cancer specific treatment(39.9%),which is also reflected by the main goal of a TCIM treatment to alleviate side effects(52.4%).However,only 28.0%of the respondents are in contact with the treating oncologist.According to the respondents,pain is most effectively treated using acupuncture,while herbal medicine is best for cancer-related fatigue.TCIM practitioners mostly use certified courses(33.1%)or online databases(28.3%)but often believe that experts are more reliable to inform their practice(37.0%)than research publications(32.7%).Conclusion Acupuncturists and herbalists commonly treat cancer patients.Most practitioners use TCIM as an adjunct to biomedicine as supportive care and use it largely in accordance with current oncological guidelines. | Matthias Huemer Sandro Graca Sarah Bitsche Guenter Hofmann Mike Armour Martin Pichler | 2024 | Journal of Integrative Medicine2024，22，1： | 0 |
| 12 | SCHGAGULER酒店显示文摘SCHGAGULER酒店位于意大利北部Alto Adige地区的Castelrotto小镇,当地因其民俗文化和自然环境而闻名,也正处于联合国教科文组织保护的Dolomites地区山脉和景观的中心地带。SCHGAGULER酒店始建于1986年,Peter Pichler建筑事务所于去年接手此案并完成酒店的改造。 | Peter Pichler Silvana Ordinas Giovannl Paterlini Danieie Colombah Cem Ozbasaran Glanluigi D’Aloisio Ugo Licciardi Oskar Dariz(摄) Martin Schgaguler(摄) 李薇(编译) 蒋鋒光 | 2019 | 现代装饰2019，0，10： | 0 |
| 13 | High-altitude illnesses:Old stories and new insights into the pathophysiology,treatment and prevention显示文摘Areas at high-altitude,annually attract millions of tourists,skiers,trekkers,and climbers.If not adequately prepared and not considering certain ascent rules,a considerable proportion of those people will suffer from acute mountain sickness(AMS)or even from life-threatening high-altitude cerebral(HACE)or/and pulmonary edema(HAPE).Reduced inspired oxygen partial pressure with gain in altitude and consequently reduced oxygen availability is primarily responsible for getting sick in this setting.Appropriate acclimatization by slowly raising the hypoxic stimulus(e.g.,slow ascent to high altitude)and/or repeated exposures to altitude or artificial,nor-mobaric hypoxia will largely prevent those illnesses.Understanding physiological mechanisms of acclimatization and pathophysiological mechanisms of high-altitude diseases,knowledge of symptoms and signs,treatment and prevention strategies will largely contribute to the risk reduction and increased safety,success and enjoyment at high altitude.Thus,this review is intended to provide a sound basis for both physicians counseling high-altitude visitors and high-altitude visitors themselves. | Martin Burtscher Urs Hefti Jacqueline Pichler Hefti | 2021 | Sports Medicine and Health Science2021，3，2： | 0 |
| 14 | Biliary tract cancer stem cells-translational options and challenges显示文摘Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells-the cancer stem cells-possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells. | Christian Mayr Matthias Ocker Markus Ritter Martin Pichler Daniel Neureiter Tobias Kiesslich | 2017 | World Journal of Gastroenterology2017，23，14： | 0 |
| 15 | Pancreatitis, panniculitis and polyarthritis syndrome: A case report显示文摘BACKGROUND Pancreatitis,panniculitis,and polyarthritis(PPP)syndrome is a rare form of pancreatic disease.It is characterized by bullous erythematous skin lesions and arthritis,and both are triggered by pancreatic malfunction.Few cases have been described in the literature thus far.Due to the inconsistency in its clinical presentation,its diagnosis can be a challenge.Early therapy initiation is essential to reduce mortality;however,there is currently no gold standard for treatment.CASE SUMMARY A 66-year-old polymorbid male patient presented with several superficial abscesses on both lower legs and painful swelling in the knee.Treatment for septic arthritis and septic skin infection over several weeks failed.His general condition deteriorated gradually and worsened with sudden onset of abdominal pain.A diagnosis of necrotizing pancreatitis was made.He subsequently underwent a laparotomy and drainage of the pancreas.Eventually,our patient improved,and his abdominal complaints,knee pain,and dermal lesions resolved.CONCLUSION PPP syndrome is rare and easily misdiagnosed,as abdominal symptoms may be delayed or absent.Clinicians should consider PPP syndrome if they encounter refractory panniculitis in combination with joint infection. | Hannes Pichler Thomas Stumpner Dietmar Schiller Martin Bischofreiter Reinhold Ortmaier | 2023 | World Journal of Clinical Cases2023，11，18： | 0 |
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