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| 1 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 2 | High-throughput screening of novel antagonists on melanin-concentrating hormone receptor-1显示文摘瞄准:通过高产量的屏蔽在人的集中黑素的荷尔蒙 receptor-1 ( MCHR-1 )上发现新对手( HTS )多样的复合 library.Methods : MCHR-1 ,[ 3H ] SNAP7941 ,并且 FlashBlue G-protein-coupled 受体祷告被用来基于焕发最近试金(矿泉)测量各种各样的混合物的受体绑定活动 technology.The 海鸟粪正弦5'(gamma-[ 35S ] thio ) triphosphate ([ 35S ] GTP γ S )有约束力的试金随后被使用机能上地描绘“点击”识别由 HTS campaign.Results :与 SPA 方法屏蔽的 48 240 混合物, 12 点击被证实拥有 MCHR-1 有约束力的活动, 8 机能上地随后被学习与[ 35S ] GTP 鲸鱼群妈 S 有约束力的试金,并且仅仅 1 混合物( NC127816 )显示了中等人的 MCHR-1 有约束力的亲密关系( K_i=115.7 nmol/L )并且相对, .This 加重的有势力对抗( K_B=23.8 nmol/L )在 group.Conclusion 与 3 另外的类似物分享新奇脚手架( 1-ethoxy-2H-2-aza-1-phospha-naphthalene 1氧化物):就在在 NC127816 之间的分子的形状和静电的地位的显著差别而言并且结构在其它地方报导了,我们预计它的衍生物可以代表有势力 MCHR-1 调节的人的一个新班。 | Jian-hua YAN Qun-yi LI Jean A BOUTIN M Pierre RENARD Yi-xiang DING Xiao-jiang HAO Wei-min ZHAO Ming-wei WANG | 2008 | Acta Pharmacologica Sinica2008，29，6： | 1 |
| 3 | Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients With Cirrhosis显示文摘 | Pierre–Emmanuel Rautou Julie Bresson Yannis Sainte–Marie Anne–Clemence Vion Valerie Paradis Jean–Marie Renard Cecile Devue Christophe Heymes Philippe Letteron Laure Elkrief Didier Lebrec Dominique Valla Alain Tedgui Richard Moreau Chantal M. Boulanger | 2012 | Gastroenterology2012，，1： | 1 |
| 4 | Structure–activity relationships of urotensin II and URP显示文摘 | Jér?me Leprince David Chatenet Christophe Dubessy Alain Fournier Bruno Pfeiffer Elizabeth Scalbert Pierre Renard Pierre Pacaud Hassan Oulyadi Isabelle Ségalas-Milazzo Laure Guilhaudis Daniel Davoust Marie-Christine Tonon Hubert Vaudry | 2007 | Peptides2007，，5： | 1 |
| 5 | Antennal sensilla and their possible functions in the host-plant selection behavior of Phenacoccus Manihoti(Matile-ferrero)(Homoptera:Pseudococcidae)显示文摘 | Bruno Pierre Le Ru T Sophie Renard | 1995 | Insect Morphol&Embryol1995，24，4： | 1 |
| 6 | W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway显示文摘最近的证据证明那高葡萄糖铺平成员糖类反应元素绑定蛋白质,它绑交往 thioredoxin 蛋白质(txnip ) 的倡导者,从而在房间调整它的表示。txnip 的 Overexpression 不仅导致房间 apoptosis 而且减少胰岛素生产。因此,禁止 TXNIP 活动或压制它的表示的混合物的发现是现在的学习的焦点。INS-1E 房间稳定地,倡导者连接了到酶记者 plasmid (CL108 ) 的有近似葡萄糖反应元素连接了到酶记者 plasmid (BG73 ) 的 txnip 或全身的 txnip 的 transfected 分别地在主要、第二等的高产量的屏蔽运动被使用。从 256 000 合成混合物,小分子混合物, W2476 [9-((1-(4-acetyl-phenyloxy )-ethyl)-2-)adenine], 作为调整 TXNIP 的发信号小径追随者的一个调节的人被识别屏蔽并且使用一组生物鉴定描绘。W2476 的预防、治疗学的性质进一步在导致 streptozotocin 的糖尿病、导致食谱的肥胖的老鼠被检验。有 W2476 (1, 5,和 15 mol/L ) 的处理 dose-dependently 在 INS-1E 房间和老鼠在 mRNA 和蛋白质层次禁止了高导致葡萄糖的 TXNIP 表示胰腺的小岛。而且, W2476 处理阻止了 INS-1E 房间高葡萄糖的长期的暴露导致并且在 vitro 提高了胰岛素生产的 apoptosis。W2476 的口头的管理(200 mg 愠潰瑰獯獩? | Ting LI Guang-yao LIN Li ZHONG Yan ZHOU Jia WANG Yue ZHU Yang FENG Xiao-qing CAI Qing LIU Olivier NOSJEAN Jean A BOUTIN Pierre RENARD De-hua YANG Ming-wei WANG | 2017 | Acta Pharmacologica Sinica2017，38，7： | 1 |
| 7 | A pollen-dispersal experiment with transgenic oilseed rape. Estimation of the average pollen dispersal of an individual plant within a field显示文摘 | C. Lavigne E. K. Klein P. Vallée J. Pierre B. Godelle M. Renard | 1998 | TAG Theoretical and Applied Genetics (-)1998，，6： | 1 |
| 8 | High-throughput screening assay for new ligands at human melatonin receptors显示文摘瞄准:Melatonin (MT ) 是首先松果状的腺以一种生理节奏的方式生产并且藏匿的神经激素,并且主要通过 2 种受体子类型行动:在人的 MT 1 和 MT 2 。在他们的织物分发的差异赞成为每种受体子类型的不同功能。选择调节的人因此被要求在病理学的过程决定这些 melatonin 受体子类型和他们的含意的生理的角色。方法:同质的 MT 1/MT2 受体绑定试金为在 hMT 1 或 hMT 2 受体的新 ligands 的高产量的屏蔽被建立。功能的性质(收缩筋或对手) 被常规 guanosine-5' 估计[γ-35 S ] triphosphate (GTP-γS ) 试金。结果:三 hMT 1 受体选择的小分子对手和 1 hMT 2 有新奇结构的特征的受体选择的小分子对手被识别跟随 48 240 合成、自然的混合物的一个高产量的屏蔽运动。结论:调查结果可以在化学探针的扩大帮助到这 2 种受体子类型。 | Jian-hua YAN Hao-ran SU Jean A BOUTIN M Pierre RENARD Ming-wei WANG | 2008 | Acta Pharmacologica Sinica2008，29，12： | 0 |
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